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视网膜中央动脉阻塞患眼超选择性眼动脉溶栓治疗前后黄斑区视网膜厚度变化

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中华眼底病杂志 2024年第4期40卷 268-272页

作者：罗天一姚裕锋宋其缘窦晓燕深圳大学医学部深圳518061 深圳市第二人民医院眼科深圳518025 汕头大学医学院汕头515041 深圳市儿童医院眼科深圳518034

目的观察视网膜中央动脉阻塞(CRAO)患眼超选择性眼动脉溶栓(IAT)治疗前后黄斑中心视网膜厚度(CRT)变化情况。方法回顾性临床研究。2022年8月至2023年9月于深圳市第二人民医院眼科检查确诊并行IAT治疗的CRAO患者12例12只眼纳入研究。其中... 详细信息

目的观察视网膜中央动脉阻塞(CRAO)患眼超选择性眼动脉溶栓(IAT)治疗前后黄斑中心视网膜厚度(CRT)变化情况。方法回顾性临床研究。2022年8月至2023年9月于深圳市第二人民医院眼科检查确诊并行IAT治疗的CRAO患者12例12只眼纳入研究。其中,男性8例8只眼,女性4例4只眼;均为单眼发病。患者年龄(47.00±15.06)岁,发病至溶栓时间为(30.00±30.42)h。所有患眼均行最佳矫正视力(BCVA)、光相干断层扫描(OCT)检查;同时行荧光素眼底血管造影(FFA)检查6只眼。BCVA检查采用标准对数视力表进行,统计时换算为最小分辨角对数(logmAR)视力。采用OCT仪测量患眼黄斑中心凹(m)以及分别距中心凹小凹1、3 mm处上方(S1、S3)、下方(I1、I3)、鼻侧(N1、N3)、颞侧(T1、T3)CRT。CRT定义为视网膜内界膜至视网膜色素上皮层强反射带内侧界面之间的垂直距离。IAT治疗后24 h采用治疗前相同设备和方法行相关检查。对比观察黄斑区不同点位CRT的变化情况;行FFA检查的6只眼,对比观察动脉显影时间的变化。治疗前后logmAR BCVA、不同点位CRT、动脉显影时间比较采用配对检验。结果IAT治疗前,患眼logmAR BCVA为3.48±1.42;行FFA检查的6只眼,动脉显影时间为(27.50±5.47)s。治疗后24 h,患眼logmAR BCVA为2.35±1.59,BCVA较治疗前不同程度提高9只眼;动脉显影时间为(24.17±7.28)s。治疗前后患眼logmAR BCVA、动脉显影时间比较,差异有统计学意义(t=2.489、3.262,Pm(t=-0.490)处CRT比较,差异均无统计学意义(P>0.05)。结论IAT可有效治疗CRAO,降低CRT,但短期内黄斑区视网膜水肿消退程度有限。

关键词：体层摄影术,光学相干视网膜中央动脉阻塞超选择性眼动脉溶栓黄斑区视网膜厚度视力

[Na(DB18-C-6)(H2O)2][Na(DB18-C-6)(SCN)2]：Two-Di-mensional Network Complex Assembled by π-π Stacking Interactios,Hydrogen Bonds and Electrostatic Interactions

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Chinese Journal of Chemistry 2002年第5期20卷 424-426页

作者： Zhu D.-Z. Song X.-m. dou J.-m. Liu Y. Wang D.-Q. Department of Chemistry Liaocheng Teacher's College Liaocheng 252000 China

A novel two-dimensional network dibenzo-18-crown-6 (DB18-C-6) complex: [Na(DB18-C-6) (H2O)2] [Na(DB18-C-6) (SCN)2] has been isolated and characterized by elemental, IR and X-ray diffraction analysis. The crystal structure belongs to monoclinic, space group P2 1/c with cell dimensions a = 1.06178(7), b = 1.40243(8), c = 3.03496(19) nm, β = 90.4220(10)°, V = 4.5292(5) nm3, Z = 4, Dcalcd = 1.351 g/cm3, F(000) = 1936, R1 = 0.0369, wR2 = 0.0821. The most interesting feature in this structure is that complex cation and complex anion form a two-dimensional network via π-π stacking interactions, hydrogen bonds and electrostatic interactions.

关键词： Crown ether Crystal structure DB18-crown-6 Hydrogen bonds π-π stacking interactions

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果园智能化作业装备自主导航技术研究进展

农业机械学报 2024年第4期55卷 1-22页

作者：窦汉杰陈震宇翟长远邹伟宋健冯凡张焱龙王秀北京市农林科学院智能装备技术研究中心北京100097 国家农业智能装备工程技术研究中心北京100097 江苏大学农业工程学院镇江212013

果园生产管理主要包括喷药、施肥、割草、修剪、授粉、疏花和采收分级等作业环节,需要大量的人力投入,随着我国人口老龄化程度加剧,亟需果园生产管理由机械化向智能化转型升级。自主导航技术是果园机械化装备实现智能化的关键技术。本... 详细信息

果园生产管理主要包括喷药、施肥、割草、修剪、授粉、疏花和采收分级等作业环节,需要大量的人力投入,随着我国人口老龄化程度加剧,亟需果园生产管理由机械化向智能化转型升级。自主导航技术是果园机械化装备实现智能化的关键技术。本文围绕果园智能化作业装备导航控制需求,结合国内外研究现状,分别阐述了包含导航定位信息和障碍物信息的果园作业场景感知技术,导航地图构建、导航路径提取和路径规划技术,行走底盘运动学模型构建、运动控制技术,多机协同控制、远程交互控制技术等。随着智慧农业发展,智慧果园已成为果园未来发展方向,果园智能化作业装备是智慧果园建设必不可少的关键环节,在此基础上,归纳了我国果园智能化作业装备自主导航技术发展面临的问题为:环境感知能力不足、路径提取不稳定、局部路径规划不灵活、导航系统环境适应性欠缺、多机协同和远程控制不成熟等,提出了多传感器融合的环境感知与路径提取、完整路径规划、强通用性果园导航、大型果园多作业环节的多机协同与远程操作等未来发展方向。

关键词：果园生产管理作业装备自主导航智慧果园

弱透水层瞬态水力参数的地质统计反演识别研究

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地质学报 2024年第1期98卷 324-331页

作者：庄超余文平严龙张健翼窦智杨蕴周志芳王锦国河海大学地球科学与工程学院江苏南京211100 水利部交通运输部国家能源局南京水利科学研究院江苏南京210029

弱透水层释水变形伴随着水力参数(渗透系数K和贮水率Ss)的瞬态变化,传统的“移动窗口”式反演方法假定每个反演窗口的初始状态是静态的,这与弱透水层释水变形存在明显滞后效应的实际情况不符。本文提出了在高维参数反演优化情境下,时间... 详细信息

弱透水层释水变形伴随着水力参数(渗透系数K和贮水率Ss)的瞬态变化,传统的“移动窗口”式反演方法假定每个反演窗口的初始状态是静态的,这与弱透水层释水变形存在明显滞后效应的实际情况不符。本文提出了在高维参数反演优化情境下,时间域上模型参数的动态变化可与空间域上模型参数的一维非均质性等价,因而可用地质统计反演方法可用于识别弱透水层瞬态K和Ss的新思路,实现了该方法在水文地质领域的创新性应用。以上海越流含水层系统为例,运用似线性地质统计反演算法,高精度地拟合了F16分层标处的长观变形数据,获取了原位透镜体状弱透水层K和Ss的瞬态特征。反演结果显示,观测时段内K的变幅为1.02×10^(-5)~5.89×10^(-4)m/a,平均值为1.38×10^(-4)m/a,Ss的变幅为4.34×10^(-4)~6.02×10^(-3)m^(-1),平均值为2.65×10^(-3)m^(-1)。基于反演所得参数瞬态特征,分析原位弱透水层在1994年前后分别以弹性和塑性变形为主,弱透水层K呈现与含水层水位相反的季节性变化特征,该现象可能与渗流力作用下细粒物质在含水层与弱透水层透镜体交界面附近的对孔隙的阻塞和疏通作用有关。该方法可获取完整观测时段内水文地质参数的动态变化轨迹,在计算评价地表水-地下水交互领域的河床渗透性、原位修复领域的渗透反应墙渗透性等的动态演化特征方面具有潜在的应用价值,并可作为构建水文地质领域、岩土工程等领域有关本构模型的有效辅助手段。

关键词：弱透水层瞬态水力参数地质统计反演时空等价性

基于网络药理学和分子对接的半枝莲黄酮类成分治疗肝细胞癌的机制研究

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中国医学工程 2024年第7期32卷 1-8页

作者：刘小妹窦锦明潍坊市中医院制剂科山东潍坊261041

目的网络药理学方法探究半枝莲黄酮类成分治疗肝细胞癌的作用机制及分子对接技术验证。方法通过TCmSP、SwissTargetPrediction、OmIm、BioGPS等数据库筛选黄酮类成分、肝特异性靶点;构建肝特异性靶点蛋白互作网络、筛选核心模块和基因;... 详细信息

目的网络药理学方法探究半枝莲黄酮类成分治疗肝细胞癌的作用机制及分子对接技术验证。方法通过TCmSP、SwissTargetPrediction、OmIm、BioGPS等数据库筛选黄酮类成分、肝特异性靶点;构建肝特异性靶点蛋白互作网络、筛选核心模块和基因;进行肝特异性靶点生物通路富集分析;将黄酮类成分和核心蛋白靶点在SwissDock平台进行分子对接。结果黄酮类成分36个,肝特异性靶点135个,核心基因4个;关键生物通路均与肝细胞癌的增殖抑制相关。黄酮成分与核心靶点有较强的结合活性。结论半枝莲黄酮类成分抗肿瘤作用可能是通过多成分-多靶点阻滞肝癌细胞的有丝分裂G1/S细胞周期,抑制肝细胞癌增殖。

关键词：网络药理学分子对接半枝莲黄酮肝细胞癌增殖抑制

Improved Hardy–Littlewood–Sobolev Inequality on S^(n)under Constraints

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Acta mathematica Sinica,English Series 2023年第11期39卷 2149-2163页

作者： Yun Yun HU Jing Bo dou School of mathematics and Statistics Shaanxi Normal UniversityXi’an 710119P.R.China

In this paper,we establish an improved Hardy–Littlewood–Sobolev inequality on Snunder higher-order moments ***,by constructing precise test functions,using improved Hardy–Littlewood–Sobolev inequality on S^(n),we show such inequality is almost optimal in critical *** an application,we give a simpler proof of the existence of the maximizer for conformal Hardy–Littlewood–Sobolev inequality.

关键词： Hardy–Littlewood–Sobolev inequality higher-order moments constraint concentration compactness principle almost optimal

metabolomics of astaxanthin hyperaccumulation in Haematococcus pluvialis under high light stress

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海洋湖沼学报(英文) 2023年第5期41卷 1876-1886页

作者： Yong dou Jiayi LI Wenli ZHOU Tianjin Agricultural University College of FisheriesTianjin Key Lab for Aquaculture Ecology and CultivationTianjin 300384China Tianjin modern Tianjiao Agricultural Technology Co. Ltd.Tianjin Key Laboratory for Green and Ecological ForageTianjin 301800China

Variation in metabolite profiles of Haematococcus pluvialis(a type of unicellular green algal)under light stress is a key issue of study at the *** investigate the effect of light intensity on accumulation of astaxanthin in ***,a 26-day batch culture experiment of *** under the light intensity levels at 73,127,182,236,and 291μmol/(m^(2)·s)was ***,the optimal light intensity and the corresponding metabolic pathways of accumulation in *** were *** show that 236μmol/(m^(2)·s)was the optimum light intensity to induce astaxanthin accumulation,at which a maximum content of 9.01 mg/L was achieved on Day 24.A total of 132 metabolites were identified and quantified,of which 38 differential metabolites were highlighted and classified,including 3 fatty acids or intermediates,5 amino acids or derivatives,5 carbohydrates or intermediates,16nucleoside derivatives,and 9 other metabolites using LC-mS/mS ***,16 statistically significant differential metabolic pathways were enriched and annotated based on Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis between the control and the 236μmol/(m^(2)·s)treatment group(Pmetabolism and signaling systems,such as carbohydrate metabolism,amino acid metabolism,glycerol and derivatives metabolism,nucleotide and derivative metabolism,and inositol phosphate metabolism were activated and regulated under strong light stress ***,4 hub metabolites containing D-glucose-6-phosphate,L-tyrosine,glycerol-3-phosphate,and L-glutamine were identified,based on which the associated metabolic network was *** study provided a metabolomic view of astaxanthin accumulation in *** under strong light stress.

关键词： Haematococcus pluvialis astaxanthin high light stress metabolomic analysis

Interfacial Engineering for Improved Stability of Flexible Perovskite Solar Cells

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Energy material Advances 2022年第1期2022卷 1-15页

作者： Jie dou Qi Chen Beijing Key Laboratory of Construction Tailorable Advanced Functional materials and Green Applications MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesExperimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Because of unique optoelectronic properties,such as extended carrier lifetime,large absorption coefficient,high defect tolerance factor,low exciton binding energy,and ambipolar diffusion,metal halide perovskites display enormous potential for the next generation of *** perovskite solar cells with low weight,high flexibility,and conformability have attracted attention for portable electronic *** interface is crucial in perovskite solar cells for both photovoltaic efficiency and operational stability.A high-quality interface could be obtained through interface ***,we summarize the degradation mechanisms and review interfacial engineering with the emphasis on their effects in flexible perovskite solar *** the basis of recent research progress in flexible devices,current challenges,possible directions,and perspectives are *** would be helpful to promote the commercialization of flexible perovskite solar cells.

关键词： stability. perovskite interface

A Preliminary Investigation of Arctic Sea Ice Negative Freeboard from in-situ Observations and Radar Altimetry

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Journal of Ocean University of China 2021年第2期20卷 307-314页

作者： LI Shutong dou Tingfeng XIAO Cunde State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Land Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China

The negative freeboard of sea ice(i.e., the height of ice surface below sea level) with subsequent flooding is widespread in the Southern Ocean, as opposed to the Arctic, due to the relatively thicker ice and thinner snow. In this study, we used the observations of snow and ice thickness from 103 ice mass balance buoys(ImBs) and NASA Operation IceBridge Aircraft missions to investigate the spatial distribution of negative freeboard of Arctic sea ice. The Result showed that seven ImBs recorded negative freeboards, which were sporadically located in the seas around Northeast Greenland, the Central Arctic Ocean, and the marginal areas of the Chukchi–Beaufort Sea. The observed maximum values of negative freeboard could reach-0.12 m in the seas around Northeast Greenland. The observations from IceBridge campaigns also revealed negative freeboard comparable to those of ImBs in the seas around North Greenland and the Beaufort Sea. We further investigated the large-scale distribution of negative freeboard using NASA CryoSat-2 radar altimeter data, and the result indicates that except for the negative freeboard areas observed by ImBs and IceBridge, there are negative freeboards in other marginal seas of the Arctic Ocean. However, the comparison of the satellite data with the ImB data and IceBridge data shows that the Cryosat-2 data generally overestimate the extent and magnitude of the negative freeboard in the Arctic.

关键词： Arctic sea ice negative freeboard ice mass balance buoy IceBridge CryoSat-2