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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh nguyen Han Yu Xingzhi Li Huiren Wang tram Gia Bao nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

Fermented calcium butyrate supplementation in post-peak laying hens improved ovarian function and tibia quality through the“gut-bone” axis

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Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

Animal Nutrition 2024年第1期16卷 350-362页

作者： Huaiyong Zhang Yongshuai Wang Yilu Wang Bin Wei Leilei Wang Minh Tu nguyen Xiangyun Lv Yanqun Huang Wen Chen College of Animal Science and Technology Key Laboratory of Animal Biochemistry and NutritionMinistry of AgricultureHenan Agricultural University Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Sciences and Aquatic EcologyGhent University Department of Agriculture and Forestry Hue University Charoen Pokphand Group Co. Ltd.

The compromised egg quality and leg abnormality during the end of the laying cycle(after 40 weeks)have been leading to poor animal welfare and substantial economic losses. Therefore, the effects of fermented calcium(Ca) butyrate, produced by fermentation by Clostridium butyricum, on production,eggshell quality, and tibial property of hens were explored. A total of 192 Hy-line brown laying hens at50-week-old were assigned to a basal diet or the basal diet with 300 mg/kg of the fermented Ca butyrate from 50 to 58 weeks of age. Each treatment had 6 replicates with 16 hens each. The diet supplemented with 300 mg/kg fermented Ca butyrate notably increased egg weight, ovarian follicle number, and eggshell strength(P = 0.072) as compared to the basal diet, which were associated with cytokine secretion, toll-like receptor signaling pathways, and intestinal immunity based on the RNA-seq data from the granulosa. Dietary Ca butyrate inclusion decreased the expression of ileal tumor necrosis factor-alpha and serum pro-inflammatory cytokine concentration, as well as increased the content of serum immunoglobulin A when compared to the basal diet(both P 0.05). In addition, the diet with fermented Ca butyrate reduced the number of osteoclasts in the proximal tibia and the level of C-terminal cross-linked telopeptide of type I collagen, a bone resorption marker(P tration of the procollagen type I N-terminal propeptide that reflects bone formation marker in serum. Moreover, the layers fed fermented Ca butyrate diets possessed higher(P trabecular number of the proximal tibia, yield load, and ultimate load than those that consumed basal diets. Collectively, dietary fermented Ca butyrate supplementa

关键词： Fermented Ca butyrate Ovarian property Tibia metabolism Layer

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Journal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini tram nguyen Ryan McGovern Andrew Kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

One-loop contributions for h→?■γ and e-e+→hγ in the U（1）B-L extension of the standard model

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Chinese Physics C 2024年第5期 27-53页

作者： tran Dzung Tri Thanh Huy nguyen Khiem Hong Phan Institute of Fundamental and Applied Sciences Duy Tan University Faculty of Natural Sciences Duy Tan University VNUHCM-University of Science

We present one-loop contributions for h→?■γ with l=ve,μ,τ,e,μ and e-e+→ hγ in the U（1）B-Lextension of the standard *** the phenomenological results,the signal strengths for h→?■γ at the Large Hadron Collider and for e-e+→hγ at future lepton colliders are analyzed in the physical parameter space for both the vector and chiral B-L *** found that the contributions from the neutral gauge boson Z' to the signal strengths are rather ***,the effects will be difficult to probe at future ***,the impacts of charged Higgs and CP-odd Higgs in the chiral B-L model on the signal strengths are significant and can be measured with the help of the initial polarization beams at future lepton colliders.

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Shilian Dashan With the Propagation of the Caodong Sect in Cochinchina in the Seventeenth Century

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Philosophy Study 2024年第4期14卷 194-203页

作者： Ngoc Phuong nguyen Guangxi University for Nationalities NanningChina

The prosperous development of the“Maritime Silk Road”in the 17th century not only brought convenience in sea transportation and promoted trade between countries,but also acted as a bridge connecting *** bridge has the function of cultural exchange between peoples,especially in introducing and promoting China’s cultural and ideological quintessence with neighboring *** this period,Linji and Caodong sects of Chinese Zen Buddhism were spread directly into Cochinchina of Dai Viet through Chinese senior monks who followed merchant ships to this *** them was the Most Venarable Shilian Dashan,a senior monk at Changshou Temple,Guangzhou,who accepted Lord nguyen Phuc Chu’s invitation to teach the Soto Dharma in Cochinchina for nearly two years(1695-1696).Based on the study of relevant historical documents and autobiographical works on this trip byMost ***,the article presents his biography and ***,this article analyzes the method of spreading Dharma,Chan ideology,as well as the significance of his Dharma propagation activities for Buddhism in Cochinchina at that time.

关键词： Shilian Dashan Buddhism in Cochinchina Caodong Chan

Stand dynamics of old-growth hemlock forests in central Bhutan are shaped by natural disturbances

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Forest Ecosystems 2024年第4期11卷 434-447页

作者： Karma Tenzin Craig R.Nitschke Kathryn J.Allen Raphael Trouve Thiet V.nguyen Patrick J.Baker School of Agriculture Foodand Ecosystem SciencesUniversity of Melbourne500 Yarra BlvdRichmondVictoriaAustralia School of Geography Planningand Spatial SciencesUniversity of TasmaniaSandy BayTasmaniaAustralia Forest Science Institute of South Vietnam 1 Pham Van Hai StreetTan Binh DistrictHo Chi Minh CityViet Nam

Understanding how past disturbances have influenced the development of forests is critical for deciphering their current structure and composition and forecasting future *** this study,dendrochronological methods were applied to uncover the disturbance history of old-growth hemlock-dominated forests in central *** of tree-ring samples from two old-growth hemlock stands,located in two different topographic settings,identified the importance of gap-phase dynamics in facilitating recruitment and growth releases and producing complex,multi-aged structure s over *** site showed evidence of a near stand-replacing disturbance in the late 1700s,while the other showed no evide nce of high-severity disturbance at any time over the last 400 *** both sites low-to medium-severity disturbances,some of which appear to be associated with cyclones originating in the Bay of Bengal,dominated the disturbance *** hemlock stands exhibited a significant positive association between cyclone occurrence and growth release events and between recruitment pulses and growth release *** 1800 to 1970 there was an increase in recruitment of angiosperm tree species at most sites and a corresponding decline in conifer *** the past 50 years there has been little new recruitment;this may be due to light limitation in the understory from shade-tolerant angiosperms and bamboo in the lower strata of these *** variations in disturbance dynamics and recruitment were observed across the study sites,suggesting that other factors,such as topography and climate,may be influencing long-term stand development *** study highlights the complex interplay between historical disturbance regimes and tree recruitment in shaping the age and size structures of old-growth hemlock forests in central *** also provides new insights into the dynamics of these forests that can be used to support effective forest conservation and management i

关键词： Forest structure Hemlock forest Himalaya Natural disturbance

High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Thanh nguyen Tadachika Nakayama Thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto Koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic ash at 1400°C for 224,and 48 *** 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

Sn nucleation and growth from Sn(II)dissolved in ethylene glycol:Electrochemical behavior and temperature effect

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transactions of Nonferrous Metals Society of China 2024年第8期34卷 2714-2732页

作者： Kiem Van DO Hieu Van nguyen Tu Manh LE Faculty of Electrical and Electronic Engineering Phenikaa UniversityYen NghiaHa-DongHanoi 10000Vietnam Phenikaa Research and Technology Institute(PRATI) A&A Green Phoenix Group167 Hoang NganHanoi 10000Vietnam Faculty of Materials Science and Engineering Phenikaa Institute for Advanced Study(PIAS)Phenikaa UniversityHanoi 10000Vietnam

Thermodynamic and kinetic aspects of Sn nucleation and growth processes onto a glassy carbon electrode from SnCl2·2H2O dissolved in ethylene glycol solutions were *** reduction and oxidation peaks observed in voltammograms have demonstrated the capability of ethylene glycol solutions to electrodeposit *** temperature-dependence of diffusion coefficient values derived from potentiodynamic and potentiostatic studies helped to determine and validate estimations of the activation energy for Sn(II)bulk *** results have identified that,the suitable model to describe the early stage of Sn electrodeposition could be composed of Sn three-dimensional nucleation and diffusion-controlled growth and water reduction contributions,which was duly validated by theoretical and experimental *** the model,typical kinetic parameters such as the nucleation frequency of Sn(A),number density of Sn nuclei(N_(0)),and diffusion coefficient of Sn(II)ions(D),were *** presence of Sn nuclei with excellent quality and their structures were verified using SEM,EDX,and XRD techniques.

关键词： Sn nucleation growth ethylene glycol nucleation kinetics electrodeposition

Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong Duong Duc Thien Hoang Hai Yen nguyen Anh Duc Trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4