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Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report

World Journal of Gastrointestinal Oncology 2019年第9期11卷 761-767页

作者： Chiaki Inagaki Daichi Maeda Akie Kimura toru otsuru Yoshifumi Iwagami Naohiro Nishida Daisuke Sakai Ryo Shitotsuki Shinichi Yachida Yuichiro Doki Taroh Satoh Department of Frontier Science for Cancer and Chemotherapy Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Department of Clinical Genomics Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Gastroenterological Surgery Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Center for Cancer Genomics and Personalized Medicine Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Department of Cancer Genome Informatics Osaka University Graduate School of MedicineSuita 5650871OsakaJapan

BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC,which sometimes becomes a point of discussion in clinical *** these cancers demonstrate significant differences in their mutational landscape,several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary *** SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2(ERBB2)activating mutation on next-generation sequencing(NGS)-based genomic *** year later,a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological *** histological findings of the hepatic lesion were similar to those of the primary ***,using NGS panel testing,the hepatic lesion was found to have ERBB2 activating mutation,which is the identical mutation detected in the sequencing result of the primary ***2 activating mutation occurs more frequently in GBC than ICA and ***,in the present case,we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic ***,this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical *** This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC.

关键词： Gall bladder cancer Bile duct cancer ERBB2 mutation Precision medicine Mutation-driven targeted treatment Case report

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Acoustic Absorption Characteristics of Perforated Thin Plate with Air Jets and Cavity

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Open Journal of Fluid Dynamics 2015年第1期5卷 1-9页

作者： Hiromitsu Hamakawa Hiroki Matsuoka Taiki Yamai Kenta Asakura toru otsuru Reiji Tomiku Eru Kurihara Hidechito Hayashi Eiichi Nishida Department of Mechanical Engineering Oita University Oita Japan Graduate School Master’s Program of Engineering Oita University Oita Japan Torishima Pump Mfg. Co. Ltd Takatsuki-shi Osaka Japan Department of Architecture Oita University Oita Japan Department of Mechanical Engineering Nagasaki University Nagasaki Japan Department of Mechanical Systems Engineering Shonan Institute of Technology Fujisawa-shi Kanagawa Japan

The present paper focuses on the effect of air jets through a perforated thin plate on the characteristics of an acoustic absorption coefficient. We measured the flow rate, internal pressure, acoustic pressure, and transfer function by using an improved acoustic impedance tube. The normal incidence absorption coefficient was calculated from the measured transfer function using transfer function methods. As a result, the frequency characteristics of the acoustic absorption coefficient against the frequency showed a maximum value at the local frequency. The peak frequency of the acoustic absorption coefficient depended on the thickness of the background air space and the thickness of the perforated plate. As the flow rate increased through the micropores, the peak level of the acoustic absorption coefficient also increased until a flow rate of 80?l /min. As the flow rate further increased, the peak level of the acoustic absorption coefficient decreased and that of the high frequency band increased.

关键词： Acoustic Absorption Coefficient Perforated Plate Cavity Micropores Air Jets Acoustic Impedance Tube

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