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Intelligent diagnosis of atrial septal defect in children using echocardiography with deep learning

虚拟现实与智能硬件（中英文） 2024年第3期6卷 217-225页

作者： Yiman LIU Size HOU Xiaoxiang HAN tongtong liang Menghan HU Xin WANG Wei GU Yuqi ZHANG Qingli LI Jiangang CHEN Shanghai Key Laboratory of Multidimensional Information Processing School of Communication&Electronic EngineeringEast China Normal UniversityShanghaiChina Department of Pediatric Cardiology Shanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Applied Mathematics Xi'an Jiaotong-Liverpool UniversitySchool of ScienceSuzhouChina School of Health Sciences and Engineering University of Shanghai for Science and TechnologyShanghaiChina Minhang District Centers for Disease Control and Prevention ShanghaiChina Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghai 201203China

Background Atrial septal defect(ASD)is one of the most common congenital heart *** diagnosis of ASD via transthoracic echocardiography is subjective and *** The objective of this study was to evaluate the feasibility and accuracy of automatic detection of ASD in children based on color Doppler echocardiographic static images using end-to-end convolutional neural *** proposed depthwise separable convolution model identifies ASDs with static color Doppler images in a standard *** the standard views,we selected two echocardiographic views,i.e.,the subcostal sagittal view of the atrium septum and the low parasternal four-chamber *** developed ASD detection system was validated using a training set consisting of 396 echocardiographic images corresponding to 198 ***,an independent test dataset of 112 images corresponding to 56 cases was used,including 101 cases with ASDs and 153 cases with normal *** The average area under the receiver operating characteristic curve,recall,precision,specificity,F1-score,and accuracy of the proposed ASD detection model were 91.99,80.00,82.22,87.50,79.57,and 83.04,*** The proposed model can accurately and automatically identify ASD,providing a strong foundation for the intelligent diagnosis of congenital heart diseases.

关键词： Deep learning Atrial septal defect Echocardiography

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上海市闵行区高血压高危人群的发病风险

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上海预防医学 2024年第1期36卷 59-63页

作者：梁彤彤李俊张金玲奥宇宏杨加丽许慧琳上海市闵行区疾病预防控制中心上海201101

【目的】探讨上海市闵行区高血压高危人群高血压发病情况和影响因素,为今后开展高血压高危人群的社区管理提供科学依据。【方法】采用回顾性队列研究方法,利用上海市闵行区2011年1月1日—2017年12月31日建档的高血压高危人群电子健康档... 详细信息

【目的】探讨上海市闵行区高血压高危人群高血压发病情况和影响因素,为今后开展高血压高危人群的社区管理提供科学依据。【方法】采用回顾性队列研究方法,利用上海市闵行区2011年1月1日—2017年12月31日建档的高血压高危人群电子健康档案数据,研究终点事件为发生高血压。于2021年12月终止随访,对最终纳入的17265名高血压高危人群进行分析。用SPSS 20.0软件进行Logrank检验和Cox回归分析。【结果】上海市闵行区平均随访6.04年后的高血压高危人群发生高血压的比例为25.5%。高血压家族史(HR=1.250,95%CI:1.168~1.338)、卒中家族史(HR=1.295,95%CI:1.080~1.553)、糖尿病疾病史(HR=1.203,95%CI:1.076~1.345)、每天吸烟(HR=1.187,95%CI:1.087~1.296)、超重(HR=1.393,95%CI:1.308~1.484)、肥胖(HR=1.903,95%CI:1.719~2.106)、血压正常高值(HR=1.275,95%CI:1.195~1.359)、年龄增加(HR=1.033,95%CI:1.030~1.036)是高血压高危人群发生高血压的危险因素,消瘦(HR=0.649,95%CI:0.500~0.840)是高血压高危人群发生高血压的保护因素。【结论】应对年龄大、有高血压家族史、卒中家族史、糖尿病疾病史、血压正常高值人群加强血压监测,达到高血压早发现的目的;对吸烟、超重、肥胖等人群应及时采取干预措施。

关键词：高血压高危人群高血压发病率影响因素生存分析

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不同信号肽对猪瘟E0蛋白在HEK-293F细胞中分泌表达的影响及E0-ELISA方法的建立

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中国兽医科学 2024年第9期54卷 1195-1201页

作者：方琪罗烨梁彤彤张珊玲冯泽中谢诗晴郑金尹德明余兴龙湖南农业大学动物医学院湖南长沙410128 湖南康保特生物科技有限公司湖南长沙410128

为建立以猪瘟病毒(CSFV)E0蛋白为包被抗原的间接ELISA方法,构建含5种常用信号肽及其内源信号肽的CSFV E0重组表达质粒,瞬时转染至HEK-293F细胞中表达。Western-blot结果显示,不同信号肽介导的E0蛋白在细胞中均能分泌表达,其中人胰岛素(I... 详细信息

为建立以猪瘟病毒(CSFV)E0蛋白为包被抗原的间接ELISA方法,构建含5种常用信号肽及其内源信号肽的CSFV E0重组表达质粒,瞬时转染至HEK-293F细胞中表达。Western-blot结果显示,不同信号肽介导的E0蛋白在细胞中均能分泌表达,其中人胰岛素(Insulin)信号肽介导的E0蛋白分泌表达水平最高。将其纯化后的E0蛋白作为包被抗原建立间接ELISA方法,并与IDEXX ELISA试剂盒平行检测173份血清,结果显示E0-ELISA与IDEXX ELISA符合率为92.49%。将两者分别与病毒中和试验(VNT)对比,结果显示E0-ELISA与VNT符合率为95.38%,IDEXX ELISA与VNT符合率为91.33%,说明E0-ELISA比IDEXX ELISA更敏感。本研究通过使用不同信号肽使猪瘟E0蛋白在HEK-293F中高效糖基化表达,以该E0蛋白作为包被抗原建立了E0-ELISA方法,为临床鉴别猪瘟野毒感染提供了技术手段。

关键词： E0蛋白信号肽猪瘟病毒 HEK-293F 间接ELISA

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Distributed Deep Reinforcement Learning:A Survey and a Multi-player Multi-agent Learning Toolbox

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Machine Intelligence Research 2024年第3期21卷 411-430页

作者： Qiyue Yin tongtong Yu Shengqi Shen Jun Yang Meijing Zhao Wancheng Ni Kaiqi Huang Bin liang liang Wang Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Automation Tsinghua UniversityBeijing 100084China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesBeijing 100190China

With the breakthrough of AlphaGo,deep reinforcement learning has become a recognized technique for solving sequential decision-making *** its reputation,data inefficiency caused by its trial and error learning mechanism makes deep reinforcement learning difficult to apply in a wide range of *** methods have been developed for sample efficient deep reinforcement learning,such as environment modelling,experience transfer,and distributed modifications,among which distributed deep reinforcement learning has shown its potential in various applications,such as human-computer gaming and intelligent *** this paper,we conclude the state of this exciting field,by comparing the classical distributed deep reinforcement learning methods and studying important components to achieve efficient distributed learning,covering single player single agent distributed deep reinforcement learning to the most complex multiple players multiple agents distributed deep reinforcement ***,we review recently released toolboxes that help to realize distributed deep reinforcement learning without many modifications of their non-distributed *** analysing their strengths and weaknesses,a multi-player multi-agent distributed deep reinforcement learning toolbox is developed and released,which is further validated on Wargame,a complex environment,showing the usability of the proposed toolbox for multiple players and multiple agents distributed deep reinforcement learning under complex ***,we try to point out challenges and future trends,hoping that this brief review can provide a guide or a spark for researchers who are interested in distributed deep reinforcement learning.

关键词： Deep reinforcement learning distributed machine learning self-play population-play toolbox

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LSDA-APF:A Local Obstacle Avoidance Algorithm for Unmanned Surface Vehicles Based on 5G Communication Environment

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工程与科学中的计算机建模(英文) 2024年第1期138卷 595-617页

作者： Xiaoli Li tongtong Jiao Jinfeng Ma Dongxing Duan Shengbin liang School of Software Henan UniversityKaifeng475004China

In view of the complex marine environment of navigation,especially in the case of multiple static and dynamic obstacles,the traditional obstacle avoidance algorithms applied to unmanned surface vehicles(USV)are prone to fall into the trap of local ***,this paper proposes an improved artificial potential field(APF)algorithm,which uses 5G communication technology to communicate between the USV and the control *** algorithm introduces the USV discrimination mechanism to avoid the USV falling into local optimization when the USV encounter different obstacles in different *** the various scenarios between the USV and other dynamic obstacles such as vessels in the process of performing tasks,the algorithm introduces the concept of dynamic artificial potential *** the multiple obstacles encountered in the process of USV sailing,based on the International Regulations for Preventing Collisions at Sea(COLREGS),the USV determines whether the next step will fall into local optimization through the *** local potential field of the USV will dynamically adjust,and the reverse virtual gravitational potential field will be added to prevent it from falling into the local optimization and avoid *** objective function and cost function are designed at the same time,so that the USV can smoothly switch between the global path and the local obstacle *** simulation results show that the improved APF algorithm proposed in this paper can successfully avoid various obstacles in the complex marine environment,and take navigation time and economic cost into account.

关键词： Unmanned surface vehicles local obstacle avoidance algorithm artificial potential field algorithm path planning collision detection

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Selective oxygen electroreduction to hydrogen peroxide in acidic media:The superiority of single-atom catalysts

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Nano Research 2024年第6期17卷 4668-4681页

作者： Ergui Luo tongtong Yang Jingyi liang Yuhong Chang Junming Zhang Tianjun Hu Junjie Ge Jianfeng Jia Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Two-electron oxygen reduction reaction(2e-ORR)provides an environmentally friendly direction for the on-site production of hydrogen peroxide(H_(2)O_(2)).Central to this technology is the exploitation of efficient,economical,and safe 2e-ORR *** overview starts with the fundamental chemistry of ORR to highlight the decisive role of adsorbing intermediates on the reaction pathway and activity,followed by a comprehensive survey of the tuning strategies to favor 2e-ORR on traditional precious *** latest achievements in designing efficient and selective precious-metal-based single-atom catalysts(SACs)and metal-nitrogen-carbon(M-Nx/C)catalysts,from the aspects of material synthesis,theoretical calculations,and mass transport promotion,are systematically *** introductions on the evaluation metrics for 2e-ORR catalysts and the primary reactor designs for cathodic H_(2)O_(2)synthesis are also *** conclude this review with an outlook on the challenges and direction of efforts to advance electrocatalytic 2e-ORR into realistic H_(2)O_(2)production.

关键词： oxygen reduction reaction H_(2)O_(2)production single-atom catalysts selectivity

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习近平关于青年工作的重要思想研究的现状与展望--基于CSSCI数据库(2013-2021)的文献计量分析

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济南大学学报（社会科学版） 2023年第1期33卷 165-172,176页

作者：梁彤彤张亮南京大学哲学系江苏南京210023

基于2013-2021年间CSSCI数据库(含扩展版)中“习近平关于青年工作的重要思想”的文献计量分析发现:十八大以来,相关研究总体呈现持续上升的趋势,在研究领域、研究队伍、研究内容等方面不断拓展丰富。学界围绕着形成背景、科学内涵与实... 详细信息

基于2013-2021年间CSSCI数据库(含扩展版)中“习近平关于青年工作的重要思想”的文献计量分析发现:十八大以来,相关研究总体呈现持续上升的趋势,在研究领域、研究队伍、研究内容等方面不断拓展丰富。学界围绕着形成背景、科学内涵与实践路径以及时代价值等主要内容对这一重要思想展开了研究和讨论。为进一步深化研究提供思路和参考,以更好地用习近平新时代中国特色社会主义思想武装头脑、指导实践。建议未来的研究要进一步关注思想的时代原创性意义,把握思想的严密逻辑性,丰富思想的科学内涵研究,完善青年工作培育目标的内涵逻辑研究,加强思想的实践性研究。

关键词：习近平青年工作重要思想计量分析

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FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 1605-1623页

作者： Zhifeng Huang tongtong Pan liang Xu Lu Shi Xiong Ma Liya Zhou Luyao Wang Jiaojiao Wang Guoqing Zhu Dazhi Chen Lingtao Song Xiaomin Pan Xiaodong Wang Xiaokun Li Yongde Luo Yongping Chen Hepatology Diagnosis and Treatment Center Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseasesthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China School of Laboratory Medicine and Life Sciences Wenzhou Medical University&Key Laboratory of Laboratory MedicineMinistry of EducationWenzhou Medical UniversityWenzhou 325035China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthState Key Laboratory for Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Hangzhou Medical College Hangzhou 311300China

Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine;however, its role in ILI remains unclear. In patients with autoimmune hepatitis (type of ILI) and mouse models of concanavalin A (ConA)- or S-100-induced ILI, we observed a biphasic pattern in hepatic FGF4 expression, characterized by an initial increase followed by a return to basal levels. Hepatic FGF4 deficiency activated the mitochondria-associated intrinsic apoptotic pathway, aggravating hepatocellular apoptosis. This led to intrahepatic immune hyper-reactivity, inflammation accentuation, and subsequent liver injury in both ILI models. Conversely, administration of recombinant FGF4 reduced hepatocellular apoptosis and rectified immune imbalance, thereby mitigating liver damage. The beneficial effects of FGF4 were mediated by hepatocellular FGF receptor 4, which activated the Ca^(2+)/calmodulin-dependent protein kinasekinase 2 (CaMKKβ) and its downstream phosphatase and tensin homologue-induced putative kinase 1 (PINK1)-dependent B-cell lymphoma 2-like protein 1-isoform L (Bcl-XL) signalling axis in the mitochondria. Hence, FGF4 serves as an early response factor and plays a protective role against ILI, suggesting a therapeutic potential of FGF4 and its analogue for treating clinical immune disorder-related liver injuries.

关键词： Fibroblast growthfactor 4 Fibroblast growth factor receptor 4 Immune liver injury Ca^(2+)/Calmodulin dependent protein

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马尔库塞的青年革命观及其启示

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晋阳学刊 2023年第1期 85-90页

作者：梁彤彤南京大学哲学系南京210023

马尔库塞与六十年代青年学生互为标签,紧密地联系在一起。青年学生的反抗吸引着马尔库塞的目光,并把他从革命的悲观情绪中拉回,重新燃起对革命前景规划的希望。马尔库塞的青年革命观的核心是对“新感性”青年的召唤,他积极参与到青年学... 详细信息

马尔库塞与六十年代青年学生互为标签,紧密地联系在一起。青年学生的反抗吸引着马尔库塞的目光,并把他从革命的悲观情绪中拉回,重新燃起对革命前景规划的希望。马尔库塞的青年革命观的核心是对“新感性”青年的召唤,他积极参与到青年学生运动当中,奔走于为鼓舞学生进行反抗的演讲、报告之中。但实际上,青年们与马尔库塞的共鸣只是浮于表面的。一方面,马尔库塞的青年革命观没有坚实的理论基础;另一方面,青年群体在思想与行动上的矛盾性使得他们无法真正系统地理解理论家们的革命与解放理论。最终这场青年革命以失败告终,但是其引起的文化与生活方式的变革却深远地影响了一代代青年。

关键词：马尔库塞六十年代青年革命观

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论贾雨村的双面人生——兼及《儒林外史》中的匡超人形象

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河南教育学院学报（哲学社会科学版） 2019年第4期38卷 7-10页

作者：梁彤彤曲阜师范大学文学院

贾雨村和匡超人有着相似的发迹和堕落过程。贾雨村由一个豁达洒脱的穷儒转变为贪婪虚伪的恶官,匡超人由一个赤诚孝子转变成一个狼子野心的小人。堕落后的二人不仅没有丢官,反而更加顺风顺水,青云直上。这种现象与他们的出身、当时的社... 详细信息

贾雨村和匡超人有着相似的发迹和堕落过程。贾雨村由一个豁达洒脱的穷儒转变为贪婪虚伪的恶官,匡超人由一个赤诚孝子转变成一个狼子野心的小人。堕落后的二人不仅没有丢官,反而更加顺风顺水,青云直上。这种现象与他们的出身、当时的社会环境和官僚体制有着密切的关系。

关键词：贾雨村发迹堕落匡超人

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