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The NF-Number of a Simplicial Complex

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Algebra Colloquium 2022年第4期29卷 643-650页

作者： Takayuki hibi Hasan Mahmood Department of Pure and Applied Mathematics Graduate School of Information Science and Technology Osaka University SuitaOsaka 565-0871Japan Department of Mathematics Government College University LahorePakistan

Let△bea simplicial complex on[n].TheNF-complex of△is the simplicial complexδ_(NF)(△)on[n]for which the facet ideal of△is equal to the Stanley-Reisner ideal ofδ_(NF)(△).Furthermore,for each k=2,3,....,we introduce the kth NF-complexδ_(NF)^(k)(△),which is inductively defined asδ_(NF)(k)(△)=δ_(NF)(δ_(NF)^(k-1)(△))by settingδ_(NF)^(1)(△)=δ_(NF)(△).One canδ_(NF)^(0)(△)=△.The NF-number of△is the smallest integer k>0 for whichδ_(NF)^(k)(△)■△.In the present paper we are especilly interested in the NF-number of a finite graph,which can be regraded as a simplicial complex of dimension *** is shown that the NF-number of the finite graph K_(n)■K_(m)on[n+m],which is the disjoint union of the complete graphs K_(n)on[n]and K_(m)on[m]for n≥2 and m≥2 with(n,m)≠(2,2),is equal to n+m+*** a corollary,we find that the NF-number of the complete bipartite graph K_(n,m)on[n+m]is also equal to n+m+2.

关键词： Stanley-Reisner complex facet ideal simplicial complex vertex cover

Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients

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World Journal of Gastroenterology 2023年第15期29卷 2283-2293页

作者： Weijie Xue Masaki Honda Taizo hibi Department of Transplantation and Pediatric Surgery Kumamoto UniversityKumamoto 860-8556Japan

Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a major global public health event,resulting in a significant social and economic *** COVID-19 was initially characterized as an upper respiratory and pulmonary infection,recent evidence suggests that it is a complex disease including gastrointestinal symptoms,such as diarrhea,nausea,and ***,it remains unclear whether the gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or are the result of systemic immune activation and subsequent dysregulation of homeostatic *** review provides a brief overview of the mechanisms by which SARS-CoV-2 disrupts the integrity of the gastrointestinal barrier including the mechanical barrier,chemical barrier,microbial barrier,and immune barrier.

关键词： Gastrointestinal barrier dysfunction SARS-CoV-2 COVID-19 Angiotensinconverting enzyme 2 Microbiome Immune cells

Locoregional therapy as a bridge to liver transplantation for hepatocellular carcinoma within Milan criteria:from a transplant oncology viewpoint

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Hepatobiliary Surgery and Nutrition 2018年第2期7卷 134-135页

作者： Taizo hibi Yasuhiko Sugawara Department of Transplantation and Pediatric Surgery Kumamoto University Graduate School of Medical SciencesChuo-kuKumamotoJapan

The role of bridging locoregional therapy(LRT)for patients with hepatocellular carcinoma(HCC)within Milan criteria before liver transplantation(LT)has been ***,Agopian et al.(1)retrospectively investigated the impact of bridging LRT on post-LT HCC recurrence and survival based on 3,601 patients undergoing LT from 2002 to 2013,collected in the US Multicenter HCC Transplant *** observed no significant differences in the recurrence-free survival(RFS)among patients not receiving RT and the type and combination of treatment modality[transarterial chemoembolization(TACE),thermal ablation(radiofrequency or microwave ablation),and others]*** increasing number of LRT and the dynamic serum alpha-fetoprotein(AFP)changes were correlated with a higher risk of HCC *** authors concluded that LRT improved survival only in the subset of patients who achieved complete pathologic response(cPR)with a superior 5-year RFS of 72%compared to both untreated patients(69%;P=0.01)and LRT-treated patients not achieving cPR(67%;P=0.01).Admittedly,this is a benchmark study,and the authors should be congratulated on undertaking a sophisticated analysis in a large,heterogeneous cohort of patients.

关键词： hepatocellular viewpoint bridging

Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking

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World Journal of Gastroenterology 2006年第36期12卷 5846-5852页

作者： Soichi Kitano Hisashi Hisatomi Nozomu hibi Katsumi Kawano Shoji Harada Technology Development Department SRL Inc. Hachioji Tokyo Japan Center for Molecular Biology and Cytogenetics SRL Inc. Hino Tokyo Japan

AIM: To develop a simple and accurate method for quantifying 8-isoprostane in plasma by employing a combination of two-step solid-phase extraction of samples and a commercially available ELISA kit, and by this method to examine the effects of drinking and smoking habits against the levels of plasma 8-isoprostane in healthy Japanese ***: Plasma 8-isoprostane was extracted with ODS gel suspension followed by NH2 Sep-Pak column. The 8-isoprostane fractions were assayed using a commercially available ELISA kit. We measured plasma 8-isoprostane levels in 157 healthy Japanese volunteers divided into three groups (64 non-habitual drinkers, 56 moderate drinkers and 37 habitual drinkers) according to their alcohol consumption per week. Genotypes of aldehyde dehydrogenase 2 (ALDH2) were also determined to investigate the plasma 8-isoprostane levels with reference to drinking habits. In addition, the plasma 8-isoprostane levels of 96 non-smokers and 61 smokers from the same subjects were ***: Our method fulfilled all the requirements for use in routine clinical assays with respect to sensitivity, intra- and inter-assay reproducibility, accuracy and dynamic assay range. Significant increases of plasma 8-isoprostane levels were observed in female habitual drinkers when compared with those of non-habitual drinkers (t = 5.494, P < 0.0001) as well as moderate drinkers (t = 3.542, P < 0.005), and 8-isoprostane levels were also significantly different between ALDH2*2/1 and ALDH2*1/1 in the female habitual drinkers (t = 6.930, P < 0.0001), suggesting that excessive drinking of alcohol may increase oxidization stress, especially in females. On the contrary, no significant difference of the plasma 8-isoprostane levels was observed between non-smokers and ***: Our present method was proved to be a simple and accurate tool for measuring plasma 8-isoprostane. However, the clinical utility of plasma 8-isoprostane for drinking and smoking habits was

关键词： 8-Isoprostane ELISA Lipid peroxidation Drinking Smoking

An antioxidant resveratrol significantly enhanced replication of hepatitis C virus

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World Journal of Gastroenterology 2010年第2期16卷 184-192页

作者： Mitsuyasu Nakamura Masanori Ikeda Ryota Hokari Nobuyuki Kato Toshifumi hibi Soichiro Miura Department of Internal Medicine 2 National Defense Medical Collage3-2 NamikiTokorozawaSaitama 3598513Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Masanori Ikeda Department of Molecular Biology Okayama University Graduate School of Medicine and Dentistry2-5-1 Shikada-choOkayama 7008558Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Masanori Ikeda

AIM:To elucidate the effect of antioxidants,resveratrol (RVT)and astaxanthin(AXN),on hepatitis C virus(HCV) replication. METHODS:We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system *** is a strong antioxidant and a kind of polyphenol that inhibits replication of various *** is also a strong *** replication of HCV RNA was assessed by the luciferase reporter *** additive effect of antioxidants on antiviral effects of interferon(IFN)and ribavirin(RBV) was ***:This is the first report to investigate the effect of RVT and AXN on HCV *** contrast to other reported viruses,RVT significantly enhanced HCV RNA *** E also enhanced HCV RNA replication as reported previously,although AXN didnot affect *** and RBV significantly reduced HCV RNA replication,but these effects were dose-dependently hampered and attenuated by the addition of *** didnot affect antiviral effects of IFN or RBV. CONCLUSION:These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C.

关键词： Replicon system Luciferase assay Ribavirin Interferon Polyphenol Astaxanthin

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

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World Journal of Gastroenterology 2010年第1期16卷 89-97页

作者： Hidetsugu Saito Hirotoshi Ebinuma Keisuke Ojiro Kanji Wakabayashi Mika Inoue Shinichiro Tada Toshifumi hibi Department of Internal Medicine School of MedicineKeio University

AIM:To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS:We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this *** formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS:Sustained virological response was obtained in 83(47.2%)of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4,12 and *** likelihood of sustained virological response could be predicted effectively bythe formulae at weeks 4,12 and 24(the area under the curve of the receiver operating characteristic:0.821, 0.802,and 0.891,respectively),but not at baseline (0.570).The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating *** by this formula was always superior to that by viral kinetics. CONCLUSION:These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

关键词： Logistic regression analysis Predictive formula Prolongation of the therapy Response-guided therapy Viral kinetics

High expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第24期11卷 3710-3713页

作者： Hiroaki Yokomori Masaya Oda Go Wakabayashi Masaki Kitajima Kazunori Yoshimura Masahiko Nomura Toshifumi hibi Department of Internal Medicine Organized Center of Clinical Medicine Department of Surgery Department of Physiology

AIM: An increase in bile ductular structures is observed in diverse human liver diseases, especially in primary biliary cirrhosis (PBC). These structures harbor the progenitor cell component of the liver. Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes including cholesterol transport. This study aims to examine the role of caveolin in ***: Immunohistochemical and Western blottingstudies were performed on human liver specimens obtained from patients with PBC and normal liver samples. The expression of caveolin (CAV)-1 and -2 was determined using specific ***: In normal liver, scanty immunostaining for CAV1 and -2 was observed in bile ductules. In PBC liver samples, the expression levels of CAV-1 and -2 were increased on proliferating bile ductules especially in stage 3 cases, but was sparse on interlobular bile duct in stage 1 specimens. Especially, the regenerating bile ductules at the interface of portal tracts and necrotic areas were immunostained intensely for CAV-1 and -2. These phenomena were confirmed by Western ***: The present results demonstrate increased expression of caveolins in proliferating bile ductules in PBC, which may be related to the homeostasis of cholesterol transport in regenerating bile ductules in PBC liver.

关键词： Proliferating bile ductule Caveolin Immunohis tochemistry Primary biliary cirrhosis

Enhanced plasma ghrelin levels in Helicobacter py/ori-colonized, interleukin-1-receptortype 1-homozygous knockout (IL-1R1-/-) mice

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World Journal of Gastroenterology 2005年第27期11卷 4148-4153页

作者： Yuka Abiko Hidekazu Suzuki Tatsuhiro Masaoka Sachiko Nomura Kumiko Kurabayashi Hiroshi Hosoda Kenji Kangawa Toshifumi hibi Department of Internal Medicine and Center for Integrated Medical Research Department of Biochemistry

AIM： Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor, and it plays a role in stimulating the growth hormone secretion, food intake,body weight gain and gastric motility. Eradication of Helicobacterpylori （H pylon） was shown to be associated with increase of the body weight. On the other hand, Hpylori infection evokes the release of gastric IL-1β. The present study was designed to investigate the involvement of the gastric IL-1 signal in the ghrelin dynamics in Hpyloricolonized ***： Twelve-week-old female IL-l-receptor type 1-homozygous-knockout mice （IL-1R1^-/-） and their wild-type littermates （WT） were orally inoculated with H pylori （Hp group）, while other cohorts received oral inoculation of culture medium （Cont group）. Thirteen weeks after the inoculation, the mice were examined. The plasma and stomach ghrelin levels and the gastric preproghrelin mRNA were ***： Although the WT mice with Hpyloriinfection showed a significantly decreased body weight as compared with that of the animals without HpyloriinfecUon,Hpyloriinfection did not influence the body weight of the IL-1Rl-knockout （IL-1R1^-/-） mice. In the Hpylori-infected IL-1R1＋ mice, the total and active ghrelin levels in the plasma were significantly increased, and the gastric ghrelin level was decreased. No significant differences were noted in the gastric preproghrelin mRNA ***： Ghrelin secretion triggered by H pylori infection might be suppressed by IL-1β, the release of which is also induced by the infection, resulting in the body weight loss of mice with Hpyloriinfection.

关键词： Ghrelin Hpylori IL-1 Body weight Myelo-peroxidase

Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically

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World Journal of Gastroenterology 2005年第4期11卷 511-515页

作者： Yoshinori Horie Shuka Mori Masahiro Konishi Mikio Kajihara Takehiko Kaneko Yoshiyuki Yamagishi Shinzo Kato Hiromasa Ishii Toshifumi hibi Department of Internal Medicine School of Medicine Keio University Tokyo Japan

AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaettn, has been clinically used for vascular diseases such as occlusive vasculitis, coronary diseases, atherosclerosis, and cerebral infarction. The main component, Salviae Miltiorrhizae, has been reported to prevent cerebral and intestinal reperfusion injury. However, little is known about the effect of CP on hepatic microcirculation. Thus, this study aimed to determine whether CP could affect hepatic microvascular dysfunction elicited by gut ischemia/ reperfusion (I/R) in rats fed ethanol chronically. METHODS: Male Wistar rats were pair-fed with a liquid diet containing ethanol or isocaloric control diet for 6 wk. After laparotomy, one lobe of the liver was examined through an inverted intravital microscope. The rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Rhodamine-6G-labeled leukocytes in the sinusoids were observed 90 min after the onset of superior mesenteric artery occlusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h after the onset of reperfusion. Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h before the onset of ischemia. RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. These changes were mitigated by pretreatment with CP. In ethanol-fed rats, the gut I/R-induced increases in the number of stationary leukocytes, plasma endotoxin levels and ALT activities were enhanced. Pretreatment with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption. CONCLUSION: These results suggest that CP prevents the gut I/R-induced hepatic microvascular dysfunction and hepatocellular inju

关键词： Intestinal reperfusion injury Hepatic microvascular dysfunction Cardiotonic Pill Ethanol