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Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis

World Journal of Gastroenterology 2007年第34期13卷 4593-4597页

作者： Masaharu Ishida Makoto Sunamura toru furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Cancer Surgery Section Hammersmith Hospital Imperial College Du Cane Road London W12 0NN United Kingdom Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan

AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer.

关键词： BNIP3 Chemosensitivity Gemcitabine Pancreatic cancer Prognosis

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Familial pancreatic cancer: Concept, management and issues

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World Journal of Gastroenterology 2017年第6期23卷 935-948页

作者： Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui toru furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki furukawa Ken Kawabe Yoshiyuki Majima toru Shimosegawa Division of Endoscopy Shizuoka Cancer Center Clinic of Genetic Medicine Shizuoka Cancer Center Department of Surgery Kyoto University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of Surgery Tohoku University Graduate School of Medicine Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East Department of Surgery Teikyo University School of Medicine Division of Cancer Genomics National Cancer Center Research Institute Institute for Integrated Medical Sciences Tokyo Women’s Medical University Department of Internal Medicine Kyorin University School of Medicine Division of Gastroenterology Yokohama City University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Medical Oncology Kanagawa Cancer Center Department of Gastroenterology Aichi Cancer Center Hospital Department of Gastroenterology Kanazawa University Graduate School of Medicine Department of Surgery Japan Bapist Hospital Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Clinical Genetics Unit Kyoto University Graduate School of Medicine Center for Genomic Medicine Kyoto University Graduate School of Medicine Osaka Medical Center for Cancer and Cardiovascular Diseases Second Department of Internal Medicine Wakayama Medical University Department of Gastroenterology Onomichi General Hospital Department of Gastroenterology NationalKyushu Cancer Center Department of Medicine and Bioregulatory Sciences Kyushu University Graduate School of Medical Science Pancreatic Cancer Action Network Department of Gastroenterology Tohoku University Graduate School of Medicine

Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (Caucasian) and a younger onset are common also in FPC. In European countries, "anticipation" is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society.

关键词： familial pancreatic cancer registry high risk genetic surveillance

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Performance Test and Flow Measurement of Contra-Rotating Axial Flow Pump

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Journal of Thermal Science 2007年第1期16卷 7-13页

作者： Akinori furukawa toru Shigemitsu Satoshi Watanabe Division of Mechanical Engineering Science Kyushu University744 MotookaNishi-kuFukuoka 819-0395JAPAN

An application of contra-rotating rotors has been proposed against a demand for developing higher specific speed axial flow pump. In the present paper, the advantage and disadvantage of using contra-rotating rotors are described in comparison with conventional type of rotor-stator, based on theoretical and experimental investigations. The advantages are as follows：（1） The pump is inherently designed as smaller sized and at lower rotational speed. （2） A stable head-characteristic curve for flow rate with negative slope appears. （3） As the rear rotor rotational speed is varied as independent control of front rotor, the wider range of high performance operation is obtained by rear rotor speed control in addition to front rotor speed control. The disadvantages are as follows：（1） The structure of double shaft system becomes complex. （2） The pump performance is inferior at over flow rate as the rear rotor loading is weakened. （3） The blade rows interaction from rear rotor to front rotor more strongly appears. Then the rear rotor design is a key to achieve higher pump performance. Some methods to overcome these disadvantages will be discussed in more details toward wider usage of contra-rotating axial flow pump in various industrial fields.

关键词： axial flow pump contra-rotating rotors multiphase flow rotational speed control blade rows interaction

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Pressure Measurement on Casing Wall and Blade Rows Interaction of Contra-Rotating Axial Flow Pump

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Journal of Thermal Science 2005年第2期14卷 142-149页

作者： toru SHIGEMITSU Tomoya TAKANO Akinori furukawa Kusuo OKUMA Satoshi WATANABE Division of Mechanical Engineering Science Kyushu University 6-10-1HakozakiHigashi-kuFukuoka 812-8581JapanDivision of Mechanical Engineering Science Kyushu University6-10-1HakozakiHigashi-kuFukuoka 812-8581JapanDivision of Mechanical Engineering Science Kyushu University6-10-1HakozakiHigashi-kuFukuoka 812-8581JapanDivision of Mechanical Engineering Science Kyushu University6-10-1HakozakiHigashi-kuFukuoka 812-8581JapanDivision of Mechanical Engineering Science Kyushu University6-10-1HakozakiHigashi-kuFukuoka 812-8581Japan

An application of contra-rotating rotors has been proposed against a demand for developing higher specific speed axial flow pump. The blade rows interaction between front and rear rotors should be clarified for its stable operation and reduction of unsteady losses. In this paper, the static pressure distributions on casing wall are provided by measuring with the phase locked sampling method. The measurements are carried out for two types of the rear rotors with different blade number and chord length, and it is found that, for both types of rotors, the unsteady pressure fluctuations are more remarkable in the front rotor than in the rear rotor and they are caused by the rear rotor pressure field. The effects of pressure fluctuations will be discussed in more details toward understanding the blade rows interaction in the contra-rotating axial flow pump.

关键词：涡轮机逆旋转转子压力场叶栅交感测量方法

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Hepatic schwannoma:Imaging findings on CT,MRI and contrast-enhanced ultrasonography

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World Journal of Gastroenterology 2012年第35期18卷 4967-4972页

作者： Yu Ota Kazunobu Aso Kenji Watanabe Takahiro Einama Koji Imai Hidenori Karasaki Ryuji Sudo Yosui Tamaki Mituyoshi Okada Yosihiko Tokusashi toru Kono Naoyuki Miyokawa Masakazu Haneda Masahiko Taniguchi Hiroyuki furukawa Division of Metabolism and Biosystemic Science Department of MedicineAsahikawa Medical University Division of Gastroenterologic and General Surgery Department of SurgeryAsahikawa Medical University Department of Pathology Asahikawa Medical University

A primary benign schwannoma of the liver is extremely rare and is difficult to preoperatively discriminate from a malignant *** compared the imaging and pathological findings,and examined the possibility of preoperatively diagnosing a benign liver schwannoma.A 72-year-old woman was admitted to our hospital because of a 4.6-cm mass in the liver.A malignant tumor was suspected,and a right hepatectomy was *** this,the diagnosis of a primary benign schwannoma of the liver was made through pathological ***-enhanced ultrasonography(CEUS) with Sonazoid showed minute blood flows into the septum and solid areas of the tumor in the vascular phase;most likely due to increased arterial flow associated with infiltration of chronic inflammatory *** the postvascular phase,CEUS showed contrast defect of cystic areas and delayed enhancement of solid areas;most likely due to aggregation of *** discriminating between a benign and malignant schwannoma of the liver is difficult,surgery is generally ***,the two key findings from CEUS may be useful in discriminating ancient schwannoma by recognizing the hemorrhage involved in the secondary degeneration and aggregation of siderophores.

关键词： Liver schwannoma Contrast-enhanced ul-trasonography Liver resection

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Risk factors for internal anal sphincter dysfunction in Japanese adults

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Open Journal of Gastroenterology 2013年第1期3卷 25-34页

作者： Tatsuya Abe toru Kono Yoshikazu Hachiro Masao Kunimoto Hiroyuki furukawa Department of Proctology Kunimoto Hospital Asahikawa Japan Division of Gastroenterologic and General Surgery Department of Surgery Asahikawa Medical University Asahikawa Japan

Purpose: The internal anal sphincter provides most of the resting anal tone and is the main muscle responseble for continence. This study was designed to estimate the prevalence of, and identify risk factors associated with, internal anal sphincter dysfunction in Japanese adults. Methods: Anorectal manometry was performed in 1193 women and 1124 men aged 20 years or older. The maximal resting pressure, measured by a rapid pull-through technique, was defined as the highest resting pressure recorded. Internal anal sphincter dysfunction was defined as a maximal resting pressure less than 30 mmHg. Potential risk factors were assessed through self-reports, interviews, physical examinations, and medical record reviews. Multivariate logistic regression analysis was used to identify independent risk factors for internal anal sphincter dysfunction. Results: Significant differences in maximal resting pressure were seen between women (58.1 ± 24.9 mmHg) and men (68.8 ± 23.5 mmHg, P < 0.001). Maximal resting pressure decreased significantly with increasing age in both sexes. The prevalence of internal anal sphincter dysfunction was 10.4% (15.5% in women, 5.1% in men). In a multivariate logistic regression model, age, mental disease, pelvic organ prolapse repair, and fecal incontinence were independently associated with a greater risk of internal anal sphincter dysfunction in women and men. Conclusions: Internal anal sphincter dysfunction is a common problem for women and men. Several of the identified risk factors are preventable or modifiable, and may direct future research in fecal incontinence therapy.

关键词： Fecal Incontinence Internal Anal Sphincter Anorectal Manometry Maximal Resting Pressure

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