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Chemical analysis and antioxidant content of various propolis samples collected from different regions and their impact on antimicrobial activities

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 436-442页

作者： Soumaya touzani Noori Al-Waili Nawal El Menyiy Bratko Filipic Adriana Pereyra Ilham EL Arabi Wail Al-Waili Badiaa Lyoussi Laboratory of Physiology Pharmacology & Environmental Health Faculty of Science University Sidi Mohamed Ben Abdellah New York Medical Care for Nephrology Institute for Microbiology and Immunology Medical Faculty of Ljubljana University of Ljubljana

Objective: To assess the antioxidant content, antimicrobial and antioxidant activities of various propolis samples. Methods: Seven propolis samples were collected from different locations in Morocco, which are characterized by different plant predominant vegetations. The resin, wax and balsam of hydroalcoholic extract of propolis content were identified, and the antioxidant content was analyzed with the use of HPLC and colorimetric methods. The antioxidant activity was assessed by DPPH, ABTS.^+ and ferric reducing power assays. The antimicrobial activity was assessed against bacterial species, including methicillin resistant Staphylococcus aureus and Candida albicans, and expressed as the minimal inhibitory concentration. Results: The propolis samples showed significant variations in the chemical composition and in the antioxidant or antimicrobial activities even when the samples were collected from the same location. Propolis with high resin and low wax content had high level of antioxidant compounds, and strong antioxidant and antimicrobial activities. Gram-positive bacteria, especially, methicillin resistant Staphylococcus aureus were more sensitive to all propolis samples than Gram-negative bacteria and Candida albicans. Conclusions: The chemical composition and the antioxidant and antimicrobial activities of various propolis samples are different and rely on the geographic and plant origin of propolis collection. Propolis samples with low wax and high resin content might be more suitable to be used in future preclinical or clinical investigations.

关键词： Propolis Antimicrobial Antioxidant Phenol Candida albicans Methicillin resistant Staphylococcus aureus

Severe Colchicine Poisoning: A Case Report

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Case Reports in Clinical Medicine 2015年第10期4卷 342-344页

作者： Abdelkarim Shimi Soumaya touzani Ali Derkaoui Mohammed Khatouf Intensive Care Unit A1 Hassan II University Hospital Sidi Mohamed Ben Abdellah University Fez Morocco

Background: Colchicine intoxication is uncommon but potentially life threatening because of the high toxicity of the drug. Colchicine binds to the intracellular protein tubulin, causing disturbed mitosis in all tissues followed by multi-organ failure. Case Presentation: We report a case of a 23-year-old woman admitted to emergency room 12 hours after a suicide attempt by ingestion of approximatively 40 mg of colchicine. Few hours after consumption, first symptoms were a hemodynamic shock and ARDS, leading to her death due to multi-organ failure. Conclusion: The colchicine intoxication has strong morbidity for doses higher than 0.5 mg/kg. The treatment is symptomatic. The immunotherapy using anti-colchicine allows improving critical form’s prognosis.

关键词： Colchicine Intoxication Shock Multiple Organ Failure

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科学健身（健尚） 2009年第12期 94-105页

作者：无 touzani 王瑛赫雪鸟喜马拉雅不详

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Cystitis Glandularis: A Rare Benign Condition Presenting as Bladder Tumor

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Open Journal of Urology 2018年第12期8卷 336-343页

作者： Sumba Harrison Hamza Lamchahab Jacquet Djamal Youness Jabbour touzani Alae Tariq Karmouni Kadir El Khader Abdelatif Koutani Ahmed Ibn Attiya Andaloussi Department of Urology “B” Ibn Sina University Hospital Rabat Morocco Faculty of Medicine and Pharmacy Mohamed V University Rabat Morocco Department of Uro-Andrology Faculty of Health Sciences Cotonou Benin

Cystitis glandularis or glandular metaplasia of the urinary bladder, is a benignreactive metaplasia of the urothelium, which occurs in the context of chronic irritation, in less than 2% of the general population. It is a condition in most casesasymptomatic, but also characterized by nonspecific symptoms and paraclinical findings, which is why this condition is underdiagnosed. Its evolution is mainly focused on the risk of malignant degeneration. This condition affects men much more commonly than women. Two forms of cystitis glandularis are recognized: typical and intestinal form. They differ in their histology, incidence, difficulty of diagnosis, and possible association with adenocarcinoma of the bladder. Diagnosis of certainty is histological by careful analysis of chips from bladder endoscopic resection. This rare pathology is managed by endoscopic bladder resection, with repeated cystoscopy as a monitoring tool. Extensive surgical is needed in severe or recurrent cases. We present here-in a case of a female patient having cystitis glandularis presenting with lower urinary tract symptoms. We review equally data reported in literature. To the best of our knowledge our case represents the fourth case of cystitis glandularis affecting a female patient reported in the English literature so far.

关键词： Cystitis Glandularis Cystoscopy Bladder Resection

The Histological Variants of Urothelial Carcinoma of the Bladder: It Is Affecting the Prognosis?

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Open Journal of Pathology 2020年第1期10卷 24-34页

作者： Souhail Regragui Mohammed Alae touzani Amine Slaoui Anas Mehedra Hafsa Elouazzani Tariq Karmouni Khalid El Khader Abdellatif Koutani Najat Mahassini Ahmed Ibn Attya Andaloussi Faculty of Medicine and Pharmacy Mohammed 5 University Rabat Morocco “B” Urology Department Ibn Sina Hospital Rabat Morocco Pathology Department Ibn Sina Hospital Rabat Morocco

Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called “histological variants of urothelial carcinoma”. They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these variants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis.

关键词： Urothelial Carcinoma Variants Prognosis