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Cancer Communications 2019年第1期39卷 620-622页

作者： trace M.Jones Claudia Espitia Wei Wang Steffan T.Nawrocki Jennifer S.Carew University of Arizona Cancer Center TucsonAZ 85724USA Division of Translational and regenerative Medicine Department of MedicineUniversity of ArizonaTucsonAZ 85721USA Department of Pharmacology and Toxicology University of ArizonaTucsonAZ 85721USA Arizona Center for Drug Discovery TucsonAZ 85721USA

Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived *** of its role in maintaining cellu-lar homeostasis,autophagy is frequently stimulated in response to stress conditions such as those imposed by chemotherapy,nutrient deprivation,and microenviron-mental *** this capacity,autophagy serves as a mechanism to generate alternative sources of metabolic fuel that promote survival when preferred energy gener-ating pathways are impaired[1].Over the past decade,stress-induced autophagy has emerged as an important driver of malignant progression and anticancer drug *** all classes of clinically relevant anti-cancer agents,as well as radiotherapy,have been dem-onstrated to stimulate autophagy in preclinical studies[2].In the overwhelming majority of cases,genetically or pharmacologically impairing autophagy has been shown to yield therapeutic benefit in a manner that significantly improves the efficacy of the relevant agents or modalities[3].

关键词： impaired autophagy beyond

Nonlinear and non-CP gates for Bloch vector amplification

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Communications in Theoretical Physics 2023年第10期75卷 51-59页

作者： Michael r Geller Center for Simulational Physics University of GeorgiaAthensGA 30602United States of America

Any state r=(x,y,z)of a qubit,written in the Pauli basis and initialized in the pure state r=(0,0,1),can be prepared by composing three quantum operations:two unitary rotation gates to reach a pure state r=(x^(2)+y^(2)+z^(2))-1/2×(x,y,z)on the Bloch sphere,followed by a depolarization gate to decrease|r|.Here we discuss the complementary state-preparation protocol for qubits initialized at the center of the Bloch ball,r=0,based on increasing or amplifying|r|to its desired value,then *** vector amplification increases purity and decreases *** can be achieved with a linear Markovian completely positive trace-preserving(CPTP)channel by placing the channel’s fixed point away from r=0,making it nonunital,but the resulting gate suffers from a critical slowing down as that fixed point is *** we consider alternative designs based on linear and nonlinear Markovian PTP channels,which offer benefits relative to linear CPTP channels,namely fast Bloch vector amplification without *** gates simulate a reversal of the thermodynamic arrow of time for the qubit and would provide striking experimental demonstrations of non-CP dynamics.

关键词： nonlinear channels non-completely positive channels Bloch vector amplification

医学应对方式问卷对206例HIV/AIDS患者测评

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昆明医科大学学报 2012年第12期33卷 160-163页

作者：张建萍邓阳杨智彬周贵 Kcrshaw trace 昆明医科大学公共卫生学院云南昆明650500 玉溪市人民医院云南玉溪653100 美国耶鲁大学公共卫生学院

目的了解云南省两地206例HIV/AIDS患者的医学应对方式基本情况,探讨影响因素.方法采用方便抽样方法选取HIV/AIDS患者较为集中的文山、玉溪两地患者作为样本;运用自行设计的一般人口学基本问卷,医学应对问卷(MCMQ),医院焦虑抑郁量表对目... 详细信息

目的了解云南省两地206例HIV/AIDS患者的医学应对方式基本情况,探讨影响因素.方法采用方便抽样方法选取HIV/AIDS患者较为集中的文山、玉溪两地患者作为样本;运用自行设计的一般人口学基本问卷,医学应对问卷(MCMQ),医院焦虑抑郁量表对目标人群进行测定.结果 HIV/AIDS患者面对因子得分低于常模,回避、屈服因子得分高于常模,差异有统计学意义(Pr=-0.162,Pr=0.429,Pr=0.401,P<0.00).结论患者多采取回避或屈服的方式应对疾病,不利于疾病的康复;提高其文化程度,消除歧视,使其能够积极面对,配合医生治疗;实施进一步的心理干预措施,以帮助他们采取有效的应对方式.

关键词：医学应对方式 HIV AIDS患者测评

Numerical Investigation of Tip Clearance Effects in an Axial Transonic Compressor

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Journal of Thermal Science 2012年第2期21卷 109-119页

作者： r. Ciorciari A. Lesser F. Blaim r. Niehuis Institute for Jet Propulsion University of Federal Armed Forces Munich Werner-Heisenberg-Weg 39 D-85577 Neubiberg

Numerical investigations of the Darmstadt transonic single stage compressor (DTC), in the rotor1-Stator1 configuration, aimed at advancing the understanding of the effect of different rotor tip gaps and transition modelling on the blade surfaces are presented. Steady three dimensional reynolds Averaged Navier Stokes (rANS) simulations were performed to obtain the flow fields for the different configurations at different operating conditions using the rANS-Solver trace. The stage geometry and the multi-block structured grid were generated by G3DMESH and a grid sensitivity analysis was conducted. For the clearance gap region, a fully gridded special H-grid was chosen. Comparisons were made between the flow characteristic at design speed, representative for a transonic flow regime, and at 65% speed, representative for a subsonic flow regime. The computations were used to analyse the flow phenomena through the tip clearance region for the different configurations and their impact on the performance of the compressor stage.

关键词： Flow in axial compressor surge and stall tip clearance flow multimode transition model.

region-Aware trace Signal Selection Using Machine Learning Technique for Silicon Validation and Debug

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Computer Modeling in Engineering & Sciences 2019年第7期120卷 25-43页

作者： r.Agalya r.Muthaiah D.Muralidharan Junior research Fellow School of ComputingSASTRA Deemed UniversityThirumalaisamudramThanjavur-613401TamilnaduIndia Associate Dean School of ComputingSASTRA Deemed UniversityThirumalaisamudramThanjavur-613401TamilnaduIndia Assistant Professor School of ComputingSASTRA Deemed UniversityThirumalaisamudramThanjavur-613401TamilnaduIndia

In today’s modern design technology,post-silicon validation is an expensive and composite *** major challenge involved in this method is that it has limited observability and controllability of internal *** will be an issue during execution how to address the useful set of signals and store it in the on-chip trace *** existing approaches are restricted to particular debug set-up where all the components have equivalent prominence at all the ***,the verification engineers will emphasis only on useful functional regions or *** to some constraints like clock gating,some of the regions can be ignored during ***,some of these regions can be verified deeply and have minimum errors compared to other control *** proposed system focusses on random signals that identify more errors which are prone to signal selection technique with low area *** enhance the observability,a machine learning technique is *** on the training samples of smaller designs,a model is developed to find out the contiguous neighbours of each *** can eliminate the obstacles of unknown *** system demonstrates using Opencores and ISCAS’89 benchmark circuits that result in easy and fast error detection compared to the state-of-theart of other *** is also verified using gate-level error models by cross-validation of each debug run.

关键词： Controllability error propagation machine learning observability signal selection

rare earth element geochemistry of Post-to Neo-archean shales from Singhbhum mobile belt, Eastern India: implications for tectonic setting and paleo-oxidation conditions

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Chinese Journal Of Geochemistry 2015年第3期34卷 401-409页

作者： Akhtar r.Mir Department of Earth Sciences University of Kashmir

In the present study, trace element(including rare earth element) chemical data has been interpreted with the aim to decipher the tectonic setting and paleo-redox conditions of the Post- to Neo-archean shales from the Singhbhum Mobile Belt, eastern India. The data show moderate enrichment of compatible elements [such as Cu(avg. 59.28 ppm), Ni(avg. 59.49 ppm), V(avg.234.24 ppm) and Cr(avg. 181.23 ppm)] relative to the Post-Archean Australian Shale. Their chondrite normalized light rare earth elements are moderately fractionated [(La/Sm)Nranges from 2.21 to 5.78], whereas heavy rare earth elements show a nearly flat pattern [(Gd/Lu)Nranges from0.74 to 1.68]; this indicates that the rare earth element(rEE) concentrations, rather than being severely affected by the diagenesis and weathering processes, decreased gradually from Gd to Lu. The Post-Archean Australian Shale normalized multi-element diagram shows the slight enrichment of Cr, V, Zr, Y, U and Sc, whereas Sr, Pb, Hf and Th are depleted. The notable negative anomaly of Sr indicates the least accumulation of plagioclase, which is also supported by the negative Eu-anomaly in these *** La–Th–Sc and Th–Zr–Sc tectonic setting diagrams indicate their continental arc setting. The geochemical parameters, such as U/Th, V/Cr, Ni/Co, and Cu/Zn, indicate that these shales were deposited under oxic to anoxic environmental conditions.

关键词：稀土元素地球化学特征新太古代页岩印度构造意义氧化条件移动氧化还原条件

Postbuckling analysis of functionally graded graphene platelet-reinforced polymer composite cylindrical shells using an analytical solution approach

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Applied Mathematics and Mechanics(English Edition) 2019年第7期40卷 1001-1016页

作者： S. BLOOrIYAN r. ANSArI A. DArVIZEH r. GHOLAMI H. rOUHI Department of Mechanical Engineering University of Guilan Rasht 41635-3756 Iran Department of Mechanical Engineering Lahijan Branch Islamic Azad University Lahijan 44169-39515Iran Department of Engineering Science Faculty of Technology and Engineering University of Guilan Rudsar-Vajargah 44891-63157 Iran

An analytical approach is proposed to study the postbuckling of circular cylindrical shells subject to axial compression and lateral pressure made of functionally graded graphene platelet-reinforced polymer composite (FG-GPL-rPC). The governing equations are obtained in the context of the classical Donnell shell theory by the von K′arm′an nonlinear relations. Then, based on the ritz energy method, an analytical solution approach is used to trace the nonlinear postbuckling path of the shell. The effects of several parameters such as the weight fraction of the graphene platelet (GPL), the geometrical properties, and distribution patterns of the GPL on the postbuckling characteristics of the FG-GPL-rPC shell are analyzed.

关键词： cylindrical shell nanocomposite graphene platelet (GPL) postbuckling analytical solution

Detecting the ?ngerprints of observed climate change on surface ozone variability

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Science Bulletin 2019年第6期64卷 359-360页

作者： Owen r.Cooper Cooperative Institute for research in Environmental Sciences University of Colorado NOAA Earth System research Laboratory

At the surface, tropospheric ozone is an air pollutant that adversely impacts human health, natural vegetation and crop yield and quality. This important trace gas also plays key roles as a greenhouse gas, and as the primary source of the hydroxyl (OH) radical, which determines the lifetime of many other trace gases in the atmosphere. Tropospheric ozone has a variety of sources including photochemical production from anthropogenic and naturally occurring precursor gases, and transport from the stratosphere. As a result of 让s high reactivity and its wide range of sources,*sozone lifetime can vary from minutes in the polluted boundary layer to several weeks in the mid- and upper troposphere.

关键词： tropospheric ozone greenhouse gas polluted boundary layer

Formation of high-silica adakites and their relationship with slab breakoff:Implications for generating fertile Cu-Au-Mo porphyry systems

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Geoscience Frontiers 2024年第6期15卷 454-468页

作者： Fazilat Yousefi David r.Lentz Department of Earth Sciences University of New BrunswickFrederictonNew Brunswick E3B 5A3Canada

In recent years,the characteristics and sources of fertile adakites has received considerable *** well,most recently the geodynamic environment of convergent margins subducting oceanic crust aiding arc formation,evolving to slab rollback,then slab break-off after collision(***-to post-collisional slab failure(arc-like magmatism)and transpression)has gained more recognition,although their relationship to each other has yet to be *** geochemical characteristics imply that adakites/adakite-like,in particular high-silica adakites(HSA),can form by partial melting of subducting hydrothermally altered oceanic crust in convergent plate boundary settings during the terminal stages of subduction,lithosphere thickening,and then failure(all late to post collisional),while the melting of the mantle wedge during subduction-related dehydration creates more typical calc-alkaline basalt-andesite-dacite-rhyolite series(ADr)to form intraoceanic island arc to intracontinental margin arc systems,before the collisional *** are characterized by high-silica(SiO2>67 wt.%),Al2O3>15 wt.%,Sr>300 ppm,Yr/Y(>50),and La/Yb(>10).Some specific geochemical features,such as high Mg#(ave 0.51),Ni(ave 924 ppm),and Cr(ave 36 ppm),in HSAs are typical,in contrast to calc-alkaline arcs,although both groups display similar but less pronounced negative anomalies of Nb,Ta,and Ti in primitive mantle-normalized trace element spider diagram *** unique geochemical features are likely ascribed to the involvement of garnet,hornblende,and titanite either during partial melting of hydrous MOrB-like oceanic crust with only minor assimilation and fractional crystallization(AFC)within the mantle and crustal during ascent in a transpressional collisional *** for origin of HSA derivative from melting in convergent margins from young,hot oceanic plates subducting into the mantle is applicable to only some a

关键词： High-silica adakites Slab break-off Altered oceanic crust Upwelling asthenosphere Fertile Cu-Au-Mo porphyry systems

Localizing root causes of performance anomalies in cloud computing systems by analyzing request trace logs

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Science China(Information Sciences) 2012年第12期55卷 2757-2773页

作者： LYU Michael r. Shenzhen research Institute The Chinese University of Hong Kong

It is hard to localize the primary cause of performance anomalies in cloud computing systems because of the complexity of interactions between *** hidden connections in the huge number of request execution paths in such systems usually contain useful information for diagnosing performance *** propose an approach to localize anomalous invoked methods and their physical locations by leveraging request trace logs,which involves two steps:(1) firstly,cluster the requests according to their corresponding call sequences,identify anomalous requests with principal component analysis,and then pick out anomalous methods with Mann-Whitney hypothesis test;(2) secondly,compare the behavior similarities of all replicated instances of the anomalous methods with Jensen-Shannon divergence,and select the ones whose behaviors are different from those of others,which will be chosen as the final culprits of performance *** conduct experiments with four real-world cases to validate our approach in Alibaba Cloud Computing *** results demonstrate that our approach can locate the prime causes of performance anomalies with the low false-positive rate and false-negative rate.

关键词： cloud computing systems performance anomalies request trace logs fault localization