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Journal of Rare Earths 2023年第8期41卷 1127-1134,I0001页

作者： Qing lin tongyu Gao Yuanhong Liu Ronghui Liu Siwei Chen Xiaole Ma Chunlei Zhao National Engineering Research Center for Rare Earth GRINM Group Co.Ltd.Beijing 100088China GRIREM Advanced Materials Co. Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China

Red phosphor,with longer wavelength,is highly desirable for full-spectrum WLEDs.Targeted deep red phosphors(Sr,Gd)Li(AI,Mg)_(3)N_(4):Eu^(2+)were designed from the initial model of SrLiAl_(3)N_(4):Eu^(2+)by structural modification.The correlations among structural evolution,crystal-field environment,and luminescence properties were elucidated.Replacing Sr^(2+)with Gd^(3+)in(Sr,Gd)LiAl_(3)N_(4):Eu^(2+)leads to the enhanced crystal field splitting,larger Stokes shift,and increased structural polyhedron distortion differences,consequently resulting in spectral red-shift and broadening.For further spectral tuning,Mg,with lower electronegativity,was also introduced to modify the local crystal structure,consequently resulting in a further red-shift towards 675 nm and enhanced photoluminescence intensity in(Sr,Gd)Li(AI,Mg)_(3)N_(4):Eu^(2+).What’s more,w-LEDs were fabricated by using blue LED chip,blue,green,red and deep red((Sr,Gd)Li(Al,Mg)_(3)N_(4):Eu^(2+))phosphors whose color rendering index were Ra 96.0 and R997.7.All above results demonstrate that the partial replacements of Sr^(2+)by Gd^(3+)and Al^(3+)by Mg^(2+)are effective methods for spectral modulation and(Sr,Gd)Li(AI,Mg)_(3)N_(4):Eu^(2+)phosphors are suitable for highquality full-spectrum WLEDs.

关键词： Full-spectrum WLEDs Structural modulation Deep red phosphor Rare earths

Current Challenges in Diagnosis and Management in emanodal NK/T-cell lymphoma nasal type

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Current Challenges in Diagnosis and Management in emanodal N...

Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study

第四届全国血液肿瘤学术大会暨第七届全国淋巴肿瘤诊治进展...

作者： Tongyu Lin Cancer center Sun Yat-sen University

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Chinese Medical Journal 2022年第4期135卷 433-440页

作者： Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Hematology The First Hospital of Jilin UniversityChangchunJilin 130015China Department of Medical Oncology Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430023China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Oncology Jiangsu Cancer HospitalNanjing Medical University Affiliated Cancer HospitalNanjingJiangsu 210009China Consultant to F.Hoffmann-La Roche Ltd BaselSwitzerlandvia GCE Solutions-an IQVIA businessSwitzerland Product Development Oncology F.Hoffmann-La Roche LtdBaselSwitzerland Department of Medical Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South Chinaand Collaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510075China

Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968.

关键词： Chinese Follicular lymphoma GALLIUM Obinutuzumab Rituximab

Research on a New Fiber-Optic Axial Pressure Sensor of Transformer Winding Based on Fiber Bragg Grating

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Photonic Sensors 2017年第4期7卷 365-371页

作者： Yuan LIU Lianqing LI lin ZHAO Jiqiang WANG tongyu LIU Shandong Provincial Key Laboratory of Optical Fiber Sensing Technologies Laser Institute of Shandong Academy ofSciences Jinan 250014 China

基于纤维布拉格栅栏的原则，为变压器弯屈的轴的力量测量的光纤的压力传感器的一种新类型被设计，它与把板横梁，包装过程的优化，和传感器的材料弄弯的结构被设计。通过刻度试验校准传感器， Taikai 变压器工厂的地测试结果证明传感器... 详细信息

基于纤维布拉格栅栏的原则，为变压器弯屈的轴的力量测量的光纤的压力传感器的一种新类型被设计，它与把板横梁，包装过程的优化，和传感器的材料弄弯的结构被设计。通过刻度试验校准传感器， Taikai 变压器工厂的地测试结果证明传感器的敏感是 0.133 pm/kPa，重覆性错误是 2.7% FS。在不同位置的光纤的压力传感器的数据维持一致、可重复，它能满足变压器弯屈的轴的力量的即时监视的要求。

关键词：光纤压力传感器光纤布拉格光栅变压器绕组轴向力材料设计封装工艺标定实验变压器厂

Natural scaffolds-inspired synthesis of CF_(3)-substituted macrolides enabled by Rh-catalyzed C–H alkylation macrocyclization

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Chinese Chemical Letters 2022年第4期33卷 2015-2020页

作者： tongyu Bi Yi Xu Xin Xu Bixi Tang Qing Yang Yi Zang Zhenyang lin Jia Li Weibo Yang Chinese Academy of Sciences Key Laboratory of Receptor Research Shanghai Institute of Materia Medica(SIMM)Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry The Hong Kong University of Science and TechnologyHong KongChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The development of innovative strategies and methods to provide natural product-like macrocycles not accessible by biosynthesis, but endowed with novel bioactivities and simplified structure, is highly desirable. Inspired by the key scaffolds of rapamycin and FR252921, herein, we report a Rh(III)-catalyzed C–H alkylation macrocyclization, which enables access to CF_(3)-substituted macrolides. DFT calculations reveal that the chemoselectivity between C–H alkylation and olefination macrocyclization was highly controllable. Moreover, the unique CF_(3)-substituted macrolides showed potent anti-inflammation activities against TNF-α, IL-6 and CCL2 m RNA expression.

关键词： Rh-catalyzed C–H alkylation Late stage macrocyclization DFT calculation Anti-inflammation

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课堂教学的知识立场辨析

现代教育管理 2023年第8期 58-66页

作者：魏同玉叶琳江苏师范大学江苏徐州221116 沈阳医学院辽宁沈阳110034

先验主义认识论的知识立场、管理主义的知识立场和实用主义的知识立场对认识和解决课堂教学场域中的知识问题具有局限性,不能作为其主导立场。从知识对学生发展的意义视角看知识与人的关系,以知识为媒介的课堂教学需要秉持厚实的知识观... 详细信息

先验主义认识论的知识立场、管理主义的知识立场和实用主义的知识立场对认识和解决课堂教学场域中的知识问题具有局限性,不能作为其主导立场。从知识对学生发展的意义视角看知识与人的关系,以知识为媒介的课堂教学需要秉持厚实的知识观,以此培育走向自立、自觉和自新的“真人”,由此,课堂教学中知识的育人立场才能得以明确。与此同时,还需要处理好知识育人的难为与应为、知识的育人立场与其他立场的关系以及知识育人立场的变与不变问题。

关键词：课堂教学知识立场厚实的知识观育人立场真人

Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma

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Cancer Biology & Medicine 2021年第3期18卷 833-840页

作者： Meiting Chen Zhao Wang Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan Xiaoqian Li Zhiming Li Qingqing Cai He Huang Tongyu Lin Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Senior Ward/PhaseⅠClinical Trial Ward Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China

Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center.We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle cytarabine.Forty-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based chemotherapy.Seventy-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC regimens.Results:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,respectively.Major grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,respectively.We observed 4 cases(3.3%)of septic shock after chemotherapy.Two treatment-related deaths occurred from severe infection.Conclusions:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens.

关键词： Sporadic Burkitt lymphoma modified chemotherapy toxicity R-CODOX-M/IVAC adults

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探究生态足迹理论下的房车营地生态景观设计

江西建材 2022年第6期 340-341,344页

作者：林桐羽厦门东方瑞禾景观设计有限公司福建厦门361000

文中对房车营地、生态足迹理论进行了概述,分析了房车营地生态景观设计的重要性,并探究了生态足迹理论下的房车营地生态景观设计。

关键词：生态足迹理论房车营地生态景观

Ridge subduction, magmatism, and metallogenesis

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Science China Earth Sciences 2020年第10期63卷 1499-1518页

作者： Qiang WANG Gongjian TANG Lulu HAO Derek WYMAN lin MA Wei DAN Xiuzheng ZHANG Jinheng LIU tongyu HUANG Chuanbing XU State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China School of Geosciences The University of SydneyNSW 2006Australia

Modern oceans contain large bathymetric highs(spreading oceanic ridges,aseismic ridges or oceanic plateaus and inactive arc ridges)that,in total,constitute more than 20–30%of the total area of the world’s ocean floor.These bathymetric highs may be subducted,and such processes are commonly referred to as ridge subduction.Such ridge subduction events are not only very common and important geodynamic processes in modern oceanic plate tectonics,they also play an important role in the generation of arc magmatism,material recycling,the growth and evolution of continental crust,the deformation and modification of the overlying plates,and metallogenesis at convergent plate boundaries.Therefore,these events have attracted widespread attention.The perpendicular or high-angle subduction of mid-ocean spreading ridges is commonly characterized by the occurrence of a slab window,and the formation of a distinctive adakite–high-Mg andesite–Nb-enriched basalt-oceanic island basalt(OIB)or a mid-oceanic ridge basalt(MORB)-type rock suite,and is closely associated with Au mineralization.Aseismic ridges or oceanic plateaus are traditionally considered to be difficult to subduct,to typically collide with arcs or continents or to induce flat subduction(low angle of less than 10°)due to the thickness of their underlying normal oceanic crust(>6–7 km)and high topography.However,the subduction of aseismic ridges and oceanic plateaus occurred on both the western and eastern sides of the Pacific Ocean during the Cenozoic.On the eastern side of the Pacific Ocean,aseismic ridges or oceanic plateaus are being subducted flatly or at low angles beneath South and Central American continents,which may cause a magmatic gap.But slab melting can occur and adakites,or an adakite–high-Mg andesite–adakitic andesite–Nb-enriched basalt suite may be formed during the slab rollback or tearing.Cu-Au mineralization is commonly associated with such flat subduction events.On the western side of the Pacific Ocean,however,aseismic ridges and oceanic plateaus are s

关键词： Spreading mid ocean ridge Aseismic ridge Oceanic plateau Inactive arc ridge Subduction Magmatism Metal minerlization Crustal growth

Phase Ⅱ/Ⅲ randomized trial of CID-ATT with radiotherapy compared with CHOP with radiotherapy as first-line treatment for previously untreated early staging extranodal NK/T-cell lymphoma, nasal type

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Phase Ⅱ/Ⅲ randomized trial of CID-ATT with radiotherapy co...