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High temperature enhances anthocyanin coloration in Asiatic hybrid lily flowers via upregulation of the MYB12 positive regulator

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Horticultural Plant Journal 2022年第6期8卷 769-776页

作者： Masumi yamagishi Research Faculty of Agriculture Hokkaido UniversityN9W9Kita-kuSapporo 060-8589Japan

Although high atmospheric temperatures suppress anthocyanin accumulation in most plant species,we show that high temperatures accelerate anthocyanin pigmentation in flower tepals of Asiatic hybrid lilies(Lilium spp.).After incubation at high temperatures(35℃)for two days,anthocyanin color became deeper in the most of tepal parts of two Asiatic hybrid lily cultivars,although the basal parts of’Montreux’tepals and top parts of’Toronto’outer tepals were *** stimuli often affect the expression of R2R3-MYB positive regulators that control anthocyanin *** their expression is often suppressed by hot temperatures in other species,the expression of lily MYB12 in tepals was upregulated by high ***828(miR828),which suppresses the action of MYB12 post-transcriptionally,exhibited reduced accumulation levels under high temperature,indicating that miR828 regulation is involved in MYB12 *** addition,transcription levels of MYB12,estimated by unspliced MYB12 transcript accumulation,were also activated by high ***,both suppressed miR828 accumulation and increased MYB12 transcription are likely to be involved in MYB12 activation at high *** the whitened basal parts of’Montreux’tepals at 35℃,expression of bHLH2 was severely suppressed while that of MYB12 was not *** present results demonstrate that plants display diverse responses to hot climatic conditions and shed new light on anthocyanin regulation under various environmental conditions.

关键词： Lilium spp Anthocyanin biosynthesis bHLH2 Global atmospheric warming microRNA828 R2R3-MYB

Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi yamagishi Masanobu Naito Yohei Yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

Body composition changes following chemotherapy for testicular germ cell tumor:obesity is the long-term problem

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Asian Journal of Andrology 2022年第5期24卷 458-462页

作者： Yuki Takai Sei Naito Hidenori Kanno Atsushi yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya Department of Urology Yamagata University Faculty of MedicineYamagata 990-9585Japan

Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor(TGCT).It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic *** this study,changes in the body composition of patients over time were quantitatively analyzed up to 24 months after *** study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December *** and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months,6 months,12 months,and 24 months after *** subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height *** total fat area had already significantly increased 3 months after the initiation of chemotherapy(P=0.004).However,it did not return to prechemotherapeutic levels even at 24 months after *** skeletal muscle area was significantly decreased at the end of chemotherapy(P<0.001);however,the value returned to baseline within 12 *** multivariable analysis,the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy(P=0.001 and P=0.027,respectively).In patients with TGCT,skeletal muscle mass decreased during chemotherapy and recovered within 12 months,whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy.

关键词： body composition chemotherapy obesity sarcopenia secondary hypogonadism testicular cancer

Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression

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World Journal of Gastroenterology 2012年第15期18卷 1781-1788页

作者： Junichi Takino Shoichi yamagishi Masayoshi Takeuchi Department of Biochemistry Faculty of Pharmaceutical SciencesHiroshima International UniversityHiroshima 737-0112Japan Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications Kurume University School of MedicineKurume 830-0011Japan Department of Advanced Medicine Medical Research InstituteKanazawa Medical UniversityIshikawa 920-0293Japan

AIM:To investigate the effect of glyceraldehyde-derived advanced glycation end-products(Glycer-AGEs) on hepatocellular carcinoma(HCC)***:Two HCC cell lines(Hep3B and HepG2 cells)and human umbilical vein endothelial cells(HUVEC)were *** viability was determined using the WST-8 *** blotting,enzyme linked immunosorbent assay,and real-time reverse transcriptionpolymerase chain reactions were used to detect protein and *** was evaluated by assessing the proliferation,migration,and tube formation of ***:The receptor for AGEs(RAGE)protein was detected in Hep3B and HepG2 ***2 cells werenot affected by the addition of *** markedly increased vascular endothelial growth factor(VEGF)mRNA and protein expression,which is one of the most potent angiogenic *** with the control unglycated bovine serum albumin(BSA) treatment,VEGF mRNA expression levels induced by the Glycer-AGEs treatment were 1.00±0.10 vs 1.92 ±0.09(P<0.01).Similarly,protein expression levels induced by the Glycer-AGEs treatment were 1.63±0.04 ng/mL vs 2.28±0.17 ng/mL for the 24 h treatment and 3.36±0.10 ng/mL vs 4.79±0.31 ng/mL for the 48 h treatment,respectively(P<0.01).Furthermore,compared with the effect of the control unglycated BSA-treated conditioned medium,the Glycer-AGEstreated conditioned medium significantly increased the proliferation,migration,and tube formation of HUVEC,with values of 122.4%±9.0%vs 144.5%±11.3%for cell viability,4.29±1.53 vs 6.78±1.84 for migration indices,and 71.0±7.5 vs 112.4±8.0 for the number of branching points,respectively(P<0.01).CONCLUSION:These results suggest that Glycer-AGEs-RAGE signaling enhances the angiogenic potential of HCC cells by upregulating VEGF expression.

关键词：血管生成因子 VEGF RAGE 肝癌细胞信号增强 mRNA表达水平血管内皮生长因子 HepG2细胞

Molecular pathogenesis of sporadiccolorectal cancers

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Chinese Journal of Cancer 2016年第1期35卷 12-19页

作者： Hidetsugu yamagishi Hajime Kuroda Yasuo Imai Hideyuki Hiraishi Department of Diagnostic Pathology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan Department of Pathology International University of Health and Welfare Hospital537‑3 IguchiNasushiobaraTochigi 329‑2763Japan Department of Diagnostic Pathology Ota Memorial HospitalFuji Heavy Industries Health Insurance Society455‑1 OshimaOtaGunma 373‑8585Japan Department of Gastroenterology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan.

Colorectal cancer(CRC)results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to *** 75%of CRCs are sporadic and occur in people without genetic predisposition or family history of *** the past two decades,sporadic CRCs were classified into three major groups according to frequently altered/mutated *** genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional *** the first half of this review,we describe the genetic pathways of sporadic CRCs and their clinicopathologic ***,large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated *** infrequently mutated genes are likely described in a limited number of ***-oriented models of CRC progression are being replaced by pathway-oriented *** the second half of this review,we summarize the present knowledge of this research field and discuss its prospects.

关键词： Sporadic colorectal cancer, Pathogenesis, Morphology, Large-scale genome analysis, Genetic pathway

Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report

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World Journal of Gastroenterology 2022年第5期28卷 594-601页

作者： Koh Fukushi Kenichi Goda Hitoshi Kino Masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu yamagishi Atsushi Irisawa Department of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Department of Diagnostic Pathology Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(***)infection and an elevated risk of *** of early-stage gastric cancer developed in ***-negative Ménétrier’s disease are extremely *** report a case of early gastric cancer in ***-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected ***-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant *** tests showed hypoproteinemia and were negative for serum *** immunoglobulin G *** 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the *** endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s *** bloc resection with ESD was performed for diagnosis and *** of ESD showed well-differentiated tubular *** cancer was confined to the mucosa,and complete curative resection was *** hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s *** years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric *** Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and ***-negative Ménétrier’s disease.

关键词： Ménétrier’s disease Helicobacter pylori Gastric cancer Endoscopic resection Endoscopic submucosal dissection Case report

Absorption events associated with solar flares

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Chinese Science Bulletin 2001年第5期46卷 369-372页

作者： N.Sato H.yamagishi Polar Research Institute of China Shanghai China Department of Physics La Trobe University Bundoora Australia STE Laboratory Nagoya University Toyokawa Japan National Institute of Polar Research Tokyo Japan

During the upward period of solar cycle 23, the imaging riometer at Zhongshan, Antarctica (geomag. lat. 74.5°S) was used to study the solar proton events and the X-ray solar flares which are associated with the absorption events. In our study, the relationship between the absorption intensity and X-ray flux is found in a power form which is consistent with the theoretical result. The imaging riometer absorption data at Ny-Alesund, Svalbard reconfirm the above relationship. We also argue that only M-class flares can generate a significant daytime absorption.

关键词： imaging riometer X-ray flare solar proton event ionospheric absorption.

Complete response to an anti-programmed cell death 1 antibody following a combination therapy of an anti-programmed cell death ligand 1 antibody and a tyrosine kinase inhibitor for metastatic renal cell carcinoma

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Asian Journal of Urology 2023年第1期10卷 103-105页

作者： Masayuki Kurokawa Sei Naito Tomoyuki Kato Masaki Ushijima Atsushi yamagishi Toshihiko Sakurai Hayato Nishida Norihiko Tsuchiya Department of Urology Yamagata University Faculty of MedicineYamagataJapan

Dear Editor,Several Phase 3 trials have demonstrated the efficacy of immune checkpoint inhibitor(ICI)-based combination therapies in the treatment of advanced clear cell renal cell carcinoma(RCC)[1-5].However,there is still no well-defined adequate treatment for patients who experience disease progression after initial ICI-based combination therapy.

关键词： death carcinoma treatment

A review of target gene specificity of flavonoid R2R3-MYB transcription factors and a discussion of factors contributing to the target gene selectivity

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Frontiers in Biology 2013年第6期8卷 577-598页

作者： Yunsong LAI Huanxiu LI Masumi yamagishi Institute of Pomology and Olericulture Siehuan Agricultural University Chengdu 611130 China Research Faculty of Agriculture Hokkaido University Kita-Ku Sapporo 060-8589 Japan

Flavonoid biosynthetic genes are often coordinately regulated in a temporal manner during flower or fruit development, resulting in specific accumulation profiles of flavonoid compounds. R2R3-MYB-type transcription factors （TFs）＂recruit＂ a set of biosynthetic genes to produce flavonoids, and, therefore, R2R3-MYBs are responsible for the coordinated expression of structural genes. Although a wealth of information regarding the identified and functionally characterized R2R3-MYBs that are involved in flavonoid accumulation is available to date, this is the first review on the global regulation of MYB factors in the flavonoid pathway. The data presented in this review demonstrate that anthocyanin, flavone/flavonol/3-deoxyflavonoid （FFD）, proanthocyanidin （PA）, and isoflavonoid are independently regulated by different subgroups of R2R3-MYBs. Furthermore, FFD-specific R2R3-MYBs have a preference for early biosynthetic genes （EBGs） as their target genes; anthocyanin-specific R2R3-MYBs from dicot species essentially regulate late biosynthetic genes （LBGs）; the remaining R2R3-MYBs have a wider range of target gene specificity. To elucidate the nature of the differential target gene specificity between R2R3-MYBs, we analyzed the DNA binding domain （also termed the MYB-domain） of R2R3-MYBs and the distribution of the recognition cis-elements. We identified four conserved amino acid residues located in or just before helix-3 of dicot anthocyanin R2R3-MYBs that might account for the different recognition DNA sequence and subsequently the different target gene specificity to the remaining R2R3-MYB TFs.

关键词： MYB cis-element DNA-binding domain flavonoid transcription factor target gene specificity