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Tomato Seed Extract Containing Lycoperoside H Improves Skin Elasticity in Japanese Female Subjects: A Randomized, Placebo-Controlled, Double-Blind Trial

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第3期11卷 217-236页

作者： Tatsuya Izumi Kazuo Yamamoto Naoko Suzuki Shin-ichiro Yamashita Shin-ichiro Iio Hayata Noguchi toshihiro kakinuma Asami Baba Shogo Takeda Wakana Yamada Hiroshi Shimoda Hiroo Dermatology Clinic & Mentors Inc. 1 & 2F Hiroo Masugi Annex Bldg. Hiroo Shibuya-ku Tokyo Japan ORTHOMEDICO Inc. 2F Sumitomo Fudosan Korakuen Bldg. Koishikawa Bunkyo-ku Tokyo Japan Oryza Oil & Fat Chemical Co. Ltd. 1 Numata Kitagata-cho Ichinomiya Aichi Japan

Background and Objective: Tomato seeds are edible seeds unconsciously ingested with the fruit. However, there are few reports regarding the constituents and biological activities of tomato seed extract (TSE). Recently, we found that saponins are major constituents of TSE including lycoperoside H. Previous reports have described that several plant-derived saponins improve skin diseases such as wounds and microangiopathy. Therefore, to discover the effect of TSE on the skin condition, we conducted a clinical trial of TSE (Tomato Seed Extract-P) standardized with lycoperoside H when orally ingested. Methods: The study was performed as a randomized, double-blind, placebo-controlled study. TSE (200 mg daily) containing 1 mg of lycoperoside H was used as the active sample. We enrolled 44 Japanese women who have concerns about facial elasticity and relatively low facial skin elasticity. All subjects were randomly allocated into either the active group (n = 22) or the placebo group (n = 22) using a computerized random-number generator. Capsules containing either the active sample or a placebo were administered for 8 weeks between October 12, 2020, and January 16, 2021. Facial elasticity, specifically the R7 value, was evaluated as the primary outcome. The remaining facial R parameters, upper arm R parameters, and other skin parameters including epidermal moisture, trans epidermal water loss, dermal parameters, and advanced glycation end products (AGEs) parameters were measured at 0, 4, and 8 weeks of ingestion. Blood, urine, and body parameters were also evaluated for safety. Results: Forty-three subjects completed the trial, and the per protocol set comprised 21 subjects in the TSE group and 22 subjects in the placebo group. After ingesting TSE for 8 weeks, the R7 value was significantly higher in the TSE group compared to the placebo group. Furthermore, the change in R7 values from the baseline at 4 and 8 weeks were also

关键词： Tomato Seed Saponin Lycoperoside Skin Elasticity Cutometer Pentosidine

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