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CMT2D neuropathy is influenced by vitamin D-mediated environmental pathway

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Journal of Molecular Cell Biology 2023年第4期15卷 64-67页

作者： Huaqing Liu Mingmin Tang Hualin Yu tongfei Liu Qinqin cui Linfan Gu Zhi-Ying Wu Nengyin Sheng Xiang-Lei Yang Linghui Zeng Ge Bai Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015China Department of Neurobiology and Department of Neurology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain–Machine IntegrationState Key Laboratory of Brain–Machine IntelligenceZhejiang UniversityHangzhou 311121China The Institute for Brain Science and Disease Chongqing Medical UniversityChongqing 400016China Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Dear Editor,Peripheral neuropathy is a group of devastating diseases affecting periphe-ral nerves and may cause symptoms such as extreme numbness,muscle weakness,and ***,there are no effective therapies for these *** progress has been made in identifying genetic causes for peripheral neuropathy owing to the advances in genetic testing in the last *** example,>100 genes have been identified to be associated with Charcot–Marie–Tooth(CMT)neuropathy,a group of disorders among the most common forms of inherited peripheral neuropathy.

关键词： neuropathy vitamin Marie

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小花清风藤中生物碱类成分的研究

中国药物化学杂志 2024年第2期34卷 120-125页

作者：朱仝飞朱小庆李志峰孙庆文李萍胡荣闫志慧王玉霞重庆医药高等专科学校重庆401331 重庆市药物制剂工程技术研究中心重庆401331 江西中医药大学江西南昌330006 贵州中医药大学贵州贵阳550025

目的对小花清风藤Sabia parviflora中的生物碱类成分进行研究。方法采用硅胶柱色谱、Sephadex LH-20色谱、制备薄层色谱及重结晶等方法,对小花清风藤中的化学成分进行分离纯化,根据理化性质和波谱数据分析鉴定化合物结构。结果从小花清... 详细信息

目的对小花清风藤Sabia parviflora中的生物碱类成分进行研究。方法采用硅胶柱色谱、Sephadex LH-20色谱、制备薄层色谱及重结晶等方法,对小花清风藤中的化学成分进行分离纯化,根据理化性质和波谱数据分析鉴定化合物结构。结果从小花清风藤中分离得到12个化合物,分别鉴定为N-反式阿魏酰基-3-甲氧基酪胺(1)、N-顺式阿魏酰基-3-甲氧基酪胺(2)、cassythicine(3)、litseglutine A(4)、鹅掌楸碱(5)、荷叶碱(6)、莲明碱(7)、白鲜碱(8)、γ-崖椒碱(9)、venoterpine(10)、桂皮酰胺(11)、莲碱(12)。结论化合物1~11为首次从清风藤属植物中分离得到,化合物12为首次从小花清风藤中分离得到。

关键词：小花清风藤化学成分生物碱鹅掌楸碱

A general strategy to the synthesis of carbon-supported PdM(M=Co,Fe and Ni)nanodendrites as high-performance electrocatalysts for formic acid oxidation

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Journal of Energy Chemistry 2017年第6期26卷 1238-1244页

作者： Yanrong Ma tongfei Li Hao Chen Xiaojie Chen Sihui Deng Lin Xu Dongmei Sun Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina

Rational synthesis of a new class of electrocatalysts with high-performance and low-cost is of great significance for future fuel cell devices. Herein, we demonstrate a general one-step simultaneous reduction method to prepare carbon-supported Pd M（M = Co, Fe, Ni） alloyed nanodendrites with the assistance of oleylamine and octadecylene. The morphology, structure and composition of the obtained Pd M nanodendrites/C catalysts have been fully characterized. The combination of the dendritic structural feature and alloyed synergy offer higher atomic utilization efficiency, excellent catalytic activity and enhanced stability for the formic acid oxidation reaction（FAOR）. Strikingly, the as-synthesized Pd Co nanodendrites/C catalyst could afford a mass current density of 2467.7 A g, which is almost 3.53 and 10.4 times higher than those of lab-made Pd/C sample(698.3 A g) and commercial Pd/C catalyst(237.6 A g), respectively. Furthermore, the PdC o nanodendrites/C catalyst also exhibit superior stability relative to the Pd/C catalysts, make it a promising anodic electrocatalyst in practical fuel cells in the future. Additionally, the present feasible synthetic approach is anticipated to provide a versatile strategy toward the preparation of other metal alloy nanodendrites/carbon nanohybrids.

关键词： PdM alloy Nanodendrites Electrocatalysts Formic acid oxidation

In Search of Regulators of LeSPL-CNRby South-Western Blotting and Yeast One-Hybrid Library Screening System

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American Journal of Plant Sciences 2018年第5期9卷 1037-1050页

作者： Xiaohong Wang Bishun Ye Ying Wang Ting Zhou tongfei Lai Research Centre for Plant RNA Signaling College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China Key Laboratory for Quality and Safety of Agricultural Products of Hangzhou City College of Life and Environmental Science Hangzhou Normal University Hangzhou China

LeSPL-CNR is a crucial transcription factor for fruit ripening of Solanum lycopersicum. The cnr (colorless non-ripening) epimutation resulted from hypermethylation in a 286 bp region of LeSPL-CNR promoter inhibits normal fruit ripening. In present study, potential regulators of LeSPL-CNR, which could bind to the specific 286 bp region, were screened via south-western blotting and yeast one-hybrid (Y1H) library screening system. Results indicated that a total of 13 and 19 candidate proteins were acquired respectively, and both ribulose-1,5-bisphosphate carboxylase/oxygenase and 40S ribosomal protein were identified by two methods. These would provide some information for revealing roles of DNA methylation and the regulatory mechanism for LeSPL-CNR.

关键词： Solanum lycopersicum LeSPL-CNR 286 bp Region South-Western Blotting Yeast One-Hybrid

Application of an Improved 2-Dimensional High-Throughput Soybean Root Phenotyping Platform to Identify Novel Genetic Variants Regulating Root Architecture Traits

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Plant Phenomics 2023年第4期5卷 728-745页

作者： Rahul Chandnani tongfei Qin Heng Ye Haifei Hu Karim Panjvani Mutsutomo Tokizawa Javier Mora Macias Alma Armenta Medina Karine C.Bernardino Pierre-Luc Pradier Pankaj Banik Ashlyn Mooney Jurandir V.Magalhaes Henry T.Nguyen Leon V.Kochian Global Institute for Food Security University of SaskatchewanSaskatoonSKCanada NRGene Canada 110 Research Dr Suite 101SaskatoonSKCanada Division of Plant Sciences and Technology University of MissouriColumbiaM065211USA School of Biological Sciences The University of Western AustraliaCrawleyWA 6009Australia Rice Research Institute Guangdong Academy of Agricultural Sciences&Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province)Ministry of Agriculture and Rural Affairs&Guangdong Key Laboratory of New Technology in Rice Breeding&Guangdong Rice Engineering LaboratoryGuangdongChina Embrapa Maize and Sorghum Sete LagoasBrazil

Nutrient-efficient root system architecture(RSA)is becoming an important breeding objective for generating crop varieties with improved nutrient and water acquisition *** variants shaping soybean RSA is key in improving nutrient and water ***,we report on the use of an improved 2-dimensional high-throughput root phenotyping platform that minimizes background noise by imaging pouch-grown root systems submerged in *** also developed a background image cleaning Python pipeline that computationally removes images of small pieces of debris and filter paper fibers,which can be erroneously quantified as root *** platform was used to phenotype root traits in 286 soybean lines genotyped with 5.4 million single-nucleotide *** was a substantially higher correlation in manually counted number of root tips with computationally quantified root tips(95%correlation),when the background was cleaned of nonroot materials compared to root images without the background corrected(79%).Improvements in our RSA phenotyping pipeline significantly reduced overestimation of the root traits influenced by the number of root ***-wide association studies conducted on the root phenotypic data and quantitative gene expression analysis of candidate genes resulted in the identification of 3 putative positive regulators of root system depth,total root length and surface area,and root system volume and surface area of thicker roots(DOF1-like zinc finger transcription factor,protein of unknown function,and C2H2 zinc finger protein).We also identified a putative negative regulator(gibberellin 20 oxidase 3)of the total number of lateral roots.

关键词： Python Root submerged

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汉语词汇识别的声调时长效应

心理与行为研究 2019年第1期17卷 24-30页

作者：于秒丁潼飞教育部人文社会科学重点研究基地天津师范大学心理与行为研究院天津300074 北京外国语大学中国语言文学学院北京100089

通过两个实验探讨声调时长在汉语词汇识别中的作用。实验1从声学角度探讨了汉语四个声调的时长差异。研究发现,汉语四个声调中,上声调长最长,去声调长最短,阴平和阳平调长无差异。实验2采用词性判断任务,考察汉语上声调长和去声调长在... 详细信息

通过两个实验探讨声调时长在汉语词汇识别中的作用。实验1从声学角度探讨了汉语四个声调的时长差异。研究发现,汉语四个声调中,上声调长最长,去声调长最短,阴平和阳平调长无差异。实验2采用词性判断任务,考察汉语上声调长和去声调长在词汇识别中的时长差异。研究发现,低频词条件下,上声词的反应时长于去声词的反应时。研究结论支持内隐韵律假说。

关键词：词汇识别声调时长内隐韵律

Proteomics-Based Analysis of Phalaenopsis amabilisin Response toward CymbidiumMosaic Virus and/or OdontoglossumRingspot Virus Infection

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American Journal of Plant Sciences 2013年第9期4卷 1853-1862页

作者： tongfei Lai Yanfu Deng Pengchen Zhang Zhijuan Chen Feng Hu Qi Zhang Yihua Hu Nongnong Shi Research Centre of Plant Signaling School of Life and Environmental Sciences Hangzhou Normal University Hangzhou China.

Stress response at the protein level to viral infection in orchid plants has not been extensively investigated to date. To understand the proteomic basis of Phalaenopsis amabilis’s responses to Cymbidium Mosaic virus (CymMV), and/or Odontoglossum ring spot virus (ORSV), the total proteins were extracted from Phalaenopsis amabilis leaves infected with CymMV, ORSV, or both respectively. Differentially expressed proteins were identified by two-dimensional electrophoresis, and 27 of these proteins that had significant changes were further examined by mass spectrometry. Comparing CymMV-infected leaves with mock-inoculated ones, 2 proteins were significantly up-regulated, 9 were significantly down-regulated and 1 previously undetected protein was identified. 10 proteins were significantly up-regulated, 3 significantly down-regulated and 1 previously undetected protein was identified in ORSV-infected leaves. 6 proteins were significantly up-regulated and 9 significantly down-regulated proteins were found in co-infected leaves. These identified proteins are involved in disease resistance, stress response, transcriptional regulation, energy metabolism, protein modification and the previously unknown proteins were not involved with known protein pathways. Proteins significantly up-regulated were ATP sulfurylase, down-regulated proteins included glutamate decarboxylase isozyme 2, RNA polymerase alpha subunit and chloroplastic peptide deformylase 1A were proteins with similar alteration trend after all infection treatments. Significantly up-regulated were Thioredoxin H-type and down-regulated Cytosolic phosphoglycerate kinase I which were proteins that have been shown to be specifically regulated by the infection with CymMV. Significantly up-regulated were proteins like Rubisco large subunit, Triosephosphate isomerase, NADP-specific isocitrate dehydrogenase and Cinnamoyl CoA reductase CCR2 by the infection of ORSV. Protein regulation in coinfected leaves followed a pattern simi

关键词： Phalaenopsis amabilis Two-Dimensional Electrophoresis Mass Spectrometry Cymbidium Mosaic Virus Odontoglossum Ringspot Virus

区域新能源电力系统AGC调频容量实时评估方法

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电力系统及其自动化学报 2023年第11期35卷 43-49页

作者：崔童飞李晓明王硕于腾凯刘茂国网河北省电力有限公司电力科学研究院石家庄050021 智能电网教育部重点实验室(天津大学) 天津300072

针对高比例可再生能源接入下电力系统惯量水平持续降低、弱频率调节能力会危及电网安全运行等问题,提出一种区域新能源电力系统自动发电控制AGC(automatic generation control)调频容量实时评估方法,以确定控制区的AGC调频能力分析需求... 详细信息

针对高比例可再生能源接入下电力系统惯量水平持续降低、弱频率调节能力会危及电网安全运行等问题,提出一种区域新能源电力系统自动发电控制AGC(automatic generation control)调频容量实时评估方法,以确定控制区的AGC调频能力分析需求。首先,依据AGC调频容量考核标准,梳理调频容量的主要影响因素,并获取调频容量、调频标准差与调频表现间的联系。其次,综合应用传统机组、负荷、新能源、联络线历史数据,基于极限学习机ELM(extreme learning machine)模型预测调频标准差,利用调频表现达标概率分布确定区域电力系统的调频容量。最后,以河北某电网为例进行AGC调频容量的评估,验证了所提方法AGC调频容量更小,调频表现更优,具有更好的安全性和经济性。

关键词：调频技术极限学习机电力系统自动发电控制

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干线公路交叉口路段车辙成因及对策研究

现代交通技术 2021年第3期18卷 7-13页

作者：崔同飞陈涛孙璋贵州省黔西公路管理段贵州黔西551500 苏交科集团股份有限公司南京211100

干线公路交叉口路段车辙“屡坏屡修”已成为干线公路建设和养护工作中的痛点。以江苏省干线公路为研究对象,从交叉口路段车辙发生层位、交通量、车辙现状及发展速率角度,对干线公路交叉口路段车辙现状进行分析。结果表明,江苏省干线公... 详细信息

干线公路交叉口路段车辙“屡坏屡修”已成为干线公路建设和养护工作中的痛点。以江苏省干线公路为研究对象,从交叉口路段车辙发生层位、交通量、车辙现状及发展速率角度,对干线公路交叉口路段车辙现状进行分析。结果表明,江苏省干线公路交叉口以双层AC结构为主,车辙变形层位主要是下面层,交叉口车辙发展速率是一般路段的两倍。交叉口路段双层AC结构、货车比例大、车速慢、频繁启停、温度场高均是导致车辙快速发展的重要因素。对交叉口抗车辙优化结构进行有限元仿真分析,得出优化结构Ⅰ竖向压应变和水平剪应力较好,且工程应用效果较好,建议干线公路交叉口路段采用上面层高强SMA-13沥青混合料、下面层高模量半柔性材料或者EME的抗车辙路面结构组合。

关键词：道路工程干线公路交叉口车辙对策