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Does Obesity without Hyperglycemia Delay Wound Healing in an Obese Mouse Model Induced by a High-Fat Diet?

Health 2017年第12期9卷 1660-1679页

作者： Tamae Urai Yukari Nakajima Kanae Mukai Kimi Asano Mayumi Okuwa Junko Sugama toshio nakatani Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative Kanazawa University Ishikawa Japan Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Ishikawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Ishikawa Japan

It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels.

关键词： Obesity Mouse Cutaneous Wound Healing Splint Inflammation

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The Relationship between Cutaneous Wounds Made on Obese Mice or Those with Decreased Body Weight and Serum Leptin Level

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Health 2016年第11期8卷 1015-1028页

作者： Tamae Urai Haryanto Kanae Mukai Tatsuhiko Matsushita Kimi Asano Yukari Nakajima Mayumi Okuwa Junko Sugama toshio nakatani Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kan-azawa Japan Division of Clinical Radiology Service Kyoto University Hospital Kyoto Japan Wellness Promotion Science Center Institute of Medical Pharmaceutical and Health Sciences Kanazawa Uni-versity Kanazawa Japan

Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding;their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.

关键词： Obesity High-Fat Diet Wound Healing Leptin Tension

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Prevalence and Risk Factor of Diabetic Foot Ulcers in a Regional Hospital, Eastern Indonesia

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Open Journal of Nursing 2016年第1期6卷 1-10页

作者： Saldy Yusuf Mayumi Okuwa Muhammad Irwan Saipullah Rassa Baharia Laitung Abdul Thalib Sukmawati Kasim Hiromi Sanada toshio nakatani Junko Sugama Division of Health Sciences Graduate School of Kanazawa University Kanazawa Japan Wound Care Clinic Griya Afiat Makassar Indonesia Department of Gerontological Nursing/Wound Care Management Faculty of Medicine University of Tokyo Tokyo Japan Wellness Promotion Science Center Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan

Indonesia is one of the top ten diabetes mellittus (DM) countries. However as the main complication of DM, there was lack of studies related to diabetic foot ulcer (DFU). Thus, the aim of this study was to survey the prevalence of DFU risk factors and DFU among type 2 diabetes mellitus (T2DM) patients. An epidemiological study was conducted at an outpatient endocrine clinic in a regional hospital, eastern Indonesia. All T2DM participants attending research setting that were ≥ 18 years were included. Demographic and foot care behavior were assessed using minimum data sheet (MDS). Meanwhile, presence of risk factors was evaluated by using 5.07/10 g Semmes-Weinsten Monofilament (SWM) for neuropathy and presence of angiopathy was evaluated with Ankle Brachial Index (ABI) by using a hand held Doppler (Bidop ES-100V3, Hadeco-Kawasaki, Japan) both dorsal and posterior tibialis foot. At the end of study, 249 T2DM participants were enrolled. The prevalence of DFU risk factors was 55.4% (95% CI: 53.7% - 57.0%), and prevalence of DFU was 12% (95% CI: 10.3% - 13.6%). Based on a logistic regression, predictors for DFU risk factors included age (OR: 1.04;95% CI: 1.005 - 1.074) and daily foot inspection (OR: 0.36;95% CI: 0.186 - 0.703). Meanwhile, the predictors for presence of DFU were insulin (OR: 9.37;95% CI: 2.240 - 39.182), shoes (OR: 0.05;95% CI: 0.007 - 0.294), spiritual belief that DM was a disease (OR: 0.04;95% CI: 0.004 - 0.326) and belief that DM was a temptation from God (OR: 0.13;95% CI: 0.027 - 0.598). In conclusion, we recommend to educate high risk patients to understand positive foot care behavior as essentially preventive strategies to prevent presence risk and DFU.

关键词： Prevalence Diabetes Complications Risk Factors Diabetic Foot Ulcers

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啮齿动物的心包:连结心包和胸膜腔的小孔

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广东解剖学通报 1989年第2期 154-154页

作者： toshio nakatani

在大白鼠、金仓鼠和小白鼠的心包可见无数的圆形小孔。小白鼠的心包小孔最多。小孔一般直径小于50微米,由厚的、呈波浪式的胶原纤维束和薄的、直的弹力纤维构成网状结构。这些小孔直接连结心包胸膜腔以及间接地连结左、右胸膜腔,

关键词：胸膜腔心包腔啮齿动物金仓鼠纤维束弹力纤维孔最巨噬细胞游离细胞肥大细胞

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Safety and efficacy of metallic stent for unresectable distal malignant biliary obstruction in elderly patients

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World Journal of Gastroenterology 2018年第1期24卷 69-75页

作者： Yuji Sakai Tomohisa Iwai Kenji Shimura Katsushige Gon Kazuya Koizumi Masashi Ijima Kazuro Chiba Seigo nakatani Harutoshi Sugiyama toshio Tsuyuguchi Terumi Kamisawa Iruu Maetani Mitsuhiro Kida Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Gastroenterology Kitasato University School of MedicineKanagawa 252-0375Japan Department of Gastroenterology Asahi Central HospitalChiba 289-2511Japan Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Ohashi Medical CenterTokyo 153-8515Japan Gastroenterology Medicine Center Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Subaru Health Insurance Society Ota Memorial HospitalGunma 373-8585Japan Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyo 113-8677Japan

AIM To study the safety of insertion of metallic stents in elderly patients with unresectable distal malignant biliary *** Of 272 patients with unresectable distal malignant biliary obstruction, 184 patients under the age of 80 were classified into Group A, and 88 subjects aged 80 years or more were classified into Group B. The safety of metallic stent insertion, metal stent patency period, and the obstruction rate were examined in each *** In Group B, patients had a significantly worse per-formance status, high blood pressure, heart disease, cerebrovascular disease, and dementia; besides the rate of patients orally administered antiplatelet drugs or anticoagulants tended to be higher(P < 0.05). Metallic stents were successfully inserted in all patients. The median patency period was 265.000 ± 26.779(1-965) d; 252.000 ± 35.998(1-618) d in Group A and 269.000 ± 47.885(1-965) d in Group B, with no significant difference between the two groups. Metallic stent obstruction occurred in 82 of the 272(30.15%) patients; in 53/184(28.80%) patients in Group A and in 29/88(32.95%) of those in Group B, showing no significant difference between the two groups. Procedural accidents due to metal stent insertion occurred in 24/272(8.8%) patients; in 17/184(9.2%) of patients in Group A and in 7/88(8.0%) of those in Group B, with no significant difference between the two groups, *** These results suggested that metallic stents can be safely inserted to treat unresectable distal malignant biliary obstruction even in elderly patients aged 80 years or more.

关键词： Elderly patients Metallic stent Malignant biliary obstruction

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