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Water Science and Engineering 2017年第2期10卷 143-153页

作者： Maziar Gholami Korzani Sergio A. Galindo-torres Alexander Scheuermann David j. Williams School of Civil Engineering The University of Queensland St Lucia Brisbane QLD 4072 Australia School of Mathematics and Physics The University of Queensland St Lucia Brisbane QLD 4072 Australia

Simulations of two-dimensional(2D) flow past a circular cylinder with the smoothed particle hydrodynamics(SPH) method were conducted in order to accurately determine the drag coefficient. The fluid was modeled as a viscous liquid with weak compressibility. Boundary conditions,such as a no-slip solid wall, inflow and outflow, and periodic boundaries, were employed to resemble the physical problem. A sensitivity analysis, which has been rarely addressed in previous studies, was conducted on several SPH parameters. Hence, the effects of distinct parameters, such as the kernel choices and the domain dimensions, were investigated with the goal of obtaining highly accurate results. A range of Reynolds numbers(1-500) was simulated, and the results were compared with existing experimental data. It was observed that the domain dimensions and the resolution of SPH particles, in comparison to the obstacle size, affected the obtained drag coefficient significantly. Other parameters, such as the background pressure, influenced the transient condition, but did not influence the steady state at which the drag coefficient was determined.

关键词： Smoothed particle hydrodynamics Drag coefficient Reynolds number Sensitivity analysis Viscous flow

Integrity and resilience in the face of multiple crises:commentary from Puerto Rico

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Forensic Sciences Research 2021年第3期6卷 316-319页

作者： Richard j.Noel jr jose A.torres-Ruiz Department of Basic Sciences School of MedicinePonce Health Sciences UniversityPoncePRUSA Office of the Chancellor Ponce Health Sciences UniversityPoncePRUSA

Since 2010,the population of Puerto Rico has declined by 11.8%and is currently 3.3 million peo-ple[1].This worrisome trend is a result of a pleth-ora of island-wide challenges spanning financial difficulties,natural disasters,and *** over a decade of economic hardship and debt,incapacitating hurricanes,Irma and Maria,destroyed large swaths of the island in *** still recovering from that disaster,a magnitude 6.4 earthquake centered about 5 miles off the south-western coast on january 7,2020,destroying build-ings and roads in southwestern Puerto *** event,and subsequent aftershocks that continue until today,further aggravate an already stressed *** the mix,viral epidemics have brought fur-ther economic,social,and health-related *** Rico was the centre of the 2016-2017 Zika virus infections,representing over 85%of the US infections in 2016[2].

关键词： island disaster southwestern

Hydrogen production by catalytic decomposition of methane using a Fe-based catalyst in a fluidized bed reactor

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journal of Natural Gas Chemistry 2012年第4期21卷 367-373页

作者： D.torres S.deLlobet j.L.Pinilla M.j.Lzaro I.Suelves R.Moliner Instituto de Carboquímica CSICMiguel Luesma Castn 450018 ZaragozaSpain

Catalytic decomposition of methane using a Fe-based catalyst for hydrogen production has been studied in this work. A Fe/Al2O3 catalyst previously developed by our research group has been tested in a fluidized bed reactor （FBR）. A parametric study ot the effects of some process variables, including reaction temperature and space velocity, is undertaken. The operating conditions strongly affect the catalyst performance. Methane conversion was increased by increasing the temperature and lowering the space velocity. Using temperatures between 700 and 900℃ and space velocities between 3 and 6 LN/（gcat·h）, a methane conversion in the range of 25%-40% for the gas exiting the reactor could be obtained during a 6 h run. In addition, carbon was deposited in the form of nanofilaments （chain like nanofibers and multiwall nanotubes） with similar properties to those obtained in a fixed bed reactor.

关键词： hydrogen production fluidized bed reactor metal catalysts

Asymmetry in genitalia is in sync with lateralized mating behavior but not with the lateralization of other behaviors

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Current Zoology 2020年第1期66卷 71-81页

作者： julian torres-DOWDALL Sina j.ROMETSCH Gaston AGUILERA Guillermo GOYENOLA Axel MEYER Department of Biology University of KonstanzKonstanzGermany Zukunftskolleg University of KonstanzKonstanzGermany Hector Fellow Academy KarlsruheGermany Unidad Ejecutora Lillo(CONICET) Fundacion Miguel LilloTucumanArgentina Departamento de Ecologia y Gestion Ambiental Centro Universitario Regional Del EsteUniversidad de la RepublicaUruguay

Asymmetries in bilateral organisms attract a lot of curiosity given that they are conspicuous departures from the *** allow the investigation of the integration at different levels of biological *** we study whether and how behavioral and asymmetrical anatomical traits coevolved and work *** ask if asymmetry is determined locally for each trait or at a whole individual level in a species bearing conspicuous asymmetrical *** genitalia evolved in many species;however,in most cases the direction of asymmetry is ***,it has been rarely determined if there is an association between the direction of asymmetry in genitalia and other *** onesided livebearer fish of the genus jenynsia(Cyprinodontiformes,Anablepidae),the anal fin of males is modified into a gonopodium,an intromittent organ that serves to inseminate *** gonopodium shows a conspicuous asymmetry,with its tip bending either to the left or the *** surveying 13 natural populations of jenynsia lineata,we found that both genital morphs are equally common in wild *** a series of experiments in a laboratory population,we discovered asymmetry and lateralization for multiple other traits;yet,the degree of integration varied highly among *** in exploratory behavior in response to different stimuli was not associated with genital ***,the direction of genital asymmetry was positively correlated with sidedness of mating preference and the number of neuromasts in the lateral *** suggests integration of functionally linked asymmetric traits;however,there is no evidence that asymmetry is determined at the whole individual level in our study species.

关键词： antisymmetry behavioral lateralization jenynsia iineata jenynsia multidentata phenotypic integration

烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点

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中华高血压杂志 2017年第2期25卷 199-199页

作者： Chen j Sysol jR Singla S Zhao S Yamamura A Valdez-jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H torres j Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan jX Garcia jG Machado RF 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑,

关键词：烟酰胺腺嘌呤二核苷酸核糖基转移酶肺血管重塑肺动脉高压治疗靶点 hypertension 磷酸 arterial

Microstructural, mechanical and corrosion characterization of an as-cast Mg-3Zn-0.4Ca alloy for biomedical applications

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journal of Magnesium and Alloys 2020年第2期8卷 510-522页

作者： N.Pulido-Gonzalez B.torres P.Rodrigo N.Hort j.Rams Department of Applied Mathematics Materials Science and Engineering and Electronics Technology.ESCETRey Juan Carlos UniversityC/Tulipan s/n28933 MdstolesMadridSpain Magnesium Innovation Centre Helmholtz-Zentrum Geesthacht21502 GeesthachtGermany

The as-cast Mg-3Zn-0.4Ca alloy shows a great potential to be used in biomedical applications due to its composition,mechanical properties and *** and Ca appear naturally in the organism accomplishing vital *** alloy consists of an a-Mg matrix and a eutectic composed of *** eutectic product enhances the mechanical properties of the studied alloy,causing strengthening and providing superior hardness *** this alloy,cracks initiate at the intermetallic compounds and progress through the matrix because of the open network formed by the *** to the corrosion results,the eutectic product presents a noble potential compared to the a-Mg *** this reason,the corrosion progresses preferentially through the matrix,avoiding the(α-Mg+Ca2Mg6Zri3)eutectic product,when the alloy is in direct contact to Hank's solution.

关键词： Mg-Zn-Ca alloys Biomaterials Biodegradable implants Nanoindentation Three-point bending test Corrosion behaviour

Multiphase modeling of fluid dynamic in ladle steel operations under non-isothermal conditions

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journal of Iron and Steel Research(International) 2017年第9期24卷 888-900页

作者： H.Gonzalez j.A.Ramos-Banderas E.torres-Alonso G.Solorio-Diaz C.A.Hernández-Bocanegra Graduate Program in Metallurgy Morelia Technological Institute(ITM)Morelia Michoacdn 58120Mexico Graduate Program in Engineering Mechanical UMSNHMorelia Michoacdn 58140Mexico CATEDRAS CONACyT Benito JuarezCDMX 03940Mexico

A numerical simulation was performed to study the flow pattern,mixing time and open-eye slag produced by argon gas injection in an industrial scale steel ladle under non-isothermal *** liquid steel remains 5min before the injection,and thermal stratification and convective flows were *** different sequences in stages employing various argon-gas flow rates were *** the first case,a sequence with the highest flow rates of argon was applied,while in the second and the third sequences,the intermediate and the lowest flow rates of argon gas were used,*** determining the chemistry homogenization,the mixing time was computed and analyzed in all three *** was found that the cold steel is located near the walls while the steel with a high temperature is accumulated in the center of the ladle above the argon-gas *** higher and lower flows promote a faster chemistry homogenization owing to the secondary recirculations that are developed closer to the *** results from steel temperature drop show a good concordance with plant trial measurements.

关键词： Thermal stratification Mixing time Open-eye slag Ladle steelmaking Multiphase modeling

A novel triple immunoenzyme staining enables simultaneous identification of all muscle fiber types on a single skeletal muscle cryosection from normal, denervated or reinnervated rats

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Neural Regeneration Research 2017年第8期12卷 1357-1364页

作者： Peng Wu Shuya Zhang Robert j.Spinner Michael torres Lizardi Yudong Gu Cong Yu Michael j.Yaszemski Anthony j.Windebank Huan Wang Department of Neurological Surgery Mayo Clinic Rochester MN USA Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Shanghai Tenth People's Hospital Tongji University Shanghai China Department of Neurology Mayo Clinic Rochesterl MN USA Department of Medicine New York Presbyterian Weill Cornell Medical Center New York NY USA Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai China Departments of Orthopedic Surgery and Biomedical Engineering Mayo Clinic Rochester MN USA

Triple immunofluorescence staining has recently been developed to simultaneously identify all muscle fibers on a single cryosection which is helpful for clinical and basic research, but it has disadvantages such as fast photobleaching and unclear outlines of muscle fibers. Triple immunoenzyme staining（TIE） is likely to avoid these disadvantages. In this study, we aimed to establish a sensitive and specific TIE technique to identify fiber types in normal, denervated, and reinnervated rat muscles, and to develop a systematic sampling method for muscle fiber quantification. Tibialis anterior and soleus from normal, denervated, and reinnervated Lewis rat hind limbs were used. Five consecutive cryosections were cut from each muscle, including one for TIE and four for single immunoenzyme staining（SIE）. The TIE was performed using the polymerized reporter enzyme staining system for the first two antigens（A4.74 for My HC-IIA, BA-F8 for My HC-I） and alkaline phosphatase staining system for the third antigen（BF-F3 for My HC-IIB）, followed by corresponding detective systems and respective chromogens. The type of muscle fibers was quantified by systematic sampling at 12.5%, 25%, 33% and 50% of all muscle fibers, and was compared with that acquired from counting all the fibers（100%）. All muscle fiber phenotypes, including pure and hybrid, could be simultaneously identified on a single TIE cryosection with clear outlines. The fiber types on TIE slides matched well with their respective counterpart on the consecutive SIE slides with a 95% match rate. Systematic sampling of 12.5% fibers could represent the true fiber type distribution of the entire muscle section. Our results suggest that novel TIE can effectively visualize fiber types in normal, denervated or reinnervated rat muscles.

关键词： nerve regeneration muscle fiber phenotyping immunohistochemistry triple immunoenzymestaining myosin heavy chain rats neural regeneration

Raman spectroscopy for detection of imatinib in plasma: A proof of concept

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journal of Innovative Optical Health Sciences 2015年第5期8卷 56-66页

作者： Sanhita Rath Aditi Sahu Vikram Gota P.G.Martínez-torres j.L.Pichardo-Molina C.Murali Krishna Department of Clinical Pharmacology ACTREC Tata Memorial CenterKharghar Navi Mumbai 410210 India Chilakapati Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Instituto de Fisica y Matematicas Universidad Michoacana de San Nicolas de Hidalgo Edificio C-3 Ciudad Universitaria CP.58040 MoreliaMichoacanMexico Centro de Investigaciones enOptica AC C.P.37#150 Leon Gto.Mexico

Imatinib is the standard first line treatment for chronic myeloid leukemia(CML).Owing to doserelated toxicities of Imatinib such as neutropenia,there is scope for treatment optimization through therapeutic drug monitoring(TDM).Trough concentration of 1g/mL is considered the therapeutic *** methods for the detection of Imatinib in plasma are limited by long read out time and expensive ***,Raman spectroscopy was explored as a rapid and objective tool for monitoring Imatinib *** approaches:conventional Raman spectroscopy(CRS),Drop coating deposition Raman(DCDR)spectroscopy and surface-enhanced Raman spectroscopy(SERS)were employed to detect the required trough concentration of 1g/mL and *** of therapeutically relevant concentrations(1g/mL)using SERS and suitable nanoparticle substrates has been ***,rigorous validation using clinical samples is necessary to confirm the utility of this approach in routine clinical usage.

关键词： Therapeutic drug monitoring Raman spectroscopy Imatinib SERS DCDR chronic myeloid leukemia

RANS simulations of the U and V grooves effect in the subcritical flow over four rotated circular cylinders

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journal of Hydrodynamics 2015年第4期27卷 569-578页

作者： ALONZO-GARCIA A. GUTIERREZ-torres C.del C. jIMENEZ BERNAL j.A. MOLLINEDO-PONCE de LEON H.R. MARTINEZ-DELGADILLO S.A. BARBOSA-SALDANA j.G. Instituto Politécnico Nacional SEPI ESIME ZacatencoLABINTHAP U.P.Adolfo López Mateos Edif.5 3er.PisoMéxicoD.F.México Instituto Politécnico Nacional UPIITAAv.IPN 2580C.P.07340MéxicoD.F.México Universidad Autónoma Metropolitana-Azcapotzalco Depto.Ciencias BásicasAv.San Pablo 180Azcapotzalco C.P 07740MéxicoD.F.México

This paper presents a CFD study about the effect of the V and U grooves in the flow over four cylinders in diamond shape configuration at subcritical flow conditions（Re= 41 000）. The k- ε Realizable turbulence model was implemented to fully structured hexahedral grids with near-wall refinements. Results showed that the numerical model was able to reproduce the impinging flow pattern and the repulsive forces present in the lateral cylinders of the smooth cylinder array. As a consequence of the flow alignment induced by the grooves, a jet-flow is formed between the lateral cylinders, which could cause an important vortex induced vibration effect especially in the rear cylinder. The magnitudes of the shear stresses at the valleys and peaks for the V grooved cylinders were lower than those of the U grooved cylinders, but the separation points were delayed due the U grooves presence. It is discussed the presence of a blowing effect caused by counter-rotating eddies located near the grooves peaks that cause a decrease of the shear stresses in the valleys, and promote them at the peaks.

关键词： RANS model grooved cylinder four cylinders subcritical flow impinging flow