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Folate and vitamin B12 in idiopathic male infertility

Asian Journal of Andrology 2011年第6期13卷 856-861页

作者： Laurel E Murphy James L Mills Anne M Molloy cong Qian tonia c carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine Division of Epidemiology Statistics and Prevention Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD 20892 USA School of Medicine Trinity College Dublin Dublin Ireland Glotech Inc Rockville MD 20850 USA Department of Obstetrics and Gynecology Sk~ne University Hospital in Lund Lund University S-221 85 Lund Sweden Reproductive Medicine centre Skane University Hospital Maimo Lund University S-205 02 Malmo Sweden

Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites and genes. We investigated whether idiopathic male infertility is associated with variants in folate, vitamin B12 （B12） and total homocysteine （tHcy）-related genes and measured these metabolites in blood. We conducted a case-control study that included 153 men with idiopathic infertility and 184 fertile male controls recruited at the Fertility center and Antenatal care center, University Hospital, Malmo and Lund, Sweden. Serum folate, red cell folate （RcF）, serum B12, plasma tHcy and semen quality were measured. Subjects were genotyped for 20 common variants in 12 genes related to folate/B12/ homocysteine metabolism. Metabolite concentrations and genotype distributions were compared between cases and controls using linear and logistic regression with adjustment for covariates. The phosphatidylethanolamine N-methyltransferase （PEMT） M 175V and TcblR rs173665 polymorphisms were significantly associated with infertility （P=0.01 and P=0.009, respectively）, but not with semen quality. Among non-users of supplements, infertile men had lower serum folate concentrations than fertile men （12.89 vs. 14.73 nmoll^- 1 P=0.02）, but there were no significant differences in RcF, B 12 or tHcy. Folate, B 12 and tHcy concentrations were not correlated with any semen parameters. This study provides little support for low folate or B12 status in the pathogenesis of idiopathic male infertility. Although additional data are needed to confirm these initial findings, our results suggest that PEMTand TcbIR, genes involved in choline and B12 metabolism, merit further investigation in idiopathic male infertility.

关键词： folate idiopathic male infertility semen quality vitamin B12

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Application of Predictive Model for Efficient cassava (Manihot esculenta crantz) Yield in the Face of climate Variability in Enugu State, Nigeria

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American Journal of climate change 2024年第2期13卷 361-389页

作者： Emeka Bright Ogbuene tonia Nkiru Nwobodo Obianuju Gertrude Aloh Achoru Fred Emeka Josiah c. Ogbuka Vivian Amarachi Ozorme Andrew M. Oroke Obiageli Jacinta Okolo Anwara Obianuju Amara E. S. Enemuo centre for Environmental Management and control (cEMAc) University of Nigeria Nsukka Nigeria Department of Geography University of Nigeria Nsukka Nigeria Department of Geography and Meteorology Enugu State University of Science and Technology (ESUT) Enugu Nigeria School of civil Engineering Newcastle University Newcastle upon Tyne UK

climate variability as occasioned by conditions such as extreme rainfall and temperature, rainfall cessation, and irregular temperatures has considerable impact on crop yield and food security. This study develops a predictive model for cassava yield (Manihot esculenta crantz) amidst climate variability in rainfed zone of Enugu State, Nigeria. This study utilized data of climate variables and tonnage of cassava yield spanning from 1971 to 2012;as well as information from a questionnaire and focus group discussion from farmers across two seasons in 2023 respectively. Regression analysis was employed to develop the predictive model equation for seasonal climate variability and cassava yield. The rainfall and temperature anomalies, decadal change in trend of cassava yield and opinion of farmers on changes in rainfall season were also computed in the study. The result shows the following relationship between cassava and all the climatic variables: R2 = 0.939;P = 0.00514;cassava and key climatic variables: R2 = 0.560;P = 0.007. The result implies that seasonal rainfall, temperature, relative humidity, sunshine hours and radiation parameters are key climatic variables in cassava production. This is supported by computed rainfall and temperature anomalies which range from −478.5 to 517.8 mm as well as −1.2˚c to 2.3˚c over the years. The questionnaire and focus group identified that farmers experienced at one time or another, late onset of rain, early onset of rain or rainfall cessation over the years. The farmers are not particularly sure of rainfall and temperature characteristics at any point in time. The implication of the result of this study is that rainfall and temperature parameters determine the farming season and quantity of productivity. Hence, there is urgent need to address the situation through effective and quality weather forecasting network which will help stem food insecurity in the study area and Nigeria at large. The study made recommendations such as a

关键词： climate Variability cassava (Manihot esculenta crantz) Predictive Model Yield

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简易设计步骤：供建筑施工承包商报价用的《华盛顿州绿色混凝土砌体体系(Gcs)指南(西北版)》内容与工作

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建筑砌块与砌块建筑 2017年第4期 21-24,41页

作者： tonia Sorrel-Neal 崔玉忠(译) 杜建东(校) 华盛顿州砌体研究所华盛顿州砌筑工程承包商协会华盛顿州建造业协会不详

需要在太平洋西北海岸地区采取新途径从2016年起,由于相应建筑规范、能效管理规范和其它标准规范中,均出现了新的要求,混凝土砌体及其配套部件的设计,变得越来越具挑战性,建筑设计、结构设计和施工（简称：A/E/c）领域的相关团体,需要... 详细信息

需要在太平洋西北海岸地区采取新途径从2016年起,由于相应建筑规范、能效管理规范和其它标准规范中,均出现了新的要求,混凝土砌体及其配套部件的设计,变得越来越具挑战性,建筑设计、结构设计和施工（简称：A/E/c）领域的相关团体,需要与混凝土砌体块材供应商共同来分担这些挑战。华盛顿砌体协会（MIW）与行业合作伙伴一起,打算开发、创建出一份便于建筑师、结构工程师和施工总承包商,

关键词：施工承包商华盛顿州 Gcs 指南绿色混凝土结构工程师砌体结构砌筑施工墙体结构报价

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苍白球刺激可缓解肌阵挛-肌张力障碍综合征

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 29-30页

作者： Magarios-Ascone c.M. Regidor I. Martnez-castr-illo J.c. 邓剑平 Neurologa Experimental Dipartimento di Investigación Hospital Ramón Y Cajal Madrid 28034 Spain Dr.

A patient with myoclonus- dystonia syndrome was treated by implanting electr odes in the internal segment of the globus pallidus (GPi) and applying deep brai n stimulation. Surgery was done in two sessions. The most affected limb was trea ted first and the other limb one year later. Neuronal recordings showed that mos t pallidal neurones discharged in bursts at a relatively low firing rate (mean ( SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson’ s d isease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke- F ahn- Marsden and disability rating scales, respectively.

关键词：苍白球肌阵挛爆发式放电帕金森病神经元放电深部脑刺激内侧部植入电极放电频率张力障碍

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