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Cetuximab Combination with Chemotherapy in Advanced Non-Small Cell lung Cancer

Chinese Journal of Cancer Research 2009年第4期21卷 265-271页

作者： Jian-chun Duan lu Yang Jie Wang Jun Zhao Mei-na Wu tong-tong An Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofThoracic Oncology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing100142 China

Objective： To observe the efficacy and safety of cetuximab combined with chemotherapy in advanced non-small-cell lung cancer （NSCLC）, and to investigate the association of status of K-RAS gene mutation and epidermal growth factor receptor （EGFR） genotype with clinical outcome. Methods： Between Jan. 2006 and Sep. 2009, nineteen patients with advanced NSCLC received cetuximab （〉4 weeks） combined with chemotherapy in Department of Thoracic Oncology at Beijing Cancer Hospital. Response, survival and toxicity were retrospectively assessed, epidermal growth factor receptor （EGFR） protein expression was evaluated by ELISA Kit. The status of K-RAS gene mutation was tested by PCR-RFLP and EGFR gene amplification was measured by EGFR fluorescence in situ hybridization （FISH）. Results： Partial response（PR） was observed in 26.3%（5/19） of the patients and stable disease（SD） in 52.6%（10/19）. Median progression free survival（PFS） was 6 months （95% CI： 3.6-8.4）. Median overall survival （MST） and 1-year survival rate（SR） were 10.6 months （95% CI： 6.6-14.6） and 47.6%, respectively. Mild or moderate skin rash was the most common toxicity related with cetuximab. K-RAS gene mutation, EGFR protein level and amplification have little correlation with prognosis. Conclusion： Cetuximab combined with chemotherapy was tolerable and the skin rash related with cetuximab was mild to moderate. Cetuximab may prolong survival of the patients who failed to previous chemotherapy.

关键词： Cetuximab Advanced non-small-cell lung cancer EGFR gene amplification EGFR protein K-RAS gene mutation

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Insulator-metal transition in CaTiO3 quantum dots induced by ultrafast laser pulses

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Chinese Physics B 2020年第5期29卷 509-515页

作者： tong Liu Hong Zhang Xin-lu Cheng College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of High Energy Density Physics and Technology of Ministry of Education Sichuan UniversityChengdu 610065China

According to time-dependent density functional theory(TDDFT),we study the interactions between ultra-fast laser pulses and two kinds of calcium titanate quantum dots(PCTO-QDs and MCTO-QDs).Under the action of localized field effect,ultrafast laser can induce quantum dots to make the transition from insulator to *** PCTO-QDs are ultimately metallic,while the MCTO-QDs are still insulator after experiencing metal *** is bacause the stability of the unsaturated atoms in the outermost layer of PCTO-QDs is weak and the geometric configuration of MCTO-QDs as a potential well will also reduce the damage of ***,laser waveforms approaching to the intrinsic frequency of quantum dots tend to cause the highest electron levels to cross the Fermi *** this paper,it is reported that the insulating quantum dots can be transformed into metal by adjusting the intensity and frequency of *** importance of local morphology is emphasized by comparing two kinds of *** importantly,it is an important step to identify the potential properties of perovskite materials.

关键词： ultra-fast laser CaTiO3 QDs metallic transformation

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Infrared small target detection based on spatial attention density peaks searching

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Optoelectronics Letters 2025年第2期21卷 90-96页

作者： RAO Junmin lu Siyu LIU Shijian LI Fanming CAS Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics University of Chinese Academy of Sciences Shanghai Institute of Technical Physics Chinese Academy of Sciences School of Information Science and Technology Shanghai Tech University

The detection of small targets poses a significant challenge for infrared search and tracking (IRST) systems,as they must strike a delicate balance between accuracy and *** this paper,we propose a detection algorithm based on spatial attention density peaks searching (SADPS) and an adaptive window selection ***,the difference-of-Gaussians (DoG) filter is introduced for preprocessing raw infrared ***,the image is processed by ***,an adaptive window selection scheme is applied to obtain window templates for the target scale ***,the small target feature is used to enhance the target and suppress the ***,the true targets are segmented through a *** experimental results show that compared with the seven state-of-the-art small targets detection baseline algorithms,the proposed method not only has better detection accuracy,but also has reasonable time consumption.

关键词： Infrared imaging

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Large conversion of energy in dielectric elastomers by electromechanical phase transition

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Acta Mechanica Sinica 2012年第4期28卷 1106-1114页

作者： tong-Qing lu Zhi-Gang Suo State Key Lab for Strength and Vibration of Mechanical Structures International Center of Applied MechanicsSchool of Aerospace EngineeringXi'an Jiaotong University 710049 Xi' an China School of Engineering and Applied Sciences Harvard University CambridgeMA 02138 USA

When air is pumped in, a tubular balloon initially inflates slightly and homogeneously. A short section of the balloon then forms a bulge, which coexists with the unbulged section of the balloon. As more air is pumped in, the bulged section elongates at the expense of the unbulged section, until the entire balloon is bulged. The phenomenon is analogous to the liquid-to-vapor phase transition. Here we study the bulging transition in a dielectric elastomer tube as air is pumped into the balloon and a voltage is applied through the thickness of the membrane. We formulate the condition for coexistent budged and unbulged sections, and identify allowable states set by electrical breakdown and mechanical rupture. We find that the bulging transition dramatically amplifies electromechanical energy conversion. Energy converted in an electromechanical cycle consisting of unbulged and bulged states is thousands of times that in an electromechanical cycle consisting of only unbulged states.

关键词： Dielectric elastomer Bulge Electromechanical energy conversion. Tubular balloon Electromechanical transition

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A meta-analysis of the yield of capsule endoscopy compared to double-balloon enteroscopy in patients with small bowel diseases

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World Journal of Gastroenterology 2007年第32期13卷 4372-4378页

作者： Xiang Chen Zhi-Hua Ran Jin-lu tong Department of gastroenterology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Disease Shanghai 200001 China

AIM:To compare the diagnostic yield of capsule endoscopy (CE) with that of double-balloon enteroscopy (DBE). METHODS:Pubmed,Embase,Elsevier ScienceDirect,the China Academic Journals Full-text Database,and Cochrane Controlled Trials Register were searched for the trials comparing the yield of CE with that of DBE. Outcome measure was odds ratio (OR) of the yield. Fixed or random model method was used for data analysis. RESULTS:Eight studies (n = 277) which prospectively compared the yield of CE and DBE were collected. The results of meta-analysis indicated that there was no difference between the yield of CE and DBE 170/277 vs 156/277,OR 1.21 (95% CI:0.64-2.29). Based on sub analysis,the yield of CE was significantly higher than that of double-balloon enteroscopy without combination of oral and anal insertion approaches 137/219 vs 110/219,OR 1.67 (95% CI:1.14-2.44),P 0.05). A focused meta-analysis of the fully published articles concerning obscure GI bleeding was also performed and showed similar results wherein the yield of CE was significantly higher than that of DBE without combination of oral and anal insertion approaches 118/191 vs 96/191,fixed model:OR 1.61 (95% CI:1.07-2.43),P luSION:With combination of oral and anal approaches,the yield of DBE might be at least as high asthat of CE. Decisions made regarding the initial approach should depend on patient's physical status,technology availability,patient's preferences,and potential for therapeutic endoscopy.

关键词： Capsule endoscopy Double balloon enteroscopy Yield Meta-analysis

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The spatial distribution of dark matter annihilation originating from a gamma-ray line signal

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Research in Astronomy and Astrophysics 2014年第5期14卷 520-526页

作者： tong-Suo lu Tie-Kuang Dong Jian Wu Key Laboratory of Dark Matter and Space Astronomy Purple Mountain Observatory Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

The GeV-TeV -γ-ray line signal is the smoking gun signature of dark matter annihilation or decay. The detection of such a signal is one of the main targets of some space-based telescopes, including Fermi-LAT and the upcoming missions CALET, DAMPE and Gamma-400. An important feature of γ-ray line photons that originate from dark-matter-annihilation is that they are concentrated at the center of the Galaxy. So far, no reliable γ-ray line has been detected by Fermi-LAT, and the upper limits on the cross section of annihilation into ＂y-rays have been reported. We use these upper limits to estimate the ＂maximal＂ number of -y-ray line photons detectable for Fermi- LAT, DAMPE and Gamma-400, and then investigate the spatial distribution of these photons. We show that the center of the distribution will usually be offset from the Galactic center （Sgr A＊） due to the limited statistics. Such a result is almost indepen- dent of models of the dark matter distribution, and will render the reconstruction of the dark matter distribution with the γ-ray line signal very challenging for foreseeable space-based detectors.

关键词： cosmology observations -- cosmology dark matter -- Galaxy center-- instrumentation detectors

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Cloning and sequence analysis of nine novel MYB genes in Taxodiaceae plants

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Journal of Forestry Research 2014年第4期25卷 795-804页

作者： Yong-quan lu Qing JIA Zai-kang tong The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry University

Myeloblastosis （MYB） is one of the largest transcribed factor families in plants. To gain an overall picture of the evolution of MYB genes in relict plants, we cloned nine novel MYB genes in Taxodiaceae plants （ Taxodium distichum, Taxodium ascendens, Cryptomeria japonica var. Sinensis, Cryptomeria japonica cv. Araucarioides, Cryptomer Ja- ponica, Metasequoia glyptostroboides, Cunninghamia lanceolata, Tai- wania cryptomerioides and Glyptostrobus pensilis）. The deduced amino acid sequences for MYBs showed that the nine MYB proteins contained two DNA binding domains. The first domain is from amino acid position 29 to 78, wherein three tryptophanes at 33, 53 and 73 were separated by 19 amino acids, respectively. The second domain is from amino acid position 82 to 127, wherein three tryptophanes at 86, 105 and 124 were separated by 18 amino acids, respectively, whereas the first tryptophane at amino acid position 86 is replaced by a phenylalanine. The characteri- zation of these conserved domains at nine MYBs indicated that they all belong to the R2R3-MYB group. The secondary structure analysis showed that a-helix and 13-turn are the major motifs of the predicted secondary structure of MYBs. The three dimensional model of each MYB protein showed that the structure is like clip, making it more flexi- ble and mobile. The similarities between the nine MYB proteins in Taxodiaceae were calculated. The highest identical value of 99% is be- tween CjsMYB, CjMYB and CjaMYB, whereas the lowest value of 82% is between TaMYB and C1MYB. According to the phylogenetic tree, the distances between different genera were relatively large whereas those within genera were relatively small. As expected, accessions of the same genus formed a subgroup before being grouped with other genera.

关键词： Myeloblastosis Taxodiaceae clone analysis R2R3-MYB group

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Development of amplified consensus genetic markers in Taxodiaceae based on Cryptomeria japonica ESTs data

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Journal of Forestry Research 2013年第3期24卷 503-508页

作者： lu Yong-quan JIA Qing tong Zai-kang The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry University

Amplified consensus genetic marker （ACGM） is a PCR-based marker technique that uses primers designed within conserved regions of coding sequences. After a comparison of Cryptomeria japonica and Arabidopsis ESTs to search for conserved sequences, 237 single e-PCR products were obtained. We randomly selected 110 candidate ACGM markers to test. Of the 110 candidate ACGM markers tested, 106 yielded stable and clear PCR products in C. japonica. We then tested the utility of these 106 primer pairs in 10 species, representing 7 genera of Taxodi- aceae. The number of specific amplification primer pairs among those 10 species varied from 49 to 103 （or 46.2±97.2%）. The 106 primer pairs （ACGM loci） were high transferable to Cryptomeria fortunei Hooibrenk （97.2%） but were low in Metasequoia glyptostroboides （46.2%）. The number of PCR bands per primer pair ranged from 1.06 to 1.15, which means that most of the ACGM primers can obtain a single band within these 10 Taxodiaceae species. In summary, our study shows that ACGM is a technique applicable for marker development even in species with limited sequence data.

关键词： ACGM Taxodiaceae Cryptomeriajaponica EST database

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An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen Zhan RongSheng Wang QuanMing lu San lu XinMin Li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

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Graphdiyene enables ultrafine Cu nanoparticles to selectively reduce CO_(2) to C_(2+)products

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Nano Research 2022年第1期15卷 195-201页

作者： Yong-Bin Chang Chao Zhang Xiu-Li lu Wen Zhang tong-Bu lu Ministry of Education International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Material Science&EngineeringTianjin University of TechnologyTianjin 300384China

Reducing the size of heterogeneous nanocatalysts is generally conducive to improving their atomic utilization and activities in various catalytic ***,this strategy has proven less effective for Cu-based electrocatalysts for the reduction of CO_(2) to multicarbon(O2+)products,owing to the overly strong binding of intermediates on small-sized(luence of graphdiyne on the selectivity of Cu-catalyzed CO_(2) electroreduction,and showcase the prospect for ultrafine Cu NPs catalysts to convert CO_(2) into value-added C_(2+)products.

关键词： electrocatalysis CO_(2)reduction graphdiyne nanofibers ultrafine copper nanoparticles multicarbon products

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