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Design and Prototyping of Micro Centrifugal Compressor for Ultra Micro Gas Turbine

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Journal of Thermal Science 2005年第4期14卷 308-313页

作者： Shimpei MIZUKI toshiyuki HIRANO Yoshiyuki KOIZUMI Gaku MINORIKAWA Hoshio TSUJITA Mitsuo IWAHARA Ronglei GU Yutaka OHTA Eisuke OUTA Department of Mechanical Engineering Hosei University Japan Graduate School of Engineering Mechanical Engineering Hosei University 7-2 Kajinocho 3 chomeKoganei-shi Tokyo 184-8584 Japan Department of Mechanical Engineering Waseda University

In order to establish the design methodology of an ultra micro centrifugal compressor, which is the most important component of an ultra micro gas turbine unit, a 10 times size of the final target compressor （impeller outer diameter 40 mm, corrected rotational speed 220,000 r/min） was designed. The problems to be solved for downsizing were examined and a 2-dimensional impeller was chosen as the first model due to its productivity. The conventional 1D prediction method and CFD were used. The prototyped compressor was tested by using cold air at the reduced speed of 110,000 r/min. Following to the 10 times model, a 5 times size of the final target model having fully 3-dimensional shape （impeller outer diameter 20mm, corrected rotational speed 500,000 r/min） was designed and tested by using hot gas at the reduced speed of 250,000 r/min.

关键词： centrifugal compressor performance characteristics 3-dimensional impeller.

Effect of Electric Field Imposition on Metal Anodizing Behavior

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Journal of Iron and Steel Research International 2012年第S2期19卷 1149-1151页

作者： KOZUKA toshiyuki IKENOMOTO Takashi KAWAHARA Masayasu Department of Materials Engineering Kumamoto University Undergraduate student of Dept.of Materials Eng.Kumamoto University

Anodic oxidation processes for metal surface have been utilized many materials,for example,porous alumina, nano-silicon crystal,and so *** these materials,anodizing surface treatment for titanium or zirconium is useful for biocompatible material,like artificial bones and *** anodizing behavior,successive dielectric breakdown makes the surface microscopic bumpy morphology,which is important for the *** field can promote the oxidation behavior at the anodizing *** the result of the anodizing experiments using titanium or zirconium plate(10mm × 10mm),it is found that the anodized film becomes thicker and the microscopic honeycomb structure becomes finer and uniform by the imposition of electric field up to 200 kV/m.

关键词： electric field imposition metal anodizing surface treatment titanium plate zirconium plate

Pancreatic schwannoma:Case report and an updated 30-year review of the literature yielding 47 cases

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World Journal of Gastroenterology 2012年第13期18卷 1538-1544页

作者： toshiyuki Moriya Wataru Kimura Ichiro Hirai Akiko Takeshita Koji Tezuka Toshihiro Watanabe Masaomi Mizutani Akira Fuse First Department of Surgery Yamagata University Faculty of Medicine2-2-2 Iida-NishiYamagata 990-9585Japan

Pancreatic schwannomas are rare neoplasms. Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature. Databases for PubMed were searched for English-language articles from 1980 to 2010 using a list of keywords, as well as references from review articles. Only 41 articles, including 47 cases, have been reported in the English literature. The mean age was 55.7 years （range 20-87 years）, with 45% of patients being male. Mean tumor size was 6.2 cm （range 1-20 cm）. Tumor location was the head （40%）, head and body （6%）, body （21%）, body and tail （15%）, tail （4%）, and uncinate process （13%）. Thirty-four percent of patients exhibited solid tumors and 60% of patients exhibited cystic tumors. Treatment included pancreati- coduodenectomy （32%）, distal pancreatectomy （21%）, enucleation （15%）, unresectable （4%）, refused opera- tion （2%） and the detail of resection was not specified in 26% of patients. No patients died of disease with a mean follow-up of 15.7 mo （range 3-65 too）, although 5 （11%） patients had a malignancy. The tumor size was significantly related to malignant tumor （13.8 ＋ 6.2 cm for malignancy vs 5.5 ＋ 4.4 cm for benign, P = 0.001） and cystic formation （7.9 ~ 5.9 cm for cystic tumor vs 3.9 ＋ 2.4 cm for solid tumor, P = 0.005）. The preoperative diagnosis of pancreatic schwannoma remains difficult. Cystic pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms and pseudocysts. In our caset intraoperative frozen sec- tion confirmed the diagnosis of a schwannoma. Simple enudeation may be adequate, if this is possible.

关键词： Pancreatic schwannoma Pancreas Schwanno-ma Neurinoma Resection Imaging Enucleation Progno-sis Cystic

Expression of vascular endothelial growth factor and its receptors VEGFR-1 and 2 in gastrointestinal stromal tumors,leiomyomas and schwannomas

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World Journal of Gastroenterology 2006年第38期12卷 6182-6187页

作者： toshiyuki Nakayama Yang Cheul Cho Yuka Mine Ayumi Yoshizaki Shinji Naito Chun Yang Wen Ichiro Sekine Department of Tumor and Diagnostic Pathology Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan Division of Pathology Research Laboratory National Ureshino Medical Center Saga 843-0301 Japan Department of Digestive Disease Affiliated hospital of Beihua University Jilin 132011 Jilin Province China

AIM： To investigate the role of vascular endothelial growth factor （VEGF/and its receptors VEGFR-1 and 2 in the growth and differentiation of gastrointestinal strornal tumors （GISTs）. METHODS： Thirty-three GISTs, 15 leiomyomas and 6 schwannomas were examined by immunohistochemistry in this study. RESULTS： VEGF protein was expressed in the cytoplasm of tumor cells, and VEGFRol and 2 were expressed both in the cytoplasm and on the membrane of all tumors. Irnrnunohistochernical staining revealed that 26 GISTs （78.8%）, 9 leiornyornas （60.0%） and 3 schwannornas （50.0%/were positive for VEGF; 24 GISTs （72.7%/, 12 leiornyornas （80.0%） and 4 schwannornas （66.7%） were positive for VEGFR-1; 30 GISTs （90.9%/, 5 leiornyornas （33.3%/and 4 schwannornas （66.7%） were positive for VEGFR-2. VEGFR-2 expression was statistically different between GISTs and leiomyomas （P 〈 0.0001）. However, there was no correlation between the expression of VEGF pathway componenets and the clinical risk categories. CONCLUSION： Our results suggest that the VEGF pathway may play an important role in the differentiation of GISTs, leiomyomas and schwannomas.

关键词： Gastrointestinal stromal tumor Leiomyoma Schwannoma Vascular endothelial growth factor Vascular endothelial growth factor receptors

Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas

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World Journal of Gastroenterology 2006年第11期12卷 1743-1746页

作者： toshiyuki Nakayama Ayumi Yoshizaki Shinji Naito Chun Yang Wen Gabit Alipov Yuichi Yakata Ichiro Sekine Department of Molecular Pathology Nagasaki University Graduate School of Biomedical Sciences1-12-4 Sakamoto Nagasaki 852-8523 Japan Division of Pathology Research Laboratory National Ureshino Medical Center Saga 843-0301 Japan Department of Digestive Disease Nanjing Drum Tower Hospital Medical School of Nanjing UniversityNanjing 210008 Jiangsu Province China Tissue and Histopathology Section Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Nagasaki 852-8523 Japan

AIM： Gastrointestinal stromal tumors （GISTs） are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract （e.g. leiornyomas and schwannomas）. The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS： Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS： Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs （96.4%）, six leiomyomas （66.7%）, and five schwannomas （83.3%） were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas （P〈0.005）. However, there was no correlation between Ets-1 expression and clinical risk categories. CONCLUSION： Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.

关键词： Ets-1 GISTs Leiomyoma Schwannoma Immunohistochemistry Risk category

Design of quaternary ammonium type-ionic liquids as desiccants for an air-conditioning system

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Green Chemical Engineering 2020年第2期1卷 109-116页

作者： Sho Maekawa Ryo Matsumoto Kenta Ito Toshiki Nokami Jian-Xin Li Hiroshi Nakayama toshiyuki Itoh Department of Chemistry and Biotechnology Graduate School of EngineeringTottori UniversityJapan Center for Research on Green Sustainable Chemistry Tottori University4-101 Koyama-minamiTottori680-8552Japan State Key Lab of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingPR China Chubu Electric Power Co.Inc.Research and Development Division Advanced Research and Innovation Center20-1 Kitasekiyama Ohtaka-choMidori-kuNagoya459-8522Japan Toyota Physical and Chemical Research Institute 41-1 YokomichiNagakute CityAichi480-1192Japan

The liquid desiccant air-conditioning system allows reducing energy consumption compared to the conventional compressor-type air *** order to develop desiccant materials for air conditioners,we have investigated the dehumidification capability of quaternary ammonium Ionic Liquids(ILs)and the equilibrium water vapor pressure of aqueous solutions of these ammonium *** the seven tested types of ILs,2-hydroxyN,N,N-trimethylethan-1-aminium dimethylphosphate([Ch][DMPO4])displayed the best dehumidification capability and the lowest equilibrium water vapor ***,the 80%aqueous solution of[Ch][DMPO4]exhibited a less corrosive effect on four types of metals,i.e.,steel(hot dip zinc-aluminum alloy plated steel),copper(C1100P),aluminum(A5052),and stainless steel(SUS:SUS304).It should be noted that this[Ch][DMPO4]is not only non-toxic but also exhibits a stable nature;the aqueous solution produced no odor after storing for over 1 year under ambient conditions.

关键词： Dehumidification Liquid desiccant Choline type ionic liquid Air-conditioner system

Hepatocellular carcinoma metastasizing to the skull base involving multiple cranial nerves

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World Journal of Gastroenterology 2006年第41期12卷 6727-6729页

作者： Soo Ryang Kim Fumio Kanda Hiroshi Kobessho Koji Sugimoto toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi Department of Gastroenterology Kobe Asahi HospitalKobeJapan Department of Neurology Kobe University HospitalKobeJapan Department of Radiology Kobe University Graduate School of MedicineKobeJapan Department of Radiology Osaka City University Medical SchoolOsakaJapan Department of Gastroenterology Kink University School of MedicineOsakasayamaJapan Division of Molecular Medicine & Medical Genetics Kobe University Graduate School of MedicineKobeJapan

We describe a rare case of HCV-related recurrent multiple hepatocellular carcinoma （HCC） metastasizing to the skull base involving multiple cranial nerves in a 50-year-old woman. The patient presented with symptoms of ptosis, fixation of the right eyeball, and left abducens palsy, indicating disturbances of the right oculomotor and trochlear nerves and bilateral abducens nerves. Brain contrast-enhanced computed tomography （CT） revealed an ill-defined mass with abnormal enhancement around the sella turcica. Brain magnetic resonance imaging （HR/） disclosed that the mass involved the clivus, cavernous sinus, and petrous apex. On contrast-enhanced HRI with gadolinium-chelated contrast medium, the mass showed inhomogeneous intermediate enhancement. The diagnosis of metastatic HCC to the skull base was made on the basis of neurological findings and imaging studies including CT and MRI, without histological examinations, Further studies may provide insights into various methods for diagnosing HCC metastasizing to the craniospinal area.

关键词： Hepatocellular carcinoma Distant metasta- sis Skull base Cranial nerve

VISUALIZATION OF TURBULENT REACTIVE JET BY USING DIRECT NUMERICAL SIMULATION

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 70-85页

作者： TOMOAKI WATANABE YASUHIKO SAKAI KOUJI NAGATA OSAMU TERASHIMA HIROKI SUZUKI toshiyuki HAYASE YASUMASA ITO Department of Mechanical Science and Engineering Nagoya University Nagoya Aichi464-8603Japan Department of Engineering Physics Nagoya Institute of Technology Nagoya Aichi466-8555Japan Institute of Fluid Science Tohoku University SendaiMiyagi980-8577Japan

Direct numerical simulation(DNS)of turbulent planar jet with a second-order chemical reaction(A+B→R)is performed to investigate the processes of mixing and chemical reactions in spatially developing turbulent free shear *** A is premixed into the jet flow,and reactant B is premixed into the ambient *** is performed at three different Damk¨ohler numbers(Da=0.1,1,and 10).Damk¨ohler number is a ratio of a time scale of a flow to that of chemical reactions,and in this study,the large Da means a fast chemical reaction,and the small Da means a slow chemical *** visualization of velocity field shows that the jet flow is developed by entraining the ambient *** visualization of concentration of reactant A shows that concentration of reactant A for Da=1 and 10 becomes very small in the downstream region because the chemical reaction consumes the reactants and reactant A is diffused with the jet *** comparison of the profiles of chemical reaction rate and concentration of product R,it is found that product R for Da=10 is produced by the chemical reaction at the interface between the jet and the ambient fluids and is diffused into the jet flow,whereas product R for Da=0.1 is produced in the jet flow after reactants A and B are well mixed.

关键词： Turbulent flow direct numerical simulation jet.

Heparin bridge therapy and post-polypectomy bleeding

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World Journal of Gastroenterology 2016年第45期22卷 10009-10014页

作者： toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura Masanori Nojima Hiroshi Nakase Department of Gastroenterology and Hepatology Sapporo Medical University Department of Gastroenterology Otaru City General Hospital Center for Translational Research the Institute of Medical Science the University of Tokyo

AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants.

关键词： Post-polypectomy bleeding Heparin bridge therapy Colonic polypectomy Anticoagulants Antiplatelets Endoscopic surgery