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Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1

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世界糖尿病杂志：英文版（电子版） 2016年第11期7卷 230-238页

作者： Akifumi Kushiyama Takako Kikuchi Kentaro Tanaka Tazu Tahara toshiko takao Yukiko Onishi Yoko Yoshida Shoji Kawazu Yasuhiko Iwamoto Division of Diabetes and Metabolism Institute for Adult Diseases Asahi Life Foundation Department of Nephrology School of Medicine Faculty of Medicine Toho University

AIM: To investigate whether active glucagon-like peptide-1(GLP-1) is a prediction Factor of Effect of sitagliptin on patients with type 2 diabetes mellitus(GLP-1 FEST:UMIN000010645). METHODS: Seventy-six patients with type 2 diabetes, who had insufficient glycemic control [Hemoglobin A1c(Hb A1c) ≥ 7%] in spite of treatment with metformin and/or sulfonylurea, were included in the investigation. Patients were divided into three groups by tertiles of fasting plasma active GLP-1 level, before the administration of 50 mg sitagliptin. RESULTS: At baseline, body mass index, serum UA, insulin and HOMA-IR were higher in the high active GLP-1 group than in the other two groups. The high active GLP-1 group did not show any decline of Hb A1c(7.6% ± 1.4% to 7.5% ± 1.5%), whereas the middle and low groups indicated significant decline of Hb A1c(7.4 ± 0.7 to 6.8 ± 0.6 and 7.4 ± 1.2 to 6.9 ± 1.3, respectively) during six months. Only the low and middle groups showed a significant increment of active GLP-1, C-peptide level, a decreased log and proinsulin/insulin ratio after administration. In logistic analysis, the low or middle group is a significantexplanatory variable for an Hb A1 c decrease of ≥ 0.5%, and its odds ratio is 4.5(1.40-17.6)(P = 0.01) against the high active GLP-1 group. This remains independent when adjusted for Hb A1 c level before administration, patients' medical history, medications, insulin secretion and insulin ***: Plasma fasting active GLP-1 is an independent predictive marker for the efficacy of dipeptidyl peptidase 4 inhibitor sitagliptin.

关键词： Dipeptidyl peptidase-4 inhibitor Active form glucagon-like peptide-1 Hemoglobin A1c Regression analysis

Using orbital sensitivity analysis to pinpoint the role of orbital interactions in thermoelectric power factor

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npj Computational Materials 2023年第1期9卷 937-945页

作者： Wenhao Zhang Jean-François Halet takao Mori WPI Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceTsukubaJapan Graduate School of Pure and Applied Sciences University of TsukubaTsukubaJapan CNRS-Saint-Gobain-NIMS Laboratory for Innovative Key Materials and Structures(LINK)National Institute for Materials ScienceTsukubaJapan

The modification of the electronic band structure is of critical importance for thermoelectric materials whose heat to electricity power generation is related to carrier effective mass and alignment of semiconductor band *** approach to optimize the electronic band structure is by modification of orbital interactions through doping or *** the current ab-initio quantum chemical calculations can help us to investigate orbital components of electronic bands,they reveal little information on the relative tunability of electronic states and transport properties with respect to orbital *** this work,we present a method,based on a symmetry-adapted tight-binding model and sensitivity analysis,that can pinpoint the role of orbital interactions in determining electronic band structure and transport *** an application,a systematic theoretical analysis is used to show how the power factor of PbTe can/cannot be improved by playing with interatomic orbital *** orbital interaction sensitivity analysis introduced in this work can easily be applied to other compounds or properties.

关键词： properties orbital symmetry

P-Frobenius问题与p-对称数值半群

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浙江理工大学学报（自然科学版） 2024年第2期51卷 265-270页

作者：应皓天小松尚夫浙江理工大学理学院杭州310018

针对p-Frobenius问题中出现的非对称性问题,利用数值半群理论以及Apery集等工具研究了p-Frobenius问题对应的p-对称数值半群。首先利用数值半群和Apery集等工具对p-Frobenius问题进行预处理,得到了对应数值半群和Apery集的各个变量;并... 详细信息

针对p-Frobenius问题中出现的非对称性问题,利用数值半群理论以及Apery集等工具研究了p-Frobenius问题对应的p-对称数值半群。首先利用数值半群和Apery集等工具对p-Frobenius问题进行预处理,得到了对应数值半群和Apery集的各个变量;并将这些变量与对称数值半群和Frobenius问题进行对比,由此定义了p-对称数值半群,并给出了p-对称性的刻画。在此基础上,首先给出了两大类p-对称数值半群,其次研究了对称数值半群与p-对称数值半群的p化关联性。这两类p-对称数值半群给出了大量具体实例,而p化关联性则可用于处理p-Frobenius问题中出现的非对称问题。

关键词：数值半群线性丢番图方程 Apery集对称性 Frobenius问题

Recent progress in solution-processed flexible organic photovoltaics

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npj Flexible Electronics 2022年第1期6卷 871-884页

作者： Lulu Sun Kenjiro Fukuda takao Someya Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Center for Emergent Matter Science(CEMS) RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Electrical Engineering and Information Systems School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The certified power conversion efficiency(PCE)of organic photovoltaics(OPV)fabricated in laboratories has improved dramatically to over 19%owing to the rapid development of narrow-bandgap small-molecule acceptors and wide bandgap polymer donor *** next pivotal question is how to translate small-area laboratory devices into large-scale commercial *** requires the OPV to be solution-processed and flexible to satisfy the requirements of high-throughput and large-scale production such as roll-to-roll *** review summarizes and analyzes recent progress in solution-processed flexible *** a detailed discussion from the perspective of the behavior of the narrow bandgap small-molecule acceptor and wide bandgap polymer donor active layer in solution-processed flexible devices,the existing challenges and future directions are discussed.

关键词： donor narrow translate

Excited state calculations using variational quantum eigensolver with spin-restricted ansätze and automatically-adjusted constraints

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npj Computational Materials 2023年第1期9卷 2204-2212页

作者： Shigeki Gocho Hajime Nakamura Shu Kanno Qi Gao takao Kobayashi Taichi Inagaki Miho Hatanaka School of Fundamental Science and Technology Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan Quantum Computing Center Keio UniversityYokohama 223-8522Japan IBM Quantum–IBM Research Tokyo Tokyo 103-8510Japan Mitsubishi Chemical Corporation Science&Innovation CenterYokohama 227-8502Japan

The ground and excited state calculations at key geometries, such as the Frank–Condon (FC) and the conical intersection (CI)geometries, are essential for understanding photophysical properties. To compute these geometries on noisy intermediate-scalequantum devices, we proposed a strategy that combined a chemistry-inspired spin-restricted ansatz and a new excited statecalculation method called the variational quantum eigensolver under automatically-adjusted constraints (VQE/AC). Unlike theconventional excited state calculation method, called the variational quantum deflation, the VQE/AC does not require the pre-determination of constraint weights and has the potential to describe smooth potential energy surfaces. To validate this strategy,we performed the excited state calculations at the FC and CI geometries of ethylene and phenol blue at the complete active spaceself-consistent field (CASSCF) level of theory, and found that the energy errors were at most 2 kcal mol−1 even on the ibm_kawasakidevice.

关键词： properties quantum variational

Saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?

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Neural Regeneration Research 2021年第3期16卷 489-495页

作者： takao Ishikawa Department of Molecular Biology Institute of BiochemistryFaculty of BiologyUniversity of WarsawWarsawPoland

The baker's yeast Saccharomyces(S.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life *** a unicellular organism,*** has some evident limitations in application to ***,yeast prions are extensively studied and they are known to share some hallmarks with mammalian prion protein or other amyloidogenic proteins found in the pathogenesis of Alzheimer's,Parkinson's,or Huntington's ***,the yeast *** has been widely used for basic research on aggregation properties of proteins in cellulo and on their ***,a yeast-based study revealed that some regions of mammalian prion protein and amyloidβ1–42 are capable of induction and propagation of yeast *** is one of the examples showing that evolutionarily distant organisms share common mechanisms underlying the structural conversion of prion proteins making yeast cells a useful system for studying mammalian prion *** has also been used to design novel screening systems for anti-prion compounds from chemical *** assays are cheap in maintenance and safe for the researcher,making them a very good choice to perform preliminary screening before further characterization in systems engaging mammalian cells infected with *** this review,not only classical red/white colony assay but also yeast-based screening assays developed during last year are *** analysis and research carried out using yeast prions force us to expect that prions are widely present in ***,the last few years brought us several examples indicating that the mammalian prion protein is no more peculiar protein–it seems that a better understanding of prion proteins nature-wide may aid us with the treatment of prion diseases and other amyloid-related medical conditions.

关键词： amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay

A passive optical fibre sensor based on Fabry-Perot interferometry for bipolar electrostatic monitoring of insulating dielectrics

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High Voltage 2023年第4期8卷 682-689页

作者： Jiawei Zhang Zifan Ye Li Wang Zelei Zhang Fan Xu Weichen Dang takao Matsumoto Sombel Diaham Chatchai Putson School of Electrical Engineering Xi'an University of TechnologyXi'anShaanxiChina Universitéde Toulouse UPSINPTLAPLACE(Laboratoire Plasma et Conversion d'Energie)Toulouse Cedex 9France Materials Physics Laboratory Department of PhysicsFaculty of SciencePrince of Songkla University(PSU)SongkhlaThailand

The measurement of the surface charge on the insulating dielectrics is critical to estimate the insulation strength of electrical equipment in *** interactions with the electromagnetic field,however,generally result in distortion measurement of active ***,it is of great significance to investigate a passive sensor for monitoring the deposited ***,a passive optical fibre electrostatic sensor is developed on the principle of Fabry–Perot interference to quantify the surface potential of the insulating *** sensitivity of quantifying the electrostatic charge is explored in terms of the wavelength shift in the interference spectrum,and the linear correlation is ***,the sensor can identify a negative quadratic trend with the increase of the surface roughness of the insulating *** merits of the proposed sensor such as passive monitoring,bipolar electrostatic detection,and the excellent ability of antielectromagnetic interference are highlighted in the ***,this sensor can serve as an effective tool to monitor the electrostatic charge in the fields of smart electrical equipment,fuel transportation,aerospace,integrate circuit etc.

关键词： electrostatic passive fibre

Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy

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Chinese Neurosurgical Journal 2023年第3期9卷 159-165页

作者： Taro Yanagawa Hiroki Sato Kaima Suzuki Hidetoshi Ooigawa Masaki takao Hiroki Kurita Department of Cerebrovascular Surgery International Medical CenterSaitama Medical University1397-1 YamaneHidaka CitySaitama 350-1298Japan Stroke Center Sagamihara Kyodo Hospital4-3-1 HashimotodaiMidori-KuSagamihara CityKanagawa-Pref 252-5188Japan Department of Clinical Laboratory National Center of Neurology and PsychiatryNational Center Hospital4-1-1Ogawa-HigashiKodairaTokyo 187-8502Japan

Background Cerebral amyloid angiopathy is a common cause of subcortical hemorrhage in older *** open hematoma removal may be performed for severe subcortical hemorrhage,its safety in patients with cerebral amyloid angiopathy has not been established,and postoperative rebleeding may ***,this study aimed to investigate factors associated with postoperative *** Out of 145 consecutive patients who had undergone craniotomy for surgical removal of subcortical intracerebral hemorrhage between April 2010 and August 2019 at a single institution in Japan,we examined 109 patients with subcortical hemorrhage who met the inclusion *** excluding 30 patients whose tissue samples were unsuitable for the study,the final study cohort comprised 79 *** Of the 79 patients,50(63%)were diagnosed with cerebral amyloid angiopathy(cerebral amyloid angiopathy group)and 29(37%)were not diagnosed with noncerebral amyloid angiopathy(noncerebral amyloid angiopathy group).Postoperative rebleeding occurred in 12 patients(24%)in the cerebral amyloid angiopathy group and in 2 patients(7%)in the noncerebral amyloid angiopathy *** prothrombin time-international normalized ratio and intraoperative bleeding volume were significantly associated with postoperative rebleeding in the cerebral amyloid angiopathy group(odds ratio=42.4,95%confidence interval=1.14-1578;p=0.042 and odds ratio=1.005,95%confidence interval=1.001-1.008;p=0.007,respectively).Conclusions Patients with cerebral amyloid angiopathy-related cerebral hemorrhage who are receiving antithrombotic therapy,particularly warfarin therapy,are at a high risk of postoperative *** registration Registry and Registration Number of the study:19-220,2019/12/23,retrospectively registered.

关键词： Amyloid-β Antithrombotic therapy Cerebral amyloid angiopathy Postoperative rebleeding Subcortical hemorrhage

Magnetic properties of soft layer/FePt-MgO exchange coupled composite perpendicular recording media

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Chinese Physics B 2008年第10期17卷 3907-3909页

作者：阴津华 takao Suzuki 潘礼庆 Department of Physics University of Science and Technology Beijing Information Storage Materials Laboratory Toyota Technological Institute

The magnetic properties of exchange coupled composite （ECC） media that are composed of perpendicular magnetic recording media FePt MgO and two kinds of soft layers have been studied by using an x-ray diffractometer, a polar Kerr magneto-optical system （PMOKE） and a vibrating sample magnetometer （VSM）. The results show that ECC media can reduce the coercivities of perpendicular magnetic recording media FePt-MgO. The ECC media with granular-type soft layers have weaker exchange couplings between magnetic grains and the magnetization process, for ECC media of this kind mainly follow the Stoner Wohlfarth model.

关键词： exchange coupled composite media perpendicular magnetic recording media magnetic properties