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心脏磁共振短轴电影成像影像组学鉴别肥厚型心肌病与健康对照

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上海交通大学学报（医学版） 2024年第1期44卷 79-86页

作者：刘启明卢启帆柴烨子姜萌卜军上海交通大学医学院附属仁济医院心内科上海200127

目的·分析肥厚型心肌病(hypertrophic cardiomyopathy,HCM)患者与健康对照人群的心脏磁共振(cardiac magnetic resonance,CMR)短轴电影(cine)成像影像组学特征差异,并对2类人群进行分类。方法·纳入201.年1.—2021.1.月就诊于上海交... 详细信息

目的·分析肥厚型心肌病(hypertrophic cardiomyopathy,HCM)患者与健康对照人群的心脏磁共振(cardiac magnetic resonance,CMR)短轴电影(cine)成像影像组学特征差异,并对2类人群进行分类。方法·纳入201.年1.—2021.1.月就诊于上海交通大学医学院附属仁济医院心内科的HCM患者1.0例,以2∶1.例随机选取同时期健康对照(healthy control,HC)50例,在放射科医师规范操作下完成CMR检查。通过CVI 42后处理软件完成对入组人员左心室心功能及形态学的测量与评估,主要包括左心室射血分数(left ventricular ejection fraction,LVEF)、舒张末期左心室容积(left ventricular end-diastolic volume,LVEDV)和舒张末期左心室心肌质量(left ventricular end-diastolic mass,LVEDM)。并从CMR短轴电影成像中获取舒张末期心肌区域3D影像组学特征。分析影像组学特征在2类人群中的分布,并构建机器学习模型对2类人群进行分类。结果·共提取3D影像组学特征1.7个。在排除高度一致的特征后采用最小绝对值收敛和选择算子(least absolute shrinkage and selection operator,LASSO)模型进行5折交叉验证后,仍有1.个系数非0的特征;利用K-best方法选择排序靠前的8个用于后续建模分析,其中4个特征在2组人群中差异具有统计学意义(均P<0.05)。随后构建支持向量机(support vector machine,SVM)和随机森林(random forest,RF)模型用于判别2类人群。结果显示:单一特征模型(一阶:熵)最大曲线下面积(area under the curve,AUC)为0.833(95%CI 0.695~0.968);多特征模型(SVM算法)最高准确率为83.3%,其对应的AUC为0.882(95%CI 0.705~0.980)。结论·HCM患者与HC人群在左心室功能和左心室形态上均有显著差异,同时3D心肌影像组学特征也有显著差异。尽管单一特征模型可以鉴别2类人群,但联合多特征构建的模型有更好的分类效果。

关键词：心脏磁共振影像组学肥厚型心肌病电影序列短轴图像

Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 352-360页

作者： Jun-Liang pu Zuo-Tian Huang Yun-Hai Luo {1. Mou Ting-Ting Li Zhong-Tang Li Xu-Fu Wei Zhong-Jun Wu Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Anatomy Basic Medical CollegeChongqing Medical UniversityChongqing 400016China

Background: Hepatic ischemia-reperfusion(I/R) injury(IRI) represents a crucial challenge in liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties. This study aimed to examine whether fisetin mitigates hepatic IRI and examine its underlying mechanisms. Methods: Sham or warm hepatic I/R operated mice were pretreated with fisetin(5, 1. or 20 mg/kg). Hepatic histological assessments, TUNEL assays and serum aminotransferase measurements were performed. An in vitro hypoxia/reoxygenation(H/R) model using RAW264.7 macrophages pretreated with fisetin(2.5, 5 or 1. μmol/L) was also used. Serum and cell supernatant concentrations of interleukin-1.β(IL-1.β), IL-1. and tumor necrosis factor-α(TNF-α) were determined by enzyme-linked immunosorbent assay(ELISA). Protein levels of p-GSK3 β, p-AMPK and NLR family pyrin domain-containing 3(NLRP3)-associated proteins were detected by Western blotting. Results: Compared with the I/R group, fisetin pretreatment reduced pathological liver damage, serum aminotransferase levels, serum concentrations of IL-1.β, IL-1. and TNF-α in the murine IRI model. Fisetin also reduced the expression of NLRP3 inflammasome-associated proteins(NLRP3, cleaved caspase-1. IL-1.β and IL-1.) in I/R-operated liver. The experiments in vitro showed that fisetin decreased the release of IL-1.β, IL-1. and TNF-α, and reduced the expression of NLRP3 inflammasome-associated proteins in H/R-treated RAW264.7 cells. Moreover, fisetin increased the expressions of p-GSK3 β and p-AMPK in both models, indicating that its anti-inflammatory effects were dependent on GSK3 β/AMPK signaling. The antiinflammatory effects of fisetin were partially inhibited by the AMPK specific inhibitor compound C. Conclusions: Fisetin showed protective effects against hepatic IRI, countering inflammatory responses through mediating the GSK3 β/AMPK/NLRP3 inflammasome pathway.

关键词： Fisetin Hepatic ischemia-reperfusion injury GSK3βAMPK NLRP3

Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

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Chinese Journal of Polymer Science 2019年第6期37卷 560-569页

作者： Juan Du Ji-Hu Wang Hai-Yan Yu Yan-Yan Zhang Li-Hui pu Jin-Cheng Wang Shu-Yang Lu Si-Hao Chen {1.-He Zhu College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai Institute of Cardiovascular Disease Department of Cardiovascular Surgery Zhongshan Hospital Fudan University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Electrospun nanofibrous mats represent a new generation of medical textiles with promising applications in heart valve tissue reconstruction. It is important for biomaterials to mimic the biological and mechanical microenvironment of native extracellular matrix(ECM). However, the major challenges are still remaining for current biomedical materials, including appropriate mechanical properties,biocompatibility, and hemocompatibility. In the present work, the novel composite nanofibrous mats of poly(p-dioxanone)(PDO) and poly(ester-urethane)ureas(PEUU) are fabricated by electrospinning system. The optimal combination ratio of PDO to PEUU may balance the mechanical properties and cellular compatibility to match the newly formed tissue. In PDO/PEUU composite nanofibrous mats, PEUU can provide the biomimetic elastomeric behavior, and PDO could endow the excellent biocompatibility. In comparison to nanofibrous mat of neat PDO, the composite showed significantly improved mechanical properties, with 5-fold higher initial elongation at ***, human umbilical vein endothelial cells(HUVECs) were cultured on the composite to evaluate its ability to rapidly endothelialize as heart valve tissue engineering. The results revealed that PDO/PEUU composite nanofibrous mats could promote cell adhesion and proliferation, especially for the ratio of 60/40. Overall, PDO/PEUU composite nanofibrous mats(60/40) show the excellent mechanical properties, appropriate biocompatibility and hemocompatibility which meet the necessary norm for tissue engineering and may be suitable for potential heart valve tissue reconstruction.

关键词： Poly(p-dioxanone) Poly(ester-urethane)ureas Electrospinning Composite nanofiber Tissue engineering

Antibiotic exposure perturbs the bacterial community in the small brown planthopper Laodelphax striatellus

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Insect Science 2020年第5期27卷 895-907页

作者： Xu Zhang tong-{1. Li Chun-Ying Zhou Dian-Shu Zhao Yu-Xi Zhu Xiao-Li Bing Hai-Jian Huang Xiao-Yue Hong Department of Entomology Nanjing Agricultural UniversityNanjingChina

Bacteria symbionts in herbivores play an important role in host biology and ecology,and are affected by environmental factors such as temperature,diet,habitat,antibiotics and so ***,the effects of antibiotics on the microbiome of the small brown planthopper Laodelphax striatellus(SBPH)remain ***,we studied the effects of tetracycline on the diversity and composition of bacterial colonies in different tissues of SBPH using high throughput sequencing of 1.S ribosomal RNA *** results show that Proteobacteria,Firmicutes,Bacteroidetes,Actinobacteria were most abundant in SBPH,and the genera Asaia and Wolbachia were most abundant in all body parts of *** treatment had persistent effects on the composition of the SBPH *** depleted the population of Firmicutes,Bacteroidetes,Tenericutes and Fusobacteria,and nearly 1.0%eliminated Wolbachia,Bacteroides and Abiotrophia in ***,these results suggest that antibiotic exposure affects the bacteria symbionts of different body parts in SBPH and will facilitate future studies of the bacterial symbionts of arthropod hosts.

关键词： antibiotics gut Laodelphax striatellus microbial structure ovary

Propagation of Coherent Gaussian Schell-Model Beam Array in a Misaligned Optical System

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Chinese Physics Letters 2011年第5期28卷 117-119页

作者： ZHOU pu WANG Xiao-Lin MA Yan-Xing MA Hao-{1. XU Xiao-Jun LIU Ze-Jin College of Optoelectric Science and Engineering National University of Defense TechnologyChangsha 410073

Based on a generalized Collins formula,the analytical formula for the propagation property of coherent Gaussian Schell-rnodel(GSM)beam array through a misaligned optical system is *** numerical examples,the propagation of a coherent GSM beam array in a typical misaligned optical system with a thin lens is *** influence of different misalignment parameters is calculated and the normalized-intensity distribution is graphically illustrated.

关键词： coherent Gaussian system

Low dimensional modules over quantum complete intersections in two variables

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Frontiers of Mathematics in China 2019年第2期14卷 449-474页

作者： Hanyang YOU pu ZHANG School of Mathematical Sciences Shanghai Jiao Tong University Shanghai 200241 China

We classify all the indecomposable modules of dimension ≤ 5 over the quantum exterior algebra k(x, y)/(x^2, y^2, xy + qyx) in two variables, and all the indecomposable modules of dimension ≤3 over the quantum complete intersection k(x,y)/(x^m,y^n,xy + qyx) in two variables, where m or n ≥3, by giving explicitly their diagram presentations.

关键词： Quantum ext erior algebra quantum comple te int ersection diagram presentation of a module

Objective Triangle Functors in Adjoint Pairs

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Algebra Colloquium 2017年第4期24卷 639-646页

作者： pu Zhang Lin Zhu School of Mathematics Shanghai Jiao Tong University Shanghai 200240 China

An additive functor F： A→B between additive categories is objective if any morphism f in A with F（f） = 0 factors through an object K with F（K） = 0. We consider when a triangle functor in an adjoint pair is objective. We show that a triangle functor is objective provided that its adjoint （whatever left adjoint or right adjoint） is full or dense. We Mso give an example to show that the adjoint of a faithful triangle functor is not necessarily objective. In particular, the adjoint of an objective triangle functor is not necessarily objective. This is in contrast to the well-known fact that the adjoint of a triangle functor is always a triangle functor. Also, for an arbitrary a^tjoint pair （F, G） between categories which are not necessarily additive, we give a sufficient and necessary condition such that F （resp., G） is full or faithful.

关键词： adjoint pair objective triangle functor unit and counit

Impedance Analysis of Forging Process and Strategy Study on Compliance for Forging Manipulator

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Chinese Journal of Mechanical Engineering 2013年第4期26卷 651-658页

作者： ZHANG pu YAO Zhenqiang DU Zhengchun State Key Lab of Mechanical System and Vibration Shanghai Jiao Tong University

In the field of heavy forging, there are numerous researches on deformation rule in forging process by FEM simulation, however, not many scholars take the equipment constraint and the mutual reaction load between the forging manipulator clamp and the forging blank into account, which will impact on safety of manipulator body and quality of forging blank. This paper presents an impedance model to describe the load and formulates compliance strategies correspondingly to reduce the mutual reaction load for forging manipulator. Firstly, an FEM model of forging process is built. Meanwhile, the clamp of forging manipulator is added to the model as movement constraint and interaction part between the manipulator and the forming process. Secondly, a typical forging process is simulated by changing the movement constraint, and then an impedance model is established to describe the relationship between the load and movement constraint. Finally, two kinds of compliance strategies are formulated according to the impedance model, one is called free compliance, and the other is initiative/passive compliance. The simulation results show that compliance strategies reduce the load amounting to 5 000 kN in z direction between the manipulator clamp and the forging blank obviously, which may lead to serious accidents, such as the capsizing of forging manipulator, the fracture of manipulator clamp, and so on. The proposed research simulates the more real forging process, gets the initiative/passive compliance strategy which is more simple and suitable to the real producing and better for forming a forging process planning and control system in the modern production, and improves the quality and efficiency of heavy forging.

关键词： forging impedance compliance manipulator

Electroacupuncture Improves Blood-Brain Barrier and Hippocampal Neuroinflammation in SAMP8 Mice by Inhibiting HMGB1.TLR4 and RAGE/NADPH Signaling Pathways

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Chinese Journal of Integrative Medicine 2023年第5期29卷 448-458页

作者： WANG Yuan WANG Qiang LUO Di ZHAO pu ZHONG Sha-sha DAI Biao WANG Jia-ju WAN Yi-{1. LIU Zhi-bin YANG Huan College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province(712046)China Department of Traditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region(014040)China

Objective: To investigate the molecular mechanisms underlying the beneficial effect of electroacupuncture(EA) in experimental models of Alzheimer’s disease(AD) in vivo. Methods: Senescenceaccelerated mouse prone 8(SAMP8) mice were used as AD models and received EA at Yingxiang(LI 20, bilateral) and Yintang(GV 29) points for 20 days. For certain experiments, SAMP8 mice were injected intravenously with human fibrin(2 mg). The Morris water maze test was used to assess cognitive and memory abilities. The changes of tight junctions of blood-brain barrier(BBB) in mice were observed by transmission electron microscope. The expressions of fibrin, amyloid-β(Aβ), and ionized calcium-binding adapter molecule 1.IBa-1. in mouse hippocampus(CA1.CA3) were detected by reverse transcription-quantitative polymerase chain reaction(qRT-PCR), Western blot or immunohistochemical staining. The expression of fibrin in mouse plasma was detected by enzyme-linked immunosorbent assay. The expressions of tight junction proteins zonula occludens-1.and claudin-5 in hippocampus were detected by qRT-PCR and immunofluorescence *** of hippocampal neurons was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) staining. Results: Fibrin was time-dependently deposited in the hippocampus of SAMP8mice and this was inhibited by EA treatment(P1.. Furthermore, EA treatment suppressed the accumulation of Aβ in the hippocampus of SAMP8 mice(P1., which was reversed by fibrin injection(P1.. EA improved SAMP8 mice cognitive impairment and BBB permeability(P1..Moreover, EA decreased reactive oxygen species levels and neuroinflammation in the hippocampus of SAMP8mice, which was reversed by fibrin injection(P1.. Mechanistically, EA inhibited the promoting effect of fibrin on the high mobility group box protein 1.HMGB1./toll-like receptor 4(TLR4) and receptor for advanced glycation end products(RAGE)/nicoti

关键词： electroacupuncture fibrin/amyloid-βdeposition high mobility group box protein 1.toll-like receptor 4 receptor for advanced glycation end products/nicotinamide adenine dinucleotide phosphate Chinese medicine