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Study on viscosity of Hydoroxypropylmethylcellulose stearoxy ether(SANGELOSE) under mechanical shearing

Study on viscosity of Hydoroxypropylmethylcellulose stearoxy...

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生物颗粒与粉体制备、应用技术研讨会

作者：稻本靖也 Toshio Shimamoto Shunji Uramatsu Shinichi Akiyama Kozo Kishi toshinobu uemura 大同化成工业株式会社

Purpose:The clarification of viscosity characteristics of aqueous polymer gel under mechanical shearing is important for formulation design of gel and emulsion dosage forms in cosmetic and pharmaceutical *** study was focused on the clarification of viscosity change of aqueous SGL gel by an agitating homogenizer and a ***: Homogenizer as a medium mechanical shearing machine and microfluidizer as an extremely mechanical high shearing one were used,*** viscosity of SGL gel was investigated by treating with respective shearing,that is revolution speed /operation time in homogenizer's case and operation pressure/ passing time in case of microfluidizer's one. Carboxyvinylpolymer was used for ***:It was found that the viscosity of SGL gel was stable under medium mechanical shearing by a *** viscosity of SGL gel under extremely high shearing by a microfluidizer was decreased,however,the decrease level of viscosity might be tolerable to prepare emulsion dosage *** the other hand,CVP gel is unstable in viscosity under medium and high shearing.

关键词： Hydoroxypropylmethylcellulose stearoxy ether SANGELOSE viscosity mechanical shearing nano-emulsion

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Moisture barrier effect of PVA copolymer(POVACOAT) with addition of talc

Moisture barrier effect of PVA copolymer(POVACOAT) with addi...

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生物颗粒与粉体制备、应用技术研讨会

作者： Shunji Uramatsu toshinobu uemura Masakazu Morizane Toshio Shimamoto Kozo Kishi Yasunari Inamoto Shinich Akiyama Hideki Ichikawa Yoshinobu Fukumori Daido Chemical Corporation Faculty of Pharmaceutical Sciences Kobe Gakuin University Pharm PolyTech Inc. Cooperative Research Center of Life Sciences Kobe Gakuin University

Purpose:PVA copolymer(POVACOAT) is a newly developed aqueous polymer which is poly(vinyl alcohol) derivative grafted with acrylic acid and methyl *** is applied to coating film,granulation binder and solid dispersion carrier *** study was focused on the improvement of moisture permeability of POVACOAT under higher relative humidity conditions by adding a pharmaceutical ***:In order to evaluate the moisture permeability, the aluminum casing with the isolated film which was attached on the opening part(40mm×40mm) was *** aluminum casing was heat sealed,after 3.0 g of calcium chlorides was put into the inside as a moisture absorption *** increase in weight per 24 hours of the calcium chloride under various relative humidity was measured,and the moisture permeability coefficient was ***:The moisture permeability coefficients of POVACOAT film showed a typical sigmoid change according to relative humidity *** was found that the permeability coefficients under higher relative humidity were excellently modified to be in a level of 1/6 against simple POVACOAT film by adding talc.

关键词： PVA copolymer POVACOAT pharmaceutical excipient film coating moisture permeability

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