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Potential role of biofeedback therapy for Parkinson’s disease

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Neural Regeneration Research 2021年第10期16卷 2021-2022页

作者： Naoya Kotani Takashi Morishita tooru Inoue Department of Neurosurgery Fukuoka University Faculty of MedicineFukuokaJapan Department of Rehabilitation Medicine Fukuoka University HospitalFukuokaJapan

Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural *** disturbance is one of cardinal symptoms of PD and affects the activities of daily living and quality of *** symptom in advanced PD patients is usually refractory to medication and surgical intervention such as deep brain stimulation(Morishita et al.,2016).

关键词： stimulation instability. al.

Gastric carditis:Is it a histological response to high concentrations of luminal nitric oxide?

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World Journal of Gastroenterology 2006年第36期12卷 5767-5771页

作者： Katsunori Iijima tooru Shimosegawa Division of Gastroenter-ology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

During the last decade, inflammation (carditis) and in- testinal metaplasia localized to immediately below the human gastro-oesophageal junction have received much attention in relation to the rising incidence of cancer at this site. Since these histological findings are frequently observed even among those who are H pylori-negative, the causative factors for such histologic events at the human gastro-oesophageal junction remain obscure. A series of recent studies have demonstrated that a high level of salivary nitrite is sustained over several hours after the ingestion of a high nitrate meal, and that the nitrite in swallowed saliva is rapidly converted to nitric oxide by an acid catalyzed chemical reaction at the gastro-oesophageal junction. Eventually, a substantial amount of nitric oxide diffuses from the lumen into the adjacent tissue. Therefore, the human gastro-oesopha- geal junction is likely to be a region of high nitrosative stress. Considering the life-time exposure of the gastro- oesophageal junction to cytotoxic levels of nitric oxide, this may account for the high prevalence of inflamma- tion, intestinal metaplasia, and subsequent development of neoplasia at this site. Although gastric acid, pepsin, and bile acid have been intensively investigated as a cause of adenocarcinoma at the gastro-oesophageal junction and the distal esophagus, nitric oxide and the related nitrosative stress should also be examined.

关键词： Nitric oxide Gastro-oesophageal junction Dietary nitrate Carditis Intestinal metaplasia at gastro-oesophageal junction

Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease

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Neural Regeneration Research 2017年第5期12卷 747-748页

作者： Takashi Morishita tooru Inoue Department of Neurosurgery Fukuoka University Faculty of Medicine Fukuoka Japan

Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric *** efforts to improve the clinical outcomes of the procedure have been prev... 详细信息

关键词： DBS Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson’s disease deep

Novel role of toll-like receptors in Helicobacter pylori-induced gastric malignancy

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World Journal of Gastroenterology 2014年第18期20卷 5244-5251页

作者： Kaname Uno Katsuaki Kato tooru Shimosegawa Division of Gastroenterology Tohoku UniversityMiyagi 981-8574Japan Center of Cancer Screening Miyagi Cancer SocietyMiyagi 980-0011Japan

Helicobacter pylori(***)infects the human stomach during infancy and develops into chronic *** majority of *** tend to colonize within the mucous gel layer of the *** lacks its own immune function,thus innateimmunity as the first line of defense is vital for specificimmunity against *** review recent discoveries in the pathophysiologic roles of toll-like receptors(TLRs),mainly TLR2 and TLR4,in ***-induced *** addition,the TLR pathways activated ***-induced inflammation have been shown to beclosely associated not only with gastric carcinogenesis,but also with formation of the tumor microenvironmentthrough the production of pro-inflammatory cytokines,chemokines,and reactive oxygen *** correlation between single nucleotide polymorphisms of TLRs and gastric cancer risk remains unclear,a recent study demonstrated that STAT3-driven upregulation of TLR2 might promote gastric tumorigenesis independent of *** research onthe regulation of TLRs in ***-associated gastriccarcinogenesis will uncover diagnostic/predictive biomarkers and therapeutic targets for gastric cancer.

关键词： Toll like receptors Helicobacter pylori Gastric cancer Pathogen-associated molecular patterns Damage-associated molecular patterns

Management of acute pancreatitis in Japan: analysis of nationwide epidemiological survey

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World Journal of Gastroenterology 2016年第28期22卷 6335-6344页

作者： Shin Hamada Atsushi Masamune tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine

Acute pancreatitis(AP) is an acute inflammatory disease of the exocrine pancreas. In Japan, nationwide epidemiological surveys have been conducted every 4 to 5 years by the Research Committee of Intractable Pancreatic Diseases, under the support of the Ministry of Health, Labour, and Welfare of Japan. We reviewed the results of the nationwide surveys focusing on the severity assessment and changes in the therapeutic strategy for walled-off necrosis. The severity assessment system currently used in Japan consists of 9 prognostic factors and the imaging grade on contrastenhanced computed tomography. By univariate analysis, all of the 9 prognostic factors were associated with AP-related death. A multivariate analysis identified 4 out of the 9 prognostic factors(base excess or shock, renal failure, systemic inflammatory response syndrome criteria, and age) that were associated with AP-related death. Receiver-operating characteristics curve analysis showed that the area under the curve was 0.82 for these 4 prognostic factors and 0.84 for the 9 prognostic factors, suggesting the comparable utility of these 4 factors in the severity assessment. We also examined the temporal changes in treatment strategy for walled-off necrosis in Japan according to the 2003, 2007, and 2011 surveys. Step-up approaches and lessinvasive endoscopic therapies were uncommon in 2003 and 2007, but became popular in 2011. Mortality has been decreasing in patients who require intervention for walled-off necrosis. In conclusion, the nationwide survey revealed the comparable utility of 4 prognostic factors in the severity assessment and the increased use of less-invasive, step-up approaches with improved clinical outcomes in the management of walled-off necrosis.

关键词： Endoscopic necrosectomy Diagnostic criteria Epidemiology Pancreatic pseudocyst Systemic inflammatory response syndrome Step-up approach Walled-off necrosis

Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第1期21卷 94-101页

作者： Yasuteru Kondo Osamu Kimura tooru Shimosegawa Division of Gastroenterology Tohoku University HospitalSendai 980-8574Japan

In addition to surgical procedures, radiofrequency ablation is commonly used for the treatment of hepatocellular carcinomas(HCCs) of limited size and number. Transcatheter arterial chemoembolization(TACE), using iodized poppy seed oil, Lipiodol and anticancer drugs, has been actively performed for the treatment of unresectable HCC, particularly in Asian countries. Recently, Sorafenib become available for advanced HCCs when the liver is still sufficiently functional. Sorafenib is an oral multikinase inhibitor with antiproliferative and antiangiogenic effects. However, the effect of sorafenib seems to be inadequate to control the progression of HCC. Radiation therapy(RT)for HCC has a potential role across all stages of HCC. However, RT is generally not considered an option in HCC consensus documents or national guidelines, primarily because of insufficient supporting evidence. However, the method of RT has much improved because of advances in technology. Moreover, combined treatment of RT plus other treatments(TACE, sorafenib and chemotherapy etc.) has become one of the alternative therapies for HCC. Therefore, we should understand the various kinds of RT available for HCC. In this review, we focus on various kinds of external beam radiation therapy.

关键词： Hepatocellular carcinoma Radiofrequency ablation T

Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey

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World Journal of Gastroenterology 2017年第16期23卷 2826-2831页

作者： Shin Hamada Atsushi Masamune tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

Treatment of acute pancreatitis(AP) is one of the critical challenges to the field of gastroenterology because of its high mortality rate and high medical costs associated with the treatment of severe cases. Early-phase treatments for AP have been optimized in Japan, and clinical guidelines have been provided. However, changes in early-phase treatments and the relationship between treatment strategy and clinical outcome remain unclear. Retrospective analysis of nationwide epidemiological data shows that time for AP diagnosis has shortened, and the amount of initial fluid resuscitation has increased over time, indicating the compliance with guidelines. In contrast, prophylactic use of broad-spectrum antibiotics has emerged. Despite the potential benefits of early enteral nutrition, its use is still limited. The roles of continuous regional arterial infusion in the improvement of prognosis and the prevention of late complications are uncertain. Furthermore, early-phase treatments have had little impact on late-phase complications, such as walledoff necrosis, surgery requirements and late(> 4 w) AP-related death. Based on these observations, earlyphase treatments for AP in Japan have approached the optimal level, but late-phase complications have become concerning issues. Early-phase treatments and the therapeutic strategy for late-phase complications both need to be optimized based on firm clinical evidence and cost-effectiveness.

关键词： Diagnostic time Fluid resuscitation Enteral nutrition Continuous regional arterial infusion Walledoff necrosis

Evaluation of D（d,n）^3 He reaction neutron source models for BNCT irradiation system design

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Nuclear Science and Techniques 2007年第6期18卷 330-335页

作者： YAO Ze＇en LUO Peng tooru KOBAYASHI Gerard BENGUA School of NuclearScience and Technology Lanzhou University Lanzhou 730000 China Research Reactor Institute Kyoto University Osaka 590-0494 Japan

A mathematical method was developed to calculate the yield,energy spectrum and angular distribution of neutrons from D(d,n)~3He(D-D)reaction in a thick deuterium-titanium target for incident deuterons in energies lower than *** data of energy spectrum and angular distribution were applied to set up the neutron source model for the beam-shaping-assembly(BSA)design of Boron-Neutron-Capture-Therapy(BNCT)using MCNP-4C code. Three cases of D-D neutron source corresponding to incident deuteron energy of 1000,400 and 150 key were inves- *** neutron beam characteristics were compared with the model of a 2.45 MeV mono-energetic and isotropic neutron source using an example BSA designed for BNCT *** results show significant differences in the neutron beam characteristics,particularly the fast neutron component and fast neutron dose in air,between the non-isotropic neutron source model and the 2.5 MeV mono-euergetic and isotropic neutron source model.

关键词：中子源反作用力中子能量放射

Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

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World Journal of Gastroenterology 2005年第22期11卷 3385-3391页

作者： Atsushi Masamune Masahiro Satoh Kazuhiro Kikuta Noriaki Suzuki tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan

AM: To clarify the role of Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway in platelet-derived growth factor (PDGF) induced proliferation in activated pancreatic stellate cells (PSCs). METHODS: PSCs were isolated from rat pancreas tissue, and used in their culture-activated, myofibroblast-like phenotype. STAT-specific binding activity was assessed by electrophoretic mobility shift assay. Activation of Src, JAK2, STAT1, STAT3, and ERK was determined by Western blotting using anti-phosphospecific antibodies. Cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxyuridine. RESULTS: PDGF-BB induced STAT-specific binding activity, and activation of Src, JAK2, STAT1, STAB, and ERK. Ethanol and acetaldehyde at clinically relevant concentrations decreased basal activation of JAK2 and STAT3. PDGF-induced activation of STAT1 and STAT3 was inhibited by a Src inhibitor PP1 and a JAK2 inhibitor AG490, whereas PDGF-induced activation of ERK was inhibited by PP1, and not by AG490. PDGF-induced proliferation was inhibited by PP1 and AG490 as well as by STAT3 antisense oligonucleotide. CONCLUSION: PDGF-BB activated JAK2-STAT pathway via Src-dependent mechanism. Activation of 3AK2-STAT3 pathway, in addition to ERK, may play a role in PDGF-induced proliferation of PSCs.

关键词： Pancreatitis Pancreatic fibrosis Pancreatic stellate cells Platelet-derived growth factor Janus kinase Signal transducers and activators of transcription