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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender sharma Melissa Mtorres sheryl Rodriguez Laxman Gangwani subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate school of Biomedical sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

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Current state-of-the-art review of footwear–ground friction

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Friction 2024年第10期12卷 2188-2204页

作者： David REBENDA Tomáš sÁHA Footwear Research Centre University InstituteTomas Bata University in ZlinZlin 76001Czech Republic Faculty of Mechanical Engineering Brno University of TechnologyBron 61600Czech Republic

The most important role of footwear is to ensure safe,functional walking,and foot *** the proper functionality of not only the work shoes,the anti-slip behavior of the shoe under various conditions and environments plays an important role in the prevention of slips,trips,falls,and consequent *** article is intended to review the current understanding of the frictional mechanisms between shoe outsoles and various counterfaces that impact the evaluation of outsole *** research focuses on the mechanisms driving outsole friction on different ground surfaces or the definition and description of parameters that influence outsole ***,the review discusses the effect of various surface contaminants on footwear ***,challenges and outlooks in the field of footwear outsoles are briefly mentioned.

关键词： shoe outsole composite slipperiness coefficient of friction(COF) adhesion safe walk

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Haba and Huitlacoche,Nutritious Foods of Little Consumption

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Journal of Environmental science and Engineering(A) 2024年第3期13卷 86-89页

作者： Edmundo Arias torres Imilla IArias Olguín Bolivar Arias Olguín Department of Applied Technology Mexican Institute of Appropriate TechnologiesS.C.Mexico City 07270México

Haba and Huitlacoche are foods of little consumption *** provide nutrients to the human body due to the fiber,antioxidants,vitamins and essential amino acids they *** broad bean can be grown alone or intercropped with corn and *** is a fungus that affects corn,however in Mexico it has been used as food since the times of the Aztec culture.

关键词： Bean Huitlacoche nutritious food

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Dynamic and electrical responses of a curved sandwich beam with glass reinforced laminate layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 155-178页

作者： N.sHAHVEIsI s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic responses and generated voltage in a curved sandwich beam with glass reinforced laminate(GRL)layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact(LVI)are *** current study aims to carry out a dynamic analysis on the sandwich beam when the impactor hits the top face sheet with an initial *** the layer analysis,the high-order shear deformation theory(HsDT)and Frostig's second model for the displacement fields of the core layer are *** classical non-adhesive elastic contact theory and Hunter's principle are used to calculate the dynamic responses in terms of *** order to validate the analytical method,the outcomes of the current investigation are compared with those gained by the experimental tests carried out by other researchers for a rectangular composite plate subject to the *** element(FE)simulations are conducted by means of the ABAQUs *** effects of the parameters such as foam modulus,layer material,fiber angle,impactor mass,and its velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved sandwich beam glass reinforced laminate(GRL) pliable core low-velocity impact(LVI) classical non-adhesive elastic contact theory

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MXenes for Bioinspired soft Actuators:Advancements in Angle-Independent structural Colors and Beyond

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Nano-Micro Letters 2024年第8期16卷 18-34页

作者： siavash Iravani Rajender s.Varma Independent Researcher W Nazar STBoostan AveIsfahanIran Centre of Excellence for Research in sustainable Chemistry Department of ChemistryFederal University of São CarlosSão CarlosSP 13565‑905Brazil

soft actuators have garnered substantial attention in current years in view of their potential appliances in diverse domains like robotics,biomedical devices,and biomimetic *** actuators mimic the natural movements of living organisms,aiming to attain enhanced flexibility,adaptability,and *** the other hand,angle-independent structural color has been achieved through innovative design strategies and engineering *** carefully controlling the size,shape,and arrangement of nanostructures,researchers have been able to create materials exhibiting consistent colors regardless of the viewing *** promising class of materials that holds great potential for bioinspired soft actuators is MXenes in view of their exceptional mechanical,electrical,and optical *** integration of MXenes for bioinspired soft actuators with angle-independent structural color offers exciting *** material compatibility issues,improving color reproducibility,scalability,durability,power supply efficiency,and cost-effectiveness will play vital roles in advancing these *** perspective appraises the development of bioinspired MXene-centered soft actuators with angleindependent structural color in soft robotics.

关键词： MXenes MXene-based composites Bioinspired soft robotics Angle-independent structural color

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The emerging role of exercise as a cancer treatment

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Journal of sport and Health science 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

Over the past few decades,exercise oncology has emerged as an important subfield within exercise *** that time,substantial progress has been made in understanding the role of exercise in people newly diagnosed with ca... 详细信息

关键词： cancer treatment exercise

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A Review on the Recent Trends of Image steganography for VANET Applications

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Computers, Materials & Continua 2024年第3期78卷 2865-2892页

作者： Arshiya s.Ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Image steganography is a technique of concealing confidential information within an image without dramatically changing its outside *** vehicular ad hoc networks(VANETs),which enable vehicles to communicate with one another and with roadside infrastructure to enhance safety and traffic flow provide a range of value-added services,as they are an essential component of modern smart transportation *** steganography has been suggested by many authors for secure,reliable message transfer between terminal/hope to terminal/hope and also to secure it from attack for privacy *** paper aims to determine whether using steganography is possible to improve data security and secrecy in VANET applications and to analyze effective steganography techniques for incorporating data into images while minimizing visual quality *** to simulations in literature and real-world studies,Image steganography proved to be an effectivemethod for secure communication on VANETs,even in difficult network *** this research,we also explore a variety of steganography approaches for vehicular ad-hoc network transportation systems like vector embedding,statistics,spatial domain(sD),transform domain(TD),distortion,masking,and *** study possibly shall help researchers to improve vehicle networks’ability to communicate securely and lay the door for innovative steganography methods.

关键词： steganography image steganography image steganography techniques information exchange data embedding and extracting vehicular ad hoc network(VANET) transportation system

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Tensor force impact on shell evolution in neutron-rich si and Ni isotopes

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Chinese Physics C 2024年第4期48卷 95-106页

作者： s.V.sidorov A.s.Kornilova T.Yu.Tretyakova Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tensor interaction of nucleons on the characteristics of neutron-rich silicon and nickel isotopes was studied in this *** forces are considered within the framework of the Hartree-Fock approach with the skyrme *** addition of a tensor component of interaction is shown to improve the description of the splittings between different single-particle states and decrease nucleon-nucleon pairing correlations in silicon and nickel *** attention was directed toward the role of isovector tensor forces relevant to the interaction of like nucleons.

关键词： nuclear shell model tensor interaction silicon isotopes nickel isotopes

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^(4)He monolayer on graphene:a quantum Monte Carlo study

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Communications in Theoretical Physics 2024年第9期76卷 149-157页

作者： s Yu M Boninsegni Department of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem of adsorption of a single^(4)He layer on graphene,focusing on the commensurate(C_(1/3))crystalline phase,specifically on whether it may possess a nonzero superfluid response,and on the existence of superfluid phases,either(metastable)liquid or vacancy-doped *** make use of canonical quantum Monte Carlo simulations at zero and finite temperature,based on a realistic microscopic model of the *** results confirm the absence of any superfluid response in the commensurate crystal,and that no thermodynamically stable uniform phase exists at lower *** evidence of a possibly long-lived,metastable superfluid phase at C_(1/3)coverage is ***,the results of ground-state projection methods and finite-temperature simulations are entirely consistent.

关键词： superfluidity low-dimensional systems quantum Monte Carlo helium supersolids

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FEA-based Geometrical Modification of switched Reluctance Motor for Radial Force Reduction

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Chinese Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： Rani s Jayapragash R school of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

switched reluctance motors(sRMs)are becoming increasingly popular in the automotive sector owing to their robust ***,sRMs are preferred particularly for EV applications owing to their fault tolerance,magnet-free structure,and high power/torque *** main concerns of sRM compared to other machines include torque ripple and *** primary cause of vibration is the radial force created by the sRM.A geometry-based modification of the sRM to reduce the radial force without significantly changing the average torque produced is *** primary goal is to design a 4-phase,8/6 sRM with a lower radial *** possible geometrical alterations are proposed:one with square windows and the other with circular holes on the rotor *** windows are sized and positioned to avoid flux *** criteria are developed for the optimal window size and *** element analysis(FEA)modelling of the sRM is used to validate its *** FEA results are compared with the performance parameters obtained using the analytical *** the multiphysics design tool ANsYs to obtain the natural frequencies and associated deformations through modal *** to the conventional geometry,the radial force is significantly reduced by providing windows.

关键词： 8/6 sRM radial force modal analysis FEA analysis natural frequencies sRM with windows

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