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Clinical Correlates Associated with Basic Ability of Social Life in Schizophrenia Inpatients

第37届中国控制会议

作者： Dongwu Xu Akinori Sakaguchi toshimitsu Ushio Graduate School of Engineering Science Osaka University

In this paper, we consider the pinning control of a discrete-time multi-agent system with a single pinning agent. We propose two design methods of a dynamic pinning controller with a full order observer and an integrator. One is based on the infinite-horizon linear-quadratic optimization technique. The other is based on the deadbeat control method. It is shown that the convergence becomes better as the overall coupling strength among agents increases. It is shown by simulation that, as the length of the longest path among all paths from the pining agent to the other ones is smaller, the convergence to the desired value becomes better and the overshoot of the pining agent becomes smaller.

关键词： Consensus Dynamic pinning control Multi-agent system Discrete-time system

来源： cnki会议评论

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Open Journal of Psychiatry 2016年第1期6卷 71-75页

作者： Shinichi Chiba Masahito Tomotake Masatomo Aono Hidefumi toshimitsu Tetsuro Ohmori Department of Mental Health Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan Department of Psychiatry Jounan Hospital Tokushima Japan Department of Psychiatry Daiichi Hospital Tokushima Japan Department of Psychiatry Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan

Objective: The aim of the present study is to explore clinical factors associated with basic ability of social life in schizophrenia inpatients. Methods: The subjects were 50 inpatients with schizophrenia (DSM-IV). Their mean age was 53.08 (SD = 12.08) years. Social life functioning was evaluated using the Rehabilitation Evaluation of Hall and Baker (REHAB). Cognitive function was assessed with the Brief Assessment of Cognition in Schizophrenia (BACS) and clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Results: The REHAB deviant behavior score showed a significant correlation with the PANSS positive syndrome score (r = 0.55, p < 0.01) and the REHAB general behavior score had significant correlations with the PANSS positive syndrome score (r = 0.28, p < 0.05), the PANSS negative syndrome score (r = 0.53, p < 0.01), and the DIEPSS score (r = 0.43, p < 0.01). However, there was no significant correlation between the scores of the REHAB and the BACS. Conclusion: These results suggest that negative and drug-induced extrapyramidal symptoms are much more important factors related to lowered basic ability of social life of schizophrenia inpatients than cognitive function.

关键词： Schizophrenia Inpatient Social Life Functioning Cognitive Function

Maillard reaction and immunogenicity of protein therapeutics

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World Journal of Immunology 2016年第1期6卷 19-38页

作者： Rositsa Tsekovska Angelina Sredovska-Bozhinov toshimitsu Niwa Ivan Ivanov Roumyana Mironova Institute of Molecular Biology Roumen Tsanev Bulgarian Academy of Sciences MIT University Nagoya University Graduate School of Medicine

The recombinant DNA technology enabled the produ-ction of a variety of human therapeutic proteins. Accumulated clinical experience, however, indicates that the formation of antibodies against such proteins is a general phenomenon rather than an exception. The immunogenicity of therapeutic proteins results in inefficient therapy and in the development of undesired, sometimes life-threatening, side reactions. The human proteins, designed for clinical application, usually have the same amino acid sequence as their native prototypes and it is not yet fully clear what the reasons for their immunogenicity are. In previous studies we have demonstrated for the first time that interferon-b （IFN-b） pharmaceuticals, used for treatment of patients with multiple sclerosis, do contain advanced glycation end products （AGEs） that contribute to IFN-b immunogenicity. AGEs are the fnal products of a chemical reaction known as the Maillard reaction or glycation, which implication in protein drugs’ immunogenicity has been overlooked so far. Therefore, the aim of the present article is to provide a comprehensive overview on the Maillard reaction with emphasis on experimental data and theoretical consideration telling us why the Maillard reaction warrants special attention in the context of the well-documented protein drugs’ immunogenicity.

关键词： Maillard reaction Glycation Advanced glycation end products Protein therapeutics Interferon-β Immunogenicity

Approach to Epidemiological Mechanism of Infection or Colonization of Egg-Laying Chicken Farms by <i>Salmonella enterica</i>Serovar Enteritidis (SE) Becoming the Main Source of Contamination in Food Poisoning (Review)

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International Journal of Clinical Medicine 2014年第7期5卷 376-392页

作者： Yukiko Toyota-Hanatani Yushi Nakagawa toshimitsu Hatabu Yuko Miyao Hiroaki Ohta CAF Laboratories Fukuyama Japan Department of Animal Science Graduate School of Natural Science and Technology Okayama University Okayama Japan Department of Biotechnology Faculty of Life Science and Biotechnology Fukuyama University Hiroshima Japan The Laboratory of Veterinary Internal Medicine School of Veterinary Science Osaka Prefectural University Izumisano Japan

Salmonella enterica serovar Enteritidis (SE)-induced diarrhea in humans is the typical non-typhoid diarrhea. It develops acutely or subacutely and may be fatal. This SE infectious disease suddenly became a major public health issue worldwide in the 1980s. The main causative food material of SE food poisoning is chicken eggs, and many outbreaks of food poisoning caused by chicken eggs occurred throughout the world. SE epidemics occurred in layer farms, and this was the main cause of SE-induced food poisoning in humans. The major subject of our epidemiological study described in this report is why SE-contaminated eggs became the main causative food. In this study, we focused on difference of molecular expression for farm-isolated SEs. That is because recent studies have demonstrated that O-antigen enlargement may be related to pathogenicity in mice as well as 22-kDa polypeptide-expression (SEp22). We have discovered that many SE strains isolated from chicken farms do not express SEp22, and a deficiency or decreased level of cellular antigen 0-12 in SE strains isolated from chicken farms was clarified in a report. Additionally, SEp22 was deficient in SE strains passaged through chickens, whereas SEp22 was expressed at a high level in SE strains passaged through mice. These findings suggest that SE infection and retention more effectively occur in layer farms than in other animal maintenance environments, which may be a basis of the epidemiological hypothesis to explain the high-levelproduction of SE-contaminated eggs (the presence of mice may be the basis of the retention of SE infection in layer farms, and this may also be the mechanism causing the high-level production of SE-contaminated eggs).

关键词： Salmonella enterica Serovar Enteritidis (SE) Epidemiological Role Mouse Outbreaks

Simple and Practical Aerobic Oxidation of Alcohols Catalyzed by a (<i>μ</i>-Oxo)tetraruthenium Cluster

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Green and Sustainable Chemistry 2011年第4期1卷 149-154页

作者： Teruyuki Kondo Yu Kimura Takashi Kanda Daisuke Takagi Kenji Wada Akio toshimitsu 不详

A (μ-oxo)tetraruthenium cluster showed high catalytic activity for a simple and practical aerobic oxidation of alcohols to aldehydes and ketones under 1 atm of O2 or air. After the reaction, this cluster catalyst was re- covered from the reaction mixture, and we believe that this (μ-oxo)tetraruthenium cluster acts as an active catalytic species throughout the reaction.

关键词： Ruthenium Cluster Catalyst Aerobic Oxidation Alcohol

Separation and Recovery of Iodine from Aqueous Solution by Permeation and Chemical Desorption (PCD) Using a Silicone Rubber Membrane

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Advances in Chemical Engineering and Science 2012年第4期2卷 508-513页

作者： Jun Sawai Hitomi Tomizuka Naoki Hatanaka Tamotsu Minami Mikio Kikuchi toshimitsu Ishii Faculty of Applied Bioscience Kanagawa Institute of Technology Atsugi Kanagawa Japan Godo Shigen Sangyo Co. Ltd. Nanaido Chosei-mura Chosei-gun Chiba Japan

New technologies for iodine separation and recovery are required to decrease environmental pollution and improve iodine production. Separation and recovery of iodine (I2) in aqueous solution was achieved using permeation and chemical desorption (PCD) with a silicone rubber membrane (SRM). The SRM separated an aqueous feed solution from an alkaline or reducing recovery solution such as a mixture of sodium hydrate and sodium sulfate. The I2 crossed the membrane from the aqueous feed solution into the recovery solution, where it was converted into iodide (I–). Iodide in the recovery solution did not return to the feed solution across the SRM. An acidic feed solution promoted a high recovery of iodine. The permeation process followed first-order kinetics, allowing the overall mass-transfer coefficient and parameters related to permeation of I2 through the SRM to be determined. Permeability of I2 increased with temperature, and the apparent activation energy (Ea) for penetration of I2 through the SRM was determined. The value of Ea for I2 was of the same order of magnitude as those for phenols and anilines. The large membrane/aqueous distribution coefficient for I2 indicated that I2 had a high affinity toward the SRM. These results indicate that the PCD method is effective and powerful for separation and recovery of iodine from aqueous solutions.

关键词： Membrane Separation Permeation and Chemical Desorption (PCD) Method Diffusion Coefficient Membrane/Aqueous Distribution Coefficient Polydimethylsiloxane

STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

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World Journal of Gastroenterology 2017年第37期23卷 6833-6844页

作者： Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura Division of Gastroenterology Department of Medicine Kurume University School of Medi-cine Liver Cancer Division Research Center for Innovative Cancer Therapy Kurume University Kurume Clinical pharmacology Clinic Department of Diagnostic pathology Kurume University hospital Department of Microbiology Immun--ology Keio University School of Medicine

AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to *** Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient *** STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration.

关键词： Hepatocellular carcinoma Ductular reaction Signal transducer and activator of transcription 3 Yesassociated protein Sex determining region Y-box9 Transdifferentiation

Successful endoscopic procedures for intraductal papillary neoplasm of the bile duct:A case report

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World Journal of Gastroenterology 2010年第7期16卷 909-913页

作者： Kohei Tsuchida Michiko Yamagata Yasuyuki Saifuku Dan Ichikawa Kazunari Kanke toshimitsu Murohisa Masaya Tamano Makoto Iijima Yukiko Nemoto Wataru Shimoda Toshiaki Komori Hirokazu Fukui Kazuhito Ichikawa Hitoshi Sugaya Kazuhito Miyachi Takahiro Fujimori Hideyuki Hiraishi Department of Gastroenterology Dokkyo Medical UniversityTochigi 321-0293Japan First Department of Surgery Dokkyo Medical UniversityTochigi 321-0293Japan Department of Surgical and Molecular Pathology Dokkyo Medical UniversityTochigi 321-0293Japan

Attention has recently been focused on biliary papillary tumors as the novel disease entity intraductal papillary neoplasm of the bile duct(IPNB),which consists of papillary proliferation of dysplastic biliary *** even benign papillary tumors are considered as premalignant,some investigators recommend aggressive surgical therapy for IPNB,although no guidelines are available to manage this *** reports have described long-term follow-up of patients with benign IPNB without radical *** patients with IPNB who are treated only with endoscopic procedures are noted,clinical profiles and alternative therapies other than resection may be *** report the case of a patient who experienced repetitive cholangitis for 10 years and was finally diagnosed with *** resection could not be recommended because of the age of the patient,therefore,endoscopic sphincterotomy was *** an endoscopic retrograde biliary drainage catheter was placed several times for repetitive cholangitis,the patient has done well during *** case may offer insights into the natural course and management decisions for the novel disease entity of IPNB.

关键词： Biliary tract neoplasms Papilloma Endoscopic sphincterotomy Endoscopic retrograde biliary drainage

Recurrent Ectopic Pregnancy in the Remnant Fallopian Tube Following Ipsilateral Partial Salpingectomy

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Open Journal of Obstetrics and Gynecology 2015年第7期5卷 373-377页

作者： Eijiro Hayata Takehiko Tsuchiya toshimitsu Maemura Yukiko Katagiri Tomonori Hasegawa Mineto Morita Department of Obstetrics and Gynecology Toho University Omori Medical Center Tokyo Japan Department of Social Medicine Toho University School of Medicine Tokyo Japan

A 39-year-old female with a history of partial salpingectomy for tubal pregnancy was diagnosed as having recurrent ectopic pregnancy in the distal portion of the fallopian tube remnant, which was successfully treated by laparoscopic surgery. The patient was multigravida (9 pregnancies) and uniparous. She had undergone right partial salpingectomy by laparotpmy for right isthmic ectopic pregnancy at the age of 31 years. At 6 weeks of the current pregnancy, she was referred to our hospital for suspected ectopic pregnancy. The gestational sac was not observed in the uterus, and a mass was observed in the right adnexal region by transvaginal ultrasonography. Emergency laparoscopic surgery revealed the pregnancy site in the ampulla of the remnant portion of the right fallopian tube;therefore, this portion was resected. Because the proximal portion of the fallopian tube remnant was completely occluded, we concluded that this was a case of ectopic pregnancy resulting from the intraperitoneal migration of a fertilized ovum. With current developments in assisted reproductive technologies, reanastomosis of the fallopian tube is rarely performed. While partial salpingectomy is less likely to contribute to the preservation of fertility, it increases the risk of recurrent ectopic pregnancy. A single-stage total salpingectomy on the affected side should be the first choice of treatment when fallopian tube preservation surgery is not selected.

关键词： Ectopic Pregnancy Laparoscopy Fallopian Tube Remnant