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小学生时代（大嘴英语） 2015年第9期 46-47页

作者： tony

Understanding China and Its Role in the World

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国际展望 2010年第5期2卷 62-75页

作者： tony Blair

Mr. President, Ambassador, everyone, ladies and gentlemen,it is a great pleasure to be with you here at Shanghai Institutes for International Studies. Thank you, Mr. President for

关键词： Understanding China and Its Role in the World very

Dilemma of first line regimens in metastatic pancreatic adenocarcinoma

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World Journal of Gastroenterology 2016年第46期22卷 10124-10130页

作者： Marwan Ghosn tony Ibrahim Tarek Assi Elie El Rassy Hampig Raphael Kourie Joseph Kattan Department of Oncology Faculty of Medicine Saint Joseph University

Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer(m PC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of m PC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel(GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score(0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.

关键词： Review Metastatic pancreatic cancer FOLFIRINOX Gemcitabine/nab-paclitaxel Pivotal trials

Apple dwarfing rootstocks exhibit an imbalance in carbohydrate allocation and reduced cell growth and metabolism

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Horticulture Research 2017年第1期4卷 311-323页

作者： Toshi M Foster Peter A McAtee Chethi N Waite Helen L Boldingh tony K McGhie The New Zealand Institute for Plant and Food Research Limited Palmerston North4474New Zealand The New Zealand Institute for Plant and Food Research Limited Auckland1142New Zealand The New Zealand Institute for Plant and Food Research Limited Hamilton3240New Zealand

Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot *** identify physiological factors responsible for rootstock-induced growth restriction,we compared vascular-enriched gene expression between two dwarfing rootstocks(‘M27’and‘M9’)and the vigorous rootstock‘M793’using RNA sequencing and quantitative reverse transcriptase *** expressed genes common to both dwarfing rootstocks belonged to five main biological processes:(1)primary metabolism,(2)cell wall synthesis and modification,(3)secondary metabolism,(4)hormone signalling and response and(5)redox *** promoting the biosynthesis of amino acids,lipids and cell walls were downregulated in dwarfing rootstocks,whereas genes promoting the breakdown of these compounds were *** only exception to this trend was the upregulation of starch synthesis genes in dwarfing ***-structural carbohydrate analysis demonstrated that starch concentrations in‘M9’roots,stems and grafted‘Royal Gala’(‘RG’)scions were double that of equivalent tissues from‘RG’homo-grafted trees(‘RG’/‘RG’).Fructose and glucose concentrations were much lower in all three tissues of the‘RG’/‘M9’***,these data indicate that dwarfing rootstocks are in a state of sugar depletion and reduced cellular activity despite having large starch *** significant finding was the over-accumulation of flavonoids and the downregulation of auxin influx transporters MdAUX1 and MdLAX2 in dwarfing *** propose that both factors reduce polar auxin *** results of this study contribute novel information about the physiological state of dwarfing rootstocks.

关键词： walls roots dwarf

Financial Appraisal of a Small Scale Wind Turbine with a Case Study in Ireland

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Journal of Energy and Power Engineering 2014年第4期8卷 620-627页

作者： tony Kealy Department of Electrical Services Engineering School of Electrical Engineering Systems Dublin Institute of Technology Dublin 8Ireland

This research seeks to evaluate the economic benefits to be gained by installing a small-scale wind turbine for a customer with a three-phase electrical supply requirement. The evidence for the claims made in this paper is obtained by using actual data obtained from the installed equipment over a three year period. The objective is to accurately appraise the financial investment using real data. There appears to be limited studies conducted into this type of research, possibly because the renewable energy sector is in the infancy stage in the host country, Ireland. There are some wind energy installations with financial appraisal techniques based on modeled data, which may, or may not, be accurate. The study concludes by claiming that the financial benefits of the wind energy turbine installation had disappointing results when compared to predicted benefits based on modeled data.

关键词： Wind turbine financial appraisal feed-in-tariffs power loss in cables preliminary load and wind tests.

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Star Light

小学生时代（大嘴英语） 2014年第6期 18-19页

作者： tony

夜晚，做完作业，抬头望望窗外的星空，你是否看到了点点繁星？快快许下一个美好的心愿，希望心想事成，愿望成真吧!

关键词：小学生英语学习学习方法阅读知识课外阅读

The Two-Way Interpretation Process in Peirce's Late Semiotics: A Priori and a Posteriori

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Language and Semiotic Studies 2016年第4期2卷 14-30页

作者： tony Jappy University of Perpignan Via Domitia France

On his own admission Peirce's priority in his work in semiotics concerned the identification of all possible signs, and it is clearly for this reason that of the two typologies announced in the letter to Lady Welby of 23 December 1908—one yielding twenty-eight classes and the other sixty-six—it was the latter that he found the more interesting, to the complete neglect of the former. And yet contributing to the originality of this particular typology is the fact that after 1906 Peirce appears no longer to employ his phaneroscopic categories as the criteria for establishing the various subdivisions in his classifications, preferring instead three modally organized universes, and, in the period from 1907 on, a growing appeal to the requirement of collateral observation of the object in definitions of the sign—both these factors being associated with a greater understanding of the nature of the dynamic object, particularly in the period 1908-1909. The paper thus seeks to demonstrate the potential for semiotic analysis of Peirce's neglected 28-class classification system by showing its originality within the fifteen or more typologies he developed between 1866 and 1908. This, it is to be hoped, will compensate for Peirce's neglect by showing how an examination of the evolving typologies sheds light on the development of his conception of signs and on the shift in the theoretical framework which underwrote it.

关键词： typology sign-system semiosis interpretant interpretative strategy

Is Language Subversive？ -- A Comparative ＂Cultural＂ Study of the Role of Language in Humor in Bakhtin＇s Rabelais and His World and Chaplin＇s Modern Times -- Possible Implications for Teaching English as a Second Language （ESL）

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Sino-US English Teaching 2006年第2期3卷 1-12页

作者： tony Momiroski Xi＇an Jiatong University

An understanding of the role of humor in language can be useful for teaching and learning ESL. Its importance is, however, to be teased out by implication. The language of humor is not merely for entertainment, but it is in helping to deal with massive change, that the role of humor can best be understood and to which it best lends itself. Bakhtin＇s interpretation of Rabelais and His World （1984）, Rabelais own writings on Gargantua and Pantagruelt, and Chaplin＇s movie Modern Times （1936） are three mediums that help highlight the role that language： verbal, written and body-language play in communication. There are parallels and implications for ESL teaching and learning. The lessons to be learnt from an analysis of the language of humour are most informing for ESL teachers. For all of them, the principal actors in these works, and ESL teachers by implication, the period in which they live offer unique challenges for themselves and for their people. ESL teachers also find themselves direct participants in a cultural and linguistic revolution at this time. As French deconstruction has argued the meaning is not self evident in the writer＇s thoughts and words alone, but there is meaning in the ＂play＂ between the words as well. Humor can be subversive, but it is in the social function, that the language of humor can best be understood. ESL teachers stand as mediums between two worlds. They act as both interpreters and navigators of spoken language and intercultural discourse. Here humour can be an important tool for teaching that bridges the two worlds of students and teachers.

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Fast Food Domination

China International Business 2007年第4期 32-37页

作者： tony VEDDER

China has proven a lucrative market for western fast food chains. Yet the business is only in its infancy here. New franchising regulations in China coming into force in May will make it easier for foreign fast food operators to open branches and roll out the franchising model, which has proven a sure path for fasttrack growth in the US and Europe. The new law, set to come into effect on May I, replaces the existing Commercial Franchise Measures, enacted in 2005, and honors China＇s promise to liberalize its franchising sector in line with WTO commitments.

关键词：中国快餐业特许经营法规外资企业市场份额

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 30-39页

作者： Roberta Gaziano Gabriella Moroni Cristina Buè Martino tony Miele Paola Sinibaldi-Vallebona Francesca Pica Department of Experimental Medicine and Surgery University of Rome Tor Vergata

Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

关键词： Sanguinarine Cancer Apoptosis Cell-cycle Chemotherapy