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Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

microsystems & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.mace mengxi Wu Jun Zou Daniel T.Laskowitz tony Jun Huang Department of mechanical Engineering and materials Science Duke UniversityDurhamNC27708USA Department of Neurology Duke UniversityDurhamNC27708USA Department of Biomedical Engineering Duke UniversityDurhamNC27708USA Department of Geriatrics Duke UniversityDurhamNC27708USA Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTX77840USA

Traumatic brain injury(TBI)is a global cause of morbidity and *** management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic *** particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue *** applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after *** isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow *** cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of *** levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma *** finding demonstrated the necessity of sample purification prior to exosomal biomarker *** acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

关键词： diagnosis separation injury

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制造业转移方式与污染控制

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财经问题研究 2013年第8期 29-34页

作者：赵大平 tony Fang 上海立信会计学院经贸学院上海201620 York University HRm School Toronto M3J1P3

中国制造业转移过程中污染扩散的特点决定了中国内陆地区不具有承接高污染产业的比较优势,制造业向内陆地区转移是否就意味着污染转移?对于这一问题,本文首先从理论上分析制造业转移的规律和动力,然后运用该理论模型,针对两个企业案例... 详细信息

中国制造业转移过程中污染扩散的特点决定了中国内陆地区不具有承接高污染产业的比较优势,制造业向内陆地区转移是否就意味着污染转移?对于这一问题,本文首先从理论上分析制造业转移的规律和动力,然后运用该理论模型,针对两个企业案例进一步分析验证制造业以并购、合资和合作等方式转移,能提高中西部地区污染企业的技术和制造规模,有效降低上游地区的污染程度,从而减少上游地区污染扩散导致的危害。

关键词：制造业产业转移污染控制

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I'm a mac

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作者： tony

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Effects of Collectors and Frothers on Copper and molybdenum Coarse Particle Recoveries—A Statistical Approach

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Journal of minerals and materials Characterization and Engineering 2019年第3期7卷 117-136页

作者： tony Di Feo Rolando Lastra Natural Resources Canada Canmet Mining Ottawa Canada

Typically, coarse dense mineral particles greater than 150 μm are difficult to float, and the recovery decreases progressively. Various physical parameters can be manipulated in an attempt to increase the recovery. These physical parameters are the following: liberation, turbulence in the flotation cell, pH, collector, frother type and dosage. The testwork discussed in this paper was performed for a copper-molybdenum operation that is experiencing coarse particle (>150 μm) losses in the tails. This operation uses Diesel No. 2 fuel and sodium ethyl xanthate for molybdenum and copper flotation, respectively and X-133 frother. In an attempt to increase coarse particle recovery, stronger collectors (potassium amyl xanthate, Aero 249 and Aero 3501) and frothers (FrothPro 618, FrothPro 630 and FrothPro 706) were used. The analysis was performed using the Analysis of Variance (ANOVA) approach. The conditions required by the ANOVA method were met. The results showed that the collector potassium amyl xanthate (PAX) with frothers X-133 and FrothPro 630 resulted in approximately 3% increase in copper rougher recovery relative to the baseline (sodium ethyl xanthate and X-133). The collectors and frothers did not have a significant effect on molybdenum recovery within the dosage limits investigated.

关键词： mineral Particles Physical Parameters Coarse Particles Flotation

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ASUS m6N——移动影音工作室

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微型计算机 2004年第7期24卷 52-53页

作者： LYZ tony

宽屏绝非m6N唯一的卖点，Pentiumm1.7GHz CPU、ATI mobility Radeon 9600移动显示芯片、DVD刻录机、1GB DDR333内存5400rpm 80GB硬盘和四声道扬声器使之成为一台真正的移动影音工作站，轻松胜任DV采集和编辑工作，并可将最终的作品刻录... 详细信息

宽屏绝非m6N唯一的卖点，Pentiumm1.7GHz CPU、ATI mobility Radeon 9600移动显示芯片、DVD刻录机、1GB DDR333内存5400rpm 80GB硬盘和四声道扬声器使之成为一台真正的移动影音工作站，轻松胜任DV采集和编辑工作，并可将最终的作品刻录成DVD光盘。

关键词：移动影音工作站 ASUS m6N DVD刻录机硬盘 DVD光盘四声道扬声器

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Electro-anatomic mapping of the right atrium:anatomic abnormality is an important substrate

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Chinese medical Journal 2003年第3期116卷 22-26页

作者：方丕华 Nancy L Radtke tony W Simmons Wesley K Haisty Jr Karthik Ramaswamy David m.Fitzgerald Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Wake Forest University School of medicine Winston-Salem North Carolina 27157 USA

Objective To map and compare the right atrium in patients with AF to those with atrioventricular nodal reentrant tachycardias (AVNRT, as control group) and to investigate the anatomical and electrophysiological abnormality of the right atrium in *** The anatomy and electrophysiology of right atrium and cavotricuspid isthmus were evaluated in 20 patients with AF (16 m/4 F, mean age 55.9±10.68 years) and 26 patients with AVNRT (9 m/17 F, mean age 47.50±19.56 years) during coronary sinus pacing at 600 ms prior to ablation with electro-anatomical mapping system. Right atrial volume (RAV), the length and width of cavotricuspid isthmus (IsL, IsW), unipolar and bipolar voltage in the right atrium (UniV-RA, BiV-RA) were measured and compared between patients with AF and those with AVNRT. Results RAV, IsL, IsW, UniV-RA, and BiV-RA were 143.22±40.72 vs 104.35±21.06 ml, 39.31±8.10 vs 32.42±9.77 mm, 30.54±7.48 vs 23.15±6.61 mm, 1.96±1.24 vs 1.53±0.91 mv and 1.47±1.47 vs 1.29±1.12 mv in AF and AVNRT *** The right atrial volume is larger; both the length and width of cavotricuspid isthmus are greater. Unipolar and bipolar voltages in the right atrium are higher in AF than in AVNRT, suggesting that the enlarged right atrium, increased length and width of cavotricuspid isthmus, and concomitant atrial hypertrophy are important substrates for initiation and perpetuation of typical AF.

关键词： atrial flutter right atrium electrophysiology

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A robust soc-mOF platform exhibiting high gravimetric uptake and volumetric deliverable capacity for on-board methane storage

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Nano Research 2021年第2期14卷 512-517页

作者： Gaurav Verma Sanjay Kumar Harsh Vardhan Junyu Ren Zheng Niu tony Pham Lukasz Wojtas Sydney Butikofer Jose C Echeverria Garcia Yu-Sheng Chen Brian Space and Shengqian ma Department of Chemistry University of South Florida4202 E.Fowler Ave.TampaFL 33637USA ChemmatCARS Center for Advanced Radiation SourcesThe University of Chicago9700 South Cass AvenueArgonneIL 60439USA Department of Chemistry Multani Mai Modi CollegePatiala 147001India Department of Chemistry Biochemistryand PhysicsThe University of Tampa401 W.Kennedy Blvd.TampaFL 33606-1490USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-ChampaignChampaignIL 61801USA

Emerging as an outperformed class of metal-organic frameworks(mOFs),square-octahedron(soc)topology mOFs(soc-mOFs)feature superior properties of high porosity,large gas storage capacity,and excellent thermal/chemical *** report here an iron based soc-mOF,denoted as Fe-pbpta(H4pbpta=4,4',4'',4'''-(1,4-phenylenbis(pyridine-4,2-6-triyl))-tetrabenzoic acid)possessing a very high Brunauer,Emmett and Teller(BET)surface area of 4,937 m2/g and a large pore volume of 2.15 cm3/*** mOF demonstrates by far the highest gravimetric uptake of 369 cm3(STP)/g under the DOE operational storage conditions(35 bar and 298 K)and a high volumetric deliverable capacity of 192 cc/cc at 298 K and 65 ***,Fe-pbpta exhibits high thermal and aqueous stability making it a promising candidate for on-board methane storage.

关键词： metal-organic framework(mOF) reticular chemistry methane storage aqueous stability high gravimetric and volumetric uptake

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manufacturing Ultra High Performance Concretes by Silica Fume, Ultra Fine Fly Ash and metakaolin Addition

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材料科学与工程（中英文A版） 2017年第3期7卷 136-142页

作者： tony Song Ion Dumitru Bob Bomstein Boral Construction materials Australia

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Spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome

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Chinese medical Journal 2005年第18期118卷 1499-1506页

作者： tony m.F. Tong Edgar W.L. Hau Ivan F.m. Lo Daniel H.C. Chan Stephen T.S. Lam Clinical Genetic Service Department of Health Hong Kong SAR China Clinical Genetic Service Department of Health Hong Kong SAR China Clinical Genetic Service Department of Health Hong Kong SAR China Clinical Genetic Service Department of Health Hong Kong SAR China Clinical Genetic Service Department of Health Hong Kong SAR China

Background Sotos syndrome is an overgrowth syndrome with characteristic facial gestalt and mental retardation of variable severity. Haploinsufficiency of the NSD 1 gene has been implicated as the major cause of Sotos syndrome, with a predominance of microdeletions reported in Japanese patients. This study was conducted to investigate into the spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome. methods Thirty-six Chinese patients with Sotos syndrome and two patients with Weaver syndrome were subject to molecular testing. Results NSD1 gene mutations were detected in 26 （72%） Sotos patients. microdeletion was found in only 3 patients, while the other 23 had point mutations （6 frameshift, 8 nonsense, 2 spice site, and 7 missense）. Of these, 19 mutations were never reported. NSD1 gene mutations were not found in the two patients with Weaver syndrome. Conclusions most cases of Sotos syndrome are caused by NSD1 gene defects, but the spectrum of mutations is different from that of Japanese patients. Genotype-phenotype correlation showed that patients with microdeletions might be more prone to congenital heart disease but less likely to have somatic overgrowth. The two patients with Weaver syndrome were not found to have NSD1 gene mutations, but the number was too small for any conclusion to be drawn.

关键词： Sotos syndrome·Weaver syndrome·NSD1 gene mutation

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Electrical Homo-Junction Delineation Techniques: A Comparative Study

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materials Sciences and Applications 2016年第6期7卷 326-347页

作者： Nicolas Vivet mélanie Diogo Amandine Aubert tony moinet Fabien Allanic Raphael Perdreau Jean-Paul Rebrassé Failure and Technology Analysis Laboratory (LAT) ST Microelectronics Tours France

In active semiconductor devices, the junction characteristics are critical for the electrical performance. As an alternative of the atomic force microscopy (AFm)-based electrical techniques which provide unique junction characterization, other methods are dedicated for the delineation of the electrical junction such as the wet chemical etching, the electrochemical plating method, the Seebeck effect imaging (SEI) method, the electron-beam induced current (EBIC) technique and the secondary electron potential contrast (SEPC) method. The aim of this paper is in the one hand to compare these five techniques in term of sample preparation, spatial application range, spatial resolution, simplicity and information displayed. In the other hand, this review aims to provide some guidelines for the appropriate delineation method(s) selection. It was confirmed that chemical based techniques are the simplest junction delineation methods but exhibit some drawbacks in term of spatial resolution and reproducibility. Despite of a limited spatial resolution, it was evidenced that EBIC can provide accurate electrical characterization of the junction. Finally, it was demonstrated that SEPC is the most promising technique providing the higher spatial resolution. The effect of the sample preparation method has been described. Even if the comparison was mainly based on homo-micro-Silicon junctions (n-p and n-p-n-p), the results were also discussed for short SiC junctions. The importance of the analysis context was considered in this paper and analysis flow was suggested for specific analysis cases.

关键词： Junction Delineation Silicon Silicon Carbide Electron Beam Induced Current Seebeck Effect Imaging Secondary Electron Potential Contrast

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