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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： baolong Liu Phuong Linh nguyen Han Yu Xingzhi Li Huiren Wang tram gia bao nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

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A Truck Scheduling Problem for Multi-Crossdocking System with Metaheuristics

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Computers, Materials & Continua 2022年第9期72卷 5165-5178页

作者： Phan nguyen Ky Phuc nguyen Van Thanh Duong bao tram International University-Vietnam National University Vietnam National UniversityHoChiMinh City70000Vietnam Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam

The cross-docking is a very important subject in logistics and supply chain *** to the definition,cross-docking is a process dealing with transhipping inventory,in which goods and products are unloaded from an inbound truck and process through a flow-center to be directly loaded onto an outbound ***-docking is favored due to its advantages in reducing the material handing cost,the needs to store the product in warehouse,as well decreasing the labor cost by eliminating packaging,storing,pick-location and order *** cross-docking,products can be consolidated and transported as a full load,reducing overall distribution *** this paper,we focus on a truck scheduling at the multidoor,multi-crossdocking network with inventory constraints and process capability *** this model,a truck can visit severals docks for loading or unloading many types *** situation is very common in *** study also developed an exact mathematical model using mixedinteger linear programming(MILP)with the objective of minimizing the makespan to obtaint the benchmark in small scale *** scale problems are solved through Simulated Annealing(SA)algorithm and Tabu Search(TS)*** of these algorithms will be compared to benchmarks obtained from solver as well as to each other.

关键词： Truck scheduling multi-door multi-crossdocking network simulated annealing tabu search

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Optimizing Bidders Selection of Multi-Round Procurement Problem in Software Project Management Using Parallel Max-Min Ant System Algorithm

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Computers, Materials & Continua 2021年第1期66卷 993-1010页

作者： Dac-Nhuong Le gia Nhu nguyen arish Garg Quyet-Thang Huynh Trinh Ngoc bao nguyen Ngoc Tuan Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Haiphong UniversityHaiphong180000Vietnam Graduate School Duy Tan UniversityDa Nang550000Vietnam School of Mathematics Thapar Institute of Engineering and TechnologyPatiala147004India Hanoi University of Science and Technology Hanoi100000Vietnam Hanoi University Hanoi100000Vietnam Department of ICT Ministry of Education and TrainingHanoi100000Vietnam

This paper presents a Game-theoretic optimization via Parallel Min-Max Ant System(PMMAS)algorithm is used in practice to determine the Nash equilibrium value to resolve the confusion in choosing appropriate bidders of multi-round procurement problem in software project *** this end,we introduce an approach that proposes:(i)A Game-theoretic model of multiround procurement problem(ii)A Nash equilibrium strategy corresponds to multi-round strategy bid(iii)An application of PSO for the determination of global Nash *** balance point in Nash Equilibrium can help to maintain a sustainable structure not only in terms of project management but also in terms of future *** an alternative of procuring entities subjectively,a methodology to support decision making has been studied using Nash equilibrium to create a balance point on benefit in procurement where buyers and suppliers need multiple rounds of *** goal focus on the balance point in Nash Equilibrium to optimizing bidder selection in multi-round procurement which is the most beneficial for both investors and selected *** PMMAS algorithm is implemented based on MPI(message passing interface)to find the approximate optimal solution for the question of how to choose bidders and ensure a path for a win-win relationship of all participants in the procurement *** also evaluate the speedup ratio and parallel efficiency between our algorithm and other proposed *** the experiment results,the high feasibility and effectiveness of the PMMAS algorithm are verified.

关键词： Parallel min-max ant system multi-objective multi-round procurement software project management project conflicts Nash equilibrium game theory MPI

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Privacy Preserving Blockchain Technique to Achieve Secure and Reliable Sharing of IoT Data

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Computers, Materials & Continua 2020年第10期65卷 87-107页

作者： bao Le nguyen E.Laxmi Lydia Mohamed Elhoseny Irina V.Pustokhina Denis A.Pustokhin Mahmoud Mohamed Selim gia Nhu nguyen K.Shankar Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Faculty of Computers and Information Mansoura UniversityMansoura35516Egypt Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow115093Russia Department of Logistics State University of ManagementMoscow109542Russia Department of Mathematics College of Science&Humanities in AlaflajPrince Sattam bin Abdulaziz UniversityAlaflaj16278Saudi Arabia Graduate School Duy Tan UniversityDa Nang550000Vietnam Department of Computer Applications Alagappa UniversityKaraikudi630003India

In present digital era,an exponential increase in Internet of Things(IoT)devices poses several design issues for business concerning security and *** studies indicate that the blockchain technology is found to be a significant solution to resolve the challenges of data security exist in *** this view,this paper presents a new privacy-preserving Secure Ant Colony optimization with Multi Kernel Support Vector Machine(ACOMKSVM)with Elliptical Curve cryptosystem(ECC)for secure and reliable IoT data *** program uses blockchain to ensure protection and integrity of some data while it has the technology to create secure ACOMKSVM training algorithms in partial views of IoT data,collected from various data ***,ECC is used to create effective and accurate privacy that protects ACOMKSVM secure learning *** this study,the authors deployed blockchain technique to create a secure and reliable data exchange platform across multiple data providers,where IoT data is encrypted and recorded in a distributed *** security analysis showed that the specific data ensures confidentiality of critical data from each data provider and protects the parameters of the ACOMKSVM model for data *** examine the performance of the proposed method,it is tested against two benchmark dataset such as Breast Cancer Wisconsin Data Set(BCWD)and Heart Disease Data Set(HDD)from UCI AI *** simulation outcome indicated that the ACOMKSVM model has outperformed all the compared methods under several aspects.

关键词： Blockchain optimization elliptical curve cryptosystem security ant colony optimization multi kernel support vector machine

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