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Esophageal cancer screening,early detection and treatment:Current insights and future directions

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-Tao Qu Qing Li Liang Hao Yan-Jing Ni Wen-Yu Luan Zhe Yang Xiao-Dong chen tong-tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

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Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

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Journal of Pharmaceutical Analysis 2024年第6期14卷 926-929页

作者： Shiyu chen Yuxuan Li Yingrui Zhang Hongren Yao tong Xu Yi Zhang Jin-Ming Lin Xian-Li Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing100084China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China

Microneurovascular units(mNVUs),comprising neurons,micro-glia,and blood-brain barrier(BBB)endothelial cells,are pivotal to the central nervous system and are associated with cerebral hypoxia and brain *** hypoxia triggers microglial overactivity,causing inflammation,neuronal injury,and disruption of the BBB[1].Salidroside(Sal),a key compound in Tibetan medicine Rhodiola crenulata,mitigates hypoxia-induced metabolic disorders and neuronal damage by preserving mitochondrial function[2].

关键词： injuries preserving Tibetan

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Single-crystalline hole-transporting layers for efficient and stable organic light-emitting devices

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Light(Science & Applications) 2024年第7期13卷 1341-1353页

作者： Gao-Da Ye Ran Ding Su-Heng Li Lei Ni Shu-Ting Dai nian-Ke chen Yue-Feng Liu Runda Guo Lei Wang Xian-Bin Li Bin Xu Jing Feng State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin Street130012 ChangchunChina. State Key Laboratory of Supermolecular Structures and Materials The Institute of Theoretical ChemistryJilin University2699 Qianjin Street130012 ChangchunChina. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology430074 WuhanChina

Efficient charge-carrier injection and transport in organic light-emitting devices(OLEDs)are essential to simultaneously achieving their high efficiency and long-term ***,the charge-transporting layers(CTLs)deposited by various vapor or solution processes are usually in amorphous forms,and their low charge-carrier mobilities,defectinduced high trap densities and inhomogeneous thickness with rough surface morphologies have been obstacles towards high-performance ***,organic single-crystalline(SC)films were employed as the hole-transporting layers(HTLs)instead of the conventional amorphous films to fabricate highly efficient and stable *** highmobility and ultrasmooth morphology of the SC-HTLs facilitate superior interfacial characteristics of both HTL/electrode and HTL/emissive layer interfaces,resulting in a high Haacke’s figure of merit(FoM)of the ultrathin top electrode and low series-resistance joule-heat loss ratio of the ***,the thick and compact SC-HTL can function as a barrier layer against moisture and oxygen *** a result,the SC-OLEDs show much improved efficiency and stability compared to the OLEDs based on amorphous or polycrystalline HTLs,suggesting a new strategy to developing advanced OLEDs with high efficiency and high stability.

关键词： crystalline amorphous charge

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Urban growth scenario projection using heuristic cellular automata in arid areas considering the drought impact

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Journal of Arid Land 2024年第4期16卷 580-601页

作者： TANG Xiaoyan FENG Yongjiu LEI Zhenkun chen Shurui WANG Jiafeng WANG Rong TANG Panli WANG Mian JIN Yanmin tong Xiaohua College of Surveying&Geo-Informatics Tongji UniversityShanghai 200092China Shanghai Key Laboratory of Space Mapping and Remote Sensing for Planetary Exploration Tongji UniversityShanghai 200092China

Arid areas with low precipitation and sparse vegetation typically yield compact urban pattern,and drought directly impacts urban site selection,growth processes,and future *** simulation and projection based on cellular automata(CA)models is important to achieve sustainable urban development in arid *** developed a new CA model using bat algorithm(BA)named bat algorithm-probability-of-occurrence-cellular automata(BA-POO-CA)model by considering drought constraint to accurately delineate urban growth patterns and project future scenarios of Urumqi City and its surrounding areas,located in Xinjiang Uygur Autonomous Region,*** calibrated the BA-POO-CA model for the drought-prone study area with 2000 and 2010 data and validated the model with 2010 and 2020 data,and finally projected its urban scenarios in *** results showed that BA-POO-CA model yielded overall accuracy of 97.70%and figure-of-merits(FOMs)of 35.50%in 2010,and 97.70%and 26.70%in 2020,*** inclusion of drought intensity factor improved the performance of BA-POO-CA model in terms of FOMs,with increases of 5.50%in 2010 and 7.90%in 2020 than the model excluding drought intensity *** suggested that the urban growth of Urumqi City was affected by drought,and therefore taking drought intensity factor into account would contribute to simulation *** BA-POO-CA model including drought intensity factor was used to project two possible scenarios(i.e.,business-as-usual(BAU)scenario and ecological scenario)in *** the BAU scenario,the urban growth dominated mainly in urban fringe areas,especially in the northern part of Toutunhe District,Xinshi District,and Midong *** exceptional and extreme drought areas as a spatial constraint,the urban growth was mainly concentrated in the"main urban areas-Changji-Hutubi"corridor urban pattern in the ecological *** results of this research can help to adjust urban planning and development *** mode

关键词： bat algorithm cellular automata(CA) probability-of-occurrence drought intensity algorithm-probability-of-occurrence-cellular automata(BA-POO-CA)model arid areas

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Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： Ming-Da Wang chen Yuan Ke-Chun Wang Nan-Ya Wang Ying-Jian Liang Hong Zhu Xiang-Min tong Tian Yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of Clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RSGB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RSGB group exhibited a significantly lower MFI score(P<0.05)compared to the control group,indicating improved fatigue ***,the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(P<0.05).Subgroup analyses among patients receiving various antitumor treatments showed similar *** linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population.

关键词： Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

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Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-tong MA Hai-Shan chen Yao-Ming SONG Bo-Tao ZHOU Shan-Lei SUN Xin-Guan DU Yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

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TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils

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Neural Regeneration Research 2024年第6期19卷 1375-1384页

作者： tong Shen Guiyun Cui Hao chen Long Huang Wei Song Jie Zu Wei Zhang Chuanying Xu Liguo Dong Yongmei Zhang Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology Xuzhou Medical University NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs Department of Neurology The Affiliated Hospital of Xuzhou Medical University

Microglia-mediated neuroinflammation is considered a pathological feature of Parkinson’s disease. Triggering receptor expressed on myeloid cell-1(TREM-1) can amplify the inherent immune response, and crucially, regulate inflammation. In this study, we found marked elevation of serum soluble TREM-1 in patients with Parkinson’s disease that positively correlated with Parkinson’s disease severity and dyskinesia. In a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease, we found that microglial TREM-1 expression also increased in the substantia nigra. Further, TREM-1 knockout alleviated dyskinesia in a mouse model of Parkinson’s disease and reduced dopaminergic neuronal injury. Meanwhile, TREM-1 knockout attenuated the neuroinflammatory response, dopaminergic neuronal injury, and neutrophil migration. Next, we established an in vitro 1-methyl-4-phenyl-pyridine-induced BV2 microglia model of Parkinson’s disease and treated the cells with the TREM-1 inhibitory peptide LP17. We found that LP17 treatment reduced apoptosis of dopaminergic neurons and neutrophil migration. Moreover, inhibition of neutrophil TREM-1 activation diminished dopaminergic neuronal apoptosis induced by lipopolysaccharide. TREM-1 can activate the downstream CARD9/NF-κB proinflammatory pathway via interaction with SYK. These findings suggest that TREM-1 may play a key role in mediating the damage to dopaminergic neurons in Parkinson’s disease by regulating the interaction between microglia and peripheral neutrophils.

关键词： 1-methyl-4-phenylpyridiniumion dopaminergic neurons infiltration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine microglia neutrophils neuroinflammation Parkinson's disease SYK TREM-1

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Wild soybean(Glycine soja)transcription factor GsWRKY40 plays positive roles in plant salt tolerance

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The Crop Journal 2024年第3期12卷 766-775页

作者： Minglong Li Man Xue Huiying Ma Peng Feng tong chen Xiaohuan Sun Qiang Li Xiaodong Ding Shuzhen Zhang Jialei Xiao Key Laboratory of Agricultural Biological Functional Genes Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Key Laboratory of Soybean Biology of Chinese Education Ministry Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China College of Life Science Leshan Normal UniversityLeshan 614000SichuanChina Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157401HeilongjiangChina

Wild soybean(Glycine soja),a relative of cultivated soybean,shows high adaptability to adverse environmental *** identified and characterized a wild soybean transcription factor gene,GsWRKY40,that promotes plant salt ***40 was highly expressed in wild soybean roots and was up-regulated by salt ***40 was localized in nucleus and demonstrated DNA-binding activities but without transcriptional *** and overexpression of GsWRKY40 altered salt tolerance of Arabidopsis *** understand the molecular mechanism of GsWRKY40 in regulating plant salt resistance,we screened a cDNA library and identified a GsWRKY40 interacting protein GsbHLH92 by using yeast two-hybrid *** physical interaction of GsWRKY40 and GsbHLH92 was confirmed by co-immunoprecipitation(co-IP),GST pull-down,and bimolecular fluorescence complementation(BiFC)***,co-overexpression of GsWRKY40 and GsbHLH92 resulted in higher salt tolerance and lower ROS levels than overexpression of GsWRKY40 or GsbHLH92 in composite soybean plants,suggesting that GsWRKY40 and GsbHLH92 may synergistically regulate plant salt resistance through inhibiting ROS ***-PCR data indicated that the expression level of GmSPOD1 gene encoding peroxidase was cooperatively regulated by GsWRKY40 and GsbHLH92,which was confirmed by using a dual luciferase report system and yeast one-hybrid *** study reveals a pathway that GsWRKY40 and GsbHLH92 collaboratively up-regulate plant salt resistance through impeding GmSPOD1 expression and reducing ROS levels,providing a novel perspective on the regulatory mechanisms underlying plant tolerance to abiotic stresses.

关键词： Wild soybean Transcription factor Salt stress ROS

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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

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Frontiers of Medicine 2024年第2期18卷 327-343页

作者： Niu Qiao Yizhu Lyu Feng Liu Yuliang Zhang Xiaolin Ma Xiaojing Lin Junyu Wang Yinyin Xie Ruihong Zhang Jing Qiao Hongming Zhu Li chen Hai Fang tong Yin Zhu chen Qiang Tian Saijuan chen Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Second Hospital of Dalian Medical UniversityDalian116021China

The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine *** an altered microenvironment is a general cancer hallmark,how APL blasts shape their plasma composition is poorly ***,we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters,proteomes,and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction *** study revealed the two prominent features of the APL plasma,suggesting a possible involvement of APL blasts in modulating plasma *** was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts,and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/***,results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage,which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular ***,our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

关键词： acute promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis treatment

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级配碎石层协调沥青混合料层温度收缩变形行为

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吉林大学学报（工学版） 2024年第4期54卷 1045-1057页

作者：万铜铜汪海年郑文华冯珀楠陈玉张琛长安大学特殊地区公路工程教育部重点实验室西安710064 西安航空学院能源与建筑学院西安710077

为揭示级配碎石基层与沥青混合料面层的温度收缩协调变形规律,本文采用动静态应变采集系统实时获取沥青混合料层的温缩应变,基于PFC6.0 Suite和FLAC3D构建了组合结构连续-离散耦合模型,探究了级配碎石层与沥青混合料层温缩协调变形宏观... 详细信息

为揭示级配碎石基层与沥青混合料面层的温度收缩协调变形规律,本文采用动静态应变采集系统实时获取沥青混合料层的温缩应变,基于PFC6.0 Suite和FLAC3D构建了组合结构连续-离散耦合模型,探究了级配碎石层与沥青混合料层温缩协调变形宏观和细观响应规律。研究结果表明:连续-离散耦合模型与室内试验的吻合度相比连续介质模型高,温缩系数相对误差最大为8.1%;沥青混合料及其组合试件温缩应变-时间关系曲线均呈先快后慢的非线性变化规律,沥青混合料类型及降温温差对级配碎石的约束作用基本无影响;组合试件温缩变形主要发生在前1 h内,沥青混合料层整体由“翘起”状逐渐过渡到“平缓”状;级配碎石层通过颗粒向内挤压运动,使两端松散膨胀及颗粒接触重组来实现与沥青混合料层的协调变形。本文从宏观应变响应与空隙率、配位数及三维组构细观响应揭示温缩协调变形机制,研究结果可为级配碎石基层沥青路面低温抗裂研究提供理论参考。

关键词：道路工程协调变形连续-离散耦合温缩开裂级配碎石细观响应

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