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Functional near-infrared spectroscopy in non-invasive neuromodulation

Neural Regeneration Research 2024年第7期19卷 1517-1522页

作者： Congcong Huo Gongcheng Xu Hui Xie Tiandi Chen Guangjian Shao Jue wang Wenhao Li Daifa wang Zengyong Li Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability National Research Center for Rehabilitation Technical AidsBeijingChina School of Mechatronic Engineering and Automation Foshan UniversityFoshanGuangdong ProvinceChina School of Rehabilitation Engineering Beijing College of Social AdministrationBeijingChina Key Laboratory of Neuro-functional Information and Rehabilitation Engineering of the Ministry of Civil Affairs BeijingChina

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental *** significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural *** r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly ***,advancements in neuroimaging have provided insight into neuromodulation *** near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic *** functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro *** aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer ***,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are *** conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system

关键词： brain-computer interface cerebral neural networks functional near-infrared spectroscopy neural circuit neurofeedback neurological diseases neuromodulation non-invasive brain stimulation transcranial electrical stimulation transcranial electrical stimulation

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Tim4 deficiency reduces CD301b+macrophage and aggravates periodontitis bone loss

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International Journal of Oral Science 2024年第2期16卷 280-292页

作者： Ziming wang Hao Zeng Can wang Jiaolong wang Jing Zhang Shuyuan Qu Yue Han Liu Yang Yueqi Ni Wenan Peng Huan Liu Hua Tang Qin Zhao Yufeng Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhanChina School of Stomatology Nanchang UniversityNanchangChina Institute of Infection and Immunity Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina

Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth *** the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone ***301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone ***,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain *** this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)*** first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA ***,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)*** single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in *** following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis ***,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in ***,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages *** a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.

关键词： period upstream eventually

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Calculation of the energy dependence of fission fragments yields and kinetic energy distributions for neutron-induced ^(235)U fission

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Chinese Physics C 2024年第8期48卷 159-169页

作者： Ya-Ning Han Zheng Wei Yi-Xuan wang Dong-Ying Huo Peng-Qi Zhang Ming Li Jun Ma Kang Wu Yong-Guang Zheng Yuan He Zhi-Yong Deng Tian-Zhi Jiang Xiang-Lin Zhuo Jin Li Yun Zhang Yu Zhang Jun-Run wang Xiao-Dong Su Ze-En yao School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Engineering Research Center for Neutron Application Technology Ministry of EducationLanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China Nuclear Power Institute of China Chengdu 610000China

Fission fragments yields and average total kinetic energy are fundamental nuclear data for nuclear energy applications and the study of nuclear *** fission products,such as ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,serve as burnup monitors,assessing the number of fissions induced by neutrons on ^(235)***,current experimental data for these fission products worldwide are inconsistent,introducing significant uncertainty into related scientific *** this study,we employed the Potential-driving Model to calculate the independent yields of ^(235)U and evaluate its advantages in such ***,we investigated the energy dependence of independent yields to select important ***,we calculated the cumulative yields of ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,and compared them with existing literature data to explore the energy dependence of fission products for ^(235)*** the lack of fission product yield data above 14.8 MeV,we extended our calculated incident neutron energy to 20 MeV,aiming to support future scientific *** Geant4 physical model does not consider the influence of incident neutron energy on the average total kinetic energy of fission fragments;thus,we introduced the excitation function of the total kinetic energy of fission fragments recommended by Madland et al.,which effectively describes the experimental data of the average total kinetic energy of fragments formed in ^(235)U *** this paper,we comprehensively discuss the energy dependence of fission product yields and average total kinetic energy.

关键词： ^(235)U(n f) potential-driving model fission yields kinetic energies energy dependence

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The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： tongyu Zhang Yingxi Zhu Xiaochen wang Danyang Chong Haiquan wang Dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring Health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

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Microscopic Analysis of Cementitious Sand and Gravel Damming Materia

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Fluid Dynamics & Materials Processing 2024年第4期20卷 749-769页

作者： Ran wang Aimin Gong Shanqing Shao Baoli Qu Jing Xu Fulai wang Feipeng Liu College of Water Conservancy Yunnan Agricultural UniversityKunming650201China Tianqi Engineering Consulting Co. Ltd.Kunming650000China Institute of International Rivers and Ecological Security Yunnan UniversityKunming650500China

The mechanical properties of cementitious sand and gravel damming material have been experimentally determined by means of microscopic SEM(Scanning Electron Microscopy)image *** results show that the combination of fly ash and water can fill the voids in cemented sand and gravel test blocks because of the presence of hydrated calcium silicate and other substances;thereby,the compactness and mechanical properties of these materials can be greatly *** every 10 kg/m^(3) increase in the amount of cementitious material,the density increases by about 2%,and the water content decreases by 0.2%.The amount of cementitious material used in the sand and gravel in these tests was 80-110 kg/m^(3),the water-binder ratio was ***,the splitting tensile strength was 1/10 of the compressive strength,and the maximum strength was 7.42 MPa at 90 *** optimal mix ratio has been found to be 50 kg of cement,60 kg of fly ash and 120 kg of water(C50F60W120).The related dry density was 2.6 g/cm^(3),the water content was 6%,and the water-binder ratio was 1.09.

关键词： Cementitious sand gravel material scanning electron microscopy optimal mix ratio maximum strength

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Effect of Nozzle Inclination Angle on Fuel-Air Mixing and Combustion in a Heavy Fuel Engine

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Fluid Dynamics & Materials Processing 2024年第2期20卷 365-382页

作者： Zhigang wang Bin Zheng Peidong Zhao Baoli wang Fanyan Meng Wenke Xu Jian Meng School of Transportation and Vehicle Engineering Shandong University of TechnologyZibo255049China

Heavy-fuel engines are widely used in UAVs(Unmanned Autonomous Vehicles)because of their reliability and high-power *** this study,a combustion model for an in-cylinder direct injection engine has been imple-mented using the AVL FIRE *** effects of the angle of nozzle inclination on fuel evaporation,mixture distribution,and combustion in the engine cylinder have been systematically studied at 5500 r/min and consider-ing full load cruise *** to the results,as the angle of nozzle inclination increases,the maximum combustion explosion pressure in the cylinderﬁrst increases and then it *** the angle of nozzle incli-nation is less than 45°,the quality of the mixture in the cylinder and the combustion performance can be improved by increasing the *** the angle of nozzle inclination is greater than 45°,however,the mixture unevenness increases slightly with the angle,leading to a deterioration of the combustion *** the angle of nozzle inclination is between 35°and 55°,the overall combustion performance of the engine is rela-tively *** the angle of nozzle inclination is 45°,the combustion chamber’s geometry and the cylinder’s airﬂow are well matched with the fuel spray,and the mixture quality is the *** with 25°,the peak heat release rate increases by 20%,and the maximum combustion burst pressure increases by 5.5%.

关键词： Aviation heavy fuel piston engine nozzle inclination angle combustion fuel-air mixing

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Effects of organic fertilizers on organic carbon accumulation in alkalized saline soil and silage maize yield

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 159-168页

作者： Lidong Ji Lei Li Rui wang Xing Xu Fengju Zhang Guilian Mao Teng wang School of Forestry and Prataculture Ningxia UniversityYinchuan750021China School of Agriculture Ningxia UniversityYinchuan750021China School of Ecological Environment Ningxia UniversityYinchuan 750021China School of Life Sciences Ningxia UniversityYinchuan 750021China

To understand the combined effect of organic and chemical fertilizers on soil carbon emissions and carbon balance of a farmland ecosystem,this study investigated the organic fertilizer nitrogen replacing different proportions of chemical fertilizer *** results showed that,compared to F_(100),the O_(15)F_(85) treatment increased the yield and net ecosystem productivity carbon sequestration of silage maize under mild,moderate,and severe salinization levels,as well as the contents of soil organic carbon,microbial carbon,and humin carbon,while reducing plant carbon *** O_(15)F_(85) treatment did not significantly increase soil carbon emissions(CEC),but O_(30)F_(70),O_(45)F_(55) and O_(100) treatments significantly increased *** soil carbon balance analysis showed that the farmland ecosystem was a“sink”for atmospheric CO_(2) under each *** O_(15)F_(85) treatment produced an“excitation effect”to enhance the carbon sink effect of silage maize farmland under mild,moderate and severe salinization levels while maintaining stable production and *** the O_(100) treatment increased the carbon sink of farmland under different salinization levels,the yield was significantly reduced and did not represent practical production *** analysis showed that soil organic carbon components and ecosystem carbon balance were closely related to soil total salt,pH and bulk density,while soil dissolved organic carbon,humus carbon components and carbon emissions were closely related to soil moisture and ***,the purpose of improving the carbon sink of saline-alkali land can be achieved through soil salt inhibition,soil structure remodeling and water supplement and warming regulation,which provides technical and theoretical support for reducing carbon emissions,achieving carbon neutrality and alleviating global warming.

关键词： carbon balance carbon component organic carbon organic substitution saline-alkali land

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Four-birds-with-one-stone:A multifunctional Ti-based material for solar-driven water evaporation

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Nano Research 2024年第5期17卷 4498-4506页

作者： Yannan Li Yaning Sun Dan Zhang Yu Xue Jie wang Nan Zhang Jun wang Jiangwei Zhang Yan Zhao Jun-Jie Liu School of Physical Science and Technology College of Energy Materials and ChemistryInner Mongolia UniversityHohhot 010021China

Sustainable,environmentally friendly and low-energy desalination materials have important research value for the increasing demand of freshwater year by ***,it is a huge challenge to maintain high heat energy transfer efficiency without reducing the heat conversion capacity of specific solar photothermal conversion ***,their efficiency and durability are greatly limited by the problems of seawater corrosion,oil,and bacteria *** now,no related work has been reported to solve all the aforementioned problems via a simple four-birds-with-one-stone ***,a class of multifunctional porous photothermal silver(Ag)modified Ti foams(Tf-TA/Ag series materials)is prepared for the development of advanced solar water evaporation devices,and provides alternative materials for alleviating freshwater crisis and treating *** oil contact angle(OCA)changes from 41°to 180°,which significantly reduces the adhesion of *** addition,Tf-TA2/Ag sample also shows an excellent and sustained antibacterial effect,which maintains above 99.9%of antibacterial rate after repeated 5 *** surface temperature of the Tf-TA2/Ag sample reaches 52.5℃ after simulated sun irradiation for 20 min,which is significantly higher than that of the contact groups(water:36.4℃,Ti foam:38.2℃ and Tf-TA2:40.9℃).The capacity of seawater evaporation and salt removal is enhanced due to the excellent photothermal properties,low reflectance,and uniform heat dissipation *** water production efficiency of Tf-TA2/Ag sample is 1.41 kg·m^(-2)·h^(-1) in artificial seawater and 0.76 kg·m^(-2)·h^(-1) in oily sewage under simulated sun ***,the hydrophilic and oleophobic properties of Tf-TA2/Ag are critical to extracting water from oil/water mixture in diverse water ***,this four-birds-with-one-stone approach provides a new perspective for the improvement of solar seawater desalination performance.

关键词： four-birds-with-one-stone photothermal material antibacterial material antifouling property

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Host-induced gene silencing of the Verticillium dahliae thiamine transporter protein gene(VdThit)confers resistance to Verticillium wilt in cotton

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Journal of Integrative Agriculture 2024年第10期23卷 3358-3369页

作者： Qi wang Guoqiang Pan Xingfen wang Zhengwen Sun Huiming Guo Xiaofeng Su Hongmei Cheng National Key Laboratory of Agricultural Microbiology/Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing100081China Xinjiang Jinfengyuan Seeds Co. Ltd.Aksu 843100China College of Agronomy Hebei Agricultural UniversityBaoding 071001China Institute of Microbiology Applications Xinjiang Academy of Agricultural SciencesUrumqi 830091China

Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant *** molecular breeding technology for the development of cotton varieties with heightened resistance to VW stands out as one of the most efficacious protective *** this study,we successfully generated two stable transgenic lines of cotton(Gossypium hirsutum L.),VdThitRNAi-1 and VdThit-RNAi-2,using host-induced gene silencing(HIGS)technology to introduce double-stranded RNA(dsRNA)targeting the thiamine transporter protein gene(VdThit).Southern blot analysis confirmed the presence of a single-copy insertion in each *** examination showed marked reductions in the colonization and spread of Vd-mCherry in the roots of VdThit-RNAi cotton compared to wild type(WT).The corresponding disease index and fungal biomass of VdThit-RNAi-1/2 also exhibited significant ***-time quantitative PCR(qRT-PCR)analysis demonstrated a substantial inhibition of VdThit expression following prolonged inoculation of VdThit-RNAi *** RNA sequencing(sRNA-Seq)analysis revealed the generation of a substantial number of VdThit-specific siRNAs in the VdThit-RNAi transgenic ***,the silencing of VdThit by the siVdThit produced by VdThit-RNAi-1/2 resulted in the elevated expression of multiple genes involved in the thiamine biosynthesis pathway in *** field conditions,VdThit-RNAi transgenic cotton exhibited significantly enhanced disease resistance and yield compared with *** summary,our findings underscore the efficacy of HIGS targeting VdThit in restraining the infection and spread of Vd in cotton,thereby potentially enabling the development of cotton breeding as a promising strategy for managing VW.

关键词： Verticillium dahliae thiamine transporter host-induced gene silencing(HIGS) RNAi

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The Protective Effects of Flavonoids from Scutellaria Baicalensis Georgi Stems and Leaves on Oligodendrocyte Damage Induced by Aβ_1-42

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Pharmacology & Pharmacy 2024年第1期15卷 1-13页

作者： Tangtang Song Yinhui yao Yazhen Shang Institute of Traditional Chinese Medicine Chengde Medical College Chengde China Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development Hebei Key Laboratory of Nerve Injury and Repair Chengde China

Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ1-42-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ1-42, an injury model was established by subjecting OLN-93 cells to Aβ1-42 exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ1-42. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ1-42-induced damage of OL.

关键词： Flavonoids form the Stem and Leaves of Scutellaria baicalensis Georgi Aβ1-42 Oligodendrocytes Damage

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