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Calcitriol-induced hypercalcemia in a patient with granulomatous mycosis fungoides and end-stage renal disease

World Journal of Nephrology 2013年第2期2卷 44-48页

作者： Takamasa Iwakura Naro Ohashi Naoko Tsuji Yoshitaka Naito Shinsuke Isobe Masafumi Ono Tomoyuki Fujikura Takayuki Tsuji Yukitoshi Sakao Hideo Yasuda Akihiko Kato toshiharu fujiyama Yoshiki Tokura Yoshihide Fujigaki First Department of Medicine Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Blood Purification Unit Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Department of Dermatology Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan

An 86-year-old man, diagnosed as having mycosis fungoides in May 2008 and treated with repeated radiation therapy, was admitted to our hospital for initiation of hemodialysis due to end-stage renal disease(ESRD) in April 2012. On admission, his corrected serum calcium level was 9.3 mg/d L, and his intact parathyroid hormone level was 121.9 pg/mL(normal range 13.9-78.5pg/mL), indicating secondary hyperparathyroidism due to ESRD. After starting hemodialysis, urinary volume diminished rapidly. The serum calcium level increased(12.7 mg/dL), and the intact parathyroid hormone level was suppressed(< 5 pg/m L), while the 1,25-dihy-droxyvitamin D3(calcitriol) level increased(114 pg/mL, normal range: 20.0-60.0 pg/m L) in June 2012. The possibilities of sarcoidosis and tuberculosis were ruled out. Skin biopsies from tumorous lesions revealed a diagnosis of granulomatous mycosis fungoides. The serum soluble interleukin-2 receptor levels and the degrees of skin lesions went in parallel with the increased serum calcium and calcitriol levels. Therefore, the patient was diagnosed as having calcitriol-induced hypercalcemia possibly associated with granulomatous mycosis fungoides. Granulomatous mycosis fungoides is rare, and its association with calcitriol-induced hypercalcemia has not been reported. Careful attention to calcium metabolism is needed in patients with granulomatous mycosis fungoides, especially in patients with ESRD.

关键词： Calcitriol-induced hypercalcemia Granulomatous mycosis

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Responses of Halophyte Salicornia bigelovii to Different Forms of Nitrogen Source

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Pedosphere 2010年第3期20卷 311-317页

作者： N. KUDO H. fujiyama The United Graduate School of Agricultural Science Tottori University4-101 Koyamacho-minamiTottori 680-8553 (Japan) Faculty of Agriculture Tottori University4-101 Koyamacho-minamiTottori 680-8553 (Japan)

Salt-affected soils are agricultural and environmental problems on a global scale. Plants suffer from saline stresses in these soils and show nitrogen （N） deficiency symptoms. However, halophytes grow soundly under saline conditions. In order to clarify the N nutrition of the halophyte Salicornia bigelovii, it was grown at several N levels （1, 2, 3, and 4 mmol L-1）, supplied in the form of NO3 or ammonium （NH4＋）, under high NaCl conditions （200 mmol L-l）. NH4^＋- fed plants showed better growth than NO3-fed plants at 1-3 mmol L-1N, and plants in both treatments showed the same growth at 4 mmol L-1 N. Nitrogen contents in NO3-fed plants increased with the N concentrations in solution; competitive inhibition of NO3- absorption by Cl- was observed under lower N conditions. In addition, shoot dry weight was significantly correlated only with shoot N content. Therefore, growth of NO3-fed plants was regulated by N absorption. In contrast, N contents of shoots in NH4＋-fed plants did not change with N concentration. Shoot Na content decreased with increasing N concentration, while K content increased. Dry weight was highly correlated only with K content in NH4＋-fed plants. These observations indicated that growth of NH4＋-fed plants was mainly regulated by K absorption.

关键词： cation absorption nitrogen nutrition plant growth saline stress

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Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease

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World Journal of Gastroenterology 2006年第28期12卷 4452-4460页

作者： Akira Andoh Yoshihide fujiyama Department of Internal Medicine Shiga University of Medical ScienceSeta TukinowaOtsu 520-2192Japan

Inflammatory bowel diseases, ulcerative colitis, and Crohn＇s disease, are chronic intestinal disorders of unknown etiology in which in genetically susceptible individuals, the mucosal immune system shows an aberrant response towards commensal bacteria. The gastrointestinal tract has developed ingenious mechanisms to coexist with its autologous microflora, but rapidly responds to invading pathogens and then returns to homeostasis with its commensal bacteria after the pathogenic infection is cleared. In case of disruption of this tightly-regulated homeostasis, chronic intestinal inflammation may be induced. Previous studies showed that some commensal bacteria are detrimental while others have either no influence or have a protective action. In addition, each host has a genetically determined response to detrimental and protective bacterial species. These suggest that therapeutic manipulation of imbalance of microflora can influence health and disease. This review focuses on new insights into the role of commensal bacteria in gut health and disease, and presents recent findings in innate and adaptive immune interactions. Therapeutic approaches to modulate balance of intestinal microflora and their potential mechanisms of action are also discussed.

关键词： Commensal bacteria Prebiotics Probiotics Innate immunity

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Lipid Peroxidation and Antioxidative Enzymes of Two Turfgrass Species Under Salinity Stress

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Pedosphere 2013年第2期23卷 213-222页

作者： R.XU M.YAMADA H.fujiyama United Graduate School of Agricultural Sciences Tottori University Faculty of Agriculture Tottori University

Salinity stress is a major factor limiting the growth of turfgrass irrigated with recycled wastewater. The change in lipid peroxidation in terms of malondialdehyde （MDA） content and the activities of superoxide dismutase （SOD）, catalase （CAT）, ascorbate peroxide （APX） and glutathione reductase （GR） in the shoots and roots of Kentucky bluegrass and tall rescue were investigated under salinity stress. Plants were subjected to 0, 50, 100, 150 and 200 mmol L-1 NaCl for 40 d. The MDA content under salinity stress was lower in tall fescue than in Kentucky bluegrass in both shoots and roots. Activities of SOD in the shoots of both species increased with salinity stress. The activities of CAT and APX decreased in Kentucky bluegrass, but no significant difference in the activities of CAT and APX was observed in tall rescue. The activities of SOD, CAT and APX in the shoots of tall fescue were higher than those in Kentucky bluegrass. In the roots of Kentucky bluegrass, SOD and GR activities increased and CAT and APX activities decreased in comparison with the control. In the roots of tall fescue, salinity increased the activities of SOD, CAT, and APX. These results suggested that tall fescue exhibited a more effective protection mechanism and mitigated oxidative stress and lipid peroxidation by maintaining higher SOD, CAT and APX activities than Kentucky bluegrass.

关键词： antioxidants malondialdehyde oxidative stress recycled wastewater salt tolerance

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Some Physiological Responses of Chinese Iris to Salt Stress

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Pedosphere 2008年第4期18卷 454-463页

作者： BAI Wen-Bo LI Pin-Fang LI Bao-Guo H. fujiyama FAN Fen-Cheng College of Resources and Environmental Sciences China Agricultural University Key Laboratory of Plant-Soil Interactions Ministry of Education Beijing 100094 （China） Faculty of Agriculture Tottori University Tottori 680-8553 （Japan） Beijing Oasis Technology Development Co. Ltd. Beijing 100094 （China）

Chinese iris （Iris lactea Pall. var. chinensis （Fisch） Koidz.）, a robust iridaceous plant, is widespread in arid and semiarid regions with high salinity. However, the mechanism of its salt tolerance is not well understood. In this study, plant growth, water status, content and distribution of inorganic ions, cell membrane permeability, and proline content of I. laetea under salt stress were investigated using nutrient solutions with six NaCl concentrations ranging from 0 to 350 mmol L^-1. The results indicated that the biomass, height, fresh weight, K^＋ content, and K^＋/Na^＋ and Ca^2＋/Na^＋ ratios decreased with increasing NaCl stress, whereas plant water deficit and contents of Na^＋ and Cl- increased with increasing NaCl stress. In all salt treatments, water deficit of shoots was found to be higher than that of roots and had a positive correlation with salt concentration. When the NaCl concentration was less than 280 mmol L^-1, the ion absorption selectivity ratio and the transportation selectivity ratio sharply increased with increasing NaCl stress. Under medium salt stress, I. lactea exhibited a strong K^＋ selective absorption and the transportation of K^＋ from roots to shoots increased, whereas Na^＋ was not transported and was mostly retained in roots. The plants were able to maintain osmotic adjustment through the accumulation of Na^＋, Cl-, and proline. On the basis of its biomass production under salt stress, I. lactea could be considered as a facultative halophyte.

关键词： inorganic ion Iris lactea Pall. var. chinensis (Fisch) Koidz. NaCl stress osmotic adjustment

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Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines

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World Journal of Gastroenterology 2010年第19期16卷 2355-2361页

作者： Ayako Kobori Shigeki Bamba Hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa Yasuharu Saito Yoshihide fujiyama Akira Andoh Division of Gastroenterology Department of Internal Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan Division of Mucosal Immunology Graduate School of Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan

AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA ***: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression.

关键词： Cytokine Histone acetylation Inflammatory bowel disease

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Preoperative blood circulation modification prior to pancreaticoduodenectomy in patients with celiac trunk occlusion:Two case reports

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1310-1319页

作者： Marco Colella Kohei Mishima Taiga Wakabayashi Yoshiki fujiyama Malek A Al-Omari Go Wakabayashi Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalAgeo 362-8588SaitamaJapan

BACKGROUND Celiac trunk stenosis or occlusion is a common condition observed in patients undergoing pancreaticoduodenectomy(PD).The risk of upper abdominal organ ischemia or failure increases if the blood circulation in the celiac arterial system is not maintained after the *** SUMMARY We present two cases of elderly patients with distal cholangiocarcinoma and celiac trunk occlusion who underwent *** performed blood circulation modification preoperatively with transcatheter coil embolization of the arterial arcades of the pancreatic head via the superior mesenteric artery to develop collateral communication between the superior mesenteric artery and the common hepatic or splenic arteries to ensure arterial blood flow to the upper abdominal *** postoperative course was marked by delayed gastric emptying,but no major surgical complications,such as biliary or pancreatic fistula,or clinical,biochemical,or radiological evidence of ischemic disease,was *** Preoperative blood circulation modification may be a valid alternative procedure for elderly patients with celiac trunk occlusion who are ineligible for interventional or surgical revascularization.

关键词： Preoperative blood circulation modification Cholangiocarcinoma Pancreaticoduodenectomy Whipple procedure Celiac trunk occlusion Atherosclerosis Transcatheter coil embolization Case report

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Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection

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World Journal of Gastroenterology 2009年第5期15卷 595-598页

作者： Kazunori Hata Akira Andoh Kiyoyuki Hayafuji Atsuhiro Ogawa Tamio Nakahara Tomoyuki Tsujikawa Yoshihide fujiyama Yasuharu Saito Department of Medicine Shiga University of Medical Science Seta-Tukinowa Otsu 520-2192 Japan Division of Endoscopy Shiga University of Medical Science Seta-Tukinowa Otsu 520-2192 Japan

AIM: To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction. METHODS: Three hundred sixty-six patients with an early-stage neoplasm of the digestive tract were enrolled. The BIS monitor (A-1050: Aspect medical systems/NIHON KOHDEN, Tokyo, Japan) was used. The appropriate sedative condition was set at 55 to 75 BIS levels (BIS value) during the endoscopic procedures. RESULTS: Among 366 cases, 13 were accompanied by adverse events during and/or after ESD. All episodes occurred in cases with BIS value between 56 and 65. Hypotension was observed in four cases, and bradycardia in six. Respiratory distress was observed in two cases with chronic pulmonary obstructive disease. All patients with adverse events were able to leave the hospital without extension of the hospitalization. CONCLUSION: BIS monitoring is useful to safely perform ESD. A BIS value of 70 to 75 is suitable for ESD.

关键词： Endoscopy Cancer Sedation Propofol CO2

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Comparison of Soil Fauna (Oribatids and Enchytraeids)Between Conventional and Organic (Tillage and No-Tillage Practices) Farming Crop Fields in Japan

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Pedosphere 2001年第1期11卷 11-20页

作者： M.FUJITA S.fujiyama InternationalNatureFarmingResearchCenter AgriculturalExperimentStation5632Hata－machiNagano390－1401（Japan） EnvironmentalSystemScience GraduateSchoolofScienceandTechnologyShinshUnive

The major soil animal groups, enchytraeid worms and oribatid mites, were compared in the abundance and diversity between conventional fields (CT) and organic farming fields with tillage (OT) or no-tillage (ON) practices. The values of abundance, species richness, diversity and evenness were significantly larger in OT and ON than in CT, indicating that the abundance and diversity in organic farming fields were greater than those in conventional farming. The community structure of enchytraeid genera was different between OT and ON. Enchytraeus was the most abundant in OT, while Fridericia in ON. The abundance of oribatids in OT was similar to that in ON, while the species richness and diversity in the former were smaller. These results suggested that no-tillage practice under organic management might contribute to the improvement in quality of soil mesofauna.

关键词： Enchytraeidae organic farming Oribatida soil management tillage

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Mechanical characterization of sisal reinforced cement mortar

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Theoretical & Applied Mechanics Letters 2014年第6期4卷 26-30页

作者： R.fujiyama F.Darwish M.V.Pereira Department of Mechanical Engineering Para Federal University Department of Civil Engineering Fluminense Federal University Department of Materials Engineering Catholic University of Rio de Janeiro

This work aims at evaluating the mechanical behavior of sisal fiber reinforced cement mortar. The composite material was produced from a mixture of sand, cement, and water. Sisal fibers were added to the mixture in different lengths. Mechanical characterization of both the composite and the plain mortar was carried out using three point bend, compression, and impact tests. Specimens containing notches of different root radii were loaded in three point bending in an effort to determine the effect of the fibers on the fracture toughness of the material. The results obtained indicate that, while fiber reinforcement leads to a decrease in compressive strength, J-integral calculations at maximum load for the different notch root radii have indicated, particularly for the case of long fibers, a significant superiority of the reinforced material in comparison with the plain cement mortar, in consistence with the impact test data.

关键词： composite material impact energy fracture initiation J-integral

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