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Benign esophageal stricture after thermal injury treated with esophagectomy and ileocolon interposition

World Journal of Gastroenterology 2014年第27期20卷 9205-9209页

作者： toshihiro kitajima Kota Momose Seigi Lee Shusuke Haruta Hisashi Shinohara Masaki Ueno Takeshi Fujii Harushi Udagawa Department of Digestive Surgery Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan Department of Pathology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Thermal injuries of the esophagus are rare causes of benign esophageal stricture, and all published cases were successfully treated with conservative management. A 28-year-old Japanese man with a thermal esophageal injury caused by drinking a cup of hot coffee six months earlier was referred to our hospital. The hot coffee was consumed in a single gulp at a party. Although the patient had been treated conservatively at another hospital, his symptoms of dysphagia gradually worsened after discharge. An upper gastrointestinal endoscopy and computed tomography revealed a pinhole like area of stricture located 19 cm distally from the incisors to the esophagogastric junction, as well as circumferential stenosis with notable wall thickness at the same site. The patient underwent a thoracoscopic esophageal resection with reconstruction using ileocolon interposition. The pathological findings revealed wall thickening along the entire length of the esophagus, with massive fibrosis extending to the muscularis propria and adventitia at almost all levels. Treatment with balloon dilation for long areas of stricture is generally difficult, and stent placement in patients with benign esophageal stricture, particularly young patients, is not yet widely accepted due to the incidence of late adverse events. Considering the curability and qualityof-life associated with a long expected prognosis, we determined that surgery was the best treatment option for this young patient. In this case, we decided to perform an esophagectomy and reconstruction with ileocolon interposition in order to preserve the reservoir function of the stomach and to avoid any problems related to the reflux of gastric contents. In conclusion, resection of the esophagus is a treatment option in patients with benign esophageal injury, especially in cases involving young patients with refractory esophageal stricture. In addition, ileocolon interposition may help to improve the quality-of-life of patients.

关键词： Thermal injury Benign esophageal stricture Esophageal resection Ileocolon interposition Video-assisted thoracic surgery

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Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer

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World Journal of Gastroenterology 2015年第11期21卷 3394-3401页

作者： toshihiro kitajima Kota Momose Seigi Lee Shusuke Haruta Masaki Ueno Hisashi Shinohara Sakashi Fujimori Takeshi Fujii Ryoji Takei Tadasu Kohno Harushi Udagawa Department of Gastroenterological Surgery Toranomon Hospital Department of Thoracic Surgery Toranomon Hospital Department of Pathology Toranomon Hospital Department of Radiology Toranomon Hospital

We herein report a case of bronchial bleeding afterradical esophagectomy that was treated with lobectomy.A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden *** the esophagectomy,bilateral vocal cord paralysis was observed,and the patient suffered from repeated episodes of aspiration *** revealed hemosputum in the right middle lobe bronchus,and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery and left subclavian artery toward the right middle lobe *** bronchial arterial embolization was performed twice to control the recurrent hemoptysis,the procedures were *** middle lobectomy was therefore performed via video-assisted thoracic *** bronchial arterys with medial hypertrophy and overgrowth of the small branches were noted near the bronchus in the resected *** patient recovered uneventfully and was discharged on postoperative day 14.

关键词： Hemoptysis Esophagectomy Recurrent laryngeal nerve

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Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第28期11卷 4382-4389页

作者： Hiroaki Yokomori Masaya Oda Mariko Ogi Go Wakabayashi Shigeyuki Kawachi Kazunori Yoshimura toshihiro Nagai Masaki kitajima Masahiko Nomura Toshifumi Hibi Department of Internal Medicine Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Organized Center of Clinical Medicine International University of Health and Welfare Tokyo 107-0052Japan Laboratory of Pathology Kitasato Institute Medical Center Hospital Saitama 364-8501Japan Department of Surgery School of Medicine Keio UniversityTokyo 160-0016Japan Physiology Saitama Medical School Saitama 350-0495Japan Electron Microscopy Laboratory School of Medicine Keio UniversityTokyo 160-0016Japan Department of Internal Medicine School of Medicine Keio UniversityTokyo 160-0016Japan

AIM：To examine the expression of intercellular adhesion molecule-1 （ICAM-1） and lymphocyte function-associated antigen-1（LFA-1）expression on canals of Hering （COH）and bile ductules associated with the autoimmune process of bile duct destruction in primary biliary cirrhosis（PBC）．METHODS：Ten wedged liver biopsies of PBC（five cases each of stages 2 and 3）were studied. The liver specimens were processed for transmission electron microscopy. Immunohistochemistry was performed using anti-ICAM-1 and anti-LFA-1 mouse *** situ hybridization was done to examine the messenger RNA expression of ICAM-1 in ***-embedded sections using peptide nucleic acid probes and the catalyzed signal amplification （CSA）***-silver staining for electron microscopy was Derrormed using anti-ICAM and anti-LFA-1 mouse *** immunogold particles on epithelial cells of bileductules and cholangiocytes of CoH cells were counted and analyzed *** blotting was performed to confirm ICAM-1 protein expression．RESULTS：In liver tissues of PBC ***-stochemistry showed aberrant ICAM-1 expression on the plasma membrane of epithelial cells lining bile ductules，and also on mature cholangiocytes but not on hepatocytes in ***-1-positive lymphocytes were closely associated with epithelial cells in bile ***-1 expression at protein level was confirmed by Western *** situ hybridization demonstrated ICAM-1 mRNA expression in bile ductules and LFA-1 mRNA in lymphocytes infiltrating the *** immunoelectron microscopy，ICAM-1 was demonstrated on the basal suface of epithelial cells in bile ductules and on the luminal surfaces of cholangiocytes in damaged *** with intermediate morphology resembling progenitor cells in Coil were not labeled with ICAM-1 and LFA-1．CONCLUSION：De novo expression of ICAM-1 both on mature cholangiocytes in COH and epithelial cells in bile ductules in PBC implies that lymphocyte-indu

关键词： Primary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopyPrimary biliary cirrhosis Canal of Hedng Small bile ductile ICAM-1 LFA-1 Immunohistochemistry Western blot Immunogold electron microscopy

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Quasi-periodic orbits of small solar sails with time-varying attitude around Earth–Moon libration points

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Astrodynamics 2024年第1期8卷 161-174页

作者： toshihiro Chujo Department of Mechanical Engineering School of EngineeringTokyo Institute of TechnologyTokyo152-8550Japan

This paper proposes new quasi-periodic orbits around Earth–Moon collinear libration points using solar *** including the time-varying sail orientation in the linearized equations of motion for the circular restricted three-body problem(CR3BP),four types of quasi-periodic orbits(two types around L1 and two types around L2)were *** them,one type of orbit around L2 realizes a considerably small geometry variation while ensuring visibility from the Earth if(and only if)the sail acceleration due to solar radiation pressure is approximately of a certain magnitude,which is much smaller than that assumed in several previous *** means that only small solar sails can remain in the vicinity of L2 for a long time without propellant *** orbits designed in the linearized CR3BP can be translated into nonlinear CR3BP and high-fidelity ephemeris models without losing geometrical *** this study,new quasi-periodic orbits are formulated,and their characteristics are ***,their extendibility to higher-fidelity dynamic models was verified using numerical examples.

关键词： solar sail libration point orbit Earth-Moon system circular restricted three-body problem(CR3BP)

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On Exit Time from Balls of Jump-type Symmetric Markov Processes

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Acta Mathematica Sinica,English Series 2010年第1期26卷 185-192页

作者： toshihiro UEMURA Department of Mathematics Faculty of Engineering Science Kansai University

We obtain upper and lower bounds of the exit times from balls of a jump-type symmetric Markov process. The proofs are delivered separately. The upper bounds are obtained by using the Levy system corresponding to the process, while the precise expression of the （L^2-）generator of the Dirichlet form associated with the process is used to obtain the lower bounds.

关键词： symmetric Dirichlet form jump-type Markov process Levy system exit times from balls

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Optimization of body configuration and joint-driven attitude stabilization for transformable spacecraft under solar radiation pressure

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Astrodynamics 2024年第1期8卷 47-60页

作者： Yuki Kubo toshihiro Chujo Institute of Space and Astronautical Science Japan Aerospace Exploration AgencyKanagawa252-5210Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo152-8550Japan

The solar sail is one of the most promising space exploration systems due to its theoretically infinite specific impulse achieved through solar radiation pressure(SRP).Recently,researchers have proposed“transformable spacecraft”capable of actively reconfiguring their body configurations using actuatable *** spacecraft,if used similarly to solar sails,are expected to significantly enhance orbit and attitude control capabilities owing to their high redundancy in control degrees of ***,controlling them becomes challenging due to their large number of inputs,leading previous researchers to impose strong constraints to limit their potential control *** study focuses on novel attitude control techniques for transformable spacecraft under *** developed two methods,namely,joint angle optimization to obtain arbitrary SRP force and torque,and momentum damping control driven by joint angle *** proposed methods are formulated in a general manner and can be applied to any transformable spacecraft comprising front faces that can predominantly receive the SRP on each *** validity of our proposed method is confirmed through numerical *** study contributes to making most of the high control redundancy of transformable spacecraft without the need for expendable propellants,thus significantly enhancing the orbit and attitude control capabilities.

关键词： solar sail transformable spacecraft attitude-joint coupled motion attitudestabilization

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Effect of Exit Geometry of Tail Pipe on the Performance of Pulse Jet Engines

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Journal of Thermal Science 2006年第3期15卷 263-268页

作者： toshihiro NAKANO ShigeruMATSUO KenbuTERAMOTO ToshiakiSETOGUCHI Department of Mechanical Engineering Saga University1 Honjo-machiSaga-shiSaga 840-8502Japan

In this paper,the effect of geometries of tube open end on the shock,compression and expansion wavespropagating in the tube was investigated numerically and *** of them is a conventional straightshock tube with an open *** other has a divergent tail tube at the *** a divergent tail tube(flaretube)to an open end shock tube,the period of one-cycle process could be shortened and the pressure behind theexpansion wave produced at the exit of the shock tube could be lowered much more below the atmosphericpressure than that produced in the straight *** results suggested that the intake air into the engine wassignificantly increased by applying a flare tube instead of a straight tube.

关键词： compressible flow shock wave expansion wave pulse jet numerical simulation

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of Forestry Research 2023年第1期34卷 187-195页

作者： Tetsuto Sugai Wataru Ishizuka toshihiro Watanabe Hokkaido Research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan Forest Research Institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

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Maintenance and induction of murine embryonic stem cell differentiation using E-cadherin-Fc substrata without colony formation

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Frontiers of Materials Science 2013年第1期7卷 51-61页

作者： Qing-Yuan MENG toshihiro AKAIKE Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Biomolecular Engineering Graduate School of Bioscience and Biotechnnology.Tokyo Institute of Technology 4259 Nagatsuta-cho Midori-ku Yokohama 226-8501 Japan

Induced embryonic stem (ES) cells are expected to be promising cell resources for the observation of the cell behaviors in developmental biology as well as the implantation in cell treatments in human diseases. A recombinant E-cadherin substratum was developed as a cell recognizable substratum to maintain the ES cells’ self-renewal and pluripotency at single cell level. Furthermore, the generation of various cell lineages in different germ layers, including hepatic or neural cells, was achieved on the chimeric protein layer precisely and effectively. The induction and isolation of specific cell population was carried out with the enhancing effect of other artificial extracellular matrices (ECMs) in enzyme-free process. The murine ES cell-derived cells showed highly morphological similarities and functional expressions to matured hepatocytes or neural progenitor cells.

关键词： cell adhesion molecule embryonic stem cell differentiation E-cadherin-Fc single cell culture system

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Combined disturbance-observer-based control and iterative learning control design for pulsed superconducting radio frequency cavities

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Nuclear Science and Techniques 2021年第6期32卷 11-22页

作者： Feng Qiu Shinichiro Michizono toshihiro Matsumoto Takako Miura High Energy Accelerator Research Organization 1-1 OhoTsukubaIbaraki 305-0801Japan The Graduate University for Advanced Studies HayamaKanagawa 240-0193Japan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

The development of iterative learning control combined with disturbance-observer-based(DOB)control for the digital low-level radio frequency(LLRF)system of the International Linear Collider project is *** objective of this study is to compensate for both repetitive(or predictable)and unpredictable disturbances in a radio frequency system(e.g.,beam loading,Lorentz force detuning,and microphonics).The DOB control approach was verified using the LLRF system at the Superconducting Test Facility(STF)at KEK in the absence of a *** method comprising DOB control combined with an iterative learning control algorithm was then demonstrated in a cavity-simulator-based test bench,where a simulated beam was *** results showed that the performance of the LLRF system was improved,as expected by this combined control *** plan to further generalize this approach to LLRF systems at the STF and the future International Linear Collider project.

关键词： Low-level radio frequency Disturbance observer Iterative learning control

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