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Depth Profiles of Absorbed Hydrogen in Ni-Nb-Zr Amorphous Alloy Ribbons by Glow Discharge Optical Emission Spectroscopy

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Open Journal of Metal 2014年第4期4卷 112-119页

作者： Rie Y. Umetsu Mikiko Saito toshio sasaki Tetsushi Sekiguchi Jun Mizuno Hiroshi Kawarada Institute for Materials Research Tohoku University Sendai Japan Institute for Nanoscience & Nanotechnology Waseda University Tokyo Japan

Depth profiles of absorbed hydrogen introduced by electrochemical charging and light elements were analyzed in Ni-Nb-Zr-H amorphous alloy ribbons using a glow discharge optical emission spectrometer. It was clarified that the absorbed hydrogen was comparatively well-distributed on the sample surface and that the content of the hydrogen decreased with increasing depth from the surface. That is, the amount of absorbed hydrogen on the surface was about 17 at %, while that inside the specimens decreased to several atomic percent. The depth profiles of the hydrogen which were close to the surface were slightly different between those on the roller side and those on the free side in the melt-spun ribbon. The difference is thought to originate from the existence of oxygen impurity on the surface and from the difference of the Zr content.

关键词： Amorphous Ribbon Hydrogen Absorption Glow Discharge Optical Emission Spectroscopy Depth Profile

Tie Up Actin Cytoskeleton To Suppress Cancer Metastasis

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Tie Up Actin Cytoskeleton To Suppress Cancer Metastasis

Transport Properties of Ni-Nb-Zr Glassy Alloys and Hydrogen Absorbed Alloys

第十届全国化学生物学学术会议

作者： Guanying Li toshio sasaki Shunsuke Asahina Toshiaki Mochizuki Ye Zhang Bioinspired Soft Matter Unit Okinawa Institute of Science and Technology Graduate School (OIST)

Cell modifies the migration mechanism in response to the surroundings, which sets the challenge for cancer therapy targeting metastasis through signaling pathways. To cope with the diversity and complexity, by the hand of synthetic molecular self-assembly, we develop a ‘ mechanical approach ’ 1 capturing membrane dynamicity to suppress cervical/ovarian cancer metastasis. Here we report a peptides modified Ru（II） complex with an octahedral geometry in the core that can discriminate targeting protein as guidance for molecular self-assembly. The Ru-complex based macromolecule captures lipid rafts2,3 through self-assembly. The self-assembled nanofibrils interact with raft-associated receptors4 interfering cell response physically. The molecular self-assemblies not just suspend the cancer migration, but also kill the normal tumor cell and cancer stem cell simultaneously. As a potential anti-cancer strategy, with sophisticated molecular design, we will be able to develop potential cancer therapy targeting drug resistant problem.5

关键词： cancer metastasis lipid raft Ru-complex self-assembly

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Open Journal of Metal 2013年第3期3卷 45-49页

作者： Rie Y. Umetsu Hajime Yoshida Mikio Fukuhara Shin-ichi Yamaura toshio sasaki Tetsushi Sekiguchi Mikiko Saito Jun Mizuno Hiroshi Kawarada Institute for Materials Research Tohoku University Sendai Japan Institute for Nanoscience & Nanotechnology Waseda University Tokyo Japan Research Institute for Electromagnetic Materials Sendai Japan

The electrical transport properties of (Ni0.8Nb0.2)100-xZrx (x = 30, 40 and 50) amorphous ribbons and hydrogen charged specimens were investigated. The amorphous ribbons indicated a negative coefficient in the temperature dependence of their electrical resistivity as well as the typical transport properties of the amorphous alloys with comparatively high values of electrical resistivity, ρ. The normalized temperature coefficient of the resistivity (TCR ≡ 1/ρ300K·dρ/dT) tended to increase with increasing x in the temperature range of 100-300 K. These behaviors would suggest that the transport properties of the present amorphous ribbons were governed by temperature variation of the Debye-Waller factor, not by electron-phonon scattering. The hydrogen charged ribbons obtained by an electrochemical method also showed similar electrical resistivity behaviors as a function of the temperature. However, TCR of x = 40 with hydrogen charged ribbon, in which the amount of absorbed hydrogen was about 14 at%, increased about three times more than that of the pre-charged amorphous ribbon.

关键词： Electrical Resistivity Amorphous Alloy Ribbon Hydrogen Absorption

Preventive Effect of Lactococcus lactis subsp. lactis JCM 5805 Yogurt Intake on Influenza Infection among Schoolchildren

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Health 2017年第4期9卷 756-762页

作者： Kiyomi Sakata Yumie sasaki Kenta Jounai toshio Fujii Daisuke Fujiwara Department of Hygiene and Preventive Medicine Iwate Medical University School of Medicine 2-1-1 Nishitokuta Yahaba-cho Shiwa-gun Iwate Japan Technical Development Center Koiwai Dairy Products Co. Ltd. 1254 Kamihirose Sayama-shi Saitama Japan Central Laboratories for Key Technologies Kirin Co. Ltd. 1-13-5 Fukuura Kanazawa-ku Yokohama Japan

Objective: A community-based intervention study was conducted to examine the effect of consumption of JCM 5805 yogurt on influenza incidence rates and the cumulative incidence rates among schoolchildren in Iwate Prefecture, Japan. Methods: Schoolchildren and their parents in Shizukuishi town were told of the purpose, frequency and duration of JCM 5805 yogurt administration. The number of elementary schoolchildren in Shizukuishi town was 780 while that of junior high school students in Shizukuishi town numbered 475. The number of elementary schoolchildren in neighboring town A was 208 and that of junior high school students in town A was 121. JCM 5805 yogurt was delivered three times a week to all elementary schools and junior high schools in Shizukuishi town from January 16 through March 18, 2015. The incidence rate was calculated every week as the maximum case number divided by the number of schoolchildren in each school. The cumulative incidence rate was calculated as the total case number during the period when JCM 5805 yogurt was delivered divided by the number of schoolchildren in each school. Results: JCM 5805 yogurt intake was associated with a two-thirds reduction in influenza incidence rates in Shizukuishi town schoolchildren compared with those of town A. Furthermore, the cumulative incidence rates of the elementary school and combined data from the elementary school and junior high school were significantly lower than those of neighbor town A. Conclusion: JCM 5805 yogurt intake reduced both the incidence rates and cumulative incidence rates of influenza.

关键词： Lactococcus lactis JCM 5805 Plasmacytoid Dendritic Cells Influenza Interferon-α Yogurt

间歇和连续静脉输注法莫替丁对消化性溃疡患者胃酸的影响

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中华消化杂志 2000年第5期20卷 331-332页

作者： Yozo Watanabe Hidenori Tsumura Hiroshi sasaki toshio Morimoto 孙钢日本Juntendo大学医学院Izunagaoka医院外科中国医学科学院中国协和医科大学北京协和医院消化科

胃十二指肠出血通常由慢性消化性溃疡、应激性溃疡或局部胃黏膜因素导致的急性胃黏膜损伤(AGML)引起.对良性疾病导致的胃十二指肠出血的治疗分为保守疗法和手术疗法.但是,内镜下止血的进展以及有效的H2受体拮抗剂(H2RA)和某些胃肠激素... 详细信息

胃十二指肠出血通常由慢性消化性溃疡、应激性溃疡或局部胃黏膜因素导致的急性胃黏膜损伤(AGML)引起.对良性疾病导致的胃十二指肠出血的治疗分为保守疗法和手术疗法.但是,内镜下止血的进展以及有效的H2受体拮抗剂(H2RA)和某些胃肠激素的应用使手术疗法在治疗胃十二指肠出血中的地位明显下降.

关键词：消化性溃疡药物疗法法莫替丁连续静输注胃酸

Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: a prospective Japanese multicenter study

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World Journal of Gastroenterology 2016年第14期22卷 3837-3844页

作者： Reina sasaki Yuji Sakai toshio Tsuyuguchi Takao Nishikawa Tatsuya Fujimoto Shigeru Mikami Harutoshi Sugiyama Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Department of Gastroenterology Kimitsu Chuo Hospital Department of Gastroenterology Kikkoman General Hospital

AIM: To determine the safety and efficacy of endoscopic duodenal stent placement in patients with malignant gastric outlet ***: This prospective, observational, multicenter study included 39 consecutive patients with malignant gastric outlet obstruction. All patients underwent endoscopic placement of a nitinol, uncovered, selfexpandable metal stent. The primary outcome was clinical success at 2 wk after stent placement that was defined as improvement in the Gastric Outlet Obstruction Scoring System score relative to the ***: Technical success was achieved in all duodenal stent procedures. Procedure-related complications occurred in 4 patients(10.3%) in the form of mild pneumonitis. No other morbidities or mortalitieswere observed. The clinical success rate was 92.3%. The mean survival period after stent placement was 103 d. The mean period of stent patency was 149 d and the patency remained acceptable for the survival period. Stent dysfunction occurred in 3 patients(7.7%) on account of tumor ***: Endoscopic management using duodenal stents for patients with incurable malignant gastric outlet obstruction is safe and improved patients' quality of life.

关键词： Duodenal stenosis Gastrointestinal stent Gastric stenosis Malignant tumors Metallic stent

New tapered metallic stent for unresectable malignant hilar bile duct obstruction

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World Journal of Clinical Cases 2015年第10期3卷 887-893页

作者： Yuji Sakai toshio Tsuyuguchi Takao Nishikawa Harutoshi Sugiyama Reina sasaki Dai Sakamoto Yuto Watanabe Masato Nakamura Shin Yasui Rintaro Mikata Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University

AIM: To examine the usefulness of a new tapered metallic stent(MS) in patients with unresectable malignant hilar bile duct ***: This new tapered MS was placed in 11 patients with Bismuth Ⅱ or severer unresectable malignant hilar bile duct obstruction, as a prospective study. The subjects were six patients with bile duct carcinoma, three with gallbladder cancer, and two with metastatic bile duct obstruction. Stenosis morphology was Bismuth Ⅱ: 7, Ⅲa: 3, and Ⅳ: 1. UMIN Clinical Trial Registry(UMIN000004758).RESULTS: MS placement was 100%(11/11) successful. There were no procedural accidents. The mean patency period was 208.401 d, the median survival period was 142.000 d, and the mean survival period was 193.273 d. Occlusion rate was 36.4%(4/11); the causes of occlusion were ingrowth and overgrowth in 2 patients each, 18.2%, respectively. Patients with occlusion underwent endoscopic treatment one more time and all were treatable. CONCLUSION: The tapered MS proved useful in patients with unresectable malignant hilar bile duct obstruction because it provided a long patency period, enabled re-treatment by re-intervention, and no procedural accidents occurred.

关键词： Malignant hilar bile duct obstruction Metallic stent Tapered metallic stent

Endoscopic papillary large balloon dilation for bile duct stones in elderly patients

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World Journal of Clinical Cases 2015年第4期3卷 353-359页

作者： Yuji Sakai toshio Tsuyuguchi Harutoshi Sugiyama Reina sasaki Dai Sakamoto Masato Nakamura Yuuto Watanabe Takao Nishikawa Shin Yasui Rintaro Mikata Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University

AIM: To investigate whether endoscopic papillary large balloon dilation(EPLBD) can be safety and effectively performed in patients aged ≥ 80 years. METHODS: Lithotomy by EPLBD was conducted in 106 patients with bile duct stones ≥ 13 mm in size or with three or more bile duct stones ≥ 10 mm. The patients were divided into group A(< 80 years) and group B(≥ 80 years). Procedure success rate, number of endoscopic retrograde cholangiopancreatographies(ERCP), and incidence of complications were examined in both ***: Group B tended to include significantly more patients with peripapillary diverticulum, hypertension, hyperlipemia, cerebrovascular disease/dementia, respiratory disease/cardiac disease, and patients administered an anticoagulant or antiplatelet agent(P < 0.05). The success rate of the initial lithotomy was 88.7(94/106)%. The final lithotomy rate was 100(106/106)%. Complications due to treatment procedure occurred in 4.72(5/106)% of the patients. There was no significant difference in procedure success rate, number of ERCP, or incidence of complications between group A and group ***: EPLBD can be safely performed in elderly patients, the same as in younger patients.

关键词： Elderly patients Endoscopic papillary large balloon dilation Endoscopic sphincterotomy Large bile duct stones Choledocholithiasis

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis by pancreatic duct stenting using a loop-tipped guidewire

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World Journal of Clinical Cases 2016年第8期4卷 213-218页

作者： Yuji Sakai toshio Tsuyuguchi Harutoshi Sugiyama Masahiro Hayashi Jun-ichi Senoo Reina sasaki Yuko Kusakabe Masato Nakamura Shin Yasui Rintaro Mikata Masaru Miyazaki Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Department of General Surgery Graduate School of Medicine Chiba University

AIM: To examine whether it is possible to prevent the occurrence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis in patients experiencing difficulties with selective biliary duct cannulation by pancreatic duct stenting using a looptipped ***: Procedure success rate, frequency of unintended insertion of the guidewire into side branches of the pancreatic duct, and incidence of procedural accidents were examined using a loop-tipped guidewire(Group A, 20 patients), and a conventional straighttype guidewire(Group B, 20 patients).RESULTS: The success rate of the procedure was 100% in both groups. Unintended insertion of the guidewire into a side branch of the pancreatic duct occurred 0.056 ± 0.23(0-1) times in Group A and 2.3 ±1.84(0-5) times in Group B; thus, unintended insertion of the guidewire into a side branch of the pancreatic duct was seen significantly less frequently in Group A. There were no procedural accidents in Group A, whereas pancreatitis occurred in one Group B patient; however, the difference between the two groups was not statistically significant. The serum amylase level after ERCP was 257.15 ± 136.4(88-628) IU/L in Group A, and 552.05 ± 534.57(101-2389) IU/L in Group B, showing a significantly lower value in Group A. Hyperamylasemia was found in two patients(10%) in Group A, and nine(45%) in Group B, showing a significantly lower value in Group ***: The results suggest that in patients who experience difficulties with biliary cannulation, the use of a loop-tipped guidewire for pancreatic duct stenting may assist with the prevention of post-ERCP pancreatitis, and thereby to a reduction of the risk of post-ERCP pancreatitis or hyperamylasemia.

关键词： Hyperamylasemia Post-endoscopic retrograde cholangiopancreatography pancreatitis Guidewire