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Effect of Foot Self-Care Behavior According to Severity of Diabetic Neuropathy in Japanese Patients with Diabetes

Health 2018年第9期10卷 1192-1199页

作者： Masuko Sumikawa Yumi Kuwamura Yasuyuki Sumikawa toshiko fujiwara Chizuru Kamiya Department of Nursing School of Health Sciences Sapporo Medical University Sapporo Japan Department of Women’s Health Nursing Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan Department of Dermatology School of Medicine Sapporo Medical University Sapporo Japan Sapporo Medical University Hospital Sapporo Japan Kansai University of Nursing and Health Sciences Awaji Japan

PURPOSE: Diabetic patients with severe diabetic neuropathy often have hypoesthesia and numbness. This study evaluated foot self-care behavior according to severity of diabetic neuropathy. METHODS: We used a hand-held nerve conduction test device DPN check (HDN-1000, Omron) to evaluate severity of diabetic neuropathy. Foot self-care was evaluated using the Japanese SDSCA (the Summary of Diabetes Self-Care Activities measure). Foot self-care comprised visual inspection, washing, wiping interdigital areas, and checking shoes, and was scored according to the number of days self-care which was performed in the previous week. RESULTS: The study evaluated 103 diabetic patients (age: 65.7 years, diabetes duration: 13.9 years, HbA1c: 7.3%). Total scores (out of 28 points) for self-care behavior according to neuropathy severity were 11.8 (Normal: n = 54), 10.6 (Mild: n = 27), 13.3 (Moderate: n = 17), and 10.8 (Severe: n = 5). Foot self-care scores were low in all groups, with particularly low scores in those with severe neuropathy. However, no statistically significant differences were observed. CONCLUSIONS: Foot self-care is essential in diabetes because lesions are more likely to occur in severe neuropathy. Living alone and the presence of recurrent foot lesions are associated with poor survival prognosis. Accordingly, foot-care intervention must take neuropathy severity and lifestyle factors into account. The severity of diabetic neuropathy must be determined and foot-care intervention should take lifestyle factors into account.

关键词： Foot Self-Care Behavior Diabetic Patients Diabetic Neuropathy Nerve Conduction Velocity Nerve Conduction Amplitude

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Spectrally resolved Franson interference

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 11-17页

作者： Rui-Bo Jin Zi-Qi Zeng Dan Xu Chen-Zhi Yuan Bai-Hong Li You Wang Ryosuke Shimizu Masahiro Takeoka Mikio fujiwara Masahide Sasaki Pei-Xiang Lu Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China School of Physics and Information Science Shaanxi University of Science and TechnologyXi'an 710021China Southwest Institute of Technical Physics Chengdu 610041China Graduate School of Informatics and Engineering University of Electro-CommunicationsTokyo 182-8585Japan Department of Electronics and Electrical Engineering Keio UniversityKanagawa 223-8522Japan National Institute of Information and Communications Technology Tokyo 184-8795Japan

Franson interference can be used to test the nonlocal features of energy-time entanglement and has become a standard in quantum ***,most of the previous Franson interference experiments were demonstrated in the time domain,and the spectral properties of Franson interference have not been fully ***,we theoretically and experimentally demonstrate spectrally resolved Franson interference using biphotons with different correlations,including positive correlation,negative correlation,and *** is found that the joint spectral intensities of the biphotons can be modulated along both the signal and idler directions,which has potential applications in generating high-dimensional frequency entanglement and time-frequency grid *** work may provide a new perspective for understanding the spectral-temporal properties of the Franson interferometer.

关键词： resolved correlation spectral

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Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

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Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi Keiko Watanabe Yuki fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere Cellular Aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder

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Impacts of invasive Iris pseudacorus L.(yellow flag) establishing in an abandoned urban pond on native semi-wetland vegetation

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Journal of Integrative Agriculture 2018年第8期17卷 1881-1887页

作者： Daisuke Hayasaka Shingo fujiwara Taizo Uchida Graduate School of Agriculture KINDAI University Faculty of Engineering Kyushu Sangyo University

Iris pseudacorus L., intentionally introduced in Japan as an ornamental plant and to improve aquatic environments, has been declared a noxious species in the Invasive Alien Species Act of Japan due to the suspected high ecological risks to the local species and ecosystems. Although prompt responses to I. pseudacorus have been sought to conserve local biodiversity, knowledge about its invasiveness is lacking. Here, we report the relationship between the establishment of I. pseudacorus and floristic changes in semi-wetland vegetation of an abandoned urban pond(Aoike), Nara City, Nara Prepecture, Japan. In total, 64 vascular plants were recorded in the pond, of which 50 were native species, seven were naturalized non-native, and seven were invasive species. On the other hand, most of these vascular plants(42 species) were grassland species and only several aquatic plants(10 species) were found in this study pond. The number of vascular plant species decreased significantly at quadrats with a coverage of I. pseudacorus above 50%. In addition, tendencies of lower number of native species and concomitant higher number of invasive species were found with increasing coverage of I. pseudacorus. From these results, we suggest that it is important to preferentially manage sites where the coverage of I. pseudacorus is above 50%, in order to preserve the local biodiversity. Additionally, as recommended in the literature, it is essential that the cut reproductive organs are kept submerged under deep water for an effective control of I. pseudacorus.

关键词： biodiversity conservation biological invasions ecological impacts exotic species hydrophytes species traits

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ANALYSIS ON PSEUDO-STEADY INDENTATION CREEP

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Acta Mechanica Solida Sinica 2008年第4期21卷 283-288页

作者： Hidenari Takagi Ming Dao Masami fujiwara Division of Applied Physics College of Engineering Nihon University Fukushima Japan Department of Materials Science and Engineering School of Engineering Massachusetts Institute of Technology Massachusetts USA

Theoretical analysis and finite element （FE） simulation have been carried out for a constant specific load rate （CSLR） indentation creep test. Analytical results indicate that both the representative stress and the indentation strain rate become constant after a transient period. Moreover, the FE simulation reveals that both the contours of equivalent stress and equivalent plastic strain rate underneath the indenter evolve with geometrical self-similarity. This suggests that pseudo-steady indentation creep occurs in the region beneath the indenter. The representative points in the region are defined as the ones with the equivalent stress equal to the representative stress. In addition, it is revealed that the proportionality between indentation strain rate and equivalent plastic strain rate holds at the representative points during the pseudo-steady indentation creep of a power law material. A control volume （CV） beneath the indenter, which governs the indenter velocity, is identified. The size of the CV at the indented surface is approximately 2.5 times the size of the impression. The stress exponent for creep can be obtained from the pseudosteady indentation creep data. These results demonstrate that the CSLR testing technique can be used to evaluate creep parameters with the same accuracy as conventional uniaxial creep tests.

关键词： indentation creep finite element method conical indenter geometrical self-similarity,pseudo-steady state control volume stress exponent

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Reaction of Silane Alkoxide with Acid Anhydride as a Novel Synthetic Method for Organic-Inorganic Hybrid Materials

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复旦学报（自然科学版） 2005年第5期44卷 682-683页

作者： Masahiro fujiwara Kansai Center National Institute of Advanced Industrial Science and Technology Ikeda Osaka 563-8577 Japan

Sol-gel method is a potent method to produce new inorganic and organic-inorganic hybrid materials. The key step of this methodology is the hydrolysis of a metal alkoxide or other metal substrates such as acetylacetonates to form hydroxyl metal species, followed by their condensation to metal-oxygen-metal (M - O - M)bonds. In this process, the utilization of water, generally in excess, is essential and alcoholic solvents such as ethanol are often required to homogenize the solution when organic compounds coexist. As the common sol-gel method using water allows for limited uses of organic substrates due to their low solubility and stability in aqueous solution, modified variations of sol-gel method are required. Recently, some processes were reported for preparing metal oxides from metal alkoxides without the utilization of water.

关键词：硅石硅烷醇盐酸酐合成方法分子结构

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东京国立博物馆文化使命的发展

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博物馆管理 2024年第4期 18-23页

作者： [日]藤原诚 [日]杨锐(译) 金燕(译) 日本东京国立博物馆东京中国国家博物馆北京100006

东京国立博物馆始建于1872年,是日本历史最悠久的国立博物馆。作为这座博物馆的第29任馆长,我与职员们共同提出了两大目标,并逐步实施。本文将介绍这两大目标,以及为履行博物馆的文化使命,我们是如何结合近年的发展情况实施各项举措的... 详细信息

东京国立博物馆始建于1872年,是日本历史最悠久的国立博物馆。作为这座博物馆的第29任馆长,我与职员们共同提出了两大目标,并逐步实施。本文将介绍这两大目标,以及为履行博物馆的文化使命,我们是如何结合近年的发展情况实施各项举措的。第一个目标是“建立具有全球影响力的博物馆”。在152年的历史中,东京国立博物馆展出了来自世界各地的文化遗产。

关键词：文化使命国立博物馆全球影响力逐步实施文化遗产馆长历史

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Chemotherapy as a component of multimodal therapy for gastric carcinoma

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World Journal of Gastroenterology 2006年第13期12卷 2000-2005页

作者： Yasuhiro Kodera Michitaka fujiwara Masahiko Koike Akimasa Nakao Department of Surgery Ⅱ Nagoya University Graduate School of Medicine 65Tsurumai-choShowa-kuNagoyaAichi 466-8550Japan

Prognosis of locally advanced gastric cancer remains poor, and several multimodality strategies involving surgery, chemotherapy, and radiation have been tested in clinical trials. Phase Ⅲ trial testing the benefit of postoperative adjuvant chemotherapy over treatment with surgery alone have revealed little impact on survival, with the exception of some small trials in Western nations. A large trial from the United States exploring postoperative chemoradiation was the first major success in this category. Results from Japanese trials suggest that moderate chemotherapy with oral fluoropyrimidines may be effective against less-advanced （T2-stage） cancer, although another confirmative trial is needed to prove this point. Investigators have recently turned to neoadjuvant chemotherapy, and some promising results have been reported from phase Ⅱ trials using active drug combinations. In 2005, a large phase Ⅲ trial testing preand postoperative chemotherapy has proven its survival benefit for resectable gastric cancer. Since the rate of pathologic complete response is considered to affect treatment results of this strategy, neoadjuvant chemoradiation that further increases the incidence of pathologic complete response could be a breakthrough, and phase Ⅲ studies testing this strategy may be warranted in the near future.

关键词： Surgery Radiation Anticancer drug Adjuvant chemotherapy Neoadjuvant chemotherapy

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Preparation of High Performance Foamed Concrete from Cement,Sand and Mineral Admixtures

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Journal of Wuhan University of Technology(Materials Science) 2007年第2期22卷 295-298页

作者：潘志华 fujiwara Hiromi Wee Tionghuan College of Materials Science & Engineering Nanjing University of Technology Faculty of Engineering Utsunomiya University7-1-2YotoUtsunomiyacity Department of Civil Engineering National University of Singapore

The titled high performance foamed concrete was developed from Portland cement, ultra fine granulated blast-furnace slag, pulverized fly ash and condensed silica fume by means of pre-foaming process. The resultant foamed concrete presents its thermal conductivity of about 0.16-0.75 W/（m·℃） and 28 d compressive strength of about 1.1-23.7 MPa when its mix proportion varies in the range of cement content 280 kg-650 kg/m^3, fly ash 42-97 kg/m^3, slag 64-146 kg/m^3, silica fume 34-78 kg/m^3, and sand 0-920 kg/m^3. The compressive strength of the foamed concrete with oven dried bulk density of 1500 kg/m^3 in appropriate mix proportion and with small amount of superplasticizer reached as high as 44.1 MPa. Meanwhile, the flesh foamed concrete behaves like an excellent flow-ability, therefore, is especially suitable for the application in case of massive foamed concrete casting in situ and in the case of filling casting into large volume underground irregular voids, except for pre-casting of building components like blocks, bricks, and wall panels.

关键词： foamed concrete density compressive strength thermal conductivity

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Spectroscopic Detection of Chiral Aggregation at Liquid-Liquid Interfaces

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Tsinghua Science and Technology 2006年第2期11卷 228-232页

作者： Hitoshi Watarai Sayaka Wada Kazuhiko fujiwara Department of Chemistry Osaka University Osaka Japan

Two new spectroscopic methods to detect the optical activity of liquid-liquid interfaces have been developed. The first one is the centrifugal liquid membrane （CLM） method combined with a conventional circular dichroism （CD） spectropolarimetry and the second one is a more interfacial specific second harmonic generation CD （SHG-CD） spectrometry. In the CLM-CD method, a cylindrical glass cell containing small amounts of organic and aqueous phases was rotated at about 7000 r/min in a sample chamber of a CD spectropolarimeter to generate an interface with a high specific interfacial area between the two-phase liquid membranes. The CD spectra of the J-aggregate of protonated 5,10,15, 20-tetraphenylporphyrin formed at the toluene-sulfuric acid interface have been measured, As for the SHG-CD, a circularly polarized wavelength-variable fs-laser system was constructed to measure the interfacial SHG spectra of a flat liquid-liquid interface. The ion-associated aggregation of a water-soluble anionic porphyrin promoted with a cationic amphiphile at the heptane-water interface was observed by this technique and the observed SHG-CD spectra proved the generation of a characteristic oPtical activity accompanied by the formation of the interfacial aggregate of inherently achiral porphyrin molecules. These methods will pioneer a new field of interfacial chiral chemistry in the studies of solvent extraction mechanisms.

关键词： chiral aggregation liquid-liquid interface spectroscopic detection centrifugal liquid membrane second harmonic generation circular dichroism

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