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Analysis of oxidative stress and antioxidative potential in premature ovarian insufficiency

World Journal of Clinical Cases 2023年第12期11卷 2684-2693页

作者： Kaoru Kakinuma toshiyuki Kakinuma Department of Obstetrics and Gynecology International Health and Welfare HospitalNasushiobara 327-2763Japan

BACKGROUND Premature ovarian insufficiency(POI)is characterized by an early decline in ovarian function,inducing secondary *** the cause of POI has not yet been identified,the function of mitochondria in the ovaries and the cytotoxicity associated with reactive oxygen species(ROS)have been implicated in follicle pool depletion and a decline in follicle *** developed tests have enabled easy measurement of diacron-reactive oxygen metabolites(d-ROMs)and biological antioxidant potential(BAP).The combination of these two tests is used to comprehensively assess oxidative stress in the *** To comprehensively assess the oxidative stress of d-ROMs and BAP in *** Participants were classified into two groups:A POI group of 11 women aged<40 years examined between January 2021 and June 2022 with a history of secondary amenorrhea for at least 4 mo in our hospital and an FSH value of≥40 mIU/mL;and a control group of healthy women of the same age with normal ovarian function in our *** d-ROMs and BAP were measured in both these groups *** between groups were assessed using the *** The mean age and mean body mass index(BMI)were 35.8±3.0 years and 20.1±1.9 kg/m2 in the control group and 35.8±2.7 years and 19.4±2.5 kg/m2 in the POI group,*** mean gravidity and parity in control and POI groups were 0.6±0.7 and 0.4±0.5 and 0.6±0.9 and 0.3±0.5,*** two groups did not differ significantly in terms of mean age,BMI,gravidity,or *** d-ROMs level was significantly higher in the POI group than in the control group(478.2±58.7 vs 341.1±35.1 ***;P<0.001);however,the BAP level did not significantly differ between the two groups(2078.5±157.4 vs 2029.0±186.4μmol/L).The oxidase stress index(d-ROMs/BAP×100)was significantly higher in the POI group than in the control group(23.7±3.3 vs 16.5±2.1;P<0.001).CONCLUSION Oxidative stress was significantly greater in the POI group than in the con

关键词： Premature ovarian insufficiency Reactive oxygen species Oxidative stress Ovary Antioxidant

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Venous thromboembolic risk and protein S deficiency: ethnic difference and remaining issues

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Journal of Geriatric Cardiology 2009年第1期6卷 11-19页

作者： Tong Yin toshiyuki Miyata Institute of Geriatric Cardiology General Hospital of People''s Liberation Army Beijing 100853 China National Cardiovascular Center Research Institute Suita Osaka Japan

Protein S deficiency is an autosomal dominant disorder that results from mutations in the protein S gene (PROS1). Inherited deficiency of protein S constitutes a risk factor for venous thromboembolism. Protein S functions as a nonenzymatic cofactor for activated protein C in the proteolytic degradation of coagulation factors V a and Villa. The frequency of protein S deficiency seems to differ between populations. More than 200 rare mutations in PROS1 have been identified in patients with protein S deficiency. Among the prevalent mutations within PROS1, the S460P substitution (known as Heerlen polymorphism) detected in Caucasians and the K196E substitution (known as protein S Tokushima) found in Japanese have been intensively studied for their structures and potential functions in the disorder of protein S deficiency. Until now, causative mutations in PROS1 have been found in only approximately 50% of cases with protein S deficiency. Co-segregation analysis of microsatellite haplotypes with protein S deficiency in families with protein S deficiency suggests that the causative defects in the PROS1 mutation-negative patients are located in or close to the PROS 1 gene. Large PROS 1 gene deletions have been identified in 3 out of 9 PROS 1 mutation-negative Swedish VTE families with protein S deficiency and 1 out of 6 PROS1 mutation-negative Japanese patients with protein S deficiency. Intensive sequencing of the entire PROS 1 gene, including introns, may be needed to identify the cryptic mutations in those patients, and these efforts might uncover the pathogenesis of protein S deficiency.

关键词： protein S deficiency PROS 1 thrombophilia mutation genetic defects

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Effect of bending and tension deformation on the texture evolution and stretch formability of Mg-Zn-RE-Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1334-1342页

作者： Yuya Ishiguro Xinsheng Huang Yuhki Tsukada toshiyuki Koyama Yasumasa Chino Department of Materials Design Innovation Engineering Nagoya UniversityFuro-choChikusa-kuNagoya464-8603Japan Multi-Material Research Institute National Institute of Advanced Industrial Science and Technology2266-98AnagahoraSimo-shidami Moriyama-kuNagoya463-8560Japan

Bending and tension deformations were performed on Mg-1.3 wt%Zn-0.2 wt%RE-0.3 wt%Zr(ZEK100)alloy sheets that initially had a transverse direction(TD)-split *** effects of bending and tension deformations on the texture formation and room-temperature formability of specimens were *** specimen subjected to 3-pass bending and tension deformations exhibited an excellent Erichsen value of 9.6 ***,the Erichsen value deterioration was observed in the specimen subjected to 7-pass *** rolling direction-split texture developed on the surface with an increasing pass number of ***,the clear TD-split texture remained at the central *** a result,a quadrupole texture was macroscopically developed with an increasing pass number of *** reduction in anisotropy by the formation of the quadrupole texture is suggested to be the main reason for the improvement in stretch *** contrast,the generation of coarse grains near the surface is suggested to be the direct cause for the deterioration of the stretch formability of the specimen subjected to 7-pass deformations.

关键词： magnesium alloy texture stretch formability bending and tension deformation mechanical properties

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Nestin:A novel angiogenesis marker and possible target for tumor angiogenesis

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World Journal of Gastroenterology 2013年第1期19卷 42-48页

作者： Yoko Matsuda Masahito Hagio toshiyuki Ishiwata Departments of Pathology and Integrative Oncological Pathology Nippon Medical SchoolTokyo 113-8602Japan

Abnormal vasculature,termed tumor vessels,is a hallmark of solid *** degree of angiogenesis is associated with tumor aggressiveness and clinical ***,exact quantification of tumor vessels is useful to evaluate ***,selective detection of newly formed tumor vessels within cancer tissues using specific markers raises the possibility of molecular targeted therapy via the inhibition of tumor ***,an intermediate filament protein,is reportedly expressed in repair processes,various neoplasms,and proliferating vascular endothelial *** expression is detected in endothelial cells of embryonic capillaries,capillaries of the corpus luteum,which replenishes itself by angiogenesis,and proliferating endothelial progenitor cells,but not in mature endothelial ***,expression of nestin is relatively limited to proliferating vascular endothelial cells and endothelial progenitor *** expression is also reported in blood vessels within glioblastoma,prostate cancer,colorectal cancer,and pancreatic cancer,and its expression is more specific for newly formed blood vessels than other endothelial cell ***-positive blood vessels form smaller vessels with high proliferation activity in *** of nestin in vascular endothelial cells suppresses endothelial cell growth and tumor formation ability of pancreatic cancers in *** nestin to more accurately evaluate microvessel density in cancer specimens may be a novel prognostic ***,nestin-targeted therapy may suppress tumor proliferation via inhibition of angiogenesis in numerous malignancies,including pancreatic *** this review article,we focus on nestin as a novel angiogenesis marker and possible therapeutic target via inhibition of tumor angiogenesis.

关键词： Nestin Angiogenesis Molecular targeting therapy Gastrointestinal cancer Pancreatic cancer Microvessel density CD34 CD31 Factor VIII

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Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

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World Journal of Gastroenterology 2011年第4期17卷 409-418页

作者： toshiyuki Ishiwata Yoko Matsuda Zenya Naito Department of Pathology Integrative Oncological Pathology Nippon Medical School

Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological conditions, nestin is expressed in repair processes in the CNS, muscle, liver, and infarcted myocardium. Furthermore, increased nestin expression has been reported in various tumor cells, including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanoma, dermatofibrosarcoma protuberances, and thyroid tumors. Nestin is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors; however, the roles of nestin in cancer cells have not been well characterized. Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers. These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis. It has received a lot of attention recently as a cancer stem cell marker in various cancer cells including brain tumors, malignant rhabdoid tumors, and uterine, cervical, prostate, bladder, head and neck, ovarian, testicular, and pancreatic cancers. The purpose of this review is to clarify the roles of nestin in cancer cells and in tumor angiogenesis, and to examine the association between nestin and cancer stem cells. Nestin has the potential to serve as a molecular target for cancers with nestin-positive cancer cells and nestin-positive tumor vasculature.

关键词： Cancer growth Intermediate filament protein Cancer invasion Tumor migration Nestin Stem cell marker Tumor angiogenesis

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Trajectories of endoscopic Barrett esophagus: Chronological changes in a community-based cohort

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World Journal of Gastroenterology 2016年第35期22卷 8060-8066页

作者： Shouji Shimoyama Toshihisa Ogawa toshiyuki Toma Gastrointestinal Unit Settlement Clinic

AIM To elucidate longitudinal changes of an endoscopic Barrett esophagus(BE), especially of short segment endoscopic BE(SSBE). METHODS This study comprised 779 patients who underwent two or more endoscopies between January 2009 and December 2015. The intervals between the first and the last endoscopy were at least 6 mo. The diagnosis of endoscopic BE was based on the criteria proposed by the Japan Esophageal Society and was classified as long segment(LSBE) and SSBE, the latter being further divided into partial and circumferential types. The potential background factors that were deemed to affect BE change included age, gender, antacid therapy use, gastroesophageal reflux disease-suggested symptoms, esophagitis, and hiatus hernia. Time trends of a new appearance and complete regression were investigated by Kaplan-Meier curves. The factors that may affect appearance and complete regression were investigated by χ~2 and Student-t tests, and multivariable Cox regression analysis. RESULTS Incidences of SSBE and LSBE were respectively 21.7% and 0%, with a mean age of 68 years. Complete regression of SSBE was observed in 61.5% of initial SSBE patients, while 12.1% of initially disease free patients experienced an appearance of SSBE. Complete regressions and appearances of BE occurred constantly over time, accounting for 80% and 17% of 5-year cumulative rates. No LSBE development from SSBE was observed. A hiatus hernia was the only significant factor that facilitated BE development(P = 0.03) or hampered(P = 0.007) BE regression. CONCLUSION Both appearances and complete regressions of SSBE occurred over time. A hiatus hernia was the only significant factor affecting the BE story.

关键词： Barrett esophagus Longitudinal vessels Progression Regression Hiatus hernia

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Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

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Chemical Research in Chinese Universities 2010年第1期26卷 66-69页

作者： QIU Xue-peng KOSOBE toshiyuki KAWASHIMA Norimichi Faculty of Biomedical Engineering Toin University of Yokohama 1614 Kurogane-cho Aoba-ku Yokohama 225-8502 Japan Laboratory of Polymer Engineering Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy（PDT） of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PplX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates（C5-S, C6-S, C8-S） exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application ofPplX-mediated PDT to cancer cell.

关键词： Photodynamic therapy Methanesulfonate salt 5-Aminolevulinic acid Derivative Cancer cell

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STUDY ON POLYMERIZATION MECHANISM OF 3, 9,-DIALLYL-3, 9, -DIBENZYL-1, 5, 7, 11-TETRAOXASPIRO [5, 5] UNDECANE

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Chinese Journal of Polymer Science 1992年第4期10卷 343-349页

作者：白如科胡悦邹应芳潘才元 toshiyuki Uryu Department of Materials Science and Engineering University of Science and Technology of China Hefei China Institute of Industrial Science University of Tokyo

A new monomer, 3,9-diallyl-3, 9-dibenzyl-1, 5,7,11 - tetraoxa- spiro [5,5] undecane (6) was prepared by the reaction of 2- allyl- 2' - benzyl- propanediol - 1.3 with dibutyltin oxide, and then treated with CS_2. Monomer 4 could be initiated by cationic initiators to give a viscous polymer (white powder in the case of polymerization at 0℃). Upon the NMR and IR spectra of the obtained polymer, the components and their relative amount were estimated. The polymerization mechanism was discussed.

关键词： Polymerization Mechanism Cationic polymerization Spirocarbonates 3, 9-diallyl-3, 9-dibenzyl-1, 5, 7, 11-tetraoxaspiro (5,5) undecane

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Catalytic liquid-phase oxidation of acetaldehyde to acetic acid over a Pt/CeO_2–ZrO_2–SnO_2/γ-alumina catalyst

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Journal of Environmental Sciences 2015年第10期27卷 63-66页

作者： Pil-Gyu Choi Takanobu Ohno toshiyuki Masui Nobuhito Imanaka Department of Applied Chemistry Faculty of EngineeringOsaka University

Pt/CeO2–ZrO2–SnO2/γ-Al2O3 catalysts were prepared by co-precipitation and wet impregnation methods for catalytic oxidation of acetaldehyde to acetic acid in water. In the present catalysts, Pt and CeO2–ZrO2–SnO2 were successfully dispersed on the γ-Al2O3 *** of platinum content and reaction time on the selective oxidation of acetaldehyde to acetic acid were investigated to optimize the reaction conditions for obtaining both high acetaldehyde conversion and highest selectivity to acetic acid. Among the catalysts, a Pt（6.4 wt.%）/Ce0.68Zr0.17Sn0.15O2.0（16 wt.%）/γ-Al2O3 catalyst showed the highest acetaldehyde oxidation activity. On this catalyst, acetaldehyde was completely oxidized after the reaction at 0°C for 8 hr, and the selectivity to acetic acid reached to 95%and higher after the reaction for 4 hr and longer.

关键词： Liquid-phase oxidation Acetaldehyde Rare earths Catalyst

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Efficient gasification of wet biomass residue to produce middle caloric gas

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Particuology 2008年第5期6卷 376-382页

作者： Guangwen Xu Takahiro Murakami toshiyuki Suda Hidehisa Tani Yutaka Mito Research Laboratory IHI Co. Ltd. (IHI) Isogo-Ku Yokohama 235-8501 Japan State Key Laboratory of Multiphase Phase Complex System Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China Energy Research Division Kobe steel Co. Ltd. Kobe Hyogo 651-2271 Japan

Various process residues represent a kind of biomass resource already concentrated but containing water as much as 60 wt.%. These materials are generally treated as waste or simply combusted directly to generate heat. Recently, we attempted to convert them into middle caloric gas to substitute for natural gas, as a chemical or a high-rank gaseous fuel for advanced combustion utilities. Such conversion is implemented through dual fluidized bed gasification （DFBG）. Concerning the high water content of the fuels, DFBG was suggested to accomplish either with high-efficiency fuel drying in advance or direct decoupling of fuel drying/pyrolysis from char gasification and tar/hydrocarbon reforming. Along with fuel drying, calcium-based catalyst can be impregnated into the fuel, without much additional cost, to increase the fuel＇s gasification reactivity and to reduce tar formation. This article reports the Ca impregnation method and its resulting effects on gasification reactivity and tar suppression ability. Meanwhile, the principle of directly gasifying wet fuel with decoupled dual fluidized bed gasification （D-DFBG） is also highlighted.

关键词： High-water content biomass Catalytic gasification Dual fluidized bed gasification Decoupled gasification Calcium

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