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Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin he Lulu Wang Dongxu Wu Fan tong.huan Zhao Hanmei Li Tao Gong Huile Gao Yang Zhou Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key Laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity Inc. WalthamMA 02451USA School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

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MnO-pillared graphene blocks enabling the ultrastable and ultrafast aqueous zinc ion batteries

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Science China Chemistry 2024年第9期67卷 2930-2940页

作者： Zheng Liu Zhipeng Qiu Zhiyuan Li tong Wei Zhuangjun Fan huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China School of Materials Science and Engineering China University of PetroleumQingdao 266580China

Due to the low cost,high theoretical capacity,and environmental friendliness,manganese-based cathodes are regarded as promising alternatives for aqueous zinc ion batteries(AZIBs).However,the practicality of the zinc-manganese system is faced with great challenges,such as the inevitable structural collapse of the cathode and controversial energy storage ***,we propose a novel concept of spatial deposition mechanism through the addition of MnSO_(4) additives in the Mn O-pillared graphene blocks(G-MnO).The covalent interface between MnO nanoparticles and multilayered graphene nanosheets can construct an in-built micro-electric field,which is beneficial for consecutive electron transfer(in both horizontal and vertical directions).On this basis,the surficial activity of MnO confined in the interlayered nano-space is greatly enhanced and provides enough spatial deposition and subsequent reaction site for MnSO_(4) additives,thus firstly extending the surficial controlled process to stereoscopic space,effectively improving the electrochemical performance of ***,the assembled Zn//G-Mn O battery exhibits an excellent rate capability of 281.5 mAhg^(-1)at 0.1 A g^(-1)and 106 mAhg^(-1)at 20 Ag^(-1),and impressive cycling stability(93 mAhg^(-1)remaining after 5,000 cycles).This finding may provide a new opportunity for the rational design of surficial controlled energy storage and conversion devices.

关键词： zinc-ion battery manganese monoxide laminated constructure ultrahigh rate performance graphene

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Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis

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Current Medical Science 2024年第2期44卷 281-290页

作者： Xin-tong JI Wen-lei YU Meng-jia JIN Lin-jie LU Hong-ping YIN huan-huan WANG School of Basic Medical Sciences Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou 311121China School of Medicine Chongqing UniversityChongqing 400030China Department of Stomatology Huzhou Wuxing District People's HospitalHuzhou Wuxing District Maternal and Child Health HospitalHuzhou 313008China School of Pharmacy Zhejiang UniversityHangzhou 310030China Department of Stomatology Haining Hospital of Traditional Chinese MedicineJiaxing 314400China

Recent studies have shown that cellular levels of polyamines(PAs)are significantly altered in neurodegenerative *** from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress,mitochondrial metabolism,cellular immunity,and ion channel *** of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative ***,in the current work,evidence was collected to determine the possible associations between cellular levels of PAs,and related enzymes and the development of several neurodegenerative diseases,which could provide a new idea for the treatment of neurodegenerative diseases in the future.

关键词： polyamine apoptosis mitochondria neurodegenerative disease

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Study of baryon number transport dynamics and strangeness conservation effects using Ω-hadron correlations

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Nuclear Science and Techniques 2024年第7期35卷 147-156页

作者： Wei-Jie Dong Xiao-Zhou Yu Si-Yuan Ping Xia-tong Wu Gang Wang huan-Zhong huang Zi-Wei Lin Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Department of Physics East Carolina UniversityGreenvilleNC 27858USA

In nuclear collisions at RHIC energies, an excess of Ω hyperons over ■ is observed, indicating that Ω has a net baryon number despite s and s quarks being produced in pairs. The baryon number in Ω may have been transported from the incident nuclei and/or produced in the baryon-pair production of Ω with other types of anti-hyperons such as Ξ. To investigate these two scenarios, we propose to measure the correlations between Ω and K and between Ω and anti-hyperons. We use two versions, the default and string-melting, of a multiphase transport(AMPT) model to illustrate the method for measuring the correlation and to demonstrate the general shape of the correlation. We present the Ω-hadron correlations from simulated Au+Au collisions at ■ =7.7 and 14.6 Ge V and discuss the dependence on the collision energy and on the hadronization scheme in these two AMPT versions. These correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

关键词： Baryon number transport Strangeness conversation Correlation Gluon junction

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Electrostatic Encapsulation of Cobalt Ions into Crystalline Framework Derived Polymer Aerogel:Ultra-light,Pressure Resistant,Hydrophobic,Photothermal Conversion,heat Insulation and Infrared Stealth

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Chinese Journal of Polymer Science 2024年第7期42卷 946-957,I0007页

作者： Yi-Fan Kang Jin-Lu Tang Ming Song Wei Wang Jia-Cheng Ma Zhan-You Ji tong Liu Wen-huan huang China Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China College of New Energy Xi’an Shiyou UniversityXi’an710065China Xi’an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials ScienceNorthwest UniversityXi’an710127China

A variety of electromagnetic wave absorption materials(EMWAs)have been reported,but the integration of powder materials and multifunctional devices should be investigated in-depth to adapt to practical ***,carbon-coated cobalt composites were prepared by adsorbing magnetic metal cations into an anionic crystalline framework through an electrostatic encapsulate *** reflection loss(RL_(min))of-40.49 d B and effective absorption bandwidth(EAB)of 5.36 GHz(RLhe sample *** commercial applications,Co@CN-4 was integrated into sodium carboxymethyl cellulose(CMC)aerogel to create an ultra-lightweight composite aerogel that is compressive resistant and heat-holding while also having photothermal conversion *** hydrophobic modification makes it more widely *** study provides a new strategy for EWAMs to integrate versatility and improve their application prospects.

关键词： Electrostatic incorporation Magnetic nanoparticle Co@CN composites Electromagnetic wave absorbing Metal-organic framework

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Generation of structured light beams with polarization variation along arbitrary spatial trajectories using tri-layer metasurfaces

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Opto-Electronic Science 2024年第5期3卷 1-11页

作者： tong Nan huan Zhao Jinying Guo Xinke Wang Hao Tian Yan Zhang School of Physics Harbin Institute of TechnologyHarbin 150001China Beijing Key Laboratory of Metamaterials and Devices Key Laboratory of Terahertz OptoelectronicsMinistry of EducationBeijing Advanced Innovation Center for Imaging Theory and TechnologyDepartment of PhysicsCapital Normal UniversityBeijing 100048China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Conventionally,the spatially structured light beams produced by metasurfaces primarily highlight the polarization modulation of the beams propagating along the optical axis or the beams'spatial transmission *** particular,along the optical axis,the polarization state is either constant or varies continuously in each output ***,we develop innovative spatially structured light beams with continually changing polarization along any arbitrary spatial transmission *** tri-layer metallic metasurfaces,the geometric characteristics of each layer structure can be adjusted to modulate the phase and polarization state of the incident terahertz(THz)*** beam will converge to the predefined trajectory along several paths to generate a Bessel-like beam with longitudinal polarization *** demonstrate the versatility of the approach by designing two THz-band structured light beams with varying polarization states along the spatial helical transmission *** linear polarization changes and linear polarization to right circular polarization(RCP)and back to linear polarization changes are realized *** experimental results are basically consistent with the simulated *** proposal for arbitrary trajectory structured light beams with longitudinally varying polarization offers a practical method for continuously regulating the characteristics of spatial structured light beams with non-axial *** technique has potential uses in optical encryption,particle manipulation,and biomedical imaging.

关键词： structured light beam tri-layer metallic metasurface longitudinal polarization non-axial transmission

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Efficacy and safety of Yangxue Qingnao Granules in treatment of migraine:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第2期12卷 335-345页

作者： Bo Zhou Gui-Shu Wang Yu-Ning Yao tong Hao huan-Qin Li Ke-Gang Cao Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Infectious Disease Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Institute for Brain Disorders Beijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China

BACKGROUND Yangxue Qingnao Granules(YXQN)is a Chinese patent medicine that has been commonly used in the clinical treatment of *** To assess the efficacy and safety of YXQN alone for the treatment of *** We searched 10 databases to identify relevant randomized controlled trials(RCTs)published before September *** review authors independently searched and screened the literature,extracted the data,and assessed the methodological quality of the studies using criteria from ROB 2.0,and analyzed the data using Review Manager 5.4 *** A total of 12 RCTs including 767 participants with migraine met the selection *** divided these studies into comparisons of YXQN with placebo,routine treatment drugs,and other Chinese patent *** meta-analysis showed the following:(1)Efficacy:The YXQN group outperformed the placebo group[relative risk(RR)=0.29,95%confidence interval(95%CI):0.15–0.43,Pheadache:There was a significant difference between YXQN vs placebo[mean difference(MD)=-1.25,95%CI:-1.60 to-0.90,Pheadache duration:We found great heterogeneity between studies,with no differences between YXQN and placebo(MD=-0.61,95%CI:-1.53 to-0.31,P=0.19)and routine treatment drugs(MD=-0.22,95%CI:-0.89 to 0.46,Pher Chinese patent medicines in reducing headache duration(MD=-1.24,95%CI:-1.70 to-0.77,Pheadache severity:There was no significant difference between YXQN vs placebo(MD=-1.67,95%CI:-3.52 to 0.19,P=0.08),routine treatment drugs(MD=-0.53,95%CI:-2.02 to 0.96,P=0.68),and other Chinese patent medicines(MD=-0.49,95%CI:-2.83 to 1.85,P=0.68).Mild gastrointestinal adverse reactions were reported

关键词： Meta-analysis Migraine Yangxue Qingnao Granules Traditional Chinese patent medicine

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Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve

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Chinese Journal of Integrative Medicine 2024年第8期30卷 729-741页

作者： WANG Yuan ZheNG A-ni YANG huan WANG Qiang DAI Biao WANG Jia-ju WAN Yi-tong LIU Zhi-bin LIU Si-yang College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China Shaanxi Key Laboratory of Acupuncture and Medicine Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine XianyangShaanxi Province712000China Department of Traditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region014040China School of Basic Medical Sciences Xi’an Medical UniversityXi’an710021China

Objective To investigate the effects and mechanisms of olfactory three-needle(OTN)electroacupuncture(EA)stimulation of the olfactory system on cognitive dysfunction,synaptic plasticity,and the gut microbiota in senescence-accelerated mouse prone 8(SAMP8)*** Thirty-six SAMP8 mice were randomly divided into the SAMP8(P8),SAMP8+OTN(P8-OT),and SAMP8+nerve transection+OTN(P8-N-OT)groups according to a random number table(n=12 per group),and 12 accelerated senescence-resistant(SAMR1)mice were used as the control(R1)*** was performed at the Yintang(GV 29)and bilateral Yingxiang(LI 20)acupoints of SAMP8 mice for 4 *** Morris water maze test,transmission electron microscopy,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)staining,Nissl staining,Golgi staining,Western blot,and 16S rRNA sequencing were performed,*** Compared with the P8 group,OTN improved the cognitive behavior of SAMP8 mice,inhibited neuronal apoptosis,increased neuronal activity,and attenuated hippocampal synaptic dysfunction(Phe expression levels of synaptic plasticity-related proteins N-methyl-D-aspartate receptor 1(NMDAR1),NMDAR2B,synaptophysin(SYN),and postsynaptic density protein-95(PSD95)in hippocampus were increased by OTN treatment(Phermore,OTN greatly enhanced the brain-derived neurotrophic factor(BDNF)/cAMP-response element binding(CREB)signaling and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling compared with the P8 group(Phe neuroprotective effect of OTN was attenuated by olfactory nerve *** with the P8 group,OTN had a very limited effect on the fecal microbial structure and composition of SAMP8 mice,while specifically increased the genera Oscillospira and Sutterella(Phe P8-N-OT group showed an abnormal fecal microbiota with higher microbialα-diversity,Firmicutes/Bacter

关键词： Alzheimer's disease olfactory threeneedle electroacupuncture olfactory nerve synaptic plasticity gut microbiota Chinese medicine

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Numerical Study of Two Opposing Weak Polyelectrolyte Brushes by the Self-consistent Field Theory

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Chinese Journal of Polymer Science 2024年第11期 1668-1678页

作者： Bei-Ning Wang huan-Da Ding Zhi-Kuan Chen Chao-Hui tong Department of Physics Ningbo University Ningbo Institute of Northwestern Polytechnical University

The self-consistent field theory(SCFT) was employed to numerically study the interaction and interpenetration between two opposing weak polyelectrolyte(PE) brushes formed by grafting weak PE chains onto the surfaces of two long and parallel columns with rectangularshaped cross-section immersed in a salty aqueous solution. The dependences of the brush heights and the average degree of ionization on various system parameters were also investigated. When the brush separation is relatively large compared with the unperturbed brush height, the degree of interpenetration between the two opposing PE brushes was found to increase with increasing grafting density and bulk degree of ionization. The degree of interpenetration also increases with the bulk salt concentration in the osmotic brush regime. Numerical results further revealed that, at a brush separation comparable to the unperturbed brush height, the degree of interpenetration does not increase further with increasing bulk degree of ionization, bulk salt concentration in the osmotic regime and grafting density. The saturation of the degree of interpenetration with these system parameters indicates that the grafted PE chains in the gap between the two columns retract and tilt in order to reduce the unfavorable electrostatic and steric repulsions between the two opposing PE brushes. Based on salt ion concentrations at the midpoint between the two opposing brushes, a quantitative criterion in terms of the unperturbed brush height and Debye screening length was established to determine the threshold value of the brush separation beyond which they are truly independent from each other.

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Graphene binding on black phosphorus enables high on/off ratios and mobility

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National Science Review 2024年第2期11卷 188-195页

作者： Fanrong Lin Zhonghan Cao Feiping Xiao Jiawei Liu Jiabin Qiao Minmin Xue Zhili Hu Ying Liu huan Lu Zhuhua Zhang Jens Martin Qingjun tong Wanlin Guo Yanpeng Liu Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics Centre for Advanced 2D Materials National University of Singapore School of Physics and Electronics Hunan University Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and MeasurementSchool of PhysicsBeijing Institute of Technology Leibniz Institute für Kristallzüchtung

Graphene is one of the most promising candidates for integrated circuits due to its robustness against short-channel effects, inherent high carrier mobility and desired gapless nature for Ohmic contact, but it is difficult to achieve satisfactory on/off ratios even at the expense of its carrier mobility, limiting its device applications. here, we present a strategy to realize high back-gate switching ratios in a graphene monolayer with well-maintained high mobility by forming a vertical heterostructure with a black phosphorus multi-layer. By local current annealing, strain is introduced within an established area of the graphene, which forms a reflective interface with the rest of the strain-free area and thus generates a robust off-state via local current depletion. Applying a positive back-gate voltage to the heterostructure can keep the black phosphorus insulating, while a negative back-gate voltage changes the black phosphorus to be conductive because of hole accumulation. Then, a parallel channel is activated within the strain-free graphene area by edge-contacted electrodes, thereby largely inheriting the intrinsic carrier mobility of graphene in the on-state. As a result, the device can provide an on/off voltage ratio of >10～3 as well as a mobility of ～8000 cm2V-1s-1at room temperature, meeting the low-power criterion suggested by the International Roadmap for Devices and Systems.

关键词： graphene on/off ratio mobility black phosphorus reflective interface

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