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Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis

World Journal of Gastroenterology 2010年第23期16卷 2918-2925页

作者： Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa toru kikuchi Minoru Nomoto Yutaka Aoyagi Department of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Department of Homeostatic Regulation and Development Graduate School of Medical and Dental SciencesNiigata University Department of Laboratory Medicine Niigata University Medical and Dental Hospital

AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this *** was staged based on Brunt *** a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ***:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several *** average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage *** a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,*** addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.

关键词： Nonalcoholic steatohepatitis Ultrasound Liver stiffness measurement Shear wave velocity Acoustic radiation force impulse

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Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 657-660页

作者： Shinichi Akahoshi toru Beppu Yasuhisa Mori Koichi Kinoshita Nobutaka Sato Ken kikuchi Department of Surgery Yamaga City Medical CenterKumamotoJapan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Adviser Sakurajuji HospitalKumamotoJapan

The recent Southampton consensus guideline and two previous international consensus meetings held in Louisville and Morioka in 2008 and 2014,respectively have recommended laparoscopic liver resection(LLR)as a standard procedure for selected patients with colorectal liver metastases(CRLM)(1-3).The Oslo-CoMet and LapOpHuva studies are the only two randomized controlled trials(RCTs)that have provided solid evidence showing that LLR is a safer,less invasive,and more cost-effective approach with higher health-related quality of life and oncological outcomes equivalent to those of open liver resection(OLR)for patients with CRLM(4-6).

关键词： resection colorectal metastases

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Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers

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World Journal of Gastroenterology 2008年第13期14卷 2049-2054页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara toru Horii Ryousuke kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences Tohoku University Hospital 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan

AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.

关键词： LPZ 30 mg orally disintegrating tablets Intragastric pH Blood drug concentration Cytochrome P450 2C19 extensive metabolizers H pylori-negative

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Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole

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World Journal of Gastroenterology 2008年第15期14卷 2406-2410页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara toru Horii Ryousuke kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences and Department of Pharmaceutical Sciences Tohoku University Hospital Sendai 9808574 Japan

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ.

关键词： Lafutidine Lansoprazole H2 receptor antagonists Proton pump inhibitors Antisecretory activity

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A Study on Diagnostic Assist Systems of Chronic Obstructive Pulmonary Disease from Medical Images by Deep Learning

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Journal of Computer and Communications 2018年第1期6卷 21-31页

作者： toru Kimura Takashi Kawakami Akihiro kikuchi Ryosuke Ooev Masaki Akiyama Hiroyuki Horikoshi Faculty of Engineering Hokkaido University of Science Sapporo Japan Department of Radiology Gunma Prefecture Cancer Center Gunma Japan

In this paper, we propose new diagnostic assist systems of medical images using deep learning algorithms. Specifically, we aim to develop a diagnostic support system for the very early stage of chronic obstructive pulmonary disease (COPD) based on the CT images. It is said that COPD is a disease that develops due to long-term smoking, and it is said that there are a large number of latent onset reserve forces. By discovering this COPD in the very early period 0 and improving the living conditions, subsequent severity can be avoided in many cases, so a system that will help diagnosis by professional radiologists is needed. We show the some experimental results examined by the constructed system.

关键词： Deep Learning CT Images Diagnostic Assist Systems Chronic Obstructive Pulmonary Disease

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The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations

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Astrodynamics 2020年第4期4卷 377-392页

作者： Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda Institute of Space and A stronautical Science Japan A erospace Exploration AgencySagamihara 252-5210Japan The Graduate University for Aduanced Studies Hayama 240-0193Japan Research and Development Directorate Japan Aerospace Exploration AgencySagamihara 252-5210Japan University of Liverpool Liverpool L693BXUK Chiba Institute of Technology Narashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan

The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are *** was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary *** weighted least-squares batch filter is used for the orbit estimator of *** orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small *** system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking *** the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the *** example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar *** large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of *** the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by *** type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before.

关键词： orbit determination optical navigation gravity measurements superior solar conjunction delta differential one-way ranging(delta-DOR)

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Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu

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Astrodynamics 2020年第4期4卷 309-329页

作者： Yusuke Oki Kent Yoshikawa Hiroshi Takeuchi Shota kikuchi Hitosi Ikeda Daniel JScheeres Jay WMcMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui Manabu Yamada toru Kouyama Shingo K ameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda Japan A erospace Exploration Agency T'sukuba 305-8505Japan Japan Aerospace Exploration Agency Sagamihara 252-5210Japan University of Colorado BoulderCO 80309USA Planetary Exploration Research Center Chiba Institute of TechnologyNarashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan Department of A erospace Engineering Tohoku UniversitySendai 980-8579Japan Kyushu Institute of Technology Kitakyusyu 804-8550Japan

This paper describes the orbit design of the deployable payload Rover 2 of MINERVA-II,installed on the Hayabusa2 *** Rover 2 did not have surface exploration capabilities,the operation team decided to experiment with a new strategy for its deployment to the *** rover was ejected at a high altitude and made a semi-hard landing on the surface of the asteroid Ryugu after several *** on the orbital analysis around Ryugu,the expected collision speed was tolerable for the rover to function *** the rover could not control its position,its motion was entirely governed by the initial ***,the largest challenge was to insert the rover into a stable orbit(despite its large release uncertainty),and avoid its escape from Ryugu due to an environment strongly perturbed by solar radiation pressure and gravitational *** study investigates the solution space of the orbit around Ryugu and evaluates the orbit’s robustness by utilizing Monte Carlo simulations to determine the orbit insertion *** analyzing the flight data of the rover operation,we verified that the rover orbited Ryugu for more than one period and established the possibility of a novel method for estimating the gravity of an asteroid.

关键词： solar radiation pressure augmented elliptic Hill three-body problem gravitational irregularity

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Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review

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World Journal of Gastroenterology 2013年第29期19卷 4827-4831页

作者： Shohei Tanaka Naoyoshi Nagata Sohtaro Mine toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi kikuchi Shinichi Oka Naomi Uemura Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Tokyo 162-8655 Japan Clinical Laboratory and Pathology National Center for Global Health and Medicine Tokyo 162-8655 Japan Division of AIDS Clinical Center National Center for Global Health and Medicine Tokyo 162-8655 Japan Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai Hospital Chiba 272-0827 Japan

Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases.

关键词： Acquired immune deficiency syndromerelated lymphoma Non-Hodgkin-lymphoma EpsteinBarr virus infection c-MYC rearrangement Endoscopic appearance

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Assessing quality of life using the brief cancer-related worry inventory for gynecological surgery

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World Journal of Obstetrics and Gynecology 2019年第1期8卷 1-7页

作者： Ami kikuchi Ryo Koide Masahiro Iwasaki Mizue Teramoto Seiro Satohisa Masato Tamate Masami Horiguchi Nozomi Niwa Tsuyoshi Saito toru Mizuguchi Department of Nursing and Surgical Science Sapporo Medical University Postgraduate School of Health ScienceSapporo 0608556Japan Department of Obstetrics and Gynecology Sapporo Medical University Postgraduate School of MedicineSapporo 0608556Japan

BACKGROUND The mental status of gynecologic patients has an important influence on their quality of life(QOL).Although high-quality QOL studies into breast cancer patients have been performed internationally,few QOL studies have examined patients with gynecological *** To investigate the brief cancer-related worry inventory(BCWI)could evaluate the mental status of gynecological *** Between July 2018 and December 2018,19 consecutive gynecological cancer patients were prospectively recruited for this *** BCWI is a 15-item selfreported questionnaire that assesses cancer-related worries on a numeric scale(0–100).RESULTS The high BCWI group was significantly younger than the low BCWI *** social status,the absence of a spouse and children was significantly more common in the high BCWI group than in the low BCWI *** operation time was longer in the worsening BCWI group than in the stable BCWI group(305.3±140.5 min vs 171.1±97.2 min;P=0.026).CONCLUSION Being young,having no family,and a long operation time were found to be risk factors for increased ***,gynecological cancer patients should be assessed using the BCWI,and specific perioperative mental care should be considered for highly anxious patients.

关键词： Gynecology Brief cancer-related worry inventory Quality of life Surgery

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Correction to: Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu

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Astrodynamics 2021年第2期5卷 183-183页

作者： Yusuke Oki Kent Yoshikawa Hiroshi Takeuchi Shota kikuchi Hitosi Ikeda Daniel J.Scheeres Jay W.McMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui Manabu Yamada toru Kouyama Shingo Kameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda Japan Aerospace Exploration Agency Tsukuba305-8505Japan Japan Aerospace Exploration Agency Sagamihara252-5210Japan University of Colorado BoulderCO80309USA Planetary Exploration Research Center Chiba Institute of TechnologyNarashino275-0016Japan National Institute of Advanced Industrial Science and Technology Koto-ku135-0064Japan Rikkyo University Toshima-ku171-8501Japan Department of Aerospace Engineering Tohoku UniversitySendai980-8579Japan Kyushu Institute of Technology Kitakyusyu804-8550Japan

Correction to:Oki,Y.,Yoshikawa,K.,Takeuchi,*** *** insertion strategy of Hayabusa2's rover with large release uncertainty around the asteroid *** 2020,4(4):309-329 https://***/10.1007/s42064-020-0080-y The article“Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu”written by Yusuke Oki,Kent Yoshikawa,Hiroshi Takeuchi et al.,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on 05 November 2020 without open *** publication in Volume 4,Issue 4,page 309–329,the author(s)decided to opt for Open Choice and to make the article an open access publication.

关键词： asteroid insertion release

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