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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

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Neural Regeneration Research 2025年第1期20卷 184-185页

作者： Teruyuki ishikura Tatsusada Okuno Department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan Department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

Docking and Molecular Dynamics Study of the Carbohydrate Binding Module from Trichoderma reesei Cel7A on the Surfaces of the Cellulose Ⅲ_(1) Crystal

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Journal of Renewable Materials 2020年第8期8卷 863-878页

作者： toshifumi Yui Takuya Uto Faculty of Engineering University of MiyazakiMiyazaki889-2192Japan Organization for Promotion of Tenure Track University of MiyazakiMiyazaki889-2192Japan

We report the systematic survey of the binding free energies at the interface between a carbohydrate binding module(CBM)of Cel7A and the celluloseⅢ_(1)crystal model using grid docking searches and molecular dynamics *** two hydrophobic crystal surfaces were involved in the distinct energy minima of the binding free *** complex models,each with the CBM at the minimum energy position,stably formed in the solution *** binding free energies of the celluloseⅢ_(1)complex models,based on both static and dynamics states,were comparable to those of the native cellulose complex ***,the celluloseⅢ_(1)crystal had a larger binding surface,which is compatible with the observed high enzymatic activity of Cel7A for the celluloseⅢ_(1)substrate.

关键词： Carbohydrate binding module Cel7A celluloseⅢ_(1) docking analysis

Wave Propagation Simulation Using the CIP Method of Characteristic Equations

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Communications in Computational Physics 2008年第1期3卷 121-135页

作者： Kazuya Shiraishi toshifumi Matsuoka Department of Civil&Earth Resources Engineering Kyoto University Kyotodaigaku-Katsura Nishikyo-kuKyoto 615-8540Japan

We apply the CIP(Cubic Interpolated Profile)scheme to the numerical sim-ulation of the acoustic wave propagation based on characteristic *** CIP scheme is based on a concept that both the wavefield and its spatial deriv ative propa-gate along the same characteristic curves derived from a hyperbolic differential *** describe the derivation of the characteristic equations for the acoustic waves from the basic equations by means of the directional splitting and the diagonaliza-tion of the coffcient matrix,and establish geophysical boundary *** the CIP scheme calculates both the wavefield and its spatial derivatives,it is easy to realize the boundary conditions *** also show some numerical simula-tion examples and the CIP can simulate acoustic w ave propagation with high stability and less numerical *** method of characteristics with the CIP scheme is a very powerful technique to deal w ith the wave propagation in complex geophysical problems.

关键词： Acoustic wave characteristi cequa tion CIP

Sleep in children with eosinophilic esophagitis

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World Journal of Pediatrics 2021年第2期17卷 111-114页

作者： Isabela A ishikura Gustavo Moreira SergioTufik Monica L.Andersen Department of Psychobiology Universidade Federal de Sao Paulo(UNIFESP)Napoleao de Barros925 Vila ClementinoSao PauloSP 04024-002Brazil

Eosinophilic esophagitis(EoE)is a chronic immune-and antigen-mediated disease caused by infiltration of eosino-phils in esophagus tissue,which leads to morphological and functional abnormalities at this site[1].This disease was discovered in 1995 by Kelly et al.[2];since then,it has become increasingly recognized and discussed by research-ers[2,3].EoE affects children and adults and is three times more prevalent in males than in *** to a recent systematic review,there are 19.1 cases of EoE per 100,000 children/year,with a higher frequency in Western countries[4].

关键词： esophagitis al. esophagus

Peroral cholangioscopy for non-invasive papillary cholangio-carcinoma with extensive superficial ductal spread

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World Journal of Gastroenterology 2005年第41期11卷 6554-6556页

作者： toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences NiigataJapan

Papillary carcinoma arising from the extrahepatic bile duct often shows superficial ductal spread. We report herein the case of a patient with extensive superficial spread of non-invasive papillary cholangiocarcinoma,which was depicted with peroral cholangioscopy. A 65-year-old woman presented with the sudden-onset of severe epigastric pain. Ultrasonography revealed acute acalculous cholecystitis. Endoscopic retrograde cholangiography found small protruding lesions around the confluence of the cystic duct, suggestive of a cholangiocarcinoma. As the contour of the middle and upper bile ducts it was slightly irregular on the cholangiogram, the presence of superficial ductal spread was suspected. Peroral cholangioscopy revealed small papillary lesions around the confluence of the cystic duct and fine granular mucosal lesions in the middle and upper bile ducts and the right hepatic duct, suggesting a superficially spreading tumor. A right hepatectomy with bile duct resection was performed and no residual tumor was found. Histological examination revealed a non-invasive papillary carcinoma arising from the cystic duct with extensive superficial spread. Our experience of this case and a review of the literature suggest that a fine granular or fine papillary appearance of the ductal mucosae on cholangioscopy indicates superficial spread of papillary cholangiocarcinoma, for which peroral cholangioscopy is an efficient diagnostic option.

关键词： Cholangiocarcinoma Bile duct neoplasms Peroral cholangioscopy Papillary carcinoma Superficial ductal spread Surgery

Regional lymphadenectomy for gallbladder cancer: Rational extent, technical details, and patient outcomes

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World Journal of Gastroenterology 2012年第22期18卷 2775-2783页

作者： Yoshio Shirai toshifumi Wakai Jun Sakata Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

AIM: To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival. METHODS: A total of 152 patients with gallbladder cancer who underwent a minimum of "extended" portal lymph node dissection (defined as en bloc removal of the first-and second-echelon nodes) from 1982 to 2010 were retrospectively analyzed. Based on previous studies, regional lymph nodes of the gallbladder were divided into first-echelon nodes (cystic duct or pericholedochal nodes), second-echelon nodes (node groups posterosuperior to the head of the pancreas or around the hepatic vessels), and more distant nodes. RESULTS: Among the 152 patients (total of 3352 lymph nodes retrieved, median of 19 per patient), 79 patients (52%) had 356 positive nodes. Among nodepositive patients, the prevalence of nodal metastasis was highest in the pericholedochal (54%) and cystic duct (38%) nodes, followed by the second-echelon node groups (29% to 19%), while more distant node groups were only rarely (5% or less) involved. Disease-specific survival after R0 resection differed according to the nodal status (P < 0.001): most node-negative patients achieved long-term survival (median, not reached; 5-year survival, 80%), whereas among nodepositive patients, 22 survived for more than 5 years (median, 37 mo; 5-year survival, 43%). CONCLUSION: The rational extent of lymphadenectomy for gallbladder cancer should include the first-and second-echelon nodes. A considerable proportion of node-positive patients benefit from such aggressive lymphadenectomy.

关键词： Gallbladder neoplasms Lymphatic metasta-sis Lymph node excision Prognosis Radical surgery

Physical and mechanical properties of municipal solid waste incineration residues with cement and coal fly ash using X-ray Computed Tomography scanners

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 640-652页

作者： toshifumi MUKUNOKI Ta Thi HOAI Daisuke FUKUSHIMA Teppei KOMIYA Takayuki SHIMAOKA Faculty of Advanced Science and Technology Graduate School of Kumamoto UniversityKumamoto city 860-8555Japan Graduate school of Science and Technology Kumamoto UniversityKumamoto city 860-8555Japan Faculty of Geology VNU University of ScienceVietnam National University Hanoi334 Nguyen TraiHanoiVietnam Water and Material Cycles System Faculty of EngineeringKyushu UniversityFukuoka city 819-0395Japan

A significant volume of Municipal Solid Waste incineration bottom ash and fly ash (i.e.,incineration residues) are commonly disposed as ***,reclamation of landfill sites to create a new land space after their closure becomes an important goal in the current fewer and fewer land availability scenario in many narrow *** objective of this study is to reclaim incineration residue materials in the landfill site by using cement and coal fly ash as stabilizers aiming at performing quality check as new developed materials before future ***,physical and mechanical properties of these new materials should be initially examined at the micro scale,which is the primary fundamental for construction at larger *** research examines quantitative influences of using the combination of cement and coal fly ash at different ratio on the internal structure and ability of strength enhancement of incineration residues when suffering from *** of industrial and micro-focus X-ray computed tomography (CT) scanners combined with an image analysis technique were utilized to characterize and visualize the behavior and internal structure of the incineration residues-cement-coal fly ash mixture under the series of unconfined compression test and curing period *** types of cement solidified incineration residues in term of different curing period (i.e.,7,14,28 days) and coal fly ash addition content (i.e.,0%,9%,18%) were scanned before and after unconfined compression *** was shown that incineration residues solidified by cement and coal fly ash showed an increase in compression strength and deformation modulus with curing time and coal fly ash ***-dimension computed tomography images observation and analysis confirmed that solidified incineration residues including incineration bottom and fly ash as well as cement and coal fly ash have the deliquescent ***,it was studied that stabilized parts play a more im

关键词： mechanical property municipal solid waste incineration residues coal fly ash unconfined compression test image analysis X-Ray Computed Tomography scanners

"Extended" radical cholecystectomy for gallbladder cancer:Long-term outcomes, indications and limitations

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World Journal of Gastroenterology 2012年第34期18卷 4736-4743页

作者： Yoshio Shirai Jun Sakata toshifumi Wakai Taku Ohashi Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental SciencesNiigata City 951-8510Japan

AIM:To delineate indications and limitations for "ex tended" radical cholecystectomy for gallbladder cancer:a procedure which was instituted in our department in 1982. METHODS:Of 145 patients who underwent a radi cal resection for gallbladder cancer from 1982 through 2006, 52 (36%) had an extended radical cholecystec tomy, which involved en bloc resection of the gallblad der, gallbladder fossa, extrahepatic bile duct, and the regional lymph nodes (first-and second-echelon node groups). A retrospective analysis of the 52 patients was conducted including at least 5 years of follow up. Residual tumor status was judged as no residual tumor (R0) or microscopic/macroscopic residual tumor (R1 2). athological findings were documented according tothe American Joint Committee on Cancer Cancer Stag ing anual (7th edition). RESULTS:he primary t mor as classified as patho-logical T1 (pT1) in 3 patients, pT2 in 36, pT3 in 12, and pT4 in 1. Twenty three patients had lymph node metastases; 11 had a single positive node, 4 had two positive nodes, and 8 had three or more positive nodes. None of the three patients with pT1 tumors had nodal disease, whereas 23 of 49 (47%) with pT2 or more advanced tumors had nodal disease. One patient died during the hospital stay for definitive resection, giv ing an in hospital mortality rate of 2%. Overall survival (OS) after extended radical cholecystectomy was 65% at 5 years and 53% at 10 years in all 52 patients. OS differed according to the p classification ( < 0.001) and the nodal status ( = 0.010). All of 3 patients with pT1 tumors and most (29 of 36) patients with pT2 tu mors survived for more than 5 years. Of 12 patients with pT3 tumors, 8 who had an R1 2 resection, distant metastasis, or extensive extrahepatic organ involve ment died soon after resection. Of the remaining four pT3 patients who had localized hepatic spread through the gallbladder fossa and underwent an R0 resection, 2 survived for more than 5 years and another survived for 4

关键词： Gallbladder neoplasms Radical surgery Hepatectomy Bile duct resection Lymph node excision Prognosis

Evaluation of thermal sprayed coating using ultrasonic inspection by means of bottom echo back reflection

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中国有色金属学会会刊：英文版 2009年第4期19卷 984-987页

作者： toshifumi KUBOHORI Toru ITO Wahidul lah WAHI Yasuyuki INUI Toshiro IKUTA School of Science and Engineering Kinki University

Thermal spraying technique is widely used in various mechanical parts as a surface reforming ***,as demand to maintain superior mechanical performance in harsh operating environment increases,the need for non-destructive evaluation method for thermal spray coating becomes more *** this purpose,we thinned the thickness of the thermal sprayed coating by abrasion with blasting and used ultrasonic inspection by means of bottom echo reflection for effective measurement of abrasion quantity in thermal sprayed *** results obtained are summarized as *** the thickness of thermal sprayed coating becomes thin,the echo height *** is because thermal sprayed coatings absorb ultrasonic *** energy absorbed by Al2O3 is smaller compared with Fe-13Cr *** sprayed coatings submerged in water have a lower echo height compared with *** mentioned above,the thermal sprayed coating thickness can be estimated using ultrasonic inspection by means of bottom echo back reflection.

关键词：超声波检测热喷涂层评价方法声反射底部热喷涂涂层涂层厚度能量吸收