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Emerging issues in peripheral nerve repair

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Neural Regeneration Research 2012年第29期7卷 2267-2272页

作者： Stefano Geuna Pierluigi tos Bruno Battiston Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences University of TurinTorino 10043 Italy Department of Traumatology Microsurgery UnitC.T.O. HospitalTorino 10126Italy

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

关键词： nerve reconstruction tissue engineering cell and tissue transplantation gene therapy biomaterials peripheral nervous system microsurgery artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration

Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects

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Neural Regeneration Research 2019年第6期14卷 1079-1084页

作者： AlessANDro Crosio Benedetta Elena Fornasari Giovanna Gambarotta Stefano Geuna Stefania Raimondo Bruno Battiston Pierluigi tos Giulia Ronchi Department of Orthopedics and Traumatology II-Surgery for Hand and Upper Limb-AOU Città della Salute e della Scienza di Torino-CTO Hospital Department of Clinical and Biological Sciences University of Torino Neuroscience Institute Cavalieri Ottolenghi University of Torino UO Microchirurgia e Chirurgia della Mano Ospedale Gaetano Pini

Nerve regeneration after delayed nerve repair is often unsuccessful. Indeed, the expression of genes associated with regeneration, including neurotrophic and gliotrophic factors, is drastically reduced in the distal stump of chronically transected nerves; moreover, Schwann cells undergo atrophy, losing their ability to sustain regeneration. In the present study, to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth, we combined the use of an effective conduit(a chitosan tube) with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers). This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction. Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft, considered the "gold standard" technique for nerve reconstruction. Since hollow tubes not always lead to good results after long defects(> 20 mm), we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps, as muscle fibers create a favorable three-dimensional environment and release trophic factors. All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number: 864/2016/PR) on September 14, 2016.

关键词： tubulization Schwann cells scaffold tissue engineering nerve reconstruction morphometrical analyses grasping test secondary repair median nerve nerve regeneration

Painful scar neuropathy:principles of diagnosis and treatment

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Plastic and Aesthetic Research 2015年第1期2卷 156-164页

作者： Pierluigi tos Alessandro Crosio Pierfrancesco Pugliese Roberto Adani Francesca Toia Stefano Artiaco Department of Orthopedics Reconstructive Microsurgery UnitCity of Health and Sciences of TurinTrauma Hospital10100 TorinoItaly Department of Hand Surgery and Microsurgery University Hospital of Verona37126 VeronaItaly Plastic and Reconstructive Surgery Department of SurgicalOncological and Oral SciencesUniversity of Palermo90127 PalermoItaly

Nerve-tissue interactions are *** nerve injuries may involve intraneural and extraneural scar formation and affect nerve gliding planes,sometimes leading to complex clinical *** of these pathological entities involve pain as the main clinical symptom and can be subsumed under the term“painful scar neuropathy”.The authors review the literature on treatment approaches to peripheral nerve scar neuropathy and the outcomes of neurolysis-associated procedures and propose a simple classification and a therapeutic approach to scar *** search retrieved twenty-one papers,twenty of which reported pain reduction or resolution with various *** is no consensus on the best therapeutic approach to neuropathic pain due to scar *** authors report good or excellent results with different techniques,from nerve wrapping with anti-adhesion devices to nerve coverage or wrapping with vascularized *** authors’classification of and therapeutic approach to peripheral nerve scar lesions aims at promoting a logical approach based on the analysis of lesion type(perineural,or endoneural and perineural),pain type(due to traction or external trauma,pain at rest),and number of previous *** need to be informed that multiple procedures may be required,that outcomes may be partial,and that surgery can potentially worsen preoperative *** review found no evidence for the best therapeutic approach to scar neuropathy,but there is consensus on a multidisciplinary approach.

关键词： Complex regional pain syndrome type II painful neuropathy painful scar neuropathy scar neuritis traction neuropathy

Lithiophilic N-doped carbon bowls induced Li deposition in layered graphene film for advanced lithium metal batteries

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Nano Research 2022年第1期15卷 352-360页

作者： Xiaoyu Feng Hong-Hui Wu Biao Gao Michai Swietostawski Xin He Qiaobao Zhang Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China The State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University oj Science and TechnologyWuhan 430081y China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Faculty of Chemistry Jagiellonian Universityul.Gronostajowa 230-387 KrakowPoland School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium(Li)metal with high theoretical capacity and low electrochemical potential is the most ideal anode for next-generation high-energy ***,the practical implementation of Li anode has been hindered by dendritic growth and volume expansion during cycling,which results in low Coulombic efficiency(CE),short lifespan,and safety ***,we report a highly stable and dendrite-free Li metal anode by utilizing N-doped hollow porous bowl-like hard carbon/reduced graphene nanosheets(CB@rGO)hybrids as three-dimensional(3D)conductive and lithiophilic scaffold *** lithiophilic carbon bowl(CB)mainly works as excellent guides during the Li plating process,whereas the rGO layer with high conductivity and mechanical stability maintains the integrity of the composite by confining the volume change in long-range order during ***,the local current density can be reduced due to the 3D conductive ***,CB@rGO presents a low lithium metal nucleation overpotential of 18 mV,high CE of 98%,and stable cycling without obvious voltage fluctuation for over 600 cycles at a current density of 1 mA cm^(-2).Our study not only provides a good CB@rGO host and pre-Lithiated CB@rGO composite anode electrode,but also brings a new strategy of designing 3D electrodes for those active materials suffering from severe volume expansion.

关键词： dendrite inhibition Li metal host lithium metal battery bowl-like carbon/reduced graphene nanosheets hybrids

STUDIES ON APPLICATION OF NEW POLISH SEED DRESSING BRASICOL 250 FS （IMIDACLOPRID） IN PROTECTION OF SPRING AND WINTER OILSEED RAPE PEST

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STUDIES ON APPLICATION OF NEW POLISH SEED DRESSING BRASICOL ...

Long-term result of guided nerve regeneration with an inert microporous polytetrafluoroethylene conduit

The ⅩⅤth International Plant Protection Congress

作者： Marek MRóWCZY■SKI Henryk WACHOWIAK Janusz ■WIêtos￡AWSKI Institute of Plan Protection Miczurina 20 60-318 Pozna Poland Institute of Plan Protection Miczurina 20 60-318 Pozna Poland Pestinova Mo■dzierzowców 6a 43-602 Jaworzno

来源： cnki会议评论

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Chinese Journal of Traumatology 2003年第3期6卷 145-151页

作者：何风春范清宇 Timothy R Cushway Robbert De Iongh Marco Lanzetta Pierluigi tos Earl R Owen Department of Orthopaedics Foshan Hospital of Traditional Chinese Medicine Center of Orthopaedic Surgery Tangdu HospitalFourth Military Medical University The Microsearch Foundation of Australia Department of Anatomy and Histology University of Sydney

Objective: To evaluate the long term outcome of Polytetrafluoroethylene (PTFE) conduit in nerve repair and to provide more evidence in view of its potential application to achieve a satisfactory functional recovery in clinical settings. Methods: Thirty six Wistar rats had their right sciatic nerve transected and were repaired with either conventional microsuture technique (Control group, n=18) or a PTFE conduit with a gap of 5 mm left between the nerve stumps (PTFE group, n=18). At 6 and 9 months after the operation, electrophysiological assessment and measurement of gastrocnemius muscle weight were conducted and morphology of the regenerated nerves were studied with image analysis. Results: At 6 months postoperatively, the nerve conduction velocity recovered to 60.86 % and 54.36 % (P> 0.05 ), and the gastrocnemius muscle weight recovered to 50.89 % and 46.11 % (P> 0.05 ) in the Control group and the PTFE group respectively. At 9 months postoperatively, the recovery rate was 65.99 % and 58.79 % for NCV (P> 0.05 ), and 52.56 % and 47.89 % for gastrocnemius muscle weight (P> 0.05 ) in the Control group and the PTFE group respectively. Regenerated nerve fibers in the PTFE group had a regular round shape with no fragmentation, wrinkling or splitting of the myelin sheath. Image analysis revealed that the ratio of the myelin area to the total fiber area was larger at 9 months than at 6 months in both groups (P< 0.01 ). Conclusions: Microporous PTFE conduit may be an alternative for nerve repair allowing of guided nerve regeneration and functional recovery with no obvious adverse effect at long term.

关键词： Nerve regeneration Polytetrafluoroethylene Polymers Myelin sheath

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水轮机密封材料的研制及其使用性能的考察

固体润滑 1989年第4期9卷 243-246页

作者：徐仁泉叶润喜甘谷石棉制品厂

作者为八盘峡水电站进口水轮机组研制了一种密封材料,它是用浸渍油改性酚醛树脂与石棉线通过缠绕模压制成的。这种材料在水介质中具有较低的摩擦系数和较好的耐磨与密封性能,其使用寿命优于进口的密封材料。

关键词：水轮机密封材料性能研制

Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma

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Cancer Communications 2023年第5期43卷 630-634页

作者： Carlotta Caterina Damanti Lavinia Ferrone Enrico Gaffo Anna Garbin Anna tosato Giorgia Contarini Ilaria Gallingani Roberta Angioni Barbara Molon Giulia Borile Elisa Carraro Marta Pillon Federico Scarmozzino Angelo Paolo Dei tos Marco Pizzi Francesco Ciscato Andrea Rasola Alessandra Biffi Stefania Bortoluzzi Federica Lovisa Lara Mussolin Maternal and Child Health Department Pediatric Hematology Oncology and Stem Cell Transplant CenterUniversity of PaduaPaduaItaly Pediatric Research Institute“Cittàdella Speranza” PaduaItaly Department of Molecular Medicine University of PaduaPaduaItaly Department of Biomedical Sciences University of PaduaPaduaItaly General Pathology and Cytopathology Unit Department of Medicine-DMEDUniversity of PaduaPaduaItaly

Dear Editor,Anaplastic lymphoma kinase-positive(ALK+)anaplastic large cell lymphoma(ALCL)is an aggressive peripheral Tcell lymphoma representing 10%-15%of pediatric lymphoid *** constitutively activated nucleophosmin-ALK(NPM-ALK)fusion protein is the main driver of ALK+ALCL oncogenesis[1].Current clinical protocols can achieve high cure rates,with 75%event-free survival(EFS)at 5 years[2],but the patients’outcome with relapsed/refractory disease still remains poor[3].Liquid biopsy is widely applied for the prognostic and therapeutic stratification of onco-hematological *** a non-invasive procedure,it can be used to identify several biomarkers,such as small extracellular vesicles(S-EVs)[4].S-EVs are stable carriers of molecules that mediate genetic exchange between distant cells,alter the microenvironment,facilitate cancer cell progression and promote drug resistance[5].

关键词： lymphoma pediatric neoplasms

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皮肤和软组织的肌周细胞瘤

临床与实验病理学杂志 2006年第1期22卷 77-77页

作者： Mentzel T Dei tos A P Sapi Z 黄文斌（摘译）陈洁宇（摘译）周晓军（审校）不详南京军区南京总医院病理科南京210002