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钢架混凝土(SRC)衬砌管片的开发

地下空间 2003年第4期23卷 448-452页

作者： S.NAGAOKA M.OZEKI K.iwata K.HONDA T.MORI S.AKITAYA M.YAMAMOTO 翟进营日本钢筋混凝土管片工业协会东京都市大学中铁隧道集团有限公司科研所河南洛阳471007

日本已开发出一种新型的、用于高荷载条件下大直径盾构隧道的钢架混凝土(SRC)衬砌管片。这种新型的衬砌管片比传统的钢筋混凝土 (RC)衬砌管片薄 ,并且设计成具有很高的强度 ,而丝毫不降低耐腐蚀性。这种衬砌管片已在实际施工现场中应用... 详细信息

日本已开发出一种新型的、用于高荷载条件下大直径盾构隧道的钢架混凝土(SRC)衬砌管片。这种新型的衬砌管片比传统的钢筋混凝土 (RC)衬砌管片薄 ,并且设计成具有很高的强度 ,而丝毫不降低耐腐蚀性。这种衬砌管片已在实际施工现场中应用。目前 ,对这种新型的衬砌管片仍在进行改进 ,或考虑改进 ,使这种新型管片具有更好的工作性能、更便于施工。

关键词：钢架混凝土衬砌管片盾构法隧道

磷酸化α-突触核蛋白对63位赖氨酸链接的泛素结合物的促成提示路易小体的形成机制

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磷酸化α-突触核蛋白对63位赖氨酸链接的泛素结合物的促成提示路...

煤焦与水蒸气的气化实验及表观反应动力学分析

华东六省一市生物化学与分子生物学学会2006年学术交流会

作者：刘超费尔康贾娜丽王洪枫陶瑞松 Atsushi iwata Nobuyuki Nukina 周江宁王光辉微尺度物质科学国家实验室＆中国科学技术大学生命科学学院 RIKEN Brain Science Institute Saitama351-0198Japan

目的研究α-突触核蛋白(alpha-synuclein,α-SN)129位丝氨酸(serine-129,S129)这一病理位点的磷酸化在帕金森病(Parkinson’s disease,PD)发病中的作用及其机制。方法将绿色荧光蛋白 (EGFP)标记的α-SN(α-SN-EGFP)129位丝氨酸突变为天冬氨酸(S129D)来模拟持久磷酸化,以共同转染α-SN-EGFP和泛素(ubiquitin,Ub)的neuro2a细胞为对象,应用免疫细胞化学和生化方法研究α- 突触核蛋白对培养细胞的泛素蛋白酶体(ubiquitin proteasome system,UPS)系统的影响。结果在细胞内共表达EGFP,野生型α-SN-EGFP,S129D α-SN-EGFP和3xFlag标记的泛素(3xFlag-Ub),S129D 突变型比野生型形成更多的泛素结合物,获得更多泛素化修饰,并形成路易小体(Lewy body,LB)样结构。当泛素63位赖氨酸突变成精氨酸后,S129D突变型不再促进泛素结合物和路易小体样结构的形成。在转染α-SN-EGFP后用无血清培养以及低浓度H2O2作用细胞,S129D突变型比野生型引起更多胞质和神经突内的α-SN-EGFP聚集物。结论 129位丝氨酸磷酸化的α-SN可能通过促成63位赖氨酸链接的泛素结合物以及自身聚集物形成在帕金森病及其他相关疾病中路易小体的形成中起重要作用。

关键词：帕金森病路易小体 α-突触核蛋白泛素泛素蛋白酶体

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中国电机工程学报 2008年第5期28卷 34-38页

作者：王明敏张建胜岳光溪吕俊复须田俊之高藤誠清华大学热科学与动力工程教育部重点实验室北京市100084 石川岛播磨重工业株式会社基础技术研究所日本横滨市235-8501

在Thermax500型热重分析仪上对褐煤煤焦与水蒸气的气化反应进行了实验研究,并采用n级速率方程和Langmuir-Hinshelwood(L-H)速率方程考察了反应气体分压的影响。实验系统压力为0.1和0.6MPa,其中0.1MPa下水蒸气浓度分别为5%,10%和20%,0.6... 详细信息

在Thermax500型热重分析仪上对褐煤煤焦与水蒸气的气化反应进行了实验研究,并采用n级速率方程和Langmuir-Hinshelwood(L-H)速率方程考察了反应气体分压的影响。实验系统压力为0.1和0.6MPa,其中0.1MPa下水蒸气浓度分别为5%,10%和20%,0.6MPa下的水蒸气浓度为20%。气化反应在恒温条件下进行,温度分别为850、875、900、925、950和1000℃。实验发现,反应速率随温度和压力的增大而加快,900℃以下为化学反应控制区,不同压力下的表观活化能数值接近,而900℃以上由于受到扩散阻力的作用,表观活化能不同程度降低。采用n级速率方程计算得到褐煤煤焦与水蒸气的反应级数n为0.34,活化能E为153.7kJ·mol-1,采用L-H方程得到活化能为207.1kJ·mol-1,其速率方程可更精确地描述水蒸气压力的影响。

关键词：褐煤水蒸气加压气化动力学

肠溶包衣压力控制结肠定位给药胶囊的体内外评价

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中国医院药学杂志 2009年第22期29卷 1928-1933页

作者：崔京浩唐丽华岩田雅树高间雅志村上正裕苏州大学医学部药学院江苏苏州215123 天藤制药株式会社大阪大谷大学药学部

目的:研究肠溶衣对压力控制结肠定位释放胶囊(Ent-PCDCs)的稳定性及其体内外释放特征。方法:压制法制备含咖啡因半合成脂肪酸脂囊芯,高效包衣机进行乙基纤维素(EC)和肠溶性包衣。测定PCDCs的体外崩解压力后,进行Ent-PC-DCs稳定性、体外... 详细信息

目的:研究肠溶衣对压力控制结肠定位释放胶囊(Ent-PCDCs)的稳定性及其体内外释放特征。方法:压制法制备含咖啡因半合成脂肪酸脂囊芯,高效包衣机进行乙基纤维素(EC)和肠溶性包衣。测定PCDCs的体外崩解压力后,进行Ent-PC-DCs稳定性、体外释放及恒河猴的口服药动学研究。结果:Ent-PCDCs的稳定性明显提高,其崩解压力与EC厚度呈线性关系;Ent-PCDCs在人工胃液中2h和人工肠液6h的累计释放量低于25%。药动学试验结果,EC厚度为32μm时咖啡因的Tmax和MRT分别为(5.67±1.21)h和(16.80±1.74)h,初步表明药物主要在结肠部位释放和吸收。结论:Ent-PCDC的稳定性符合要求,EC厚度对药物结肠定位释放具有重要影响。

关键词：肠道压力结肠定位肠溶衣药物释放

Present Status of NIRS ECR Ion Sources

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Chinese Physics C 2007年第S1期31卷 60-62页

作者： M.Muramatsu A.Kitagawa Y.iwata K.Yamamoto H.Ogawa S.Hojo Y.Sakamoto T.Honma W.Takasugi M.Wakaisami Y.Yoshida T.Kubo Y.Kato S.Biri A.G.Drentje Graduate school of Engineering Toyo UniversityJapan National Institute of Radiological Sciences4-9-1 AnagawaInageChiba 263-8555Japan National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan Accelerator Engineering Corporation Ltd.2-13-I KonakadaiInageChiba 263-0043Japan Department of Mechanical Engineering Toyo University2100 KujiraiKawagoeSaitarna 350-0815Japan Osaka University 2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute of Nuclear Research (ATOMKI) H-4026 DebrecenBen ter 18/cHungary National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan K.V.I.University of GroningenZernikelaan 259747AA GroningenNetherlands

Four ECR ion sources have been operated in National Institute of Radiological Sciences(NIRS). Two ECR ion sources supply various ion species for the Heavy Ion Medical Accelerator in Chiba(HIMAC). The 10GHz NIRS-ECR ion source mainly produces C^(2+) ions for the heavy-ion *** of Si,Ar,Fe,Kr and Xe are usually produced by the 18GHz NIRS-HEC ion source for physical and biological *** other two compact ECR ion sources with all permanent magnet configuration have been developed for the new generation carbon therapy *** of these,the Kei-source,is a prototype which has been installed to the NIRS-930 cyclotron for axial *** other source,Kei2-source,is a demonstration source and utilized for the new generation *** addition,both Kei sources have been used to study fundamental properties. In this paper,present status of the ion sources and recent developments are reported.

关键词： heavy ion therapy ECR

Upreguration of Ki-67 in human oral squamous cell carcinomas enhanced the cervical lymph node metastasis through the increased lymphangioplasty

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中国口腔颌面外科杂志 2008年第B5期6卷 185-185页

作者： Nakasone toshiyuki Akira Matayoshi Syoko Makishi Shigeki Sawada Hiroyuki Takemoto Hajime Sunakawa Department of Oral and Maxillofacial Functional Rehal~ilitation School of Medicine University of the Ryukyus Okinawa Japan

Purpose: To investigated the relationship between the number of tumor cells expressing Ki-67 and the frequency of lymph node metastasis in 44 surgically treated patients with OSCCs. Methods- All participants provided informed consent to participate in this study. None of the patients showed evidence of lymph node metastasis at initial clinical evaluation. lmmunohistochemical study with anti-Ki-67 monoclonal antibodies was performed to quantitate the number of tumour cells expression Ki-67 in the formalin-fixed, paraffin-embedded biopsy samples and the acquired images were analyzed using NIH image. Results: In 16 of 44 patients, secondary lymph node metastasis occurred. As compared with other Grade types of OSCCs, the frequency secondary lymph node metastasis was increased in Grade 4C and 4D type, in which the number of tumor cells expressing of Ki-67 was increased. Conclusion:

关键词：口腔舌鳞癌治疗方法临床分析 Ki-67 疗效

Determination of the cut-off score of an endoscopic scoring method to predict whether elderly patients with dysphagia can eat pureed diets

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World Journal of Gastrointestinal Endoscopy 2016年第6期8卷 288-294页

作者： Torao Sakamoto Akira Horiuchi toshiyuki Makino Masashi Kajiyama Naoki Tanaka Masamitsu Hyodo Department of Rehabilitation Showa Inan General Hospital Digestive Disease Center Showa Inan General Hospital Department of Otolaryngology Head and Neck Surgery Kochi Medical School

AIM: To identify the cut-off value for predicting the ability of elderly patients with dysphagia to swallow pureed diets using a new endoscopy scoring method. METHODS: Endoscopic swallowing evaluation of pureed diets were done in patients ≥ 65 years with dysphagia. The Hyodo-Komagane score for endoscopic swallowing evaluation is expressed as the sum(0-12) of four degrees(0-3) with four parameters:(1) salivary pooling in the vallecula and piriform sinuses;(2) the response of glottal closure reflex induced by touching the epiglottis with the endoscope;(3) the location of the bolus at the time of swallow onset assessed by "white-out" following swallowing of test jelly; and(4) pharyngeal clearance after swallowing of test jelly. We used receiver operating characteristic(ROC) curve analysis to retrospectively analyze the association between the total score and successful oral intake of pureed diets. RESULTS: One hundred and seventy-eight patients were enrolled including 113 men(63%), mean age 83 years(range, 66-98). One hundred and twenty-six patients(71%) were able to eat pureed diets during the observation period(mean ± SD, 19 ± 14 d). In ROC analysis, the cut-off value of the score for eating the pureed diets was 7(sensitivity = 0.98; specificity = 0.91).CONCLUSION: The Hyodo-Komagane endoscopic score is useful to predict the ability to eat pureed diets in elderly patients with dysphagia.

关键词： Dysphagia Endoscopy Pureed diets Percutaneous endoscopic gastrostomy

An event mixing technique for Bose-Einstein correlations of two pions in photoproduction around 1 GeV

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Chinese Physics C 2016年第11期40卷 67-74页

作者：何庆华 H.Fujimura H.Fukasawa R.Hashimoto Y.Honda T.Ishikawa T.iwata S.Kaida J.Kasagi A.Kawano S.Kuwasaki K.Maeda S.Masumoto M.Miyabe F.Miyahara K.Mochizuki N.Muramatsu A.Nakamura K.Nawa S.Ogushi Y.Okada Y.Onodera K.Ozawa Y.Sakamoto M.Sato H.Shimizu H.Sugai K.Suzuki Y.Tajima S.Takahashi Y.Taniguchi Y.Tsuchikawa H.Yamazaki R.Yamazaki H.Y.Yoshida Research Center for Electron Photon Science Tohoku University Institute of Fluid Physics China Academy of Engineering Physics Department of Physics Wakayama Medical University Department of Physics Yamagata University Department of Information Science Tohoku Gakuin University Department of Physics Tohoku University Department of Physics University of Tokyo Accelerator Laboratory KEK Institute of Particle and Nuclear Studies KEK Wakasa-wan Energy Research Center

We have developed an event mixing technique to observe Bose-Einstein correlations （BEC） between two identical neutral pions produced in photo-induced reactions in the non-perturbative QCD energy region. It is found that the missing-mass consistency cut and the pion-energy cut are essential for the event mixing method to effectively extract BEC observables. A Monte Carlo （MC） simulation is used to validate these constraints and confirms the efficiency of this method. Our work paves the way for similar BEC studies at lower energies where the multiplicity of emitted bosons is limited.

关键词： Bose-Einstein correlations photoproduction event mixing

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日本建筑节能对策

福建工程学院学报 2009年第3期7卷 244-252页

作者：李积权渡边俊行赤司泰义福建工程学院建筑与规划系福建福州350108 日本九州大学人类环境学研究院

通过对日本建筑节能对策的介绍,从法规、技术标准、评价制度、节能服务等方面分析了日本当前建筑节能状况。借鉴日本的经验,认为我国在完善建筑节能法规体系的同时,应制定有效的建筑节能评价体系和节能认证制度,实施节能建筑建设的经济... 详细信息

通过对日本建筑节能对策的介绍,从法规、技术标准、评价制度、节能服务等方面分析了日本当前建筑节能状况。借鉴日本的经验,认为我国在完善建筑节能法规体系的同时,应制定有效的建筑节能评价体系和节能认证制度,实施节能建筑建设的经济激励政策,加强建筑节能知识的普及与教育。

关键词：京都议定书建筑节能节能评价日本