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Characterization of phenanthrene degradation by strain Polyporus sp. S133

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Journal of Environmental Sciences 2010年第1期22卷 142-149页

作者： tony Hadibarata Sanro Tachibana Department of Applied Bioscience Faculty of AgricultureEhime University laboratorium of Pulp and Paper Department of Forest TechnologyMulawarman University Kampus Gunung Kelua

Polyporus sp. S133, a fungus collected from contaminated soil, was used to degrade phenanthrene, a polycyclic aromatic hydrocarbon, in a mineral salt broth liquid culture. A maximal degradation rate （92%） was obtained when Polyporus sp. S133 was cultured for 30 days with agitation at 120 r/min, as compared to 44% degradation in non-agitated cultures. Furthermore, the degradation was affected by the addition of surfactants. Tween 80 was the most suitable surfactant for the degradation of phenanthrene by Polyporus sp. S 133. The degradation rate increased as the amount of Tween 80 added increased. The rate in agitated cultures was about 2 times that in non-agitated cultures. The mechanism of degradation was determined through the identification of metabolites; 9,10-phenanthrenequinone, 2,2＇-diphenic acid, phthalic acid, and protocatechuic acid. Several enzymes （manganese peroxidase, lignin peroxidase, laccase, 1,2-dioxygenase and 2,3-dioxygenase） produced by Polyporus sp. S133 were detected during the incubation. The highest level of activity was shown by 1,2-dioxygenase （187.4 U/l） after 20 days of culture.

关键词： phenanthrene biodegradation metabolites Polyporus sp. S 133

Hotspot of Adult Cuban Treefrog and Cane Toad Multi-organ Abnormality in Suburban South-west Florida

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Asian Herpetological Research 2020年第2期11卷 139-154页

作者： Sharon Pratt ANZAlDUA Javier goldberg Private University 27427 Horne Ave Bonita SpringsFlorida 34135USA Instituto de Bio y Geociencias del NOA(IBIGEO-CONICET) CCT-Salta9 de Julio 14Rosario de LermaSalta 4405Argentina

This study represents a continuation of the Florida hotspot of tadpole abnormality found in the Southwest Florida suburban roadside drainage ditches in 2012 to determine if the adult frogs and toads frequenting the study sites were anatomically *** gross examination of all organs included 397 adult anurans and 40 metamorphs representing five anuran species:Osteopilus septentrionalis(N=364),Rhinella marina(N=60),lithobates sphenocephala(N=7),Anaxyrus terrestris(N=5)and Anaxyrus americanus(N=1).The gonads,liver,kidney and intestines were abnormal at a frequency of 87.4%.The few normal anurans(12.6%)were females and young male *** found a significant difference in organ abnormality type and f requency between *** all f rog and toad males had testicular abnormality(92%)with only 6%with normal testes,whereas the female gonad abnormality was lower,at 41.6%.Hermaphroditism was found in both sexes at a frequency of 26.2%.The toads had a significantly higher frequency of hermaphroditism than the *** toad hermaphroditism frequency was found to be 40%,whereas the frog hermaphroditism 23.3%.A hermaphrodite Cane toad male with a female phenotype coexisted with the normal male phenotype *** fertility of 27 in situ pairs was *** fertile testicular abnormal male and hermaphrodite pairs produced offspring with abnormal larval *** information adds new evidence of the effect of chemicals on wild populations and the effect on non-target species which has always been underestimated.

关键词： gonad hermaphrodite malformation Osteopilus septentrionalis Rhinella marina

Epidemiological, Clinical and Evolutionary Aspects of Human African Trypanosomiasis in Children in Nola

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Open Journal of Pediatrics 2024年第2期14卷 344-358页

作者： Brice Olivier Bogning Mejiozem Gaspard Tékpa Synthia Ningatoloum Nazita Jocelyn tony Nengom Danebera lydie Verlaine Carine Judith Kiteze Nguinzanémou Rostand Juste Koyangboi Kombaya Iris Vanessa Gaspiet Sonny Jean Chrysostome Gody Complexe Hospitalier Pédiatrique de Bangui Bangui République Centrafricaine Service des Maladies Infectieuses H&#244pital de l’Amitié Bangui République Centrafricaine Faculté des Sciences de la Santé de l’Université de Bangui Bangui République Centrafricaine Centre Hospitalo Universitaire Communautaire de Bangui Bangui République Centrafricaine Faculté de Médecineet des Sciences Biomédicales Université de Yaoundé 1 Yaoundé Cameroun

Background: Human African trypanosomiasis (HAT) occurs in three historical foci in the Central African Republic. Objective: To describe the morbi-mortality of childhood HAT in rural Central African Republic with the aim of early management. Methods: Descriptive and analytic cross-sectional study conducted from January 1, 2017 to March 30, 2018 at Nola prefectural hospital. This study was included all children seen as outpatients and/or hospitalized in the pediatric wards, in whom the diagnosis of HAT was confirmed. Statistical analysis was performed using Epi-info software. Results: Forty children were included from Bilolo (60%), Nola (30%) and Salo (10%). The sex ratio was 0.66 with a median age of 8.65 ± 12.48 years. Fever (82.5%), nocturnal insomnia (75%), daytime somnolence (67.5%), headache (65%), polyarthralgia (62.5%), convulsions 52.5% (n = 21), tremor (27.5%), trypanidism (7.5%) and delirium (2.5%) were the main functional signs. Examination signs were adenopathy (52.5%), paresthesia (30%), decreased cutaneous-abdominal reflexes (25%) and osteoarticular reflexes (17.5%), hyperesthesia (20%), extrapyramidal hypertonia (15%) and depression (2.5%). The children were in the lymphatic-blood phase in 65% of cases, and meningoencephalitis in 35%. Pentamidine was administered in 65% of cases. Four children died and 6 had neurological sequelae. There was an association between age under 5, Bilolo’s focus, the children’s history and the severity of the disease. Age under 5, gender, household, children’s activity, history and occurrence of sequelae were also associated. Conclusion: HAT remains a permanent threat to Central African children. Any clinical presentation combining long-term infectious signs and unexplained neurological or neuropsychological disorders must be treated with caution.

关键词： Morbidity-Mortality Child HAT Nola CAR

Role of myelin auto-antigens in pain:a female connection

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Neural Regeneration Research 2016年第6期11卷 890-891页

作者： Veronica I.Shubayev Alex Y.Strongin tony l.Yaksh Department of Anesthesiology University of CaliforniaSan DiegoLa JollaCAUSA VA San Diego Healthcare System La JollaCAUSA Sanford-Burnham-Prebys Medical Discovery Institute La jollaCAUSA

Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly *** origins are poorly understood and the pain is often refractory to common analgesic *** past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.

关键词： myelin understood stimulation poorly refractory analgesic microglia immunity signaling likely

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医学科学的大局观

中国社会组织 2016年第22期 53-55页

作者： Julian Gresser Jeffrey l.goldberg Alfredo A.Sadun

当在全球范围内，与脑相关性疾病每年的花销就超过了两万亿美金。在过去的一年里，阿尔兹海默病和老年痴呆两种疾病的全球支出就超过了6050亿美金，相当于全世界GDP的1％。按照目前的这个趋势，到2050年。单单阿尔兹海默病在美国的健康... 详细信息

当在全球范围内，与脑相关性疾病每年的花销就超过了两万亿美金。在过去的一年里，阿尔兹海默病和老年痴呆两种疾病的全球支出就超过了6050亿美金，相当于全世界GDP的1％。按照目前的这个趋势，到2050年。单单阿尔兹海默病在美国的健康医疗支出就可能超过1．1万亿美金。

关键词：医学科学大局观医疗支出老年痴呆性疾病 GDP

Development of an Explicit Symplectic Scheme that Optimizes the Dispersion-Relation Equation of the Maxwell’s Equations

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Communications in Computational Physics 2013年第4期13卷 1107-1133页

作者： tony W.H.Sheu l.Y.liang J.H.li Department of Engineering Science and Ocean Engineering National TaiwanUniversityNo.1Sec.4Roosevelt RoadTaipeiTaiwan Taida Institute of Mathematical Science(TIMS) National Taiwan UniversityTaiwan Center for Quantum Science and Engineering(CQSE) National Taiwan UniversityTaiwan

In this paper an explicit finite-difference time-domain scheme for solving the Maxwell’s equations in non-staggered grids is *** proposed scheme for solving the Faraday’s and Amp`ere’s equations in a theoretical manner is aimed to preserve discrete zero-divergence for the electric and magnetic *** inherent local conservation laws in Maxwell’s equations are also preserved discretely all the time using the explicit second-order accurate symplectic partitioned Runge-Kutta *** remaining spatial derivative terms in the semi-discretized Faraday’s and Amp`ere’s equations are then discretized to provide an accurate mathematical dispersion relation equation that governs the numerical angular frequency and the wavenumbers in two space *** achieve the goal of getting the best dispersive characteristics,we propose a fourth-order accurate space centered scheme which minimizes the difference between the exact and numerical dispersion relation *** the computational exercises,the proposed dual-preserving solver is computationally demonstrated to be efficient for use to predict the long-term accurate Maxwell’s solutions.

关键词： Maxwell’s equations non-staggered grids zero-divergence fourth-order dualpreserving solver dispersion relation equations

Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells

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Acta Pharmacologica Sinica 2007年第4期28卷 459-472页

作者： Sujit NAIR Ah-Ng tony KONG Graduate Program in Pharmaceutical Sciences Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe StateUniversity of New JerseyPiscatawayNew Jersey 08854USA

Many dietary phytochemicals exhibit health-beneficial effects including preven-tion of diseases such as cancer,as well as neurological,cardiovascular,inflam-matory,and metabolic ***,herbivorous and omnivorousanimals have been ingesting *** interaction between"animal-plant"ecosystems has resulted in an elaborate system of detoxification and defensemechanisms evolved by animals including *** cells,includinghuman cells,respond to these dietary phytochemicals by"non-classical receptorsensing"mechanisms of electrophilic chemical-stress typified by"thiol-modu-lated"cellular signaling events primarily leading to the gene expression of phar-macologically beneficial effects,but sometimes unwanted cytotoxicity *** has been studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols),which areeffective in chemical-induced,as well as genetically-induced,animal carcinogen-esis *** compounds typically generate"cellular stress"and modulategene expression of phase Ⅱ detoxifying/antioxidant ***,reac-tive oxygen species,and reactive nitrogen species are known to act as secondmessengers in the modulation of many cellular signaling pathways leading togene expression changes and pharmacological ***-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2),AP-1,NF-κB,tocite a few examples,sense and transduce changes in the cellular redox status andmodulate gene expression responses to oxidative and electrophilic stresses,pre-sumably via sulfhydryl modification of critical cysteine residues found on theseproteins and/or other upstream redox-sensitive molecular *** the currentreview,we will explore dietary cancer chemopreventive phytochemicals,discussthe link between oxidative/electrophilic stresses and the redox circuitry,and con-sider different redox-sensitive transcription *** will also discuss thekelch-l

关键词： redox Nrf2 Keapl NES NlS gene expression profiles

Novel in-capsule synthesis of metal-organic framework for innovative carbon dioxide capture system

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Green Energy & Environment 2023年第3期8卷 767-774页

作者： Wei Yu Ming Gao Guanhe Rim tony G.Feric Mark l.Rivers Ammar Alahmed Aqil Jamal Ah-Hyung Alissa Park State Key laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China lenfest Center for Sustainable Energy The Earth InstituteColumbia University918 S.W.Mudd HallMail Code 4711500 W 120th St.New YorkNY10027USA Department of Earth and Environmental Engineering 918 S.W.Mudd HallMail Code 4711500 W 120th St.New YorkNY10027USA Department of Chemical Engineering Columbia UniversityNew YorkNY10027USA University of Chicago ChicagoIL60637USA Research and Development Center Saudi AramcoDhahran31311Saudi Arabia

Metal-Organic Frameworks(MOFs)have been developed as solid sorbents for CO_(2) capture applications and their properties can be controlled by tuning the chemical blocks of their crystalline units.A number of MOFs(e.g.,HKUST-1)have been developed but the question remains how to deploy them for gas-solid ***,the direct use of MOFs as nanocrystals would lead to serious problems and ***,for the first time,we report a novel MOF-based hybrid sorbent that is produced via an innovative in-situ microencapsulated *** a custom-made double capillary microfluidic assembly,double emulsions of the MOF precursor solutions and UV-curable silicone shell fluid are ***,HKUST-1 MOF is successfully synthesized within the droplets enclosed in the gas permeable *** developed MOF-bearing microcapsules uniquely allow the deployment of functional nanocrystals without the challenge of handling ultrafine particles,and further,can selectively reject undesired compounds to protect encapsulated MOFs.

关键词： Encapsulation Metal-Organic Frameworks(MOFs) Carbon capture In-situ microencapsulated synthesis

Improved Growth and Stress Tolerance in the Arabidopsis oxtl Mutant Triggered by Altered Adenine Metabolism

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Molecular Plant 2012年第6期5卷 1310-1332页

作者： Suchada Sukrong Kil-Young Yun Patrizia Stadler Charan Kumar tony Facciuolo Barbara A.Moffatt Deane l.Falconec Department of Plant and Soil Science University of KentuckyLexingtonKY 40546USA Present address:Department of Pharmacognosy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand Department of Biological Sciences University of MassachusettsOne University AvenueLowellMA 01854USA Present address:Fungi and Plant Co.ltd Chungcheongbuk-doRepublic of Korea Department of Biology University of WaterlooWaterlooOntarioCanada

Plants perceive and respond to environmental stresses with complex mechanisms that are often associ- ated with the activation of antioxidant defenses. A genetic screen aimed at isolating oxidative stress-tolerant lines of Arabidopsis thaliana has identified oxtl, a line that exhibits improved tolerance to oxidative stress and elevated temperature but displays no apparent deleterious growth effects under non-stress conditions. Oxtl harbors a muta- tion that arises from the altered expression of a gene encoding adenine phosphoribosyltransferase （APT1）, an enzyme that converts adenine to adenosine monophosphate （AMP）, indicating a link between purine metabolism, whole-plant growth responses, and stress acclimation. The oxtl mutation results in decreased APT1 expression that leads to reduced enzymatic activity. Correspondingly, oxtl plants possess elevated levels of adenine. Decreased APT enzyme activity dir- ectly correlates with stress resistance in transgenic lines that ectopically express APT1. The metabolic alteration in oxtl plants also alters the expression of several antioxidant defense genes and the response of these genes to oxidative chal- lenge. Finally, it is shown that manipulation of adenine levels can induce stress tolerance to wild-type plants. Collectively, these results show that alterations in cellular adenine levels can trigger stress tolerance and improve growth, leading to increases in plant biomass. The results also suggest that adenine might play a part in the signals that modulate responses to abiotic stress and plant growth.

关键词： abiotic/oxidative environmental stress acclimation priming purine signaling salvage pathway thermotolerance.