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From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger tran hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

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Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests

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Journal of Forestry Research 2020年第5期31卷 1713-1722页

作者： tran Van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai hung Hoang Van Thang tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang hung tran Hoang Quy Pham Quang Tuyen Trinh Ngoc Bon Nguyen Thi Thu Phuong Ninh Viet Khuong Nguyen Van Tuan Dang Thi Hai Ha tran Hai Long Dang Van Thuyet Dang Thinh Trieu Nguyen Van Thinh tran Anh Hai Duong Quang Trung Nguyen Van Bich Dinh Hai Dang Pham Tien Dung Nguyen Huy Hoang Le Thi Hanh Phan Minh Quang Nguyen Thi Thuy Huong Hoang Thanh Son Nguyen Thanh Son Nguyen Thi Van Anh Nguyen Thi Hoai Anh Pham Dinh Sam Hoang Thi Nhung Hoang Van Thanh Nguyen Huu Thinh tran Hong Van Ho Trung Luong Bui Kieu hung Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyotoJapan Silviculture Research Institute Vietnamese Academy of Forest SciencesNorth Tu LiemHanoiVietnam Center for Southeast Asian Studies Kyoto UniversityKyotoJapan Vietnamese Academy of Forest Sciences North Tu LiemHanoiVietnam Vietnam Administration of Forestry No.2 Ngoc HaBa DinhHanoiVietnam

Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest *** study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was *** results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of *** area and AGB are positively correlated with trees>30 cm *** areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-*** percent of the areas surveyed had stand densities of 300–600 ***^-1,and 64%had basal areas of 20–40 m^2 ha^-*** is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in *** causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density.

关键词： Aboveground biomass Carbon storage Climatic variables Ecoregion Edaphic variables Oldgrowth forest

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Experimental Study of the Collective and Cyclic Pitch Propeller for an Underwater Vehicle

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Journal of Marine Science and Application 2018年第4期17卷 592-602页

作者： Minh tran Jonathan Binns Shuhong Chai Alex Forrest hung Nguyen Australian Maritime College College of Sciences and EngineeringUniversity of Tasmania Department of Civil and Environmental Engineering University of California

A series of experimental studies of the innovative propulsor named Collective and Cyclic Pitch Propeller(CCPP) applied to an underwater vehicle were designed and performed at the Australian Maritime College, University of Tasmania. The bollard pull and captive model tests were conducted to investigate the characteristics of CCPP and to examine the effect of different parameter settings to its performance. The results show that the CCPP is able to generate effective manoeuvring forces in various operational condition. In addition, the obtained results in the form of force coefficients provide a useful empirical model for the simulation and control of an underwater vehicle equipped with this propulsor.

关键词： Collective and cyclic pitch propeller Underwater vehicle propulsion Towing tank test Bollard pull test Captive model test Autonomous underwater vehicle

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A Study on Modelling Surface Finish in Electrical Discharge Machining Tablet Shape Punches Using Response Surface Methodology

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Journal of Environmental Science and Engineering(B) 2017年第7期6卷 387-390页

作者： Le Xuan hung tran Thanh Hoang Vu Ngoc Pi Mechanical Engineering Faculty Thai Nguyen University of Technology Thai Nguyen 23000 Vietnam Center for Technical Practice Thai Nguyen University of Technology Thai Nguyen 23000 Vietnam

This paper introduces a study on modelling surface finish in EDM （Electrical Discharge Machining） of tablet shape punches when using copper as electrode material. In this study, 27 experiments were performed based on BBD （Box-Behnken Design） and the work-piece material was 9CrSi steel. The input process parameters were the current, the pulse on time, the pulse off time and the voltage. The effects of the input parameters on the surface finish were evaluated by analysing variance. Besides, from the results of the experiments, a regression equation for determining the surface roughness is introduced. Also, the optimum input parameter values were found in order to get the minimum surface roughness.

关键词： EDM (Electrical Discharge Machining) EDM sinking surface roughness RSM (Response Surface Methodology) BBD(Box-Behken Design).

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An Analytical Approach for Nonlinear Buckling Analysis of Torsionally Loaded Sandwich Carbon Nanotube Reinforced Cylindrical Shells with Auxetic Core

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Advances in Applied Mathematics and Mechanics 2023年第2期15卷 468-484页

作者： Dang Thuy Dong Nguyen Thi Phuong Vu Hoai Nam Le Ngoc Ly Nguyen Van Tien Vu Minh Duc tran Quang Minh Vu Tho hung Nguyen Thi Huong Giang Faculty of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan Faculty of Fundamental Science for Engineering University of Transport TechnologyHanoi 100000Vietnam

The main aim of this paper is to present an analytical approach on the postbuckling for torsionally loaded sandwich carbon nanotube(CNT)reinforced cylindrical shells with the auxetic *** considered shells consist of three layers,external and internal CNT reinforced layers,and the auxetic lattice core made by isotropic *** homogenization model for honeycomb auxetic lattice core is utilized,and the equilibrium equations are formulated based on the nonlinear Donnell’s thin shell theory with von Karman geometrical *** three terms of deflection are considered,the Airy’s stress function and Galerkin’s method are utilized,the explicit expression of critical buckling of torsionally loaded shells and load-deflection expression of postbuckling states are *** effects of two carbon nanotube reinforced layers,the auxetic core layer,the volume fraction of carbon nanotube on the torsional buckling behavior are examined and remarked.

关键词： Nonlinear postbuckling carbon nanotube reinforced composite cylindrical shell torsion auxetic core

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Prediction of human microRNA hairpins using only positive sample learning

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Journal of Biomedical Science and Engineering 2008年第2期1卷 141-146页

作者： Dang hung tran Tho Hoan Pham Kenji Satou Tu Bao Ho Hanoi National University of Education Japan Advanced Institute of Science and Technology

MicroRNAs(miRNA) are small molecular non-coding RNAs that have important roles in the post-transcriptional mechanism of animal and plant. They are commonly 21-25 nucleotides (nt) long and derived from 60-90 nt RNA hairpin structures, called miRNA hairpins. A larger num-ber of sequence segments in the human genome have been computationally identified with such 60-90 nt hairpins, however a majority of them are not miRNA hairpins. Most computational meth-ods so far for predicting miRNA hairpins were based on a two-class classifier to distinguish between miRNA hairpins and other sequence segments with hairpin structures. The difficulty of these methods is how to select hairpins as negative examples of miRNA hairpins in the classifier-training datasets, since only a few miRNA hairpins are available. Therefore, their classifier may be mis-trained due to some false negative examples of the training dataset. In this paper, we introduce a one-class support vector machine (SVM) method to predict miRNA hair-pins among the hairpin structures. Different from existing methods for predicting miRNA hairpins, the one-class SVM model is trained only on the information of the miRNA class. We also illus-trate some examples of predicting miRNA hair-pins in human chromosomes 10, 15, and 21, where our method overcomes the above disad-vantages of existing two-class methods.

关键词： MicroRNA Hairpin One-class SVM

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Evaluation of the Ability to Apply Near-Infrared Spectroscopy on Direct Assay of Acyclovir in Tablets

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 841-849页

作者： Le Dinh Chi tran Viet hung Bui Van Trung Doan Cao Son . The Department of Analytical Chemistry and Toxicology Hanoi University of Pharmacy Hanoi 110403 Vietnam Director Institute of Drug Quality Control Ho Chi Minh City Ho Chi Minh City 712161 Vietnam The Laboratory of Physical Measurements National Institute of Drug Quality Control Hanoi 110116 Vietnam Director National Institute of Drug Quality Control Hanoi 110116 Vietnam

This paper aimed at developing a simple and fast approach using chemometrics processing for direct assay of acyclovir in tablets by NIR （near infrared） spectroscopy in diffuse reflectance mode. In making trials with 5 different tablet matrices, the experimental results showed that regardless the matrix variation, it was always possible to construct a quantitative model with suitable linear range, accuracy and precision for direct assay of acyclovir in tablet from NIR spectra. Therefore, the approach used in this study was suitable for on-site fast assay of APIs in tablets during manufacturing process or in post-marketing surveillance of drug quality.

关键词： Near-infrared spectroscopy chemometrics acyclovir tablet partial least square regression direct assay.

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苦苣苔科凹柱苣苔属在越南的发现及水晶凹柱苣苔的补充描述

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广西植物 2020年第10期40卷 1445-1449页

作者：陆昭岑 NGUYEN Khang Sinh PHAN Ke loc tran Thi Phuong Anh 许为斌广西喀斯特植物保育和恢复生态学重点实验室广西壮族自治区中国科学院广西植物研究所中国广西桂林541006 越南科学技术研究院生态与生物资源研究所越南河内10072 越南科学技术研究院科学技术研究生院越南河内10000 越南国立大学河内科学院越南河内11416

中越边境喀斯特地区有着异乎寻常的植物多样性,已经成为全球生物多样性研究和保护的热点区域,近年来在该区发现了多个苦苣苔科植物的新种或新属。凹柱苣苔属是2010年才被建立的新属,该属的花与叶相比,花较大,叶相对较小,叶片边缘稍外卷... 详细信息

中越边境喀斯特地区有着异乎寻常的植物多样性,已经成为全球生物多样性研究和保护的热点区域,近年来在该区发现了多个苦苣苔科植物的新种或新属。凹柱苣苔属是2010年才被建立的新属,该属的花与叶相比,花较大,叶相对较小,叶片边缘稍外卷,花序仅单花,柱头盘状或凹坑状,蒴果长椭球形而有别于苦苣苔科的其他属。凹柱苣苔属为喀斯特专性植物,目前仅包括分布于黔西南的凹柱苣苔和分布于滇东南的水晶凹柱苣苔两个物种。作者在开展中越边境喀斯特地区植物多样性调查时,在越南北部的河江省发现了水晶凹柱苣苔,基于该新发现居群的植物标本,对其进行了补充描述,确认其花期为11月—12月,并对该物种濒危状况进行了重新评估,同时提供了野外生态照片以资辨认。目前,越南已记录苦苣苔科植物32属150余种,凹柱苣苔属在越南北部的发现,不仅丰富了该国苦苣苔科植物的多样性,再一次充分证明了中越边境喀斯特地区是一个完整的植物区系地理单元,而且为稀有的水晶凹柱苣苔提供了更加丰富的野外本底资料,对其将来的深入研究和保护具有重要的生物地理学和保护生物学意义。

关键词：越南植物区系石灰岩植物区系中越边境喀斯特地貌

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Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis Isolates from Swine in Quang Binh and Thua Thien Hue Provinces, Vietnam

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Engineering 2020年第1期6卷 40-48页

作者： Chao Nguyen Van Lijun Zhang Tam Vu Thi Thanh hung Pham Hoang Son Tuan tran Ngoc Qi Huang Rui Zhou State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Faculty of Animal Science and Veterinary Medicine University of Agricultural and ForestryHue UniversityHue 53000Vietnam Mientrung Institute for Scientific Research Vietnam Academy of Science and TechnologyHue 53000Vietnam Guangdong Provincial Key Laboratory of Marine Biology Shantou UniversityShantou 515063China Cooperative Innovation Center of Sustainable Pig Production Wuhan 430070China International Research Center for Animal Diseases The Ministry of Science and TechnologyWuhan 430070China

Haemophilus parasuis (H. parasuis) is one of the bacterial pathogens of great concern as it causes huge economic losses to the swine industry worldwide. One of the reasons why the control of H. parasuis has failed is the increase in antimicrobial resistance (AMR). The country of Vietnam has the second-largest pig production in Asia. However, there is still a lack of data about the AMR prevalence of H. parasuis in *** purpose of this study is to investigate the prevalence of AMR and analyze the association between AMR and AMR genes (ARGs). The H. parasuis strains used in this research were isolated from swine in the Quang Binh and Thua Thien Hue Provinces, Central Vietnam, as reported in our previous study. All of the strains were tested for AMR against 25 antibacterial agents using the broth microdilution method and for the presence of ARGs using the polymerase chain reaction (PCR) method. The tested strains were shown to have a high frequency of resistance to trimethoprim/sulfamethoxazole (94.6%), followed by resistance to colistin, chloramphenicol, gentamicin, penicillin, lincomycin, and amoxicillin. The most prevalent ARGs in these strains were blaTEM-1 (94.6%), int (76.8%), gyrA (58.9%), and rmtD (50.0%). Cefuroxime, chloramphenicol, and tobramycin resistances were strongly correlated with the presence of the ARGs blaROB-1 (odds ratio (OR) = 26.3, 95% confidence interval (CI) 2.7–255.7, p = 0.002), catl (OR = 25.1, 95% CI 2.4–258.9, p = 0.004), and strB (OR = 23.5, 95% CI 2.6–212.6, p = 0.001), *** study reveals for the first time the current situation of H. parasuis AMR in Central Vietnam, which is helpful for the clinical control of this disease, as well as for the development of policies and clinical practice guidelines to reduce AMR in swine production in Central Vietnam.

关键词： Haemophilus parasuis Antimicrobial resistance Antimicrobial resistance gene Vietnam

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Strategic Collision Avoidance Based on Planned Route and Navigational Information transmitted by AIS

Strategic Collision Avoidance Based on Planned Route and Nav...

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Asia Navigation Conference 2005

作者： tran Viet hung Hideki HAGIWARA Hitoi TAMARU Kohei OHTSU Ruri SHOJI Graduate school Tokyo University of Marine Science and Technology 2-1-6 EtchujimaKoto-ku Tokyo135-8533Japan Tokyo University of Marine Science and Technology 2-1-6 Etchujima Koto-ku Tokyo135-8533Japan Tokyo University of Marine Science and Technology 2-1-6 Etchujima Koto-ku Tokyo135-8533Japan Tokyo University of Marine Science and Technology 2-1-6 Etchujima Koto-ku Tokyo135-8533Japan Tokyo University of Marine Science and Technology 2-1-6 Etchujima Koto-ku Tokyo135-8533Japan

＜正＞In order to improve the safety and efficiency of ship operations, PTMS （Port Traffic Management System） developed from 2001 is applied to find out an optimal route of own ship in congested waters. In this study, the optimal route is calculated based on planned routes and navigational information of target ships transmitted by AIS （Automatic Identification System） using Dynamic Programming. As the results of simulations, it was found that in congested waters with dangerous crossing encounters, only altering course of own ship is not adequate to navigate fast and safely;on the other hand, reducing speed of own ship is effective to shorten passage time and also increase the safety of navigation. Furthermore, in order to confirm the effectiveness of the optimal route, actual data of vessel traffic obtained from radar observation of Tokyo Bay and AIS were used to carry out some simulations. As the results, it could be concluded that in the actual waters such as off Ogishima and the south of Uraga Suido Traffic Route, it is very beneficial to obtain information of other ships’ planned routes and speeds for making a safe and fast route of own ship.

关键词： PTMS Dynamic Programming Optimal route Reducing speed Radar observation AIS

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