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Oral tolerance is inducible during active dextran sulfate sodium-induced colitis

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 242-253页

作者： Satoshi Ino Chikara Kohda Kosuke Takeshima Hiroki Ishikawa Tomoko Norose toshiko yamochi Masafumi Takimoto Hiroshi Takahashi Kazuo Tanaka Department of Microbiology and Immunology School of Medicine Showa University Department of Pathology and Laboratory Medicine School of Medicine Showa University Division of Gastroenterology Department of Internal Medicine Showa University

AIM:To investigate whether oral tolerance is inducible during the active phase of dextran sulfate sodium(DSS)-induced ***:Colitis was induced in 6-to 8-wk-old female BALB/c mice by the administration of 2%*** induce oral tolerance,mice that received water with DSS[DSS(+)]and mice that received autoclaved water[DSS(-)]were intragastrically(i.g.)administered ovalbumin(OVA)as a tolerogen before systemic challenge with *** this,serum levels of OVA-specific Ig E antibodies were *** mice with activecolitis,CD4+CD25+Foxp3+cell and B10 cell frequencies were evaluated using flow *** m RNA expression profiles were evaluated by reverse transcription real-time polymerase chain ***:Regardless of the presence of DSS colitis,OVA-specific immunoglobulin E concentrations were significantly reduced in mice that were *** OVA compared to mice that were *** PBS[DSS(+):4.4(4.2-9.5)ng/m L vs 83.9(66.1-123.2)ng/m L,P<0.01;DSS(-):27.7(0.1-54.5)ng/m L vs116.5(80.6-213.6)ng/m L,P<0.01].These results demonstrated that oral tolerance was induced in both the presence and absence of *** the spleen and mesenteric lymph nodes(MLN),the frequencies of CD4+CD25+Foxp3+cells and B10 cells,both of which are associated with oral tolerance,did not significantly *** the spleen,interferon-γm RNA expression significantly decreased in mice with colitis[DSS(+):0.42(0.31-0.53)vs DSS(-):1.00(0.84-1.39),P<0.01].The expression levels of other cytokines did not significantly ***:Oral tolerance is inducible during active DSS *** stability of regulatory cell populations in the spleen and MLN in colitis might correlate with these results.

关键词： Cytokine Dextran sulfate sodium colitis Oral tolerance Regulatory T cell Regulatory B cell

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Right colon cancer presenting as hemorrhagic shock

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World Journal of Gastrointestinal Pathophysiology 2011年第1期2卷 15-18页

作者： Tomoyuki Iwata Kazuo Konishi Takahisa Yamazaki Katsuya Kitamura Atsushi Katagiri Takashi Muramoto Yutaro Kubota Yuichiro Yano Yoshiya Kobayashi toshiko yamochi Nobuyuki Ohike Masahiko Murakami Takehiko Gokan Nozomi Yoshikawa Michio Imawari Division of Gastroenterology Department of MedicineShowa University School of Medicine Second Department of Pathology Showa University School of Medicine First Department of Pathology Showa University School of Medicine Division of Gastroenterogical Surgery Department of SurgeryShowa University School of Medicine Department of Radiology Showa University School of Medicine Endoscopic Center Showa University HospitalShowa University School of Medicine

A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic *** abdominal computed tomography scan re-vealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extra-vasation of blood from the gastroduodenal artery(GDA) into the *** revealed an irregular ulcerative lesion and stenosis in the ascending ***,right hemicolectomy combined with pylorus-preser ving pancreaticoduodenectomy was ***,the tumor was classified as a moderately differentiated ***,cancer cells were mainly located in the colon but had also invaded the duode-num and pancreas and involved the ***,the tumor cells were positive for cytokeratin(CK)20 and carcinoembryonic antigen(CEA)but not forCK7 and carbohydrate antigen(CA)*** patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis *** En bloc resection of the tumor with pancreatico duodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival,patients undergoing these procedures should be carefully monitored,particularly when the tumor involves the main artery.

关键词： Colon cancer Hemorrhagic shock Adjacent organs invasion En bloc resection Complication

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