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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy miriam E.A.Tschaffon-müller Shan Jiang Tobias malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa melanie Haffner-Luntzer David J.Beech Frank Timo Beil michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and metabolic medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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Comparison of three types of warm-up upon sprint ability in experienced soccer players

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Journal of Sport and Health Science 2019年第6期8卷 574-578页

作者： Roland van den Tillaar Eirik Lerberg Erna von Heimburg Department of Teacher Education Nord Tr?ndelag University College

Purpose:The study aimed to compare the effects of a long general warm-up,a long specific warm-up,and a short specific warm-up upon sprint ability in soccer ***:Twelve male soccer players(age:18.3±0.8 years,mean±SD;body mass:76.4±7.2 kg;body height:1.79±0.05 m) conducted 3 types of warm-ups with 1 week in between:a long general warm-up,a long specific warm-up,and a short specific warm-up followed by 3 sprints of 40 m *** best,average,and total sprinting times together with heart rate and ratings of perceived exertion were ***:The sprint times(best,average,and total time) were significantly better when performing a long specific or short specific warm-up compared with the long general warm-up(all p m-up(4.92 ± 0.90) compared with the longer ones(6.00 ± 0.74 and 6.25 ± 0.87,respectively).Conclusion:Specificity is more important in a warm-up routine before sprint performance than the duration of the warm-up.

关键词： Duration Performance Received perception exertion Running Specificity Total sprinting times

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Population Characteristics of Ozark Bass (<i>Ambloplites constellatus</i>) in the Upper White River Basin of Northern Arkansas

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Natural Resources 2019年第5期10卷 121-138页

作者： Ashley Rodman Kristofor R. Brye Daniel magoulick stan Todd Buffalo National River National Park Service Harrison AR USA Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville USA U.S. Geological Survey Arkansas Cooperative Fish and Wildlife Research Unit Department of Biological Sciences University of Arkansas Fayetteville USA Arkansas Game and Fish Commission Little Rock AR USA

Ozark Bass (Ambloplites constellatus) is an understudied, endemic fish species in the Upper White River Basin of northern Arkansas. This study was part of an effort by fisheries managers to gather baseline data about the Ozark Bass to aid in understanding population dynamics and contribute to the limited data available for use in determining the efficacy of harvest regulations. Select population characteristics of Ozark Bass in two northern Arkansas streams were determined, population characteristics of Ozark Bass were compared to Shadow Bass (Ambloplites ariommus) and Rock Bass (Ambloplites rupestris) data collected from previous studies in southern missouri, and relative condition, length-at-age, and annual survival of Ozark Bass were compared between sample streams. Sampling occurred in Crooked Creek and the Buffalo River during summer 2013 via boat electroshocking. Length and weight data were recorded for all Ozark Bass collected, and fish ages were determined through selective otolith retrieval and age-length keys. Ozark Bass in Crooked Creek had greater relative condition than Ozark Bass in Buffalo River (P P > 0.05) between sexes for fish collected from only the Buffalo River. Ozark Bass mean annual survival was similar between Crooked Creek (55% ± 5% as 95% confidence interval (CI)) and the Buffalo River (50% ± 7% CI) for fish age 2 to 9. Calculated Ozark Bass lengths-at-age for fish from both streams were comparable to the von Bertalanffy growth estimates, except the Buffalo River age 7 category where there was only one observation. The relationship between Ozark Bass age and length differed between sampled streams, and variability in growth rates and length-at-age were observed among Ambloplites species. Results of this study contribute to the understanding of the population dynamics of the Ozark Bass that will lead to improved fisheries management.

关键词： Endemic Fish measurements Fishing Regulations Ozarks

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Das Bettelweib von Locarno

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德语学习 2011年第6期 7-10页

作者： Heinrich von Kleist

Am Fuβe der Alpen , bei Locarno im oberen Italien , befand sich ein altes , einem marchese gehriges Schloβ, das man jetzt , wenn man vom *** kommt , in Schutt und

关键词： der St ab Am Das Bettelweib von Locarno

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婴幼儿术后气腹吸收时间的动物实验

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放射学实践 1986年第2期 63-64页

作者： von maria Kuntz J. trger G. Alzen 吴亚群同济医科大学附属同济医院

X线检查证实非人为的腹腔游离气体,即可诊断为胃肠道穿孔(肠壁囊样积气症除外)。为区别剖腹术后X线所见腹腔气体属于术中进入的空气抑或术后吻合口瘘所致,就需了解腹腔气体生理吸收时间。许多学者对婴幼儿术后腹腔气体正常吸收时间进行... 详细信息

X线检查证实非人为的腹腔游离气体,即可诊断为胃肠道穿孔(肠壁囊样积气症除外)。为区别剖腹术后X线所见腹腔气体属于术中进入的空气抑或术后吻合口瘘所致,就需了解腹腔气体生理吸收时间。许多学者对婴幼儿术后腹腔气体正常吸收时间进行研究,结果很不一致。也有学者对家兔、鼠等动物进行实验研究腹腔气体的吸收时间,但选用的实验动物不适于人类。本文选用小家

关键词：吸收时间婴幼儿动物实验生物检验气腹

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Ein traum im traume

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德语人文研究 2011年第1期 9-11+8页

作者： marie von Ebner-Eschenbach

mir trumte,ich htte das vollkommene Luftschiff erfunden und sei mit ihm an eine so ferne Stelle im Weltenraum gelangt,daβ erst jetzt Bilder von Ereignissen zu ihr drangen,die sich vor tausend und aber tausend Jah... 详细信息

关键词： der Ein traum im traume

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斑岩铜矿系统中深成岩-火山岩联系的锆石成岩年代学证据

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矿物岩石地球化学通报 2017年第5期36卷 806-806页

作者： Yannick Buret Jrn-Frederik Wotzlaw stan Roozen marcel Guillong Albrecht von Quadt Christoph A.Heinrich 袁超

建立深成岩与火山岩研究之间的有机联系,对于理解从火山喷发到岩浆-热液矿床形成的各种岩浆过程是非常必要的。斑岩铜矿床普遍与规模较大且长期活动的火山中心有密切联系,但是关于矿化侵入体与火山喷发的时间和动力学机制方面的联系仍... 详细信息

建立深成岩与火山岩研究之间的有机联系,对于理解从火山喷发到岩浆-热液矿床形成的各种岩浆过程是非常必要的。斑岩铜矿床普遍与规模较大且长期活动的火山中心有密切联系,但是关于矿化侵入体与火山喷发的时间和动力学机制方面的联系仍存在很大的争议。

关键词：斑岩铜矿床火山岩深成岩年代学证据锆石系统火山喷发

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临床磁共振体层摄影的前途展望

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放射学实践 1987年第3期 105-110页

作者： von Hermann Knig ,窦永充同济医科大学附属同济医院

在磁共振体层摄影临床应用的第一阶段,与CT相比,显示了一系列优越性,因而希望它进一步发展和专用化.特别是对某些器官的测量技术标准化和信息处理尤为重要.尽管KST与CT相比既昂贵又费时,但现在对有些脑脊髓病变的费用/效果关系已倾向有... 详细信息

在磁共振体层摄影临床应用的第一阶段,与CT相比,显示了一系列优越性,因而希望它进一步发展和专用化.特别是对某些器官的测量技术标准化和信息处理尤为重要.尽管KST与CT相比既昂贵又费时,但现在对有些脑脊髓病变的费用/效果关系已倾向有利于***不需射线曝光和造影剂即可在任何切层平面显示组织的病变过程.

关键词：合成图象 tr TE 层厚冠状面体层摄影图象质量磁共振

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内脏恶性肿瘤在眼周皮脂腺癌患者中的发生率及临床特征

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 27-28页

作者： Conway R.m. von moller A. Ballhausen W. 陈立军 Department of Oph thalmology Eye Hospital University of Erlangen-Nürnberg Erlangen Germany

Purpose: To report the frequency and clinical features of internal visceral ma lignancy in an unselected series of patients with sebaceous gland carcinoma (SGC ).methods: A non-comparative retrospective case series of consecutive patients with a histologically proven diagnosis of periocular sebaceous cell carcinoma tr eated at the University Eye Hospital, University of Erlangen-Nürnberg between 1981 and 2000. Results: Twenty three patients were identified, each with one tum or. men and women were almost equally affected with a mean age at diagnosis of 6 2 years (range 37-83 years). The majority of tumors were located in the upper l id, but five tumors were situated in the lower lid or caruncle. In 22 of the 23 patients the diagnosis at referral was either incorrect or not suspected. In all cases, the SGC was treated by surgical excision. In the systems review, 11 of t he 23 patients (48%) had evidence of previous systemic malignancy, the most com mon being colorectal cancer followed by liver and bronchial carcinoma. Forty-fi ve percent of patients with SGC and internal visceral malignancy eventually died as a result of their tumors. Conclusion: Periocular SGC remains an underdiagnos ed entity for which a high level of clinical suspicion is critical for early rec ognition. Almost half the patients additionally had an internal visceral maligna ncy. Internal visceral malignancy in unselected patients with SGC may be more co mmon and have a more guarded prognosis than has been appreciated.

关键词：皮脂腺癌眼周下睑泪阜上睑单发肿瘤病理组织学检查支气管肺癌眼科医院结肠癌

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Tierexperimentelle Untersuchung zur Effektivit tder transarteriellen Chemoembolisation unter Einsatz von Poly-Laktide-co-Glykolide-mikrosph ren

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Journal of Huazhong University of Science and Technology(medical Sciences) 2002年第4期22卷 346-349页

作者：钱骏 Rntgenabteilung

Evaluierung der Effektivit t von Poly- L aktide- co- Glykolide (PL CG ) - mikrosph ren als Em bolisationsm aterial in der transarteriellen Chem oem bolisation(TACE) im tierexperimentellen *** m nnlichen ACI- Ratten(n=11) erfolgte die Im plantation eines soliden morris Hepatomas(1m m3) subkapsul r in den linken L eberlappen. 13Tage nach Implan- tation wurden die Tumorvolumina kernspintom ographisch bestim *** Tiere wurden in Thera- piegruppe (n =4 ) und Kontrollgruppe (n=7) geteilt. Nach L aparotomie und retrograder Ka- theterisierung der Arteria gastroduodenalis wurden 4 0 mg PL CG- mikrosph ren und 0 ,0 5 m g mit- omycin in Therapiegruppe,1,5 ml 0 ,9% Kochsalzl sung in Kontrollgruppe zum Vergleich *** Effektivit tsbeurteilung der beiden methoden erfolgte14 Tage nach Katheter- isierung eine erneute kernspintomographische Volumenbestimm ung der Tum *** deutliche Tumorvolumenzunahme von2 7,12 fache in Kontrollgruppe wurde im Beobachtungszeitraum gese- *** Vergleich zur Kontrollgruppe zeigte die Therapiegruppe eine sehr geringere Tumorvolu- menzunahme von 2 ,87fache im Beobachtungszeitraum . Die Tum orvolumenzunahm e zwischen der beiden Gruppen zeigten beim T- Test einen signifikanten U nterschied (Pm des L ebertum ors wurde unter Einsatz von PL CG- mikrosph ren in der TACE im tierexperi- mentellen modell deutlich gehemmt.

关键词： L eber Tumor TACE PL CG mikrosph ren

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