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Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 86-90页

作者： Kyoko Kashima Nobuyuki Ohike Seishiro Mukai Masashi Sato Manabu Takahashi toshio morohoshi Department of Pathology Showa University School of Medicine Department of Internal MedicineShowa University Toyosy Hospital Department of Pathology Showa University School of Medicine Department of Pathology Showa University School of Medicine Department of SurgeryShowa University School of Medicine Division of Pathology Ebara HospitalTokyo Japan

BACKGROUND: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis. We examined maspin expression immunohistochemically and assessed its significance in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. METHODS: We examined 39 surgically resected specimens of IPMN that included 17 adenomas (IPMAs), 5 borderline tumors (IPMBs), 4 non-invasive carcinomas (non-invasive IPMCs), and 13 invasive carcinomas (invasive IPMCs). Immunostaining was performed according to the EnVision ChemMate method. The degree of maspin expression was scored and assessed according to the percentage and staining intensity of positive cells. RESULTS: Maspin expression was minimal in normal pancreatic duct epithelium, whereas in IPMNs, maspin was expressed in neoplasms of all stages. Maspin expression increased with increasing grade from IPMAs, IPMBs, to non-invasive IPMCs but decreased significantly in invasive IPMCs. No specific association between maspin expression and mucin type was found. Analysis of maspin expression with respect to clinicopathologic factors in cases of invasive IPMC revealed a greater extent of invasion in cases of low maspin expression and significantly fewer apoptotic cells in the ***: Maspin was expressed at high levels in IPMNs at various stages from adenoma to invasive carcinoma, and our results suggest that maspin may be involved in the occurrence and progression of IPMN. In addition, our data suggest that the apoptosis-inducing action of maspin suppresses invasion and progression of IPMN.

关键词： maspin intraductal papillary mucinous neoplasm pancreas apoptosis immunohistochemistry

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Gastric-and intestinal-type marker expression in invasive ductal adenocarcinoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 424-428页

作者： Yuichi Takano Nobuyuki Ohike Takuma Tajiri Kunio Asonuma Kenji Harada Hiroshi Takahashi toshio morohoshi First Department of Pathology Showa University School of MedicineTokyo 142-8555Japan Division of Gastroenterology KanagawaJapan Department of Diagnostic Pathology KanagawaJapan

BACKGROUND:Although invasive ductal adenocarcinoma of the pancreas(PDAC) manifests as a relatively uniform histomorphological feature of the pancreatobiliary type,it may be complicated by metaplastic changes and heterogeneous gastric and intestinal *** study aimed to investigate the complication rate and clinicopathological significance of such heterogeneous ***:Fifty-nine patients who underwent resection of PDAC were examined in this ***,tumors showing high expression(>25%) of the intestinal-type(INT) marker CDX2 were classified as PDAC with *** with high expression(>25%) of the gastric-type(GAS) marker MUC5AC were classified as PDAC with GAS,while those with high expression of both markers were classified as PDAC with INT/*** patients were compared with those with PDAC of the negative group in which neither markers was highly expressed to examine their clinicopathological ***:In the 59 patients,31(52.5%) showed high CDX2 or MUC5AC ***-eight patients(47.5%) belonged to a negative group,11(18.6%) to a PDAC with INT group,15(25.4%) to a PDAC with GAS group,and 5(8.5%) to a PDAC with INT/GAS *** significant differences were observed for age,gender,size,localization,T classification,or prognosis among the four *** the PDAC with GAS group had well differentiated types significantly more than the other groups,the rate of lymph node metastasis in this group was significantly higher(PDAC with GAS:73%;other groups:36%).CONCLUSION:Complications with heterogeneous elements are not uncommon in PDAC,and this should be considered during the diagnosis and treatment of PDAC along with histogenesis of the disease.

关键词： ductal adenocarcinoma pancreatic neoplasms gastric-type intestinal-type immunohistochemistry

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