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Cathepsins in neuronal plasticity

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Neural Regeneration Research 2021年第1期16卷 26-35页

作者： Amanda phuong tran Jerry Silver Center for Integrative Brain Research Seattle Children’s Research InstituteSeattleWAUSA Department of Neurosciences Case Western Reserve UniversityClevelandOHUSA

Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins,resulting in protein ***,specifically,encompass a class of at least twenty proteases with potent endopeptidase *** are located subcellularly in lysosomes,organelles responsible for the cell’s degradative and autophagic processes,and are vital for normal lysosomal *** cathepsins are involved in a multitude of cell signaling activities,this chapter will focus on the role of cathepsins(with a special emphasis on Cathepsin B)in neuronal *** will broadly define what is known about regulation of cathepsins in the central nervous system and compare this with their dysregulation after injury or ***,we will delineate what is currently known about the role of cathepsins in axon regeneration and plasticity after spinal cord *** is well established that normal cathepsin activity is integral to the function of *** normal lysosomal function,autophagy and other homeostatic cellular processes become dysregulated resulting in axon ***,controlled activation of cathepsins at specialized neuronal structures such as axonal growth cones and dendritic spines have been positively implicated in their *** chapter will end with a perspective on the consequences of cathepsin dysregulation versus controlled,localized regulation to clarify how cathepsins can contribute to both neuronal plasticity and neurodegeneration.

关键词： axon regeneration cathepsin CSPGs extracellular matrix growth cone lysosomes neuronal plasticity protease remodeling spinal cord injury synaptogenesis

GLOBAL BOUND ON THE GRADIENT OF SOLUTIONS TO p-LAPLACE TYPE EQUATIONS WITH MIXED DATA

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Acta Mathematica Scientia 2024年第4期44卷 1394-1414页

作者： Minh-phuong tran The-Quang tran Thanh-Nhan NGUYEN Applied Analysis Research Group Faculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam Nguyen Huu Huan High School Thu Duc CityVietnam Group of Analysis and Applied Mathematics Department of MathematicsHo Chi Minh City University of EducationVietnam

In this paper,the study of gradient regularity for solutions of a class of elliptic problems of p-Laplace type is *** particular,we prove a global result concerning Lorentz-Morrey regularity of the non-homogeneous boundary data problem:-div((s^(2)+|▽u|^(2)p-2/2)▽u)=-div(|f|^(p-2)f)+g inΩ,u=h in■Ω,with the(sub-elliptic)degeneracy condition s∈[0,1]and with mixed data f∈L^(p)(Q;R^(n)),g∈Lp/(p-1)(Ω;R^(n))for p∈(1,n).This problem naturally arises in various applications such as dynamics of non-Newtonian fluid theory,electro-rheology,radiation of heat,plastic moulding and many *** on the idea of level-set inequality on fractional maximal distribution functions,it enables us to carry out a global regularity result of the solution via fractional maximal *** to the significance of M_(α)and its relation with Riesz potential,estimates via fractional maximal functions allow us to bound oscillations not only for solution but also its fractional derivatives of orderα.Our approach therefore has its own interest.

关键词： gradient estimates p-Laplace quasilinear elliptic equation fractional maximal operators Lorentz-Morrey spaces

Evaluation of Weathering Performance of Rosin-Copper Based Treated Wood

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Journal of Renewable Materials 2022年第11期10卷 2765-2780页

作者： Thi Thanh Hien Nguyen Nho Quyet tran Thi Minh Nguyet Nguyen Hien mai Trinh Xuan phuong Le Trong Kien Nguyen College of Wood Industry and Interior Design Vietnam National University of ForestryHa NoiViet Nam College of Economics and Management Northeast Forestry UniversityHarbinChina

This study aimed to evaluate the effect of natural weathering on some surface characteristics and mechanical properties of Styrax wood treated with mixtures of 1.0%,2.0%,or 4.0%rosin sizing agent and 3%copper *** samples after treatment were exposed to outdoor conditions for one year and changes in color,glossiness,weight loss,compression strength parallel to grain(CSPG),modulus of rupture(MOR),and modulus of elasticity(MOE)were investigated after 6 and 12-month of natural *** results showed that rosin-copper treatment could improve color stability and gloss of samples after *** losses of all rosin-copper treated samples after 12 months of exposure were negligible compared with the untreated control *** addition,rosin-copper treatment enhanced the CSPG compared to untreated controls,but slightly decreased the MOR and MOE of Styrax wood before *** weathering factors induced a reduction for all strength properties,however,the decrease rate for strength properties of rosin-copper treated samples was negligible compared with the untreated control samples after 12-month natural weathering *** FTIR and SEM-EDX confirmed that the use of the rosin-copper formulations to impregnate wood could decrease the hazard of the copper preservative leaching into the environment,while also enhancing more resistance against weathering factors and other biotic factors.

关键词： Rosin-copper weathering color stability CSPG MOR MOE

Fabrication of zinc-based coordination polymer nano-cubes and post-modification through copper decoration

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Nano Research 2018年第11期11卷 5890-5901页

作者： Ngoc Minh tran Hien Duy mai Hyojong Yoo Department of Chemistry Hallym University Chuncheon Gangwon-do 24252 Republic of Korea

Coordination polymer particles (CPPs) with a high degree of porosity and multi-functional reaction sites are promising for diverse applications. The integration of open sites favorable for the post-modification of CPPs presents a unique opportunity for the rational design of inorganic materials with target-oriented functions. Herein, we report a shape-controllable synthetic protocol for zinc-based coordination polymer nanocubes (Zn-CPNs). In the synthesis, 2,6-bis[(4-carboxyanilino)carbonyl] pyridine ([N3]) ligand is employed as an efficient shape-directing modulator to control the size and shape of Zn-CPNs. More importantly, the [N3] ligand provides metal binding sites suitable for the decoration of other functional metals such as copper ions. The copper-modified Zn-CPNs (Cu_Zn-CPNs) show good activities in a heterogeneous catalytic reaction.

关键词： zinc-based coordination polymer nanocubes shape-directing modulator size and shape controls post-modification heterogeneous catalytic reaction

Prediction of acute stroke progression by the National Institutes of Health Stroke Scale

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Journal of Geriatric Cardiology 2007年第4期4卷 225-228页

作者： Vinh phuong tran Van Huy Department of Geriatric Cardiology Khanh Hoa HospitalVietnam

Objective To determine the occurrence of neurological changes during the first 48 hours after acute stroke as it relates to the initial stroke severity assessment. Methods The assessment with the National Institutes of Health Stroke Scale (NIHSS) was performed serially for the first 48 hours on 68 consecutive ischemic stroke patients admitted to the Department of Geriatric Cardiology at the Khanh Hoa Hospital, Nha trang, Vietnam. Incidence of stroke progression (a ≥ 3-point increase on the NIHSS) was recorded and analysis performed to determine its association with initial stroke severity and other demographic and physiological variables. Deficit resolution by 48 hours, defined as an NIHSS score of 0 or 1, measured the frequency of functional recovery predicted by the initial deficit. Results Overall progression was noted in 28% of events (19/68). Applying Bayes' solution to the observed frequency of worsening, the greatest likelihood of predicting future patient progression occurred with NIHSS score of =7 and >7. Patients with an initial NIHSS score of =7 experienced a 13% (6/47) worsening rate versus those of an initial score of >7 with a 62% (13/21) worsening rate (P7 returned to a normal examination within this period (χ2, P<0.05). Conclusions This study suggests that the early clinical course of neurological deficit after acute stroke be dependent on the initial stroke severity and that a dichotomy in early outcome exist surrounding an initial NIHSS score of 7. These findings may have significant implications for the design and patient stratification in treatment protocols with respect to primary clinical outcome.(J Geriatr Cardiol 2007;4:225-228.)

关键词： stroke prediction

Viral co-infections among children with confirmed measles at hospitals in Hanoi,Vietnam,2014

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 164-167页

作者： Hang Le Khanh Nguyen Loan phuong Do Van Thanh Thi Trieu Son Vu Nguyen phuong Vu mai Hoang Hien Thi Pham Thanh Thi Le Huong Thi Thu tran Cuong Duc Vuong mai Thi Quynh Le National Institute of Hygiene and Epidemiology No 1-Yesrsin streetHanoiVietnam

Objective:To characterize viral co-infections among representative hospitalized measles cases during the 2014 Hanoi ***:Throat swabs were collected from 54 pediatric patients with confirmed measles,and molecular diagnostics performed for 10 additional viral respiratory pathogens(Influenza A/H1N1pdm09;A/H3N2 and influenza B;Parainfluenza 1,2,3;Respiratory Synctial Virus,RSV;human Metapneumovirus,hM PV;Adenovirus and Picornavirus).Results:Twenty-one cases(38.9%) showed evidence of infection with other respiratory viruses:15 samples contained measles plus one additional virus,and 6 samples contained measles plus 2 additional *** was detected as a predominant cause of co-infections(13 cases;24.1%),followed by RSV(6 cases;11.1%),A/H1N1pdm09(3 cases;5.6%),PIV3(3 cases;3.7%),Rhinovirus(3 cases;3.7%) and hM PV(1 case;1.96%).Conclusions:Viral co-infections identified from pediatric measles cases may have contributed to increased disease severity and high rate of fatal *** treatment of measles cases may require control of multiple viral respiratory pathogens.

关键词： Measles virus Respiratory viruses Co-infection

Perspectives on “the biology of spinal cord regeneration success and failure”

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Neural Regeneration Research 2018年第8期13卷 1358-1359页

作者： Philippa Mary Warren Amanda phuong tran Jerry Silver School of Biomedical Sciences University of Leeds Department of Neurosciences Case Western Reserve University

In our recently co-authored Physiological Reviews manuscript entitled ＂The biology of regeneration failure and success after spinal cord injury＂（tran et al., 2018b）, we sought to provide a comprehensive and up-to-date de- scription of how the glial scar develops following spinal cord injury （SCI） to chronically inhibit axon regeneration.

关键词： the biology of spinal cord regeneration success and failure SCI

An isogeometric approach to free vibration analysis of bi-directional functionally graded porous doubly-curved shallow microshells with variable length-scale parameters

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Frontiers of Structural and Civil Engineering 2023年第12期17卷 1871-1894页

作者： Khuat Duc DUONG Dao Nhu mai Phung Van MINH tran Van KE Faculty of Mechanical Engineering Hanoi University of IndustryHanoi 100000Vietnam Institute of Mechanics Vietnam Academy of Science and TechnologyHanoi 100000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam

This study uses iso-geometric investigation,which is based on the non-uniform rational B-splines(NURBS)basis function,to investigate natural oscillation of bi-directional functionally graded porous(BFGP)doublycurved shallow microshells placed on Pasternak foundations with any boundary *** characteristics of the present material vary in both thickness and axial directions along the *** be more specific,a material length-scale coefficient of the microshell varies in both thickness and length directions as the material's mechanical *** is able to develop a differential equation system with varying coefficients that regulate the motion of BFGP double-curved shallow microshells by using Hamilton principle,Kirchhoff-Love hypothesis,and modified couple stress *** numerical findings are reported for thin microshells that are spherical,cylindrical,and hyperbolic paraboloidal,with a variety of planforms,including rectangles and *** validity and effectiveness of the established model are shown by comparing the numerical results given by the proposed formulations with previously published findings in many specific *** addition,influences of length scale parameters,power-law indexes,thickness-to-side ratio,and radius ratio on natural oscillation responses of BFGP microshells are investigated in detail.

关键词： Kirchhoff-Love's shell theory isogeometric analysis bi-directional functionally graded free vibration variable length-scale parameter

A Life-cycle Assessment on the Environmental Impacts of Photovoltaic Panels in Vietnam ——A Case Study in TTC Krongpa Plant

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A Life-cycle Assessment on the Environmental Impacts of Phot...

作者： Bui mai phuong Thao 中国石油大学(北京)

学位级别：硕士

Solar power is undergoing rapid change in its production,performance and *** a high average annual radiation volume due to its geographical location situated in the sub-equatorial region,Vietnam has much potential for the development of solar ***,there is a significant change in solar energy industry which is the geographical shift in solar panel *** panel factories are being built more and more in Asian countries,including *** is necessary to conduct an in-depth evaluation to assess the potential environmental effects of the photovoltaic（PV）panel life-cycle in Vietnam,including raw materials extraction and manufacturing,transportation,as well as its operation,maintenance,and recycling or disposal over its *** assessment will make a substantial contribution to the evolution of the solar power sector in *** study aims to analyze the development of Vietnam photovoltaic systems,and propose an all-inclusive method to evaluate the environmental impacts of PV panels life cycle from *** study chose the TTC Krongpa solar plant in Vietnam as a case-study plant to *** life cycle assessment（LCA）method was used to assess impacts of PV cell life-cycle on the environment with the help of Open LCA *** Energy Demand methodology was used in the system to determine the CED value,which was important for determining *** IPCC GWP 20a and IPCC GWP 100a methods were used to analyzed the GWP over the periods of 20 and *** this study,the environmental impacts were assessed by utilizing the IMPACT2002+approach,which evaluated both midpoints and endpoints for each *** assessment was conduct by TRACI 2.1 and Recipe 2016 methodologies to make a broader *** the study,the cumulative energy demand（CED）and the mean energy pay back time（EPBT）of the system were obtained as the value of 9740.51 MJ and 6.5 years,*** global warming potential（GWP）was

关键词： Solar Power Photovoltaic Panel Life Cycle Assessment Vietnam