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Trend of Respiratory Tract-Associated Streptococcus dysgalactiae Subsp. Equisimilius at General Japanese Hospital from 2013 to 2015

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Journal of Biosciences and Medicines 2016年第12期4卷 11-17页

作者： Masaaki Minami Ryoko sakakibara Taichi Imura Mika Watanabe Hideo Morita Naoto Kanemaki Michio Ohta Department of Bacteriology Graduate School of Medical Sciences Nagoya City University Nagoya Japan Department of Clinical Investigation Daido Hospital Nagoya Japan Department of Gastroenterology Daido Hospital Nagoya Japan School of Nursing Sugiyama Jyogakuen University Nagoya Japan

Streptococcus dysgalactiae subsp. equisimilius are pathogenic bacteria which cause various infectious diseases from acute pharyngitis to streptococcal toxic shock syndrome. Although Streptococcus dysgalactiae subsp. equisimilius infection has been increasing recently, the recent characteristic investigation of respiratory tract associated Streptococcus dysgalactiae subsp. equisimilius has not been performed in Japan. In this study, we analyzed the relationship between respiratory tract and norespiratory tract associated Streptococcus dysgalactiae subsp. equisimilius by investigating the recent clinical characteristics and antimicrobial susceptible patterns of 98Streptococcus dysgalactiae subsp. equisimilius isolated during 2013-2015 in Japan. There was significant difference of gender between respiratory tract and no respiratory tract associated Streptococcus dysgalactiae subsp. equisimilius. No Streptococcus dysgalactiae subsp. equisimilius from no respiratory tract were found under 18 years-old patients. The prevalence of clindamycin non susceptible Streptococcus dysgalactiae subsp. equisimilius isolates from respiratory tract was significant greater than those from non-respiratory tract. We also analyzed the relationship between respiratory tract associated Streptococcus dysgalactiae subsp. equisimilius and Streptococcus pyogenes in *** was no significant difference of gender between Streptococcus dysgalactiae subsp. equisimilius and Streptococcus pyogenes. The numbers of Streptococcus pyogenes-infected patients were significantly greater than those of Streptococcus dysgalactiae subsp. equisimilius-infected patients in children from 1 to 18 years old. From antimicrobial resistance, we found that the numbers of clarithromycin resistant Streptococcus pyogenes were greater than those of clarithromycin resistant Streptococcus dysgalactiae subsp. equisimilius among respiratory tract isolation. Our results suggest that the clinical and antimicrobial susceptible

关键词： Streptococcus dysgalactiaesusp. equsimilius Susceptibility Antimicrobial Resistance Epidemiology

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Clinical Characteristics of Respiratory Tract-Associated Streptococcus pyogenes at General Japanese Hospital in 2014

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Journal of Biosciences and Medicines 2015年第12期3卷 26-31页

Streptococcus pyogenesis most popularpathogen caused respiratory tract infection disease. This study was conducted to find out the recent clinical characteristics of Streptococcus pyogenes isolates from respiratory tract at Japanese hospital in 2014. Streptococcus pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Respiratory tract isolates were defined as isolation from pharynx, nasal discharge, tonsillar, and sputum. Total one hundred sixty-one Streptococcus pyogenes were isolated among which 136 were from respiratory tract and 25 were from non- respiratory tract. Respiratory tract-associated Streptococcus pyogenes was isolated among which 102 were from male and 59 were from female. The age incidence among 0 - 1 years age group was 8, among 1 - 18 years age group, 131 (p < 0.01), among 19 - 64 years age group, 17 (p < 0.01), and in 65-years it was 5. Although we investigated the relationship between season and bacterial isolation, we did not find any significant differences between respiratory tract and no respiratory tract isolation. However, our study revealed that clarithromycin was less antimicrobial effective in respiratory tract disease than in no respiratory tract disease significantly (p < 0.01). Although several antibiotics such as penicillin are still effective against Streptococcus pyogenes, incidence of Streptococcus pyogenes infection is not decreasing worldwide. Our study suggests the need for continuous epidemiological surveillance of Streptococcus pyogenes.

关键词： Streptococcus pyogenes Susceptibility Antimicrobial Resistance Epidemiology Clarithromycin

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Effect of zinc supplementation in patients with type C liver cirrhosis

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Open Journal of Gastroenterology 2011年第2期1卷 28-34页

作者： Kazuhiro Katayama Mitsuru sakakibara Kazuho Imanaka Kazuyoshi Ohkawa Takashi Matsunaga Masafumi Naito Toshifumi Ito Department of Hepatobiliary and Pancreatic Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases

Zinc is often deficient in patients with liver cirrhosis, and treatment with zinc provides short-term improvement in protein metabolism. However, the long-term effects of zinc have not been fully clarified. The present study aimed to analyze the effect of zinc on the long-term clinical course, especially hepatocarcinogenesis, in type C liver cirrhosis. Am- ong patients with type C liver cirrhosis visiting our hospital between June 1998 and January 2009, th- ose with a serum albumin level ≤3.5 g/dL and a serum zinc level ≤70 μg (1.07 μmol)/dL were selected. Thirty-seven patients were randomly divided into 2 groups: group B (12 g/day branched-chain amino acid granules) and group BZ (same as group B plus 100 mg/day - 600 mg/day zinc sulfate or 150 mg/day - 225 mg/day polaprezinc). Multivariate analysis revealed that the administration of zinc was not a significant determinant, but pretreatment serum zinc levels (hazard ratio [HR], 0.921;95% confidence interval [CI], 0.853–0.994) and serum zinc levels less than 80 μg (1.22 μmol)/dL 12 months after beginning this study (HR, 6.866;95% CI, 1.399 - 33.707) were significant determinants of carcinogenesis and death. Serum albumin levels in patients whose serum zinc levels had not increased up to 80 μg/dL by the third year of this study were significantly lower (p = 0.023) than those of patients that had increased up to 80 μg/dL. Conclusions: In type C liver cirrhosis with zinc deficiency, administration of zinc does not improve cancer-free survival. However, serum zinc levels can predict outcomes in patients with type C liver cirrhosis. However, although zinc may play a role in hepatocarcinogenesis, the precise implications remain to be clarified.

关键词： Hepato-Carcinogenesis Trace Element Protein Metabolism

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MHD Instabilities and Their Effects on Plasma Confinement in Large Helical Device Plasmas with Intense Neutral Beam Injection

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Plasma Science and Technology 2004年第3期6卷 2269-2274页

作者： K.Toi S.Ohdachi S.Yamamoto S.sakakibara K.Y.Watanabe N.Nakajima X.Ding J.Li S.Morita K.Narihara K.Tanaka T.Tokuzawa H.Yamada Q.Yang National Institute for Fusion Science Toki 509-5292 Japan Dep. Energy Eng. Sci. Nagoya Univ. Nagoya 464-8603 Japan Southestern Institute of Physics Chengdu China Institute of Plasma Physics Chinese Academy of Science China

MHD stability of the Large Helical Device (LHD) plasmas produced with intenseneutral beam injection is experimentally studied. When the steep pressure gradient near the edge isproduced through L-H transition or linear density ramp experiment, interchange-like MHD modes whoserational surface is located very close to the last closed flux surface are strongly excited in acertain discharge condition and affect the plasma transport appreciably. In NBI-heated plasmasproduced at low toroidal field, various Alfven eigenmodes are often excited. Bursting toroidalAlfven egenmodes excited by the presence of energetic ions induce appreciable amount of energeticion loss, but also trigger the formation of internal and edge transport barriers.

关键词： interchange instabilities L-H transition alfven eigenmodes

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低风压紧密架空导线的开发

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电线电缆 1987年第3期 18-23页

作者： Akiyasu sakakibara ,郭良藩

为了降低架空导线风压,曾在传统导线上进行过扩大风洞试验.结果是,通过改变导线表面粗糙度似有可能降低导线的风压.因此,又在具有不同的表部粗糙度的导线上进行了一系列的扩大风洞试验.由此导出的一个方程,能给出最优表面形态而表面阻... 详细信息

为了降低架空导线风压,曾在传统导线上进行过扩大风洞试验.结果是,通过改变导线表面粗糙度似有可能降低导线的风压.因此,又在具有不同的表部粗糙度的导线上进行了一系列的扩大风洞试验.由此导出的一个方程,能给出最优表面形态而表面阻力系数最小的实用导线.据此,制造的供在自然风条件下现场试验用的导线样品,与传统导线相比,710毫米2导线约可降低风压80%,410毫米2导线约可降低风压95%.

关键词：钢芯铝绞线(低风压) 选型运行试验

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LHD高β等离子体中MHD活性对压力分布的影响

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国外核聚变 2003年第2期 60-63页

作者： S.sakakibara 陈信

在大螺旋装置(LHD)上研究了NBI等离子体中≤3％范围内MHD活性对压力分布的影响。重点是在芯部区n/m＝1／2模和在周围区ι＝1共振模与的依赖关系。在小于2．3％的范围内已观察到n/m＝1／2，且当等离子体到达默西埃稳定区时，n/m＝1／2模... 详细信息

在大螺旋装置(LHD)上研究了NBI等离子体中≤3％范围内MHD活性对压力分布的影响。重点是在芯部区n/m＝1／2模和在周围区ι＝1共振模与的依赖关系。在小于2．3％的范围内已观察到n/m＝1／2，且当等离子体到达默西埃稳定区时，n/m＝1／2模消失，压力分布随着的增大变宽，且大压力梯度在周围区形成。在周围区ι＝1共振模的幅度随单调增大。

关键词：大螺旋装置 LHD 等离子体压力分布 β极限 MHD活性磁约束系统

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Prevalence and Antimicrobial Susceptibility Pattern of Streptococcus pneumoniae at General Hospital in the Central Region of Japan from December 2013 to February 2014

Prevalence and Antimicrobial Susceptibility Pattern of Strep...

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2014 Conference on Epidemiology and Infectious Diseases(EID2014) & The Healthy and Active Aging Conference(HAAC2014)

作者： Masaaki Minami Ryoko sakakibara Taichi Imura Hideo Morita Naoto Kanemaki Michio Ohta Department of Bacteriology Graduate School of Medical Sciences Nagoya City University Department of Clinical Investigation Daido Hospital Department of Gastroenterology Daido Hospital School of Nursing Sugiyama Jyogakuen University

Streptococcus pneumonia infection is important cause of morbidity and mortality. This study was conducted to find out the prevalence and antimicrobial susceptibility pattern of Streptococcus pneumoniae isolates at general hospitalin the central region of Japan from December 2013 to February 2014. Streptococcus pneumoniae was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. One hundred fifty-three Streptococcus pneumoniae were isolated among which 80(52.2%) were males and 73(47.8%) were females. Nasal discharge(134%/87.6%) contributed more than other biological materials. The age incidence of(0- 1) years,(1- 10) years,(11- 40) years,(41- 60) years and >60 years age groups were 26(17.0%), 110(71.9%), 3(2.0%), 10(6.5%), and 4(2.6%) respectively. Positive samples were received mostly from the pediatrics(137%/89.5%), respiratory medicine(12%/7.8%) and lowest from gastroenterology(1%/0.6%) and neurology(1/ 0.6%) department. Vancomycin and rifampicin were the most active antibiotics with 100% susceptibility rates. The next best were levofloxacin, penicillin G and ceftriaxone. Our study revealed that 82 Streptococcus pneumonia isolates had multidrug resistant ability(53.6%). Streptococcus pneumoniae infection spreads among community easily and inappropriate use of antibiotics contributes to their resistance. Continuous antimicrobial susceptible surveys are essential to guide policy on the adequate use of antibiotics to reduce the morbidity and mortality and reduce the emergency of antimicrobial resistance.

关键词： Streptococcus pneumoniae,Susceptibility,Antimicrobial Resistance,Multi Drug Resistance

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用心率变异性谱分析法研究振动性白指患者自主神经系统对冷刺激的反应(英文)

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航天医学与医学工程 1999年第1期12卷 6-9页

作者：罗进神原久孝朱善宽航天医学与医学工程

目的研究振动性白指患者的自主神经系统对冷刺激的反应。方法２２名振动性白指患者（ＶＷＦ组）及１９名正常对照（对照组）进行了局部冷水刺激实验，记录受试者的心电信号，实验后将记录的心电信号通过处理转化为ＲＲ间期信号，然后... 详细信息

目的研究振动性白指患者的自主神经系统对冷刺激的反应。方法２２名振动性白指患者（ＶＷＦ组）及１９名正常对照（对照组）进行了局部冷水刺激实验，记录受试者的心电信号，实验后将记录的心电信号通过处理转化为ＲＲ间期信号，然后对这些ＲＲ间期信号进行功率谱分析，计算标准化的ＬＦ（０．０２～０．１５Ｈｚ）功量（ＬＦ％），标准化的ＨＦ（０．１５～０．４０Ｈｚ）功量（ＨＦ％），以及ＬＦ／ＨＦ比率。结果冷暴露开始后，ＶＷＦ组及对照组的ＨＦ％与暴露前的水平相比都有显著下降，ＶＷＦ组的ＬＦ／ＨＦ比率与暴露前的水平相比有显著增大，而且冷暴露中ＶＷＦ组的ＬＦ／ＨＦ比率显著高于对照组的相应的ＬＦ／ＨＦ比率。结论冷刺激导致ＶＷＦ组和对照组的副交感神经活动减弱，但对照组还能保持交感与副交感的平衡，而ＶＷＦ组却不能保持两者平衡，交感神经活动明显占优，冷刺激中ＶＷＦ组ＬＦ／ＨＦ比率明显高于对照组的ＬＦ／ＨＦ比率说明振动性白指患者的交感神经系统对冷刺激可能存在过敏反应。

关键词：振动性白指心率变异性自主神经系统冷应激

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Formation of Edge Transport Barriers by L-H Transition and Large Reversed Plasma Current on LHD

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Plasma Science and Technology 2006年第1期8卷 5-9页

作者： K. TOI S. OHDACHI F. WATANABE K. NARIHARA T. MORISAKI 高翔 M. GOTO K. IDA S. MASUZAKI K. MIYAZAWA S. MOR.ITA S. sakakibara K. TANAKA T. TOKUZAWA K.W. WATANABE 严龙文 M. YOSHINUMA National Institute for Fusion Science Toki Japan Department of Energy Science and Engineering Nagoya University Nagoya Japan Institute of Plasma Physics Chinese Academy of Science Hefei 230031 China Southwestern Institute of Physics Chengdu 610041 China

On the Large Helical Device （LHD） where nested magnetic surfaces are surrounded by the ergodic field layer, edge transport barrier （ETB） was produced in neutral-beam-injection （NBI） heated plasmas through transition and non-transition processes. The former case is the ETB formation by L-Htransition, where characteristics of L-H transition observed in a tokamak plasma are clearly recognized. The confinement improvement is the modest （- 10%）, compared with the ISS95 international stellarator scaling. The threshold power for the transition is comparable or slightly lower than the ITER scaling law established by tokamaks and compact tori. The ETB is formed inside the ergodic field layer of the vacuum field. The ETB formation destabilizes edge coherent modes such as m/n = 1/1, 2/3 and 1/2, of which rational surfaces are in the magnetic hill. The formed ETB is partially and transiently destroyed by these coherent edge MHD modes and edge localized modes （ELMs） typically observed in Ha signals. The latter ETB is observed in a plasma with large reversed NBI-driven current more than 100 kA at Bt = 1 T. In these plasmas, the edge magnetic shear is enhanced by the current and the rotational transform in the core region is expected to be appreciably reduced. Thus reduced rotational transform in the plasma central region will enhance outward heat and particle fluxes toward ergodic edge layer. The ETB with steep electron temperature gradient up to - 5 keV/m is formed by blocking enhanced outward heat flux.

关键词： edge transport barrier ergodic field layer L-H transition ELMs edge MHD modes

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Contribution of the Large Helical Device Plasmas to Alfvén Eigenmode Physics in Toroidal Plasmas

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Plasma Science and Technology 2009年第4期11卷 377-380页

作者： K. TOI M. ISOBE M. OSAKABE F. WATANABE K. OGAWA T. TOKUZAWA A. SHIMIZU T. IDO K. IDA, T. ITO S. MORITA K. NAGAOKA K. NARIHARA M. NISHIURA S. OHDACHI S. sakakibara K. TANAKA LHD Experiment Group National Institute for Fusion Science Toki 509-5292 Japan Department of Energy Engineering and Science Nagoya University Nagoya 464-8601 Japan

In the large helical device （LHD） having three dimensional configuration, Alfven eigenmodes （AEs） destabilized by energetic ions are widely investigated using neutral beam heated plasmas with monotonic and non-monotonic rotational transform （l/2π） profiles. In a plasma with monotonic l/2π-profile, core-localized toroidicity-induced Alfven eigenmode （TAE） as well as global one are often observed. With the increase in the averaged toroidal beta value, defined as the ratio of total plasma pressure to toroidal magnetic pressure, core-localized TAE with low toroidal mode number becomes global. In a relatively high beta plasma with monotonic l/2π-profile, two TAEs with different toroidal mode number often interact nonlinearly and generate another modes through three wave coupling. In a plasma with non-monotonic l/2π-profile generated by intense counter neutral beam current drive, reversed shear Alfven eigenmode （RSAE） and geodesic acoustic mode （CAM） excited by energetic ions were observed for the first time in a helical plasma. Nonlinear coupling was also observed between RSAE and GAM.

关键词： alpha particles Alfven eigenmodes geodesic acoustic mode helical/stellarator

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