检索结果-南通市图书馆

Journal of Coal Science & Engineering(China) 2011年第4期17卷 397-400页

作者： liU Ting-ting LU Guo-bin tong li-ming School of Mining Liaoning Technical University Fuxin 123000 China

In view of the study on mining transferred from open-pit to underground, the research on the problem of the stabil- ity of slope is less. This article combined the actual situation of the Gaohai Coal Mine in Fuxin City and set up a three-dimensional model of the part of Huizhou open-pit slope by the finite difference software. Through the three-dimensional numerical simulation study of the influence on the stability of slope by underground mining, the basic characteristics of the open-pit slope deformation and the situation of basic stability were discussed. The simulation results of the mining slope of the displacement and deformation analysis of the state for mining provide a reference to the slope stability research.

关键词： numerical simulation slope stability open-pit mine pit mining

Microarray-based identification of tomato microRNAs and time course analysis of their response to Cucumber mosaic virus infection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 116-125页

作者： Qiu-lei LANG Xiao-chuan ZHOU Xiao-lin ZHANG Rafal DRABEK Zhi-xiang ZUO Yong-liang REN tong-bin li Ji-shuang CHEN Xiao-lian GAO College of life Sciences Zhejiang University Hangzhou 310058 China Institute of Bioengineering Zhejiang Sci- Tech University Hangzhou 310018 China LC Sciences 2575 W. Bellfort Suite 270 Houston ZY 77054 USA Department of Biology and Biochemistry University of Houston Houston TX 77004 USA

A large number of plant microRNAs (miRNAs) are now documented in the miRBase, among which only 30 are for Solanum lycopersicum (tomato). Clearly, there is a far-reaching need to identify and profile the expression of miRNAs in this important crop under various physiological and pathological conditions. In this study, we used an in situ synthesized custom microarray of plant miRNAs to examine the expression and temporal presence of miRNAs in the leaves of tomato plants infected with Cucumber mosaic virus (CMV). Following computational sequence homology search and hairpin structure prediction, we identified three novel tomato miRNA precursor genes. Our results also show that, in accordance with the phenotype of the developing leaves, the tomato miRNAs are differentially expressed at different stages of plant development and that CMV infection can induce or suppress the expression of miRNAs as well as up-regulate some star miRNAs (miRNA*s) which are normally present at much lower levels. The results indicate that developmental anomalies elicited by virus infection may be caused by more complex biological processes.

关键词： Solanum lycopersicum Plant miRNA Cucumber mosaic virus miRNA array miRNA response

Elevated Circulating Levels of Osteopontin Are Associated with Metastasisin Advanced Non-Small Cell Lung Cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2011年第1期23卷 64-68页

作者： Yong liang Hui li bin Hu Xing Chen Jin-bai Miao tong li bin You Qi-rui Chen Yi-li Fu Yang Wang Sheng-cai Hou Department of Thoracic Surgery and Central Laboratory Beijing Key Laboratory of Respiratory and CirculationBeijing Chao-Yang HospitalBeijing Institute of Respiratory MedicineCapital Medical UniversityBeijing 100020China

Objective：To investigate the relationship between postoperative metastasis and circulating levels of osteopontin in non-small cell lung cancer（NSCLC）.Methods：The expression of osteopontin mRNA were detected with RT-PCR *** circulating levels of osteopontin were measured through ELASA in 46 NSCLC cases that had not been received any anti-cancer treatment at the time of *** tissues from fifteen patients with benign pulmonary diseases were studied as control ***：The overall median mRNA expression level of osteopontin was approximately 70-fold higher in tumor tissues than in matched normal lung tissues（P0.001）.Over-expression of osteopontin mRNA was significantly associated with clinical stage（P=0.009）.Advanced disease states had higher circulating level of osteopontin（stage I＋II versus stage III＋VI）.In multivariate analysis,stage was the only independent factor influencing circulating levels of *** patients were followed up for 12 months,2 of the 46 patients with both osteopontin mRNA expression and elevated plasma osteopontin levels had local recurrence and 10 had distant *** was a significant difference in the osteopontin levels between metastasis group and non-metastasis ***：Preoperative plasma levels of osteopontin are significantly associated with post-operative metastasis in advanced NSCLC.

关键词： Osteopontin Non-small cell lung cancer Metastasis Prognosis

多路径下研发对高技术产业增长的差异化驱动效应——基于技术相似度和吸收能力视角的经验解释

在线全文

学校读者我要写书评

暂无评论

系统工程 2016年第8期34卷 93-99页

作者：张同斌李金凯东北财经大学经济学院辽宁大连116025 东北财经大学经济计量分析与预测研究中心辽宁大连116025

基于技术相似度和研发两面性等理论,考察研发直接影响、溢出效应和吸收能力三种路径下,不同分位上和不同区制中研发对高技术产业产出增长的差异化驱动效应。结论认为,随着分位点的增大,在研发要素边际收益递减规律作用下,研发存量对高... 详细信息

基于技术相似度和研发两面性等理论,考察研发直接影响、溢出效应和吸收能力三种路径下,不同分位上和不同区制中研发对高技术产业产出增长的差异化驱动效应。结论认为,随着分位点的增大,在研发要素边际收益递减规律作用下,研发存量对高技术产业产出呈现先增强后减弱的正向影响。各分位上研发投入均呈现出正外部性,但溢出程度较低。高技术产业中技术引进和消化吸收支出分配的结构失衡不利于引进技术的消化吸收和高技术产业的产出增长。门限面板回归的结果显示,在低区制和中区制中随着研发资源的累积,研发的规模效应开始显现,而在研发存量很高的高区制中,高技术生产、研发活动在中心省份的集聚阻碍了溢出效应的发挥。此外,研发推动的技术进步导致技术差距逐步缩小,技术消化吸收对产出增长的影响开始减弱,并且由正转负。

关键词：研发高技术产业驱动效应技术相似度面板分位数模型

在线全文

学校读者我要写书评

暂无评论

儒道文化精神在现代室内设计中的运用

闽江学院学报 2015年第3期36卷 98-105页

作者：童黎彬福州职业技术学院人文系福建福州350108

中国古代建筑思想及装饰风格深深植根于以儒道思想为主干的传统文化精神土壤里;现代室内设计也积极汲取儒家以人为本、和而不同、尚中之道,以及道家师法自然、天人合一等文化精神,巧妙地调动色彩、空间、材料等因素,设计出具有传统文化... 详细信息

中国古代建筑思想及装饰风格深深植根于以儒道思想为主干的传统文化精神土壤里;现代室内设计也积极汲取儒家以人为本、和而不同、尚中之道,以及道家师法自然、天人合一等文化精神,巧妙地调动色彩、空间、材料等因素,设计出具有传统文化底蕴的空间造型。对于现代室内设计来说,儒道文化精神无疑具有重要的借鉴意义。

关键词：儒道思想文化精神以人为本师法自然室内设计

在线全文

学校读者我要写书评

暂无评论

二环己基并18冠6的制备方法

应用化学 2000年第2期17卷 163-164页

作者：童利斌田国新宋崇立清华大学核能技术设计研究院北京102201

For hydrogenation of dibenzo 18 crown 6 the catlalyst RuO 2 on alumina was used instead of reported Pichler ruthenium. The separation and purification processes of the targ et product also have been improved. The meth... 详细信息

关键词：二苯并-18-冠-6 二环乙基并-18冠-6 制备冠醚

BIM模型在适老室内环境智能布局系统设计研究

在线全文

学校读者我要写书评

暂无评论

智能城市 2023年第1期9卷 1-4页

作者：童黎彬福州职业技术学院福建福州350108

在对室内环境进行布局时,由于缺乏对设施空间要求的分析,导致实际布局的时间成本投入较大。文章提出BIM模型在适老室内环境智能布局系统设计研究,将具有高效处理能力的MYCC7Z020-V2核心板作为系统的硬件结构,结合不同的布局阶段,计算有... 详细信息

在对室内环境进行布局时,由于缺乏对设施空间要求的分析,导致实际布局的时间成本投入较大。文章提出BIM模型在适老室内环境智能布局系统设计研究,将具有高效处理能力的MYCC7Z020-V2核心板作为系统的硬件结构,结合不同的布局阶段,计算有效室内空间,以提高有限室内空间利用率为前提,利用BIM模型对室内环境进行布局,在布局过程中引入不同设施之间的组合应用关系,确保有效室内空间满足设施布局需求。结果表明,设计系统在适老布局要求下,室内环境布局的综合评价结果均为0.70以上,与对照组相比具有明显优势。

关键词： BIM模型适老室内环境智能布局布局阶段有效室内空间

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

室内设计中光线与空间的关系研究

湖南城市学院学报（自然科学版） 2016年第3期25卷 45-47页

作者：童黎彬福州职业技术学院福建福州350000

据统计，在引起全球气候变暖的有害物质中，有50％是在建筑的建造和使用过程中产生的，在建筑层面其中的40％是来自于采暖、制冷、通过和照明等来自于人工的室内环境能耗产生的。本文围绕大课题空间与光影的演绎，进一步分析室内设计中... 详细信息

据统计，在引起全球气候变暖的有害物质中，有50％是在建筑的建造和使用过程中产生的，在建筑层面其中的40％是来自于采暖、制冷、通过和照明等来自于人工的室内环境能耗产生的。本文围绕大课题空间与光影的演绎，进一步分析室内设计中光线与空间的存在关系和设计方案，从而做到更加节约型、节能型、低耗型的室内装潢设计。

关键词：空间光影室内设计光线与空间

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming li Jianfeng li Guoliang Chen Tao lin Penghui Zhang Kuileung tong Ningning Chen Shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2