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Qualitative analysis of the Dix-Hallpike maneuver in multi-canal BPPV using a biomechanical model: Introduction of an expanded Dix-Hallpike maneuver for enhanced diagnosis of multi-canal BPPV

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第3期3卷 163-168页

作者： henri traboulsi Michael Teixido Christiana Care Health Systems NewarkDEUSA Department of Otolaryngology University of PennsylvaniaPAUSA Department of Otolaryngology Thomas Jefferson UniversityPAUSA

Introduction/Objective:Multiple canal BPPV can be a diagnostic challenge to the *** is due in part to the complex anatomy of the labyrinth but also to complex and often simultaneous ocular responses that result from stimulation of multiple canals during traditional diagnostic *** objective was to analyze the Dix-Hallpike maneuver used in the diagnosis of BPPV to look for patterns of simultaneous canal response and to develop a diagnostic maneuver that will allow separation of canal responses in multiple canal ***:A previously created and published 3D biomechanical model of the human labyrinths for the study of BPPV was used to analyze and compare the position and movement of otoliths in the Dix-Hallpike maneuver as well as in a proposed expanded version of the traditional DixHallpike ***:The traditional Dix-Hallpike maneuver with the head hanging may promote movement of otoliths in 5 of the six semicircular *** Dix-Hallpike maneuver with the head lowered only to the horizontal position allows for otoconia in only the lowermost posterior canal to fall to the most gravity dependent *** position allows for minimal or no movement of otoconia in the contralateral posterior canal,or in either superior *** the head ninety degrees to the opposite side while still in the horizontal position will provoke otolith movement in only the contralateral posterior *** superior canals can then be examined for free otolith debris by extending the neck to a head-hanging *** positions may be assumed directly from one to the next in the lying *** seems to be no advantage to sitting up between ***:The Dix-Hallpike maneuver may cause simultaneous movement of otoliths present in multiple canals and create an obstacle to accurate diagnosis in multi-canal *** expanded Dix-Hallpike maneuver is described which adds intermediate steps with the head positioned to the right and left

关键词： Benign paroxysmal positional vertigo Dizziness Multiple canal Dix-Hallpike Canalithiasis Biomechanical model

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BPPV Viewer: A downloadable 3D BPPV model for study of otolith disease

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第1期7卷 34-39页

作者： traboulsi henri Teixido Michael Texas Children’s Hospital HoustonTXUSA Christiana Care Health Systems NewarkDEUSA

Objective:To develop a downloadable three-dimensional(3D)study tool of the membranous labyrinth in order to facilitate the study of benign paroxysmal positional vertigo(BPPV).Background:The diagnosis and treatment of BPPV depend on an understanding of the anatomy of the vestibular labyrinth and its position relative to the *** date,many illustrations have been made to explain principles of diagnosis and treatment of BPPV,but few have been based on anatomical studies of the membranous ***:A previously reported 3D model of a human labyrinth was transposed to a 3D development software to allow the creation of markers along the semicircular ducts and *** markers represent otoliths at different positions during movement of the model within the 3D ***-friendly tools were created to navigate the model,to allow clear documentation and communication of studied problems,and to study the model across relevant *** final model can be downloaded and is available for general useat https://***/download/.Results:The model allows visualization of true membranous labyrinth anatomy in both ears *** dependent portion of each semicircular duct,the planes of the cristae,and the position of the utricle can easily be visualized in any head *** markers can mark the expected progress of otolith debris with changes in head position and images can be captured to document simulations in various draw ***:This simple model could offer insights that lead to more accurate diagnosis and treatment of *** may also be useful as a tool to teach BPPV.

关键词： BPPV 3D-model Semicircular canals Crista plane

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Modelling the Survival of Western Honey Bee Apis mellifera and the African Stingless Bee Meliponula ferruginea Using Semiparametric Marginal Proportional Hazards Mixture Cure Model

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Journal of Data Analysis and Information Processing 2024年第1期12卷 24-39页

作者： Patience Isiaho Daisy Salifu Samuel Mwalili henri E. Z. Tonnang Department of Statistics and Actuarial Sciences Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Data Management Modelling and Geo-Information Unit International Centre of Insect Physiology and Ecology (icipe) Nairobi Kenya

Classical survival analysis assumes all subjects will experience the event of interest, but in some cases, a portion of the population may never encounter the event. These survival methods further assume independent survival times, which is not valid for honey bees, which live in nests. The study introduces a semi-parametric marginal proportional hazards mixture cure (PHMC) model with exchangeable correlation structure, using generalized estimating equations for survival data analysis. The model was tested on clustered right-censored bees survival data with a cured fraction, where two bee species were subjected to different entomopathogens to test the effect of the entomopathogens on the survival of the bee species. The Expectation-Solution algorithm is used to estimate the parameters. The study notes a weak positive association between cure statuses (ρ1=0.0007) and survival times for uncured bees (ρ2=0.0890), emphasizing their importance. The odds of being uncured for A. mellifera is higher than the odds for species M. ferruginea. The bee species, A. mellifera are more susceptible to entomopathogens icipe 7, icipe 20, and icipe 69. The Cox-Snell residuals show that the proposed semiparametric PH model generally fits the data well as compared to model that assume independent correlation structure. Thus, the semi parametric marginal proportional hazards mixture cure is parsimonious model for correlated bees survival data.

关键词： Mixture Cure Models Clustered Survival Data Correlation Structure Cox-Snell Residuals EM Algorithm Expectation-Solution Algorithm

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Comparison of Semi-Parametric Shared Frailty Models for Bees’Survival

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Journal of Data Analysis and Information Processing 2024年第2期12卷 267-288页

Survival analysis is a fundamental tool in medical science for time-to-event data. However, its application to colony organisms like bees poses challenges due to their social nature. Traditional survival models may not accurately capture the interdependence among individuals within a colony. Frailty models, accounting for shared risks within groups, offer a promising alternative. This study evaluates the performance of semi-parametric shared frailty models (gamma, inverse normal, and positive stable-in comparison to the traditional Cox model using bees’ survival data). We examined the effect of misspecification of the frailty distribution on regression and heterogeneity parameters using simulation and concluded that the heterogeneity parameter was more sensitive to misspecification of the frailty distribution and choice of initial parameters (cluster size and true heterogeneity parameter) compared to the regression parameter. From the data, parameter estimates for covariates were close for the four models but slightly higher for the Cox model. The shared gamma frailty model provided a better fit to the data in comparison with the other models. Therefore, when focusing on regression parameters, the gamma frailty model is recommended. This research underscores the importance of tailored survival methodologies for accurately analyzing time-to-event data in social organisms.

关键词： Correlated Failure Times Frailty Survival Analysis Unobserved Heterogeneity

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Incidence and Management of Occupational Blood Exposure (OBE) among Medical Students at the University of Bangui

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 68-77页

作者： Hermione Dahlia Mossoro-Kpinde Caleb Koyambenguia Yves Kpangba Mangbé Saint Calvaire henri Diemer Ministè re du Travail de l&#8217Emploi de la Protection Sociale et de la Formation Professionnelle Bangui Central African Republic Dé partement de Sant&#233 Publique &#224 la Facult&#233 des Sciences de la Sant&#233 de l&#8217Universit&#233 de Bangui Bangui Central African Republic Centre Hospitalier Universitaire de l’ Amiti&#233 Sino-Centrafricaine de Bangui Bangui Central African Republic Département de Formation Continue à la Faculté des Sciences de la Santé de l’Université de Bangui Bangui Central African Republic

Introduction: Like healthcare workers, medical students are also exposed to a risk of accidental contamination during their hospital internships. However, they do not benefit from prevention services in the same way as workers in this sector, although they actively participate in the routine care provided to patients in the various hospital departments. The objective of our study is to determine the incidence of these accidents and their medical and administrative management among these victims (medical students) not classified in the category of workers. Materials and Method: This was a cross-sectional study carried out over three months from January 15 to March 14, 2023. The study population consisted of all medical students at the Faculty of Health Sciences at the University of Bangui. Regularly enrolled students from 2nd to 7th year, on placement in hospitals in the Central African Republic and who gave their informed consent were included. Data were collected through a self-administered questionnaire. Results: A cross-sectional study was carried out among medical students concerning the incidence and management of accidents involving exposure to blood in the Central African Republic. Of the 254 students included, three (9%) had already been correctly vaccinated against the viral hepatitis B virus, 198 (77.9%) reported still having access to personal protective equipment, 133 students (52.4%) reported being victims of OBE in the past 12 months. The main types of OBE were stings (62%), followed by liquid splashes (32%) and cuts (6%). Among the 133 victims, 92.9% carried out immediate hand disinfection or abundant eye washing, 41.9% obtained the serology of the source patient and 37% reported the accident to their supervisor. Conclusion: It is important that students benefit from better prevention and management of these accidents.

关键词： Incidence of Blood Exposure Accidents Medical Student Treatment Bangui

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High Dimension Multivariate Data Analysis for Small Group Samples of Chemical Volatile Profiles of African Nightshade Species

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Journal of Data Analysis and Information Processing 2024年第2期12卷 210-231页

作者： Lorna Chepkemoi Daisy Salifu Lucy Kananu Murungi henri E. Z. Tonnang International Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya Department of Horticulture and Food Security Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya

Quantitative headspace analysis of volatiles emitted by plants or any other living organisms in chemical ecology studies generates large multidimensional data that require extensive mining and refining to extract useful information. More often the number of variables and the quantified volatile compounds exceed the number of observations or samples and hence many traditional statistical analysis methods become inefficient. Here, we employed machine learning algorithm, random forest (RF) in combination with distance-based procedure, similarity percentage (SIMPER) as preprocessing steps to reduce the data dimensionality in the chemical profiles of volatiles from three African nightshade plant species before subjecting the data to non-metric multidimensional scaling (NMDS). In addition, non-parametric methods namely permutational multivariate analysis of variance (PERMANOVA) and analysis of similarities (ANOSIM) were applied to test hypothesis of differences among the African nightshade species based on the volatiles profiles and ascertain the patterns revealed by NMDS plots. Our results revealed that there were significant differences among the African nightshade species when the data’s dimension was reduced using RF variable importance and SIMPER, as also supported by NMDS plots that showed S. scabrum being separated from S. villosum and S. sarrachoides based on the reduced data variables. The novelty of our work is on the merits of using data reduction techniques to successfully reveal differences in groups which could have otherwise not been the case if the analysis were performed on the entire original data matrix characterized by small samples. The R code used in the analysis has been shared herein for interested researchers to customise it for their own data of similar nature.

关键词： Random Forest Similarity Percentage PERMANOVA ANOSIM Non-Metric Multi-Dimensional Scaling

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Epidemiological Profile of Men Who Have Sex with Men: First Data about Male Sex Workers in Central African Republic (CAR)

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Advances in Sexual Medicine 2024年第1期14卷 1-11页

作者： Hermione Dahlia Mossoro-Kpinde Balekouzou Augustin Paola Julienne Demba henri Saint Calvaire Diemer Direction de la Médecine du Travail Ministère du Travail de l’Emploi de la Protection Sociale et de la Formation Professionnelle Ban-gui République Centrafricaine Comité National de Lutte contre le Sida Bangui République Centrafricaine Faculté des Sciences de la Santé Université de Bangui Bangui République Centrafricaine Département de Santé Publique Faculté des Sciences de la Santé Université de Bangui Bangui République Centrafricaine

Objectives: Sex work is not well documented among African men. The aim of this study was to describe the epidemiological profile of men who have sex with men (MSM) and eventually to determine the proportion of sex workers (SW) among them, as well as the proportion of MSM who have been victims of gender-based violence (GBV). Material and Methods: A cross-sectional study coordinated by the Direction de la Médecine du Travail was carried out at the headquarters of the association ALTERNATIVES in Bangui Bangui from July 1 to October 31, 2021. Consenting MSM present during the study period were systematically included. Sociodemographic variables, those relating to the future vision of the activity and to GBV were collected and analyzed using Epi-Info version 7 software. Results: Forty MSM with an average age of 23 years and mainly secondary education (75.0%) were included. The vast majority of MSM were unemployed (85.0%). 45.0% had been victims of GBV and wanted to stop working as an MSM (47.5%), and almost 2/3 (65.0%) would accept another income-generating activity in exchange for the MSM. Violence was sexual (32.5%), economic (22.5%), physical (20.0%), verbal (12.5%) and psychological (12.5%). Conclusion: The MSM were mainly young, poorly educated, unemployed, and almost half were victims of GBV. The desire to change MSM activity to another income-generating activity alongside that of MSM shows that many of them are SW, workers in the informal sector. This must be taken into account in prevention activities, even if the data needs to be confirmed on a much larger sample.

关键词： Men Who Have Sex with Men Sex Workers Gender-Based Violence Informal Sector Central Africa

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空中楼阁?

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科技纵览 2024年第6期 22-29,4页

作者： henri Barde Tavis Coburn(插图) 不详

怀疑论者对从太空向地球传输能量的看法。地球上太阳能发电场的加速建设遇到了-些障碍,包括公众反对占用大量土地,以及积压了越来越多的对新输电线路和电网连接的需求。能源专家警告说,除非用能够随时可运行的发电机来支持那些因阳光和... 详细信息

怀疑论者对从太空向地球传输能量的看法。地球上太阳能发电场的加速建设遇到了-些障碍,包括公众反对占用大量土地,以及积压了越来越多的对新输电线路和电网连接的需求。能源专家警告说,除非用能够随时可运行的发电机来支持那些因阳光和风力条件不稳定而时增时减的可再生能源,否则电力可能会变得更加昂贵和不可靠。对于太空爱好者来说,这引出了一个显而易见的问题:为什么不把太阳能发电厂建在始终有阳光照耀的地方?

关键词：太阳能发电厂可再生能源能源专家传输能量输电线路电网连接空中楼阁

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Socio-Demographic and Occupational Aspects of HIV-HBV Co-Infection in Bangui, Central African Republic (CAR): Hospital-Based Cross-Sectional Study

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Advances in Infectious Diseases 2024年第2期14卷 310-321页

作者： Gaspard Tékpa Hermione Dahlia Mossoro-Kpinde Jessy Guylaine Nazilari Gertrude Komoyo Saint Calvaire henri Diémer Centre Hospitalier Universitaire de lAmiti Bangui Central African Rpublic (CAR) Dpartement de Mdecine Facult des Sciences de la Sant Universit de Bangui Bangui Central African Republic (CAR) Direction de la Mdecine du Travail Ministre du Travail de lemploi et de la Protection Sociale Bangui Central African Rpublic (CAR) Dpartement de Sant Publique Facult des Sciences de la Sant Universit de Bangui Bangui Central African Rpublic (CAR)

Objective: HIV-HBV co-infection is a major public health problem that has not been sufficiently explored in the Central African workplace. The aim of this study was to assess the frequency of HIV-HBV co-infection among people who living with HIV (PLHIV) in the infectious and tropical diseases department of the Centre Hospitalier Universitaire de lAmiti Sino-Centrafricaine in Bangui. Methods: A retrospective study was carried out from January 1, 2010 to December 31, 2021 in the Infectious and Tropical Diseases Department at the Amiti Sino-Centrafricaine University Hospital. It included the files of all PLHIV, which included the results of HBV serology. A standardized form was used to collect socio-demographic and professional data by documentary review. Data was analysed using Epi-Info 7 software. Means, proportions were calculated as well as Chi square witch was significant if p-value was below 0.05. Results: The study included 265 patients, 188 were women (70.1%) and 77 men (29.1%), giving a sex ratio of 0.45. Mean age was 35.8 years, higher in men (40 years) than in women (35.8 years) (p 0.0001). The age groups 25 to 34 (37.7%) and 35 to 44 (33.6%) were in the majority (71.3%). The majority of PLHIV were unemployed (57.1%), including housewives (43.0%). HBV prevalence was 14.3%, including 7.2% among the unemployed, who account for half of all co-infections. The search for associations between HIV-HBV co-infection and all socio-demographic characteristics (age, sex, marital status) and socio-professional categories showed no significant difference (p 0.05). Conclusion: PLHIV were predominantly young adults, female, and unemployed;no occupation was significantly associated with co-infection. The vast majority of co-infected people were not covered by the occupational health system (unemployed or informal sector). Urgent action is needed to improve workers access to occupational medicine in CAR.

关键词： People Living with HIV HIV-HBV Co-Infection Occupation Informal Sector

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