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Theoretical & Applied Mechanics Letters 2024年第1期14卷 48-56页

作者： Jiaxuan ma Sheng Sun materials Genome Institute Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai 200444China

Dielectric elastomers(DEs)require balanced electric actuation performance and mechanical integrity under applied *** high dielectric particles as fillers provides extensive design space to optimize concentration,morphology,and distribution for improved actuation performance and material *** study presents an integrated framework combining finite element modeling(FEM)and deep learning to optimize the microstructure of DE *** first calculates actuation performance and the effective modulus across varied filler combinations,with these data used to train a convolutional neural network(CNN).Integrating the CNN into a multi-objective genetic algorithm generates designs with enhanced actuation performance and material modulus compared to the conventional optimization approach based on FEM approach within the same *** framework harnesses artificial intelligence to navigate vast design possibilities,enabling optimized microstructures for high-performance DE composites.

关键词： Dielectric elastomer composites Multi-objective optimization Finite element modeling Convolutional neural network

Exploring the functional roles of small-molecule metabolites in disease research:recent advancements in metabolomics

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Chinese Chemical Letters 2024年第8期35卷 93-100页

作者： Aolei Tan Xiaoxiao ma Department of Precision Instrument Tsinghua UniversityBeijing 100084China

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in ***,an essential scientific discipline,is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during *** the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and *** comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic *** scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

关键词： Metabolites Small molecules Biological functions Physiological processes Diseases

Nuclear phylogenomics of angiosperms and insights into their relationships and evolution

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Journal of Integrative Plant Biology 2024年第3期66卷 546-578页

作者： Guojin Zhang Hong ma College of Life Sciences Hunan Normal UniversityChangsha 410081China Department of Biology 510 Mueller LaboratoryHuck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

Angiosperms(flowering plants) are by far the most diverse land plant group with over 300,000 species. The sudden appearance of diverse angiosperms in the fossil record was referred to by Darwin as the “abominable mystery,”hence contributing to the heightened interest in angiosperm evolution. Angiosperms display wide ranges of morphological, physiological,and ecological characters, some of which have probably influenced their species richness. The evolutionary analyses of these characteristics help to address questions of angiosperm diversification and require well resolved phylogeny. Following the great successes of phylogenetic analyses using plastid sequences,dozens to thousands of nuclear genes from next-generation sequencing have been used in angiosperm phylogenomic analyses, providing well resolved phylogenies and new insights into the evolution of angiosperms. In this review we focus on recent nuclear phylogenomic analyses of large angiosperm clades, orders, families,and subdivisions of some families and provide a summarized Nuclear Phylogenetic Tree of Angiosperm Families. The newly established nuclear phylogenetic relationships are highlighted and compared with previous phylogenetic results. The sequenced genomes of Amborella,Nymphaea, Chloranthus, Ceratophyllum, and species of monocots, magnoliids, and basal eudicots, have facilitated the phylogenomics of relationships among five major angiosperms clades. All but one of the 64 angiosperm orders were included in nuclear phylogenomics with well resolved relationships except the placements of several orders. Most families have been included with robust and highly supported placements, especially for relationships within several large and important orders and ***, we examine the divergence time estimation and biogeographic analyses of angiosperm on the basis of the nuclear phylogenomic frameworks and discuss the differences compared with previous analyses. Furthermore,we discuss the implicatio

关键词： angiosperms evolution flowering plants nuclear gene phylogenomics phylogeny

Catalysis by subsurface metal atoms in Al(001) through electron transfer

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National Science review 2024年第4期11卷 12-13页

作者： Bo Sun Ding ma Beijing National Laboratory for Molecular Science New Cornerstone Science Laboratory College of Chemistry and Molecular Engineering Peking University

Heterogeneous catalysis plays a crucial role in the chemical industry, which has evolved from the investigation of chemisorption to an electronic structure[1]. Diverse strategies, such as alloying,doping, and confining, have been applied to enhance the catalytic properties of active sites through electronic modulation. The electron transfer between active sites and substrates profoundly influences catalytic activity [2].

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Clinical applications of metagenomics next-generation sequencing in infectious diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 471-484页

作者： Ying LIU Yongjun ma Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to human *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unbiased and comprehensive approach for detecting all rNA and DNA in a *** the development of sequencing and bioinformatics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host background and low-biomass samples;and(3)lack of standardized instructions for mass data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review briefly introduces the history of next-generation sequencing,mainstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cerebrospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microbiome

Spatial Distribution Pattern and Influencing Factors of Bed-and-breakfasts(B&Bs)from the Perspective of Urban-rural Differences:A Case Study of Jiaodong Peninsula,China

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Chinese Geographical Science 2024年第4期34卷 752-763页

作者： WANG Xinyue ma Qian management College Ocean University of ChinaQingdao 266100China

There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial *** identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration *** study used density-based spatial clustering of applications with noise(DBSCAN)and the multi-scale geographically weighted regression(MGWr)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to *** results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to ***,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and *** B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level *** the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban ***,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial *** terms of differences,populati

关键词： urban-rural bed-and-breakfasts(B&Bs) spatiotemporal evolution density-based spatial clustering of applications with noise(DBSCAN)model multi-scale geographically weighted regression(MGWr) Jiaodong Peninsula China

Two-stage aging treatment to accelerate aging kinetics without impairing strength in B_4C/7A04Al composite

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Science China(Technological Sciences) 2024年第8期67卷 2485-2492页

作者： CHEN YunTao ma GuoNan ZHU ShiZe WANG Dong XIAO BoLv ma ZongYi Shi-Changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Centre of Excellence for Advanced materials Dongguan 523808China

Aging treatments are the key process to obtain satisfactory strength for 7xxxAl alloys and their composites. However, traditional single-stage(SS) aging is time-consuming to reach a peak strength condition. In this study, an efficient 120℃ + 160℃ two-stage(TS) aging treatment was proposed on a B_4C/7A04Al composite fabricated via powder metallurgy(PM) technology, which could acquire similar peak-aging strength but only took about 15% of the time compared to traditional 120℃ SS aging. The evolution of precipitation during the TS aging was investigated, as well as those of the 7A04Al alloys for comparison. In the second stage aging process, the higher aging temperature accelerated the nucleation of η′ phases inside the grains and thus increased the density of precipitates. Moreover, the short aging time limited the coarsening of precipitates and the broadening of precipitatefree zones. The above factors were beneficial for quickly obtaining satisfactory precipitation strengthening effects. The B_4C/7A04Al composite exhibited slower aging kinetics than the 7A04Al alloy in the TS aging. Mg elements consumption by the chemical reaction between B impurities introduced by B_4C particles and the Al matrix was considered to potentially retard the aging kinetics of the B_4C/7A04Al composite. Nevertheless, the precipitation sequence was not affected.

关键词： aluminum matrix composites aging treatment powder metallurgy mechanical properties precipitation

Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer

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World Journal of Clinical Oncology 2024年第5期15卷 635-643页

作者： Xiao-Ting ma Kai ou Wen-Wei Yang Bi-Yang Cao Lin Yang Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGrouND Although treatment options for gastric cancer(GC)continue to advance,the overall prognosis for patients with GC remains *** present,the predictors of treatment efficacy remain controversial except for high microsatellite *** To develop methods to identify groups of patients with GC who would benefit the most from receiving the combination of a programmed cell death protein 1(PD-1)inhibitor and *** We acquired data from 63 patients with human epidermal growth factor receptor 2(HEr2)-negative GC with a histological diagnosis of GC at the Cancer Hospital,Chinese Academy of Medical Sciences between November 2020 and October *** of the patients screened received a PD-1 inhibitor combined with chemotherapy as the first-line *** As of July 1,2023,the objective response rate was 61.9%,and the disease control rate was 96.8%.The median progression-free survival(mPFS)for all patients was 6.3 *** median overall survival was not *** analysis showed that patients with a combined positive score(CPS)≥1 exhibited an extended trend in progression-free survival(PFS)when compared to patients with a CPS of 0 after receiving a PD-1 inhibitor combined with oxaliplatin and tegafur as the first-line *** exhibited a trend for prolongation as the expression level of HEr2 *** on PFS,we divided patients into two groups:A treatment group with excellent efficacy and a treatment group with poor *** mPFS of the excellent efficacy group was 8 months,with a mPFS of 9.1 months after excluding a cohort of patients who received interrupted therapy due to *** mPFS was 4.5 months in patients in the group with poor efficacy who did not receive *** good/poor efficacy as the endpoint of our study,univariate analysis revealed that both CPS score(P=0.004)and HEr2 expression level(P=0.015)were both factors that exerted significant influence on the efficacy of treatment the combina

关键词： First line Gastric cancer Human epidermal growth factor receptor 2 Programmed cell death protein 1 Progression-free survival

Quantifying Contribution of recycled Moisture to Precipitation in Temperate Glacier region,Southeastern Tibetan Plateau,China

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Chinese Geographical Science 2024年第4期34卷 764-776页

作者： ma Yanwei PU Tao SHI Xiaoyi ma Xinggang YU Hongmei College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China National Field Science Observation and research Station of Yulong Snow Mountain Cryosphere and Sustainable Development Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-environment and ResourcesChinese Academy of SciencesLanzhou 730000China

recycled moisture is an important indicator of the renewal capacity of regional water *** to the existence of Yulong Snow Mountain,Lijiang in Yunnan Province,southeast of the Qinghai-Tibet Plateau,China,is the closest ocean glacier area to the equator in *** precipitation samples were collected from 2017 to 2018 in Lijiang to quantify the effect of sub-cloud evaporation and recycled moisture on precipitation combined with the d-excess model during monsoon and non-monsoon *** results indicated that the d-excess values of precipitation fluctuated between–35.6‰and 16.0‰,with an arithmetic mean of 3.5‰.The local meteoric water line(LMWL)wasδD=7.91δ^(18)O+2.50,with a slope slightly lower than the global meteoric water line(GMWL).Subcloud evaporation was higher during the non-monsoon season than during the monsoon *** tended to peak in march and was primarily influenced by the relative *** source of the water vapour affected the proportion of recycled *** to the results of the Hybrid Single-Particle Lagrangian Integrated trajectory(HYSPLIT)model,the main sources of water vapour in Lijiang area during the monsoon period were the southwest and southeast *** the non-monsoon period,water vapour was transported by a southwesterly *** recycled moisture in Lijiang area between march and October 2017 was 10.62%.Large variations were observed between the monsoon and non-monsoon seasons,with values of 5.48%and 25.65%,*** differences were primarily attributed to variations in the advection of water *** recycled moisture has played a supplementary role in the precipitation of Lijiang area.

关键词： recycled moisture stable isotope precipitation d-excess Hybrid Single-Particle Lagrangian Integrated trajectory(HYSPLIT)model southeastern Tibetan Plateau China

High-density lipoprotein regulates angiogenesis by affecting autophagy via mirNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun ou Jing-Song ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,mirNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of mir-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or mir-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or mir-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing mir-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing mir-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 mirNA endothelial nitric oxide synthase