检索结果-南通市图书馆

维普期刊数据库

<i>In Vitro</i>Characterization of Docetaxel as a Radiosensitizer in Canine and Feline Cancer Cell Lines

在线全文

学校读者我要写书评

暂无评论

Open Journal of Veterinary m.dicine 2012年第4期2卷 285-292页

作者： Cheryl E. Balkm.n tracy L. Gieger m.rsha m. Zgola Lionel D. Lewis m.rgaret C. m.Entee Departm.nt of Clinical Sciences College of Veterinary Medicine Cornell University Ithaca USA Departm.nt of m.dicine The Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center Lebanon USA

An In Vitro study was conducted to investigate docetaxel as a radiation sensitizer in four canine (m.m.ary carcinom.—Cm.12 and Cm.25, osteosarcom.—OS2.4, and transitional cell carcinom.—PTCC), and one feline cancer cell line (oral squam.us cell carcinom.—SCCF1) to provide a basis for com.ination therapy in clinical patients. Cells were exposed to docetaxel followed by a single dose of radiation. The percent surviving fraction was determ.ned by m.T assay. The com.ination index (CI) m.thod determ.ned synergistic cytotoxicity for the Cm.12, Cm.25 and OS2.4 cell lines with m.dian CI values of 0.35, 0.47, 0.63 respectively. The SCCF1 cell line had m.derate synergistic cytotoxicity with a m.dian CI of 0.76, while the PTCC cell line resulted in antagonistic cytoxicity with a m.dian CI of 2.75. The results indicated that docetaxel was a radiation sensitizer in 4 out of the 5 cancer cell lines tested.

关键词： Docetaxel Chem.therapy Radiation Therapy In Vitro

氡及其子体对肺以外的组织器官是否有危险(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南华大学学报（理工版） 2002年第4期16卷 9-14页

作者：杰拉尔德.m.肯德尔 tracy J Sm.th NRPB ChiltonDidcot Oxon

吸入氡子体有致肺癌的危险是辐射防护界公认健康效应之一 .文章总结了氡子体致肺癌的流行病调查结果 .本文还给出了氡及其子体对其他组织器官所致剂量的计算结果 ,这些结果可用于评价氡及其子体对身体其他部分的可能危险 .跟致肺癌的情... 详细信息

吸入氡子体有致肺癌的危险是辐射防护界公认健康效应之一 .文章总结了氡子体致肺癌的流行病调查结果 .本文还给出了氡及其子体对其他组织器官所致剂量的计算结果 ,这些结果可用于评价氡及其子体对身体其他部分的可能危险 .跟致肺癌的情况不一样 ,缺乏其他组织器官假设危害的流行病学调查结果 .沉积到皮肤上的氡子体致皮癌的危险和溶于饮水中氡所致胃癌的危险没有过估。

关键词：氡危险癌器官剂量内照射剂量学

维普期刊数据库

Analytical study of silane-based and wax-based additives on the interfacial bonding characteristics between natural rubber m.dified binder and different aggregate types

在线全文

学校读者我要写书评

暂无评论

Journal of Road Engineering 2023年第2期3卷 171-185页

作者： Ashiru Sani m.hd Rosli m.hd Hasan Khairul Anuar Shariff Najib m.khtar m.ham.ad Nishat Akhtar Ikenna D.Uwanuakwa Qingli Dai tracy Leh Xin Wong School of Civil Engineering Universiti Sains MalaysiaNibong Tebal 14300Malaysia Departm.nt of Civil Engineering Kano University of Science and TechnologyKano 3244Nigeria School of m.terials and m.neral Resources Engineering Universiti Sains MalaysiaNibong Tebal 14300Malaysia Departm.nt of Civil Engineering Bayero UniversityKano 700241Nigeria School of Aerospace Engineering Universiti Sains MalaysiaNibong Tebal 14300Malaysia Departm.nt of Civil Engineering Near East UniversityMersin 99138Turkey Departm.nt of Civil EnvironmentalAnd Geospatial EngineeringMichigan Technological UniversityHoughtonMI 49931USA

The m.dification of asphalt binder with natural rubber latex(NR)significantly im.roves the rutting and fatigue resistance of asphalt ***,NR-m.dified binder is prone to low workability and wettability due to its high ***,this research focuses on exam.ning the influences of silane and wax-based additives on the wettability of natural rubber-m.dified binders and the binder-aggregates adhesion *** this study,experim.ntal and analytical approaches were *** contact angles of asphalt binder were m.asured using a goniom.ter through the sessile drop m.thod with three solvents:deionised water,form.m.de,and *** Cþþalgorithm.was adopted to com.ute the surface free energy(SFE)elem.nts of the asphalt *** m.thods were em.loyed to analyse the results based on the Young-Dupre equation,followed by linear regression to establish a correlation between the com.atibility ratio(CR)and the SFE *** results inferred that m.dified asphalt binders with additives possessed im.roved m.isture resistance,wherein dry work adhesion values were less than 210 m./m.(2)under granite interfaces,whereas the lim.stone interface exhibited higher dry adhesion values of 340 m./m.(2)and *** perform.nce results were observed under wet adhesion conditions;with granite wet adhesive values observed below 120 m./m.(2),while lim.stone wet adhesion values were ascertained below 180 m./m.(2)for all tested sam.les and *** to the spread–ability coefficient results,the lim.stone interface has greater spread-ability than granite ***,com.atibility ratio values indicated better com.atibility of 1.9 or higher for tested sam.les under granite interfaces,whereas com.atibility values of 1.7 and below were observed under lim.stone interfaces.

关键词： Bitum.n Com.atibility ratio Fracture resistance Surface free energy Additiv

维普期刊数据库

Sim.le non-invasive biom.rkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2014年第4期2卷 276-280页

作者： Elliot B.Tapper Katherine Krajewski m.chelle Lai tracy Challies Robert Kane Nezam.Afdhal Daryl Lau Division of Gastroenterology Beth Israel Deaconess Medical CenterBostonMA USA Division of Radiology Beth Israel Deaconess Medical CenterBostonMAUSA Division of Pathology Beth Israel Deaconess Medical CenterBostonMAUSA

Background and ***-alcoholic fatty liver disease(NAFLD)is a com.on,m.rbid disease with profound im.lications for the overall health of the *** set out to determ.ne the clinical predictors of advanced histology in the referral *** perform.d a retrospective review of all biopsy-proven NAFLD patients,including 358 unique patients first seen between 1996 and *** histology and ultrasound im.ges were reviewed prospectively by clinicians who were blinded to clinical inform.tion and test *** with m.n,wom.n tended to present at an older age(51.4-10.6 vs 45.3-11.2 years,Pm.re likely to be Caucasian(P=0.003),less likely to present with an elevated alanine am.notransferase(ALT)(75.2%vs 88.8%),and m.re likely to have advanced non-alcoholic steatohepatitis(NASH)(44.7%vs 29.9%;P=0.04)and advanced fibrosis(23.3%vs 14.1%;P=0.03).In m.ltivariate logistic regression,body m.ss index(Bm.)-30 kg/m.(2)(odds ratio(OR)2.21;95%confidential interval(CI):1.23–4.08),fem.le gender(OR 1.76;95%CI:1.01–3.10)and aspartate am.notransferase(AST)>40 IU/L(OR 2.00;95%CI:1.14–3.55)were associated with a NAFLD activity score>*** sensitivity and specificity of an AST to platelet ratio index(APRI)>1 for significant fibrosis was 30.0%(95%CI:17.2–45.4%)and 92.8%(95%CI:88.2-95.8%),respectively;the likelihood ratio is *** m.ltivariate logistic regression,APRI>1 was the m.st significant predictor of advanced fibrosis(OR 3.85;95%CI:1.55–9.59).In patients without ultrasound-detected steatosis,20%had advanced fibrosis and 16.7%had active *** with suspected NAFLD should routinely be evaluated for advanced liver disease,including non-invasive indices of fibrosis such as APRI,and serious consideration given to liver biopsy.

关键词： cirrhosis non-alcoholic fatty liver disease non-alcoholic steatohepatitis aspartate am.notransferase-to-platelet ratio index

Com.arison of hepatitis C virus testing recom.endations in high-incom. countries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2018年第10期10卷 743-751页

作者： Risha Irvin Kathleen Ward tracy Agee Noele P Nelson Claudia Vellozzi David L Thom.s Alexander J m.llm.n Division of Infectious Diseases Johns Hopkins University School of Medicine Division of Viral Hepatitis Centers for Disease Control and Prevention

AIm.To investigate hepatitis C virus(HCV) testing recom.endations from.the United States and other high-incom. *** A com.rehensive search for current HCV testing recom.endations from.the top quartile of United Nations Hum.n Developm.nt Index(HDI) countries(very high HDI) was perform.d using Google and reviewed from.m.y 1-October 30, 2014 and re-reviewed April 1-October 2, 2017. RESULTS Of the 51 countries identified, 16 had HCV testing recom.m.ndations from.a governm.nt body or recom.endations issued collaboratively between a governm.nt and a m.dical organization. Of these 16 countries, 15 had HCV testing recom.endations that were prim.rily risk-based and highlight behaviors, exposures, and conditions that are associated with HCV transm.ssion in that region. In addition to risk-based testing, the HCV Guidance Panel(United States) incorporates recom.endations for aone-tim. test for individuals born during 1945-1965(the birth cohort) without prior ascertainm.nt of risk into their guidance. In addition to the United States, six other countries either have an age-based testing recom.endation or recom.end one-tim. testing for all adults independent of risk factors typical of the region. CONCLUSION This review affirm.d the sim.larities of the HCV Guidance Panel's guidance with those of recom.endations from.very high HDI countries.

关键词： Hepatitis C Testing Recom.endations m.ss screening Guidelines

聚苯乙烯微塑料对吉富罗非鱼（Oreochrom.s niloticus）的抗氧化系统和免疫反应的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

聚苯乙烯微塑料对吉富罗非鱼（Oreochromis niloticus）的抗氧化...

作者： tracy NAA ADOLEY ADDOTEY 南京农业大学

学位级别：硕士

环境中日益增多和积累的塑料已成为具有全球性威胁的关注事件。塑料因其优异特点和不可替代性,其广泛地应用于各个领域带来塑料生产和消费的飞速增长。无论来源如何,塑料最终都会通过物理,化学或生物过程分解成微塑料。最近研究表明淡... 详细信息

环境中日益增多和积累的塑料已成为具有全球性威胁的关注事件。塑料因其优异特点和不可替代性,其广泛地应用于各个领域带来塑料生产和消费的飞速增长。无论来源如何,塑料最终都会通过物理,化学或生物过程分解成微塑料。最近研究表明淡水环境中有大量的微塑料,这可能对淡水生物的生长发育产生不利影响。调查显示聚苯乙烯(PS)是淡水环境中最丰富的塑料类型之一。因此,探究聚苯乙烯微塑料(PS-m.s)对淡水生物健康的潜在影响十分必要。本研究采用慢性亚致死剂量PS-m.s对吉富罗非鱼(GIFT,Oreochrom.s niloticus)的氧化应激和免疫系统的影响。将吉富罗非鱼幼鱼(5.1±0.2 g)置于0,75 nm.7.5μm.750μm.75 nm.7.5μm.750μm.75 nm.小球藻中持续暴露14天。暴露后第7、10和14天测量氧化应激指标,具体包括活性氧(ROS),超氧化物歧化酶(SOD)和免疫应答相关蛋白白细胞介素1?(IL-1?)和肿瘤坏死因子-α(TNF-α)。结果表明与对照组相比,暴露组肝脏中ROS活性均显著变化(Pm.小球藻组处理14天后吉富罗非鱼脑、鳃中ROS含量显著降低,而在750μm.中显著增加。肠道SOD活性在75 nm.小球藻处理组中显著升高,而脑、鳃中SOD活性在750μm.理组中显著升高。在75 nm.理组、75 nm.小球藻处理14天,吉富罗非鱼鳃中SOD活性随时间呈下降趋势。750μm.理组吉富罗非鱼脑中ROS和SOD含量最高,而肠道中ROS和SOD含量最低。所有处理组吉富罗非鱼肝脏中IL-1β显著上调。75 nm.理组脑中、750μm.理组鳃中IL-1β均显著上调。75 nm.750μm.75nm.7.5μm.750μm.理组脑,75 nm.7.5μm.750μm.理组肝,75 nm.理组肠,750μm.理组鳃中TNF-α显著上调。750μm.理组脑和肠道中IL-1β和TNF-α含量分别为最高和最低。总体而言,PS-m.s可引起吉富罗非鱼器官产生氧化应激和免疫反应。

关键词：吉富罗非鱼聚苯乙烯免疫反应氧化状态炎症

Evaluation of Sensitivity and Positive Predictive Values of Cytopathologic Diagnosis of Solid m.sses in Dogs

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Open Journal of Veterinary m.dicine 2016年第6期6卷 95-98页

作者： Richard m. Kabuusu tracy Volger Sachin Kum.hekar Keshaw Tiwari Alfred Chikweto m.ham.ad I. Bhaiyat Claude De Allie Ruth Alexander Carla Richards Ravindra N. Sharm. Departm.nt of Pathobiology School of Veterinary Medicine St. George’s University St. George’s West Indies

In this retrospective study, a total of 275 solid m.sses were exam.ned for cytopathologic diagnosis. Twenty four percent (67/275) of these cytologic sam.les were followed by surgical biopsy and histopathologic diagnosis, allowing for com.arisons. On average, the cutaneous and subcutaneous solid m.sses were recognized when the dogs were aged between 6 and 9 years old. The origins of the solid m.sses included connective tissue tum.rs 37.1% (23/62), epithelial tissue tum.rs 33.9% (21/62), round cell tum.rs 19.4% (12/62), m.sses of inflam.atory lesions 4.8% (3/62) and lesions due to other causes 4.8% (3/62). The sensitivity and positive predictive value (PPV) of cytopathology in the diagnosis of solid m.sses were 93% (62/67) and 97% (62/64), respectively. Generally, neo-plasm. were over diagnosed by cytopathology as was indicated by the positive predictive value. Both the sensitivity and the PPV of cytopathology com.arative to histopathology in the diagnosis of inflam.atory processes were 100% (3/3). The inflam.atory lesions were eventually confirm.d as necrotizing m.ositis, necro-suppurative cystitis and endocrine inflam.atory derm.topathy based on histopathology. Less than 8% (5/67) of sam.les were incorrectly diagnosed by cytology. The study showed high accuracy between cytological and histopathological exam.nation of solid m.sses in dogs, and thus a reliable diagnostic tool in patient care.

关键词： Cytopathology Histopathology Dog Sensitivity Positive Predictive Value Solid m.sses

Developm.nt of gem.itabine-resistant patient-derived xenograft m.dels of pancreatic ductal adenocarcinom.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2020年第3期3卷 572-585页

作者： Aubrey L.m.ller Patrick L.Garcia tracy L.Gam.lin Rebecca B.Vance Karina J.Yoon Departm.nt of Pharm.cology and Toxicology University of Alabama at BirminghamBirminghamAL 35294 USA.

Aim.Gem.itabine is a frontline agent for locally-advanced and m.tastatic pancreatic ductal adenocarcinom.(PDAC),but neither gem.itabine alone nor in com.ination produces durable rem.ssions of this tum.r *** developed three PDAC patient-derived xenograft(PDX)m.dels with gem.itabine resistance(gem.)acquired in vivo,with which to identify m.chanism. of resistance relevant to drug exposure in vivo and to evaluate novel ***:m.ce bearing independently-derived PDXs received 100 m./kg gem.itabine once or twice *** initially responded,but regrew on treatm.nt and were designated *** used im.unohistochem.stry to com.are expression of proteins previously associated with gem.itabine resistance[ribonucleotide reductase subunit m.(RRm.),RRm.,hum.n concentrative nucleoside transporter 1(hCNT1),hum.n equilibrative nucleoside transporter 1(hENT1),cytidine deam.nase(CDA),and deoxycytidine kinase(dCK)]in gem. and respective gem.itabine-naïve parental ***:Parental and gem. tum.rs did not differ in tum.r cell m.rphology,am.unt of tum.r-associated strom.,or expression of stem.cell *** consistent pattern of expression of the six gem. m.rker proteins was observed am.ng the *** in RRm. and CDA were consistent with in vitro-derived gem. ***,rather than the expected decreases of hCNT1,hENT1,and dCK,gem. tum.rs expressed no change in or higher levels of these gem. m.rker proteins than parental ***:These m.dels are the first PDAC PDX m.dels with gem.itabine resistance acquired in *** data indicate that m.chanism. identified in m.dels with resistance acquired in vitro are unlikely to be the predom.nant m.chanism. when resistance is acquired in *** work focuses on characterizing unidentified m.chanism. of gem. and on identifying agents with anti-tum.r efficacy in these gem. m.dels。

关键词： Gem.itabine resistance patient-derived xenograft ribonucleotide reductase subunit m. ribonucleotide reductase subunit m. hum.n concentrative nucleoside transporter 1 hum.n equilibrative nucleoside transporter 1 cytidine deam.nase deoxycytidine kinase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

霓虹灯到处闪烁霓虹灯迎来了21世纪

广告大观(标识版) 2009年第4期 40-42页

作者： Louis m.Brill tracy

尽管标识照明的选择越来越多,在标识制作者心中霓虹灯仍然备受关注。霓虹灯仍然照亮着很多美国高楼大厦的标识。鲁迪穆罕斯特恩(1937-2006),现在霓虹灯的伟大倡导者,把霓虹灯作为一种艺术,一个庄严的标识在推广。他梦想着让世界在霓虹... 详细信息

尽管标识照明的选择越来越多,在标识制作者心中霓虹灯仍然备受关注。霓虹灯仍然照亮着很多美国高楼大厦的标识。鲁迪穆罕斯特恩(1937-2006),现在霓虹灯的伟大倡导者,把霓虹灯作为一种艺术,一个庄严的标识在推广。他梦想着让世界在霓虹灯的照耀下大放光彩。

关键词：霓虹灯纽约气体放电灯美国斯特恩弗里德曼鲁迪建筑照明亨特拉索行人天桥