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TTF-1 is useful for primary site determination in duodenal metastasis

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 360-363页

作者： Tomofumi Miura Yuichi Shimaoka Junichiro Nakamura Satoshi Yamada Tsutomu Miura Masahiko Yanagi Kazuhiro Sato Hiroyuki Usuda iwao Emura toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Respiratory Medicine Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

We report here on a case of duodenal metastasis from primary lung adenocarcinoma. A 69-year old man was diagnosed with primary lung adenocarcinoma. Four courses of combined chemotherapy with carboplatin and paclitaxel associated with irradiation of 60 Gy shrunk the lung tumor. However, soon after,the para-aortic lymph node became swollen. Esophagogastroduodenoscopy revealed three duodenal tumors. Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a complete remission in this duodenal metastasisand para-aortic lymph node swelling with only scarring remaining in computed tomography. He is now on the continuous generalized chemotherapy. In conclusion, duodenal metastasis from primary lung adenocarcinoma is rare and hard to diagnose. In such an instance, TTF-1 immunostaining is crucial to obtain the correct diagnosis.

关键词： Lung adenocarcinoma Duodenal metastasis Thyroid transcription factor-1

Experimental Study of the Flow in Helical Circular Pipes:Torsion Effect on the Flow Velocity and Turbulence

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Journal of Thermal Science 2008年第3期17卷 193-198页

作者： Yasutaka HAYAMIZU Kyoji YAMAMOTO ShinichiroYANASE toru HYAKUTAKE toru SHINOHARA Shinichi MORITA Department of Mechanical Engineering Yonago National College of Technology Graduate School of Natural Science and Technology Okayama University

An objective of the present paper is to experimentally clarify the torsion effect on the flow in helical circular pipes. We have made six helical circular pipes having different pitches and common non-dimensional curvature δ of about 0.1. The torsion parameter β0, which is defined by β0 = τ/（2δ）1/2 with non-dimensional torsion r, are taken to be 0.02, 0.45, 0.69, 1.01, 1.38 and 1.89 covering from small to very large pitch. The velocity distributions and the turbulence of the flow are measured using an X-type hot-wire anemometer in the range of the Reynolds number from 200 to 20000. The results obtained are summarized as follows： The mean secondary flow pattern in a cross section of the pipe changes from an ordinary twin-vortex type as is seen in a curved pipe without torsion （toroidal pipe） to a single vortex type after one of the twin-vortex gradually disappears as β0 increases. The circulation direction of the single vortex is the same as the direction of torsion of the pipe. The mean velocity distribution of the axial flow is similar to that of the toroidal pipe at small β0, but changes its shape as β0 increases, and attains the shape similar to that in a straight circular pipe when ,β0 = 1.89. It is also found that the critical Reynolds number, at which the flow shows a marginal behavior to turbulence, decreases as ,β0 increases for small ,β0, and then increases after taking a minimum at ,β0 ≈ 1.4 as ,β0 increases. The minimum of the critical Reynolds number experimentally obtained is about 400 at ,β0 ≈ 1.4.

关键词： Helical Circular Pipe Torsion Effect Critical Reynolds Number Turbulence

Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon

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World Journal of Hepatology 2010年第11期2卷 416-418页

作者： Tomofumi Miura Nobuaki Suzuki Junichiro Nakamura Satoshi Yamada Tsutomu Miura Masahiko Yanagi Hiroyuki Usuda iwao Emura toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

Hepatocarcinogenesis after a sustained virological response (SVR) in type C chronic hepatitis and cirrhosis is an important issue in endemic areas; hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) therapy is especially very hard. We herein report a first case in which combination therapy with interferon-α and continuous intra-arterial infusion of 5-fluorouracil (designated as FAIT) provided a complete response in HCC with PVTT after SVR. Therefore, we think that FAIT is a good option to treat HCC with or without PVTT, even after SVR.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Sustained virological response 5-Fluorouracil intra-arterial infusion

Anti-viral therapy to reduce recurrence and improve survival in hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8861-8866页

作者： toru Ishikawa Department of Gastroenterology and Hepatology Saiseikai Niigata Daini HospitalNiigata 950-1104Japan

Hepatocellular carcinoma(HCC)is the most common malignancy and the third leading cause of cancer death *** infection with hepatitis B virus(HBV)and hepatitis C virus accounts for approximately75%-80%of HCC cases *** particular,chronic HBV infection is a predominant risk factor for HCC in Asia and *** resection and radiofrequency ablation are increasingly used for the curative treatment of HCC,and good local control can be ***,the high rate of recurrence is a major obstacle to improving prognosis.A high viral load of HBV DNA is the most important correctable risk factor for ***,interferon and/or nucleotide analogues may decrease HBV ***,these drugs may decrease *** this article,treatment strategies for HBV-related HCC are described in order to reduce recurrence and improve survival.

关键词： Hepatocellular carcinoma Hepatitis B virus Recurrence Nucleotide analogues Interferon

interleukin 28B genetic polymorphism and hepatitis B virus infection

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World Journal of Gastroenterology 2014年第34期20卷 12026-12030页

作者： toru Takahashi Division of Gastroenterology and Hepatology Uonuma HospitalOjiyashiNiigata 947-0028Japan

Interleukin (IL) 28B genetic polymorphism is significantly associated with the sustained virological response rate in patients with chronic hepatitis C treated with pegylated interferon-α (PEG-IFN) plus ribavirin and with spontaneous hepatitis C virus clearance. However, a consensus on the relationship between IL28B genetic polymorphism and the favorable outcome of chronic hepatitis B virus infection defined by hepatitis B e antigen seroconversion, and/or hepatitis B surface antigen seroclearance in patients treated with interferon or PEG-IFN has not been reached. Several reports failed to show a positive association, while some studies demonstrated a positive association in certain subject settings. More prospective studies including large cohorts are needed to determine the possible association between IL28B genetic polymorphism and the outcome of interferon or PEG-IFN treatment for chronic hepatitis B.

关键词： interleukin 28B Polymorphism Hepatitis B virus interferon Pegylated interferon

Performance Test and Flow Measurement of Contra-Rotating Axial Flow Pump

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Journal of Thermal Science 2007年第1期16卷 7-13页

作者： Akinori Furukawa toru Shigemitsu Satoshi Watanabe Division of Mechanical Engineering Science Kyushu University744 MotookaNishi-kuFukuoka 819-0395JAPAN

An application of contra-rotating rotors has been proposed against a demand for developing higher specific speed axial flow pump. In the present paper, the advantage and disadvantage of using contra-rotating rotors are described in comparison with conventional type of rotor-stator, based on theoretical and experimental investigations. The advantages are as follows：（1） The pump is inherently designed as smaller sized and at lower rotational speed. （2） A stable head-characteristic curve for flow rate with negative slope appears. （3） As the rear rotor rotational speed is varied as independent control of front rotor, the wider range of high performance operation is obtained by rear rotor speed control in addition to front rotor speed control. The disadvantages are as follows：（1） The structure of double shaft system becomes complex. （2） The pump performance is inferior at over flow rate as the rear rotor loading is weakened. （3） The blade rows interaction from rear rotor to front rotor more strongly appears. Then the rear rotor design is a key to achieve higher pump performance. Some methods to overcome these disadvantages will be discussed in more details toward wider usage of contra-rotating axial flow pump in various industrial fields.

关键词： axial flow pump contra-rotating rotors multiphase flow rotational speed control blade rows interaction

Distributed dynamic pricing based on demand-supply balance and voltage phase difference in power grid

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Control Theory and Technology 2015年第2期13卷 90-100页

作者： Yoshihiro OKAWA toru NAMERIKAWA Graduate School of Science and Technology Keio University

This paper discusses a distributed decision procedure for determining the electricity price for a real-time electricity market in an energy management system. The price decision algorithm proposed in this paper derives the optimal electricity price while considering the constraints of a linearized AC power grid model. The algorithm is based on the power demand-supply balance and voltage phase differences in a power grid. In order to determine the optimal price that maximizes the social welfare distributively and to improve the convergence speed of the algorithm, the proposed algorithm updates the price through the alternating decision making of market participants. In this paper, we show the convergence of the price derived from our proposed algorithm. Furthermore, numerical simulation results show that the proposed dynamic pricing methodology is effective and that there is an improvement in the convergence speed, as compared with the conventional method.

关键词： Smart gird real-time pricing AC model of power grid

Risk management of hepatocellular carcinoma occurrence after hepatitis Cvirus eradication-from IFN based era to IFN-free DAA era

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 227-229页

作者： toru Ishikawa Department of Gastroenterology and Hepatology Saiseikai Niigata HospitalNiigataJapan

Chronic hepatitis C virus(HCV)infection is a public health issue which effects people throughout the world,with more than 71 million people effected,and 400,000 deaths annually(1).HCV,which is when active carriage of HCV RNA is in the blood,is the leading cause of cirrhosis,liver failure,and hepatocellular carcinoma(HCC)(2).Among HCV infected cirrhotic patients,the incidence rate of HCC steadily increases with increased degree of fibrosis,with annual reported incidence of 1.4%to 7%respectively(3).The eradication of the virus and therefore prevention of HCC development and liver related death is the ultimate treatment objective for chronic *** 1991,the first treatment approved by the Food&Drug Administration(FDA)to treat chronic hepatitis C(CHC)was IFNα-2b monotherapy(4),which allowed 15-20%of sustained virological response(SVR)and also induced major side effects such as asthenia,neutropenia,myalgia and influenzalike syndromes(5).

关键词： hepatocellular prevention sustained

Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer

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World Journal of Gastroenterology 2007年第28期13卷 3829-3835页

作者： iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama Department of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical ScienceHiroshimaJapan Department of Endoscopy Hiroshima University HospitalHiroshimaJapan Health Service Center Hiroshima UniversityHiroshimaJapan Department of Pathology Hiroshima University HospitalHiroshimaJapan Department of Health Science Prefectural University of HiroshimaFaculty of Human Culture and SocietyHiroshimaJapan

AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections.

关键词： Submucosal colorectal cancer Microvessel density Lymphatic vessel density Mucin 1 Ki-67 Cathepsin D Matrix metalloproteinase-7 Lymph node metastasis Immunohistochemistry